Update on morphea: Part II. Outcome measures and treatment

Journal of the American Academy of Dermatology

Volumn 64, Issue 2, 2011, Pages 231-242

  Fett, Nicole ^a   Werth, Victoria P ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

autoimmune connective tissue disorder; fibrosing disorders; localized scleroderma; morphea; scleroderma; systemic sclerosis

Indexed keywords

BETAMETHASONE DIPROPIONATE; CALCIPOTRIOL; CALCITRIOL; CYCLOSPORIN; GAMMA INTERFERON; IMIQUIMOD; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PENICILLAMINE; STEROID; TACROLIMUS;

ARTICLE; CONTINUING EDUCATION; DISEASE ACTIVITY; DISEASE SEVERITY; ECHOGRAPHY; EVIDENCE BASED MEDICINE; HUMAN; LOCALIZED SCLERODERMA CUTANEOUS ASSESSMENT TOOL; MEDICAL EDUCATION; MORPHEA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PUVA; RARE DISEASE; SCORING SYSTEM; SKIN FIBROSIS; STEROID THERAPY; THERMOGRAPHY; ULTRAVIOLET A RADIATION;

EID: 78751507136     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2010.05.046     Document Type: Review

References (66)

1. N. Hunzelmann, S. Anders, G. Fierlbeck, R. Hein, K. Herrmann, and M. Albrecht Double-blind, placebo-controlled study of intralesional interferon gamma for the treatment of localized scleroderma J Am Acad Dermatol 36 1997 433 435
2. M.M. Hulshof, J.N. Bouwes Bavinck, W. Bergman, A.A. Masclee, L. Heickendorff, and F.C. Breedveld Double-blind, placebo-controlled study of oral calcitriol for the treatment of localized and systemic scleroderma J Am Acad Dermatol 43 2000 1017 1023
3. A. Kreuter, J. Hyun, M. Stucker, A. Sommer, P. Altmeyer, and T. Gambichler A randomized controlled study of low-dose UVA1, medium-dose UVA1, and narrowband UVB phototherapy in the treatment of localized scleroderma J Am Acad Dermatol 54 2006 440 447
4. E.B. Kroft, T.J. Groeneveld, M.M. Seyger, and E.M. de Jong Efficacy of topical tacrolimus 0.1% in active plaque morphea: randomized, double-blind, emollient-controlled pilot study Am J Clin Dermatol 10 2009 181 187
5. V.D. Steen, T.A. Medsger Jr., and G.P. Rodnan D-Penicillamine therapy in progressive systemic sclerosis (scleroderma): a retrospective analysis Ann Intern Med 97 1982 652 659
6. P. Clements, P. Lachenbruch, J. Siebold, B. White, S. Weiner, and R. Martin Inter and intraobserver variability of total skin thickness score (modified Rodnan TSS) in systemic sclerosis J Rheumatol 22 1995 1281 1285
7. J.E. Pope, M. Baron, N. Bellamy, J. Campbell, S. Carette, and I. Chalmers Variability of skin scores and clinical measurements in scleroderma J Rheumatol 22 1995 1271 1276
8. H. Zachariae, P. Bjerring, L. Halkier-Sorensen, L. Heickendorff, and K. Sondergaard Skin scoring in systemic sclerosis: a modification - relations to subtypes and the aminoterminal propeptide of type III procollagen (PIIINP) Acta Derm Venereol 74 1994 444 446
9. A. Kreuter, T. Gambichler, F. Breuckmann, S. Rotterdam, M. Freitag, and M. Stuecker Pulsed high-dose corticosteroids combined with low-dose methotrexate in severe localized scleroderma Arch Dermatol 141 2005 847 852
10. A. Kreuter, T. Gambichler, A. Avermaete, T. Jansen, M. Hoffmann, and K. Hoffmann Combined treatment with calcipotriol ointment and low-dose ultraviolet A1 phototherapy in childhood morphea Pediatr Dermatol 18 2001 241 245
11. M.M. Seyger, F.H. van den Hoogen, T. de Boo, and E.M. de Jong Reliability of two methods to assess morphea: skin scoring and the use of a durometer J Am Acad Dermatol 37 1997 793 796
12. M.M. Seyger, F.H. van den Hoogen, T. de Boo, and E.M. de Jong Low-dose methotrexate in the treatment of widespread morphea J Am Acad Dermatol 39 1998 220 225
13. T. Arkachaisri, S. Vilaiyuk, S. Li, K.M. O'Neil, E. Pope, and G.C. Higgins The localized scleroderma skin severity index and physician global assessment of disease activity: a work in progress toward development of localized scleroderma outcome measures J Rheumatol 36 2009 2819 2829
14. T. Arkachaisri, S. Vilaiyuk, K.S. Torok, and T.A. Medsger Jr. Development and initial validation of the localized scleroderma skin damage index and physician global assessment of disease damage: a proof-of-concept study Rheumatology (Oxford) 49 2010 373 381
15. J. Albrecht, L. Taylor, J.A. Berlin, S. Dulay, G. Ang, and S. Fakharzadeh The CLASI (Cutaneous Lupus Erythematosus Disease Area and Severity Index): an outcome instrument for cutaneous lupus erythematosus J Invest Dermatol 125 2005 889 894
16. F. Zulian, D. Meneghesso, E. Grisan, F. Vittadello, A. Belloni Fortina, and B. Pigozzi A new computerized method for the assessment of skin lesions in localized scleroderma Rheumatology (Oxford) 46 2007 856 860
17. C. Andres, A. Kollmar, M. Mempel, R. Hein, J. Ring, and B. Eberlein Successful ultraviolet A1 phototherapy in the treatment of localized scleroderma: a retrospective and prospective study Br J Dermatol 162 2010 445 447
18. M.A. de Rie, D.N. Enomoto, H.J. de Vries, and J.D. Bos Evaluation of medium-dose UVA1 phototherapy in localized scleroderma with the cutometer and fast Fourier transform method Dermatology 207 2003 298 301
19. N. Birdi, A. Shore, P. Rush, R.M. Laxer, E.D. Silverman, and B. Krafchik Childhood linear scleroderma: a possible role of thermography for evaluation J Rheumatol 19 1992 968 973
20. G. Martini, K.J. Murray, K.J. Howell, J. Harper, D. Atherton, and P. Woo Juvenile-onset localized scleroderma activity detection by infrared thermography Rheumatology (Oxford) 41 2002 1178 1182
21. S.E. Bendeck, and H.T. Jacobe Ultrasound as an outcome measure to assess disease activity in disorders of skin thickening: an example of the use of radiologic techniques to assess skin disease Dermatol Ther 20 2007 86 92
22. H.T. Jacobe, J.J. Leitenberger, and P.R. Bergstresser Understanding clinical trial outcomes: design, analysis, and interpretation Dermatol Ther 20 2007 77 85
23. S.C. Li, and M.S. Liebling The use of Doppler ultrasound to evaluate lesions of localized scleroderma Curr Rheumatol Rep 11 2009 205 211
24. S.C. Li, M.S. Liebling, and K.A. Haines Ultrasonography is a sensitive tool for monitoring localized scleroderma Rheumatology (Oxford) 46 2007 1316 1319
25. K. Hoffmann, U. Gerbaulet, S. el-Gammal, and P. Altmeyer 20-MHz B-mode ultrasound in monitoring the course of localized scleroderma (morphea) Acta Derm Venereol Suppl (Stockh) 164 1991 3 16
26. M. Kerscher, M. Meurer, C. Sander, M. Volkenandt, P. Lehmann, and G. Plewig PUVA bath photochemotherapy for localized scleroderma. Evaluation of 17 consecutive patients Arch Dermatol 132 1996 1280 1282
27. M. Kerscher, M. Volkenandt, C. Gruss, T. Reuther, G. von Kobyletzki, and M. Freitag Low-dose UVA phototherapy for treatment of localized scleroderma J Am Acad Dermatol 38 1998 21 26
28. H. Stege, M. Berneburg, S. Humke, M. Klammer, M. Grewe, and S. Grether-Beck High-dose UVA1 radiation therapy for localized scleroderma J Am Acad Dermatol 36 1997 938 944
29. J. Serup Decreased skin thickness of pigmented spots appearing in localized scleroderma (morphoea). Measurement of skin thickness by 15 MHz pulsed ultrasound Arch Dermatol Res 276 1984 135 137
30. J. Serup Localized scleroderma (morphoea): thickness of sclerotic plaques as measured by 15 MHz pulsed ultrasound Acta Derm Venereol 64 1984 214 219
31. E.B. Kroft, M.C. Creemers, F.H. van den Hoogen, J.B. Boezeman, and E.M. de Jong Effectiveness, side-effects and period of remission after treatment with methotrexate in localized scleroderma and related sclerotic skin diseases: an inception cohort study Br J Dermatol 160 2009 1075 1082
32. L. Weibel, M.C. Sampaio, M.T. Visentin, K.J. Howell, P. Woo, and J.I. Harper Evaluation of methotrexate and corticosteroids for the treatment of localized scleroderma (morphoea) in children Br J Dermatol 155 2006 1013 1020
33. P.G. Fitch, P. Rettig, J.M. Burnham, T.H. Finkel, A.C. Yan, and E. Akin Treatment of pediatric localized scleroderma with methotrexate J Rheumatol 33 2006 609 614
34. D. Cox, G. O'Regan, S. Collins, A. Byrne, A. Irvine, and R. Watson Juvenile localised scleroderma: a retrospective review of response to systemic treatment Ir J Med Sci 177 2008 343 346
35. Y. Uziel, B.M. Feldman, B.R. Krafchik, R.S. Yeung, and R.M. Laxer Methotrexate and corticosteroid therapy for pediatric localized scleroderma J Pediatr 136 2000 91 95
36. M. Kerscher, M. Volkenandt, M. Meurer, P. Lehmann, G. Plewig, and M. Rocken Treatment of localised scleroderma with PUVA bath photochemotherapy Lancet 343 1994 1233
37. M. Kerscher, T. Dirschka, and M. Volkenandt Treatment of localised scleroderma by UVA1 phototherapy Lancet 346 1995 1166
38. A. Morita, K. Kobayashi, I. Isomura, T. Tsuji, and J. Krutmann Ultraviolet A1 (340-400 nm) phototherapy for scleroderma in systemic sclerosis J Am Acad Dermatol 43 2000 670 674
39. J. Grabbe, P. Welker, S. Humke, M. Grewe, E. Schopf, and B.M. Henz High-dose ultraviolet A1 (UVA1), but not UVA/UVB therapy, decreases IgE-binding cells in lesional skin of patients with atopic eczema J Invest Dermatol 107 1996 419 422
40. E.B. Kroft, P.C. van de Kerkhof, M.J. Gerritsen, and E.M. de Jong Period of remission after treatment with UVA-1 in sclerodermic skin diseases J Eur Acad Dermatol Venereol 22 2008 839 844
41. M. El-Mofty, W. Mostafa, S. Esmat, R. Youssef, M. Bousseila, and N. Nagi Suggested mechanisms of action of UVA phototherapy in morphea: a molecular study Photodermatol Photoimmunol Photomed 20 2004 93 100
42. H.T. Jacobe, R. Cayce, and J. Nguyen UVA1 phototherapy is effective in darker skin: a review of 101 patients of Fitzpatrick skin types I-V Br J Dermatol 159 2008 691 696
43. F. Wang, L.A. Garza, S. Cho, R. Kafi, C. Hammerberg, and T. Quan Effect of increased pigmentation on the antifibrotic response of human skin to UV-A1 phototherapy Arch Dermatol 144 2008 851 858
44. C. Gruss, J.A. Reed, P. Altmeyer, N.S. McNutt, and M. Kerscher Induction of interstitial collagenase (MMP-1) by UVA-1 phototherapy in morphea fibroblasts Lancet 350 1997 1295 1296
45. C.J. Gruss, G. Von Kobyletzki, S.C. Behrens-Williams, J. Lininger, T. Reuther, and M. Kerscher Effects of low dose ultraviolet A-1 phototherapy on morphea Photodermatol Photoimmunol Photomed 17 2001 149 155
46. P.G. Sator, S. Radakovic, K. Schulmeister, H. Honigsmann, and A. Tanew Medium-dose is more effective than low-dose ultraviolet A1 phototherapy for localized scleroderma as shown by 20-MHz ultrasound assessment J Am Acad Dermatol 60 2009 786 791
47. N. Usmani, A. Murphy, D. Veale, V. Goulden, and M. Goodfield Photochemotherapy for localized morphoea: effect on clinical and molecular markers Clin Exp Dermatol 33 2008 698 704
48. M. El-Mofty, H. Zaher, M. Bosseila, R. Yousef, and B. Saad Low-dose broad-band UVA in morphea using a new method for evaluation Photodermatol Photoimmunol Photomed 16 2000 43 49
49. M. El-Mofty, W. Mostafa, M. El-Darouty, M. Bosseila, H. Nada, and R. Yousef Different low doses of broad-band UVA in the treatment of morphea and systemic sclerosis Photodermatol Photoimmunol Photomed 20 2004 148 156
50. V. Falanga, and T.A. Medsger Jr. D-penicillamine in the treatment of localized scleroderma Arch Dermatol 126 1990 609 612
51. G. Martini, A.V. Ramanan, F. Falcini, H. Girschick, D.P. Goldsmith, and F. Zulian Successful treatment of severe or methotrexate-resistant juvenile localized scleroderma with mycophenolate mofetil Rheumatology (Oxford) 48 2009 1410 1413
52. N. Roos, N. Poulalhon, D. Farge, I. Madelaine, A. Mauviel, and F. Verrecchia In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil J Pharmacol Exp Ther 321 2007 583 589
53. H. Shimizu, M. Takahashi, S. Takeda, S. Inoue, J. Fujishiro, and Y. Hakamata Mycophenolate mofetil prevents transplant arteriosclerosis by direct inhibition of vascular smooth muscle cell proliferation Transplantation 77 2004 1661 1667
54. R. Gao, Y. Lu, Y.P. Xin, X.H. Zhang, J. Wang, and Y.P. Li The effects of different immunosuppressants on chronic allograft nephropathy by affecting the transforming growth factor-beta and Smads signal pathways Transplant Proc 38 2006 2154 2157
55. C.T. Derk, E. Grace, M. Shenin, M. Naik, S. Schulz, and W. Xiong A prospective open-label study of mycophenolate mofetil for the treatment of diffuse systemic sclerosis Rheumatology (Oxford) 48 2009 1595 1599
56. R.M. Strauss, M. Bhushan, and M.J. Goodfield Good response of linear scleroderma in a child to ciclosporin Br J Dermatol 150 2004 790 792
57. M.P. Crespo, I.B. Mas, J.M. Diaz, A.L. Costa, and I.B. Nortes Rapid response to cyclosporine and maintenance with methotrexate in linear scleroderma in a young girl Pediatr Dermatol 26 2009 118 120
58. R.M. Knobler, L.E. French, Y. Kim, E. Bisaccia, W. Graninger, and H. Nahavandi A randomized, double-blind, placebo-controlled trial of photopheresis in systemic sclerosis J Am Acad Dermatol 54 2006 793 799
59. J.H. Neustadter, F. Samarin, K.R. Carlson, and M. Girardi Extracorporeal photochemotherapy for generalized deep morphea Arch Dermatol 145 2009 127 130
60. M. Dytoc, P.T. Ting, J. Man, D. Sawyer, and L. Fiorillo First case series on the use of imiquimod for morphoea Br J Dermatol 153 2005 815 820
61. M.T. Dytoc, I. Kossintseva, and P.T. Ting First case series on the use of calcipotriol-betamethasone dipropionate for morphoea Br J Dermatol 157 2007 615 618
62. B.B. Cunningham, I.D. Landells, C. Langman, D.E. Sailer, and A.S. Paller Topical calcipotriene for morphea/linear scleroderma J Am Acad Dermatol 39 1998 211 215
63. R. Batchelor, S. Lamb, V. Goulden, G. Stables, M. Goodfield, and W. Merchant Photodynamic therapy for the treatment of morphoea Clin Exp Dermatol 33 2008 661 663
64. S.L. Buckley, S. Skinner, P. James, and R.K. Ashley Focal scleroderma in children: an orthopaedic perspective J Pediatr Orthop 13 1993 784 790
65. N. Hunzelmann, K. Scharffetter Kochanek, C. Hager, and T. Krieg Management of localized scleroderma Semin Cutan Med Surg 17 1998 34 40
66. P.G. Shekelle, S.H. Woolf, M. Eccles, and J. Grimshaw Clinical guidelines: developing guidelines BMJ 318 1999 593 596