The relaxant effect of nociceptin on porcine coronary arterial ring segments

Canadian Journal of Physiology and Pharmacology

Volumn 82, Issue 11, 2004, Pages 993-999

  Xu, Pei Han ^a   Chang, Ming ^a   Cheng, Li Xiang ^a   Cheng, Qiang ^a   Yan, Xiang ^b   Wang, Rui ^a  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU MEDICAL COLLEGE   (China)

Author keywords

NO; Nociceptin; ORL1; Porcine coronary artery

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYCLIC GMP; METHYLENE BLUE; MORPHINE; N(G) NITROARGININE; NALOXONE; NITRIC OXIDE; NOCICEPTIN; NOCICEPTIN RECEPTOR ANTAGONIST; NOCICEPTIN[1-13][1 NORPHENYLALANINE] AMIDE; OPIATE ANTAGONIST; OPIATE RECEPTOR; OPIATE RECEPTOR LIKE 1 RECEPTOR; PROPRANOLOL; PROSTAGLANDIN F2 ALPHA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY CONSTRICTION; CORONARY ARTERY DILATATION; DRUG EFFECT; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; SWINE; VASCULAR SMOOTH MUSCLE;

ANIMALS; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; OPIOID PEPTIDES; SWINE; VASODILATION;

EID: 13544269407     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y04-091     Document Type: Article

References (26)

1. Arndt, M.L., Wu, D., Soong, Y., and Szeto, H.H. 1999. Nociceptin/orphanin FQ increases blood pressure and heart rate via sympathetic activation in sheep. Peptides, 20: 465-470.
2. Bigoni, R., Giuliani, S., and Calo, G. 1999. Characterization of nociceptin receptors in the periphery: in vitro and in vivo studies. Naunyn-Schmiedebergs Arch. Pharmacol. 359: 160-167.
3. Bunzow, J.R., Saez, C., and Morerud, M. 1994. Molecular cloning and tissue distribution of putative member of the rat opioid receptor gene family that is not mu, delta or kappa opioid receptor typs. FEBS Lett. 347: 284-288.
4. Carter, D.A., and Lightman, S. 1984. Inhibition of vasopressin secretion by a k-opioid receptor agonist. Neuroendocrinol. Lett. 6: 95-100.
5. Champion, H.C., and Kadowitz, P.J. 1997. Nociceptin, an endogenous ligand for the ORL1 receptor, has novel hypotensive activity in the rat. Life Sci. 60: 241-245.
6. Champion, H.C., Czapla, M.A., and Kadowitz, P.J. 1997. Nociceptin, an endogenous ligand for the ORL1 receptor, decreases cardiac output and total peripheral resistance in the rat. Peptides, 18: 729-732.
7. Champion, H.C., Pierce, R.L., and Kadowith, P.J. 1998. Nociceptin a noval endogenous ligand for the ORL1 receptor, dilates isolated resistance arteries from the rat. Regulpeptides, 78: 69-74.
8. Chu, X., Xu, N., Li, P., and Wang, J.Q. 1998. Profound inhibition of cardiomotor neurons in the rat rostral ventrolateral medulla by nociceptin (Orphanin FQ). Neuroreport, 9: 1081-1084.
9. Civelli, O., Nothacker, H.-P., Bourson, A., Ardati, A., Monsma, F., and Reinscheid, R. 1997. Orphan receptors and their natural ligands. J. Recept. Signal Transduct. Res. 17: 545-500.
10. Czapla, M.A., Champion, H.C., and Kadowitz, RJ. 1997. Decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not inhibited by naloxone in the rat. Peptides, 18: 1197-1200.
11. 2, a new selective nociceptin receptor antagonist. Br. J. Pharmacol. 129: 1183-1193.
12. Giuliani, S., Tramontara, M., Lecci, A., and Maggi, C.A. 1997. Effect of nociceptin on heart rate and blood pressure in unanesthetized rats. Eur. J. Pharmacol. 333: 177-179.
13. Grisel, J.E., Mogil, J.S., and Belknap, J.K. 1996. Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide. Neuroreport, 7: 2125-2129.
14. Gumusel, B., Hao, Q., Hymen, A., Chang, J.-K., Kapusta, D.R., Lippton, H. 1997. Nociceptin an endogenous agonist for central opioid like1 (ORL1) receptors possesses systemic vasorelaxant properties. Life Sci. 60: 142-145.
15. Howell, R.E., Albeda, S.M., Daise, M.L., and Levine, E.M. 1988. Characterization of beta-adrenergic receptors in cultured human and bovine endothelial cells. J Appl. Physiol. 65: 1251-1257.
16. Hugghins, S.Y., Champion, H.C., Cheng, G., Kadowitz, P.J., and Jeter, R. 2000. Vasorelaxant responses to endomorphins, nociceptin, albuterol and adrenomedullin in isolated rat aorta. Life Sci. 67: 471-476.
17. Kuriyama, H., Ito, Y., Suzuki, H., Kitamura, K., and Itoh, T. 1982. Factors modifying contraction-relaxation cycle in vascular smooth muscles. Am. J. Physiol. 243: H641-H642.
18. Madeddu, P., Salis, M.B., and Milia, A.F. 1999. Cardiovascular effects of nociceptin in unanesthetizesd mice. Hypertension, 33: 914-919.
19. Martin, W., Villani, G.M., Jothianandan, D., and Furchgott, R.F. 1985. Selective blockage of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J. Pharmacol. Exp. Ther. 232: 708-716.
20. Meunier, J.C., Mollereau, C., and Toll, L. 1995. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature (London), 377(12): 532-535.
21. Molenaar, P., Malta, E., Jones, C.R., Buxton, B.F., and Summers, R.J. 1988. Autoradiographic localization and function of beta-adrenoceptors on the human internal mammary artery and saphenous vein. Br. J. Pharmacol. 95: 225-233.
22. Qi, Y.M., Yang, D.J., Duan, X., Yang, F., Li, S.R., Shen, J.M., and Wang, R. 2002. Endomorphins inhibit contractile responses of rat thoracic aorta rings induced by phenylephrine and angiotension 2 in vitro. Acta Pharmacol. Sin. 23(1): 40-44.
23. Rees, D.D., Palmer, R.M., Schulz, R., Hodson, H.F., and Moncada, S. 1990. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol. 101: 746-752.
24. Reinscheid, P.K., Nothacker, H.P., and Bourson, A. 1995.Orphanin FQ: a neuropeptide that activates an opioid-like G protein-coupled receptor. Science, 270: 792-794.
25. Rossi, G.C., Perlmuttera, M., and Leventhala, L. 1998. OrphaninFQ/nociceptin analgesia in the rat. Brain Res. 792: 327-330.
26. Shirasaka, T., Kunitake, T., Kato, K., Takasaki, M., and Kannan, H. 1999. Nociceptin modulates renal sympathetic nerve activity through a central action in conscious rats. Am. J. Physiol. 277: R1025-R1032.