메뉴 건너뛰기




Volumn 29, Issue 1, 2011, Pages 23-28

Nociceptin/Orphanin Phenylalanine Glutamine (FQ) Receptor and Cardiovascular Disease

Author keywords

Cerebral ischemia; Nociceptin; Opioids; Signaling; Stroke; Traumatic brain injury

Indexed keywords

NOCICEPTIN ORPHANIN PHENYLALANINE GLUTAMINE; NOCICEPTIN ORPHANIN PHENYLALANINE GLUTAMINE RECEPTOR; RECEPTOR; UNCLASSIFIED DRUG; VASODILATOR AGENT;

EID: 78751486385     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/j.1755-5922.2010.00241.x     Document Type: Review
Times cited : (7)

References (71)
  • 1
    • 0028971215 scopus 로고
    • Orphanin FQ: A neuropeptide that activates an opioid-like G protein-coupld receptor
    • Reinscheid RK, Nothacker HP, Bourson A, et al. Orphanin FQ: A neuropeptide that activates an opioid-like G protein-coupld receptor. Science 1995;270:792-794.
    • (1995) Science , vol.270 , pp. 792-794
    • Reinscheid, R.K.1    Nothacker, H.P.2    Bourson, A.3
  • 3
    • 0028284167 scopus 로고
    • Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta, or kappa opioid receptor type
    • Bunzow JR, Saez C, Mortrud M, Bouvier C, Williams JT, Low M, Grandy DK. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta, or kappa opioid receptor type. FEBS Lett 1994;347:284-288.
    • (1994) FEBS Lett , vol.347 , pp. 284-288
    • Bunzow, J.R.1    Saez, C.2    Mortrud, M.3    Bouvier, C.4    Williams, J.T.5    Low, M.6    Grandy, D.K.7
  • 4
    • 0030614373 scopus 로고    scopus 로고
    • Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro
    • Vaughan CW, Ingram SL, Christie MJ. Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro. J Neurosci 1997;17:996-1003.
    • (1997) J Neurosci , vol.17 , pp. 996-1003
    • Vaughan, C.W.1    Ingram, S.L.2    Christie, M.J.3
  • 5
    • 0032523741 scopus 로고    scopus 로고
    • Modulation of Ca channel currents of acutely dissociated rat periaqueductal grey neurons
    • Connor M, Christie MJ. Modulation of Ca channel currents of acutely dissociated rat periaqueductal grey neurons. J Physiol 1998;509:47-58.
    • (1998) J Physiol , vol.509 , pp. 47-58
    • Connor, M.1    Christie, M.J.2
  • 6
    • 0033821477 scopus 로고    scopus 로고
    • Nociceptin/orphanin FQ and neurotransmitter release in the central nervous system
    • Schlicker E, Morari M. Nociceptin/orphanin FQ and neurotransmitter release in the central nervous system. Peptides 2000;21:1023-1029.
    • (2000) Peptides , vol.21 , pp. 1023-1029
    • Schlicker, E.1    Morari, M.2
  • 7
    • 0031974718 scopus 로고    scopus 로고
    • A new selective antagonist of the nociceptin receptor
    • Guerrini R, Calo G, Rizzi A, et al. A new selective antagonist of the nociceptin receptor. Br J Pharmacol 1998;123:163-165.
    • (1998) Br J Pharmacol , vol.123 , pp. 163-165
    • Guerrini, R.1    Calo, G.2    Rizzi, A.3
  • 8
    • 0142026969 scopus 로고    scopus 로고
    • Peripheral tissue distribution of orphanin FQ precursor mRNA in stroke prone spontaneously hypertensive rats
    • Wei Y, Ouyang D, Liu Y, Chang Z, Tang J, Ding J. Peripheral tissue distribution of orphanin FQ precursor mRNA in stroke prone spontaneously hypertensive rats. Chin Med Sci J 1999;14:67-70.
    • (1999) Chin Med Sci J , vol.14 , pp. 67-70
    • Wei, Y.1    Ouyang, D.2    Liu, Y.3    Chang, Z.4    Tang, J.5    Ding, J.6
  • 10
    • 0031575422 scopus 로고    scopus 로고
    • Nociceptin: An endogenous agonist fro central opioid like 1 (ORL1) receptors possesses system vasorelaxant properties
    • Gumusel B, Hao Q, Hyman A, Chang JK, Kapusta DR, Lippton H. Nociceptin: An endogenous agonist fro central opioid like 1 (ORL1) receptors possesses system vasorelaxant properties. Life Sci 1997;60:PL141-PL145.
    • (1997) Life Sci , vol.60
    • Gumusel, B.1    Hao, Q.2    Hyman, A.3    Chang, J.K.4    Kapusta, D.R.5    Lippton, H.6
  • 11
    • 0034674660 scopus 로고    scopus 로고
    • Vasorelaxant responses to endomorphins, nociceptin, albuterol, and adrenomedullin in rat aorta
    • Hugghins SY, Champion HC, Cheng C, Kadowitz PJ, Jeter JR Jr. Vasorelaxant responses to endomorphins, nociceptin, albuterol, and adrenomedullin in rat aorta. Life Sci 2000;67:471-476.
    • (2000) Life Sci , vol.67 , pp. 471-476
    • Hugghins, S.Y.1    Champion, H.C.2    Cheng, C.3    Kadowitz, P.J.4    Jeter Jr, J.R.5
  • 13
    • 0032583136 scopus 로고    scopus 로고
    • Nociceptin, a novel endogenous ligand for the ORL1 receptor, dilates isolated resistance arteries from the rat
    • Champion HC, Pierce RL, Kadowitz PJ. Nociceptin, a novel endogenous ligand for the ORL1 receptor, dilates isolated resistance arteries from the rat. Regul Pept 1998;78:69-74.
    • (1998) Regul Pept , vol.78 , pp. 69-74
    • Champion, H.C.1    Pierce, R.L.2    Kadowitz, P.J.3
  • 14
    • 0030878302 scopus 로고    scopus 로고
    • Nociceptin, an endogenous ligand for the ORL1 receptor, decreases cardiac output and total peripheral resistance in the rat
    • Champion HC, Czapla MA, Kadowitz PJ. Nociceptin, an endogenous ligand for the ORL1 receptor, decreases cardiac output and total peripheral resistance in the rat. Peptides 1997;18:729-732.
    • (1997) Peptides , vol.18 , pp. 729-732
    • Champion, H.C.1    Czapla, M.A.2    Kadowitz, P.J.3
  • 15
    • 4243325445 scopus 로고    scopus 로고
    • Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ)
    • Kapusta DR, Sezen SF, Chang JK, Lippton H, Kengis VA. Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ). Life Sci 1997;60:PL15-PL21.
    • (1997) Life Sci , vol.60
    • Kapusta, D.R.1    Sezen, S.F.2    Chang, J.K.3    Lippton, H.4    Kengis, V.A.5
  • 16
    • 0030885415 scopus 로고    scopus 로고
    • Effect of nociceptin on heart rate and blood pressure in anesthetized rats
    • Giuliani S, Tramontana M, Lecci A, Maggi CA. Effect of nociceptin on heart rate and blood pressure in anesthetized rats. Eur Pharmacol 1997;333:177-179.
    • (1997) Eur Pharmacol , vol.333 , pp. 177-179
    • Giuliani, S.1    Tramontana, M.2    Lecci, A.3    Maggi, C.A.4
  • 17
    • 0002418273 scopus 로고    scopus 로고
    • Nociceptin receptor activation produces nitric oxide-mediated systemic hypotension
    • Lin B, Waterman R, Lippton H. Nociceptin receptor activation produces nitric oxide-mediated systemic hypotension. Life Sci 2000;66:PL99-PL104.
    • (2000) Life Sci , vol.66
    • Lin, B.1    Waterman, R.2    Lippton, H.3
  • 18
    • 0032439817 scopus 로고    scopus 로고
    • Nitric oxide release mediates vasodilator responses to endomorphin 1 but not nociceptin/OFQ in the hindquarters vascular bed of the rat
    • Champion HC, Bivalacqua TJ, Friedman DE, Zadina JE, Kastin AJ, Kadowitz PJ. Nitric oxide release mediates vasodilator responses to endomorphin 1 but not nociceptin/OFQ in the hindquarters vascular bed of the rat. Peptides 1998;19:1595-1602.
    • (1998) Peptides , vol.19 , pp. 1595-1602
    • Champion, H.C.1    Bivalacqua, T.J.2    Friedman, D.E.3    Zadina, J.E.4    Kastin, A.J.5    Kadowitz, P.J.6
  • 19
    • 34548300014 scopus 로고    scopus 로고
    • Cardiovascular and renal effects of nociceptin/orphanin FQ: A new mediator to target?
    • Doggrell SA. Cardiovascular and renal effects of nociceptin/orphanin FQ: A new mediator to target? Curr Opin Invest Drugs 2007;8:742-749.
    • (2007) Curr Opin Invest Drugs , vol.8 , pp. 742-749
    • Doggrell, S.A.1
  • 20
    • 0032888369 scopus 로고    scopus 로고
    • Nociceptin/orphanin FQ increases blood pressure and heart rate via sympathetic activation in sheep
    • Arndt ML, Wu D, Soong Y, Szeto HH. Nociceptin/orphanin FQ increases blood pressure and heart rate via sympathetic activation in sheep. Peptides 1999;20:465-470.
    • (1999) Peptides , vol.20 , pp. 465-470
    • Arndt, M.L.1    Wu, D.2    Soong, Y.3    Szeto, H.H.4
  • 21
    • 0033811692 scopus 로고    scopus 로고
    • Studies of the cardiovascular effects of nociceptin and related peptides
    • Salis MB, Emanueili C, Milia AF, Guerrini R, Madeddu P. Studies of the cardiovascular effects of nociceptin and related peptides. Peptides 2000;21:985-993.
    • (2000) Peptides , vol.21 , pp. 985-993
    • Salis, M.B.1    Emanueili, C.2    Milia, A.F.3    Guerrini, R.4    Madeddu, P.5
  • 22
    • 0033811694 scopus 로고    scopus 로고
    • Neurohumoral effects of orphanin FQ/nociceptin: Relevance to cardiovascular and renal function
    • Kapusta DR. Neurohumoral effects of orphanin FQ/nociceptin: Relevance to cardiovascular and renal function. Peptides 2000;21:1081-1099.
    • (2000) Peptides , vol.21 , pp. 1081-1099
    • Kapusta, D.R.1
  • 24
    • 0030864569 scopus 로고    scopus 로고
    • Prejunctional modulation by nociceptin of nerve-mediated inotropic responses in guinea pig left atrium
    • Giuliani S, Maggi CA. Prejunctional modulation by nociceptin of nerve-mediated inotropic responses in guinea pig left atrium. Eur J Pharmacol 1997;332:231-236.
    • (1997) Eur J Pharmacol , vol.332 , pp. 231-236
    • Giuliani, S.1    Maggi, C.A.2
  • 25
    • 0031593482 scopus 로고    scopus 로고
    • ORL1 receptor-mediated inhibition by nociceptin of noradrenaline release from perivascular sympathetic nerve endings of the rat tail artery
    • Bucher B. ORL1 receptor-mediated inhibition by nociceptin of noradrenaline release from perivascular sympathetic nerve endings of the rat tail artery. Naunyn Schmiedebergs Arch Pharmacol 1998;358:682-685.
    • (1998) Naunyn Schmiedebergs Arch Pharmacol , vol.358 , pp. 682-685
    • Bucher, B.1
  • 26
    • 0029926668 scopus 로고    scopus 로고
    • Neurochemical modulation of cardiovascular control in the nucleus tractus solitarius
    • Lawrence AJ, Jarrott B. Neurochemical modulation of cardiovascular control in the nucleus tractus solitarius. Prog Neurobiol 1996;48:21-53.
    • (1996) Prog Neurobiol , vol.48 , pp. 21-53
    • Lawrence, A.J.1    Jarrott, B.2
  • 27
    • 0033917938 scopus 로고    scopus 로고
    • Microinjection of nociceptin (orphanin FQ) into nucleus tractus solitarii elevates blood pressure and heart rate in both anesthetized and conscious rats
    • Mao L, Wang JQ. Microinjection of nociceptin (orphanin FQ) into nucleus tractus solitarii elevates blood pressure and heart rate in both anesthetized and conscious rats. J Pharmacol Exp Ther 2000;294:255-262.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 255-262
    • Mao, L.1    Wang, J.Q.2
  • 28
    • 0033594774 scopus 로고    scopus 로고
    • Inhibition of cardiovascular activity following microinjection of novel opioid-like neuropeptide nociceptin (orphanin FQ) into the rat rostral ventrolateral medulla
    • Chu X, Xu N, Li P, Mao L, Wang JQ. Inhibition of cardiovascular activity following microinjection of novel opioid-like neuropeptide nociceptin (orphanin FQ) into the rat rostral ventrolateral medulla. Brain Res 1999;829:134-142.
    • (1999) Brain Res , vol.829 , pp. 134-142
    • Chu, X.1    Xu, N.2    Li, P.3    Mao, L.4    Wang, J.Q.5
  • 29
    • 22144456753 scopus 로고    scopus 로고
    • Microinjections of nociceptin into the nucleus ambiguous elicits tachycardia in the rat
    • Chitravanshi VC, Sapru HN. Microinjections of nociceptin into the nucleus ambiguous elicits tachycardia in the rat. Brain Res 2005;1051:199-204.
    • (2005) Brain Res , vol.1051 , pp. 199-204
    • Chitravanshi, V.C.1    Sapru, H.N.2
  • 30
    • 0141788603 scopus 로고    scopus 로고
    • Glycinergic inputs to cardiac vagal neurons in the nucleus ambiguous are inhibited by nociceptin and μ-selective opioids
    • Venkatesan P, Baxi S, Evans C, Neff R, Wang X, Mendelowitz D. Glycinergic inputs to cardiac vagal neurons in the nucleus ambiguous are inhibited by nociceptin and μ-selective opioids. J Neurophysiol 2003;90:1581-1588.
    • (2003) J Neurophysiol , vol.90 , pp. 1581-1588
    • Venkatesan, P.1    Baxi, S.2    Evans, C.3    Neff, R.4    Wang, X.5    Mendelowitz, D.6
  • 31
    • 0032720276 scopus 로고    scopus 로고
    • Cardiovascular and renal responses produced by central orphanin FQ/nociceptin occur independent of renal nerves
    • Kapusta DR, Kenigs VA. Cardiovascular and renal responses produced by central orphanin FQ/nociceptin occur independent of renal nerves. Am J Physiol 1999;277:R987-R995.
    • (1999) Am J Physiol , vol.277
    • Kapusta, D.R.1    Kenigs, V.A.2
  • 32
    • 0014128266 scopus 로고
    • Direct evidence for neurogenic inflammation and its prevention by denervation and pretreatment with capsaicin
    • Jansco G, Jansco-Gabor A, Szolcsanji J. Direct evidence for neurogenic inflammation and its prevention by denervation and pretreatment with capsaicin. Br J Pharmacol 1967;31:138-151.
    • (1967) Br J Pharmacol , vol.31 , pp. 138-151
    • Jansco, G.1    Jansco-Gabor, A.2    Szolcsanji, J.3
  • 33
    • 33749368966 scopus 로고    scopus 로고
    • Stimulation of sensor neuropeptide release by nociceptin/orphanin FQ leads to hyperaemia in acutely inflamed rat knees
    • Zhang C, McDougall JJ. Stimulation of sensor neuropeptide release by nociceptin/orphanin FQ leads to hyperaemia in acutely inflamed rat knees. Br J Pharmacol 2006;148:938-946.
    • (2006) Br J Pharmacol , vol.148 , pp. 938-946
    • Zhang, C.1    McDougall, J.J.2
  • 34
    • 36148944453 scopus 로고    scopus 로고
    • Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine
    • Brooks ZLS, Stedman E, Guerrini R, Lawton BK, Calo G, Lambert DG. Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine. AJP 2007;293:H2977-H2985.
    • (2007) AJP , vol.293
    • Brooks, Z.L.S.1    Stedman, E.2    Guerrini, R.3    Lawton, B.K.4    Calo, G.5    Lambert, D.G.6
  • 35
    • 0030954560 scopus 로고    scopus 로고
    • Inhibition by nociceptin of neurogenic inflammation and the release of SP and CGRP from sensory nerve terminals
    • Helyes Z, Nemeth J, Pinter E, Szolcsanyi J. Inhibition by nociceptin of neurogenic inflammation and the release of SP and CGRP from sensory nerve terminals. Br J Pharmacol 1997;121:613-615.
    • (1997) Br J Pharmacol , vol.121 , pp. 613-615
    • Helyes, Z.1    Nemeth, J.2    Pinter, E.3    Szolcsanyi, J.4
  • 36
    • 0345055792 scopus 로고    scopus 로고
    • Inhibition of nociceptin on sensory neuropeptide release and mast cell-mediated plasma extravasation in rats
    • Nemeth J, Helyes Z, Oroszi G, Than M, Pinter E, Szolcsanyi J. Inhibition of nociceptin on sensory neuropeptide release and mast cell-mediated plasma extravasation in rats. Eur J Pharmacol 1998;347:101-104.
    • (1998) Eur J Pharmacol , vol.347 , pp. 101-104
    • Nemeth, J.1    Helyes, Z.2    Oroszi, G.3    Than, M.4    Pinter, E.5    Szolcsanyi, J.6
  • 37
    • 0033600515 scopus 로고    scopus 로고
    • ca channel activation
    • ca channel activation. Brain Res 1999;835:315-323.
    • (1999) Brain Res , vol.835 , pp. 315-323
    • Armstead, W.M.1
  • 38
    • 0034011980 scopus 로고    scopus 로고
    • Relationship between nociceptin/orphanin FQ and cerebral hemodynamics following hypoxia/ischemia in piglets
    • Armstead WM. Relationship between nociceptin/orphanin FQ and cerebral hemodynamics following hypoxia/ischemia in piglets. Am J Physiol 2000;278:H477-H483.
    • (2000) Am J Physiol , vol.278
    • Armstead, W.M.1
  • 39
    • 0031659683 scopus 로고    scopus 로고
    • Brain injury in the premature infant: Overview of clinical aspects, neuropathology, and pathogenesis
    • Volpe JJ. Brain injury in the premature infant: Overview of clinical aspects, neuropathology, and pathogenesis. Semin Pediatr Neurol 1998;5:135-151.
    • (1998) Semin Pediatr Neurol , vol.5 , pp. 135-151
    • Volpe, J.J.1
  • 41
    • 0024600704 scopus 로고
    • Postischemic microvascular cerebral responses to norepinephrine and hypotension in newborn pigs
    • Leffler CW, Busija DW, Beasley DG, Armstead WM, Mirro R. Postischemic microvascular cerebral responses to norepinephrine and hypotension in newborn pigs. Stroke 1989;20:541-546.
    • (1989) Stroke , vol.20 , pp. 541-546
    • Leffler, C.W.1    Busija, D.W.2    Beasley, D.G.3    Armstead, W.M.4    Mirro, R.5
  • 42
    • 0024585269 scopus 로고
    • Ischemia alters cerebral vascular responses to hypercapnia and acetylcholine in piglets
    • Leffler CW, Busija DW, Armstead WM, Mirro R, Beasley DG. Ischemia alters cerebral vascular responses to hypercapnia and acetylcholine in piglets. Ped Res 1989;25:180-183.
    • (1989) Ped Res , vol.25 , pp. 180-183
    • Leffler, C.W.1    Busija, D.W.2    Armstead, W.M.3    Mirro, R.4    Beasley, D.G.5
  • 43
    • 0034677875 scopus 로고    scopus 로고
    • Altered release of prostaglandins contributes to hypoxic/ischemic impairment of NOC/oFQ cerebrovasodilation
    • Armstead WM. Altered release of prostaglandins contributes to hypoxic/ischemic impairment of NOC/oFQ cerebrovasodilation. Brain Res 2000;859:104-112.
    • (2000) Brain Res , vol.859 , pp. 104-112
    • Armstead, W.M.1
  • 44
    • 33750797818 scopus 로고    scopus 로고
    • cGMP and cAMP in prostaglandin induced pial artery dilation and increased CSF opioid concentration
    • Armstead WM. cGMP and cAMP in prostaglandin induced pial artery dilation and increased CSF opioid concentration. Am J Physiol 1996;271:H166-H172.
    • (1996) Am J Physiol , vol.271
    • Armstead, W.M.1
  • 45
    • 0034711578 scopus 로고    scopus 로고
    • + channel dependent mechanisms in piglet hypoxic/ischemic impaired nociceptin/orphanin FQ induced cerebrovasodilation
    • + channel dependent mechanisms in piglet hypoxic/ischemic impaired nociceptin/orphanin FQ induced cerebrovasodilation. Brain Res 2000;884:51-58.
    • (2000) Brain Res , vol.884 , pp. 51-58
    • Ben-Haim, G.1    Armstead, W.M.2
  • 48
    • 0034674573 scopus 로고    scopus 로고
    • NOC/oFQ contributes to hypoxic/ischemic impairment of N-methyl-D-Aspartate-induced cerebral vasodilation
    • Armstead WM. NOC/oFQ contributes to hypoxic/ischemic impairment of N-methyl-D-Aspartate-induced cerebral vasodilation. Brain Res 2000;868:48-55.
    • (2000) Brain Res , vol.868 , pp. 48-55
    • Armstead, W.M.1
  • 49
    • 0029902430 scopus 로고    scopus 로고
    • Nociceptin induced inhibition of K evoked glutamate release from rat cerebrocortical slices
    • Nicol B, Lambert DG, Rowbotha DJ, Smart D, McKnight At. Nociceptin induced inhibition of K evoked glutamate release from rat cerebrocortical slices. Br J Pharmacol 1996;189:1081-1083.
    • (1996) Br J Pharmacol , vol.189 , pp. 1081-1083
    • Nicol, B.1    Lambert, D.G.2    Rowbotha, D.J.3    Smart, D.4    McKnight, A.5
  • 50
    • 0029818991 scopus 로고    scopus 로고
    • Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro
    • Faber ESL, Chambers JP, Evans R, Henderson G. Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro. Br J Pharmacol 1996;189:189-190.
    • (1996) Br J Pharmacol , vol.189 , pp. 189-190
    • Faber, E.S.L.1    Chambers, J.P.2    Evans, R.3    Henderson, G.4
  • 51
    • 0034530525 scopus 로고    scopus 로고
    • NOC/oFQ PKC dependent superoxide generation contributes to hypoxic/ischemic impairment of NMDA cerebrovasodilation
    • Armstead WM. NOC/oFQ PKC dependent superoxide generation contributes to hypoxic/ischemic impairment of NMDA cerebrovasodilation. Am J Physiol 2000;279:H2678-H2684.
    • (2000) Am J Physiol , vol.279
    • Armstead, W.M.1
  • 52
    • 0037428709 scopus 로고    scopus 로고
    • Newborn pig nociceptin/orphanin FQ activates protein tyrosine kinase and mitogen activated protein kinase to impair NMDA cerebrovasodilation after ischemia
    • Philip S, Armstead WM. Newborn pig nociceptin/orphanin FQ activates protein tyrosine kinase and mitogen activated protein kinase to impair NMDA cerebrovasodilation after ischemia. Neuro Report 2003;14:201-203.
    • (2003) Neuro Report , vol.14 , pp. 201-203
    • Philip, S.1    Armstead, W.M.2
  • 53
    • 0036241638 scopus 로고    scopus 로고
    • NOC/oFQ and NMDA contribute to piglet hypoxic ischemic hypotensive cerebrovasodilation impairment
    • Armstead WM. NOC/oFQ and NMDA contribute to piglet hypoxic ischemic hypotensive cerebrovasodilation impairment. Ped Res 2002;51:586-591.
    • (2002) Ped Res , vol.51 , pp. 586-591
    • Armstead, W.M.1
  • 54
    • 0036160905 scopus 로고    scopus 로고
    • NOC/oFQ activates PKC and generates superoxide to impair hypotensive cerebrovasodilation after hypoxia/ischemia
    • Armstead WM. NOC/oFQ activates PKC and generates superoxide to impair hypotensive cerebrovasodilation after hypoxia/ischemia. Med Sci Monit 2002;8:BR8-BR14.
    • (2002) Med Sci Monit , vol.8
    • Armstead, W.M.1
  • 55
    • 0034864102 scopus 로고    scopus 로고
    • Nociceptin/orphanin FQ contributes to hypoxic ischemic impairment of hypercapnic cerebrovasodilation
    • Jagolino AL, Armstead WM. Nociceptin/orphanin FQ contributes to hypoxic ischemic impairment of hypercapnic cerebrovasodilation. Brain Res Bulletin 2001;55:465-468.
    • (2001) Brain Res Bulletin , vol.55 , pp. 465-468
    • Jagolino, A.L.1    Armstead, W.M.2
  • 56
    • 0037230343 scopus 로고    scopus 로고
    • PTK, MAPK, and NOC/oFQ impair hypercapnic cerebrovasodilation after hypoxia/ischemia
    • Jagolino AL, Armstead WM. PTK, MAPK, and NOC/oFQ impair hypercapnic cerebrovasodilation after hypoxia/ischemia. Am J Physiol 2003;284:H101-H107.
    • (2003) Am J Physiol , vol.284
    • Jagolino, A.L.1    Armstead, W.M.2
  • 57
    • 0025367685 scopus 로고
    • Childhood injuries in the United States. A priority issue
    • Rodriguez JG. Childhood injuries in the United States. A priority issue. Am J Dis Child 1990;144:625-626.
    • (1990) Am J Dis Child , vol.144 , pp. 625-626
    • Rodriguez, J.G.1
  • 58
    • 0018874222 scopus 로고
    • Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats
    • Wei EP, Dietrich WD, Povlishock JT, Navari RM, Kontos HA. Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats. Circ Res 1980;46:37-47.
    • (1980) Circ Res , vol.46 , pp. 37-47
    • Wei, E.P.1    Dietrich, W.D.2    Povlishock, J.T.3    Navari, R.M.4    Kontos, H.A.5
  • 59
    • 0027999170 scopus 로고
    • Animate models of human head injury
    • Gennarelli TA. Animate models of human head injury. J Neurotrauma 1994;11:357-368.
    • (1994) J Neurotrauma , vol.11 , pp. 357-368
    • Gennarelli, T.A.1
  • 60
    • 0033797154 scopus 로고    scopus 로고
    • Role of nociceptin/orphanin FQ in age dependent cerebral hemodynamic effects of brain injury
    • Armstead WM. Role of nociceptin/orphanin FQ in age dependent cerebral hemodynamic effects of brain injury. J Neurotrauma 2000;17:751-764.
    • (2000) J Neurotrauma , vol.17 , pp. 751-764
    • Armstead, W.M.1
  • 61
    • 0034515277 scopus 로고    scopus 로고
    • Role of altered cyclooxygenase metabolism in impaired cerebrovasodilation to nociceptin/orphanin FQ following brain injury
    • Armstead WM. Role of altered cyclooxygenase metabolism in impaired cerebrovasodilation to nociceptin/orphanin FQ following brain injury. Brain Res Bulletin 2000;53:807-812.
    • (2000) Brain Res Bulletin , vol.53 , pp. 807-812
    • Armstead, W.M.1
  • 62
    • 0033673946 scopus 로고    scopus 로고
    • NOC/oFQ contributes to age dependent impairment of NMDA induced cerebrovasodilation after brain injury
    • Armstead WM. NOC/oFQ contributes to age dependent impairment of NMDA induced cerebrovasodilation after brain injury. Am J Physiol 2000;279:H2188-H2195.
    • (2000) Am J Physiol , vol.279
    • Armstead, W.M.1
  • 63
    • 0033859298 scopus 로고    scopus 로고
    • Superoxide generation links nociceptin/orphanin FQ (NOC/oFQ) release to impaired N-methyl-D-aspartate cerebrovasodilation after brain injury
    • Kulkarni M, Armstead WM. Superoxide generation links nociceptin/orphanin FQ (NOC/oFQ) release to impaired N-methyl-D-aspartate cerebrovasodilation after brain injury. Stroke 2000;31:1990-1996.
    • (2000) Stroke , vol.31 , pp. 1990-1996
    • Kulkarni, M.1    Armstead, W.M.2
  • 64
    • 0036673683 scopus 로고    scopus 로고
    • Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury
    • Kulkarni M, Armstead WM. Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury. J Neurotrauma 2002;19:965-973.
    • (2002) J Neurotrauma , vol.19 , pp. 965-973
    • Kulkarni, M.1    Armstead, W.M.2
  • 65
    • 0030008108 scopus 로고    scopus 로고
    • Influence of brain injury on vasopressin induced pial artery vasodilation: Role of superoxide anion
    • Armstead WM. Influence of brain injury on vasopressin induced pial artery vasodilation: Role of superoxide anion. Am J Physiol 1996;70:H1272-H1278.
    • (1996) Am J Physiol , vol.70
    • Armstead, W.M.1
  • 66
    • 0034976313 scopus 로고    scopus 로고
    • Age dependent vasopressinergic modulation of NOC/oFQ induced impairment of NMDA cerebrovasodilation after brain injury
    • Armstead WM. Age dependent vasopressinergic modulation of NOC/oFQ induced impairment of NMDA cerebrovasodilation after brain injury. J Neurotrauma 2001;18:615-623.
    • (2001) J Neurotrauma , vol.18 , pp. 615-623
    • Armstead, W.M.1
  • 67
    • 0032733317 scopus 로고    scopus 로고
    • Role of endothelin-1 in age dependent cerebrovascular hypotensive responses after brain injury
    • Armstead WM. Role of endothelin-1 in age dependent cerebrovascular hypotensive responses after brain injury. Am J Physiol 1999;277:H1884-H1894.
    • (1999) Am J Physiol , vol.277
    • Armstead, W.M.1
  • 68
    • 0035134130 scopus 로고    scopus 로고
    • Age dependent endothelin contribution to NOC/oFQ induced impairment of NMDA cerebrovasodilation after brain injury
    • Armstead WM. Age dependent endothelin contribution to NOC/oFQ induced impairment of NMDA cerebrovasodilation after brain injury. Peptides 2001;22:39-46.
    • (2001) Peptides , vol.22 , pp. 39-46
    • Armstead, W.M.1
  • 69
    • 0037111481 scopus 로고    scopus 로고
    • Age dependent NMDA contribution to impaired cerebral hemodynamics following brain injury
    • Armstead WM. Age dependent NMDA contribution to impaired cerebral hemodynamics following brain injury. Develop Brain Res 2002;139:19-28.
    • (2002) Develop Brain Res , vol.139 , pp. 19-28
    • Armstead, W.M.1
  • 70
    • 0033573761 scopus 로고    scopus 로고
    • ca channel activation
    • ca channel activation. Brain Res 1999;816:158-164.
    • (1999) Brain Res , vol.816 , pp. 158-164
    • Armstead, W.M.1
  • 71
    • 0037067797 scopus 로고    scopus 로고
    • ca channel impairment after brain injury
    • ca channel impairment after brain injury. Brain Res 2002;943:276-282.
    • (2002) Brain Res , vol.943 , pp. 276-282
    • Armstead, W.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.