Insulinlike growth factor-1Ec (MGF) expression in eutopic and ectopic endometrium: Characterization of the MGF E-peptide actions in vitro

Molecular Medicine

Volumn 17, Issue 1-2, 2011, Pages 21-28

  Milingos, Dimitrios S ^a   Philippou, Anastassios ^a   Armakolas, Athanassios ^a   Papageorgiou, Efstathia ^a   Sourla, Antigone ^b   Protopapas, Athanassios ^a   Liapi, Anthi ^a   Antsaklis, Aris ^a   Mastrominas, Minas ^c   Koutsilieris, Michael ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b Endo/OncoResearch Medical Laboratories   (Greece)

^c Embryogenesis Inc   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN LIKE GROWTH FACTOR 1EC; INSULIN RECEPTOR; MESSENGER RNA; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL GROWTH; ENDOMETRIOSIS; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STROMA CELL;

ADULT; ALTERNATIVE SPLICING; CELL LINE, TUMOR; CYTOPLASM; ENDOMETRIUM; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MIDDLE AGED; PROTEIN ISOFORMS; PROTEIN TRANSPORT; RNA, SMALL INTERFERING; STROMAL CELLS;

EID: 78651518753     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2010.00043     Document Type: Article

References (32)

1. Giudice LC, Kao LC. (2004) Endometriosis. Lancet 364:1789-1799.
2. Gao X, Outley J, Botteman M, Spalding J, Simon JA, Pashos CL. (2006) Economic burden of endometriosis. Fertil. Steril. 86:1561-1572.
3. Gebel HM, Braun DP, Tambur A, Frame D, Rana N, Dmowski WP. (1998) Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis. Fertil. Steril. 69:1042-1047.
4. Koutsilieris M, Mastrogamvrakis G, Lembessis P, Sourla A, Miligos S, Michalas S. (2001) Increased insulin-like growth factor 1 activity can rescue KLE endometrial-like cells from apoptosis. Mol. Med. 7:20-26.
5. Kim JG, Suh CS, Kim SH, Choi YM, Moon SY, Lee JY. (2000) Insulin-like growth factors (IGFs), IGFbinding proteins (IGFBPs), and IGFBP-3 protease activity in the peritoneal fluid of patients with and without endometriosis. Fertil. Steril. 73:996-1000.
6. Koutsilieris M, Lavergne E, Lemay A. (1997) Association of protease activity against IGFBP-3 with peritoneal fluid mitogens: possible implications for the ectopic growth of endometrial cells in women with endometriosis. Anticancer Res. 17:1239-44.
7. Lembessis P, Kalariti N, Koutsilieris M. (2004) Glucocorticoid receptor function suppresses insulin- like growth factor 1 activity in human KLE endometrial-like cells. In Vivo 18:43-7.
8. Siegfried JM, Kasprzyk PG, Treston AM, Mulshine JL, Quinn KA, Cuttitta F. (1992) A mitogenic peptide amide encoded within the E peptide domain of the insulin-like growth factor IB prohormone. Proc. Natl. Acad. Sci. U. S. A. 89:8107-11.
9. Gilmour RS. (1994) The implications of insulinlike growth factor mRNA heterogeneity. J. Endocrinol. 140:1-3.
10. Chew SL, Lavender P, Clark AJ, Ross RJ. (1995) An alternatively spliced human insulin-like growth factor-I transcript with hepatic tissue expression that diverts away from the mitogenic IBE1 peptide. Endocrinology 136:1939-44.
11. Shavlakadze T, Winn N, Rosenthal N, Grounds MD. (2005) Reconciling data from transgenic mice that overexpress IGF-I specifically in skeletal muscle. Growth Horm. IGF Res. 15:4-18.
12. Kuo YH, Chen TT. (2002) Novel activities of pro- IGF-I E peptides: regulation of morphological differentiation and anchorage-independent growth in human neuroblastoma cells. Exp. Cell Res. 280:75-89
13. Samani AA, Yakar S, LeRoith D, Brodt P. (2007) The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr. Rev. 28:20-47.
14. Jones JI, Clemmons DR. (1995) Insulin-like growth factors and their binding proteins: biological actions. Endocr. Rev. 16:3-34.
15. LeRoith D, Werner H, Beitner-Johnson D, Roberts CT. (1995) Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr. Rev. 16:143-163.
16. Kornfeld S. (1992) Structure and function of the mannose-6-phosphate/insulinlike growth factor II receptors. Annu. Rev. Biochem. 61:307-330.
17. Hameed M, Orrell RW, Cobbold M, Goldspink G, Harridge SD. (2003) Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise. J. Physiol. 547:247-254.
18. Bickel CS, Slade J, Mahoney E, Haddad F, Dudley GA, Adams GR. (2005) Time course of molecular responses of human skeletal muscle to acute bouts of resistance exercise. J. Appl. Physiol. 98:482-488.
19. Kim JS, Cross JM, Bamman MM. (2005) Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women. Am. J. Physiol. Endocrinol. Metab. 288:E1110-E1119.
20. Philippou A, et al. (2009) Expression of IGF-1 isoforms after exercise-induced muscle damage in humans: characterization of the MGF E peptide actions in vitro. In Vivo 23:567-575.
21. Carpenter V, et al. (2008) Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. Heart Lung Circ. 17:33-39.
22. Stavropoulou A, Halapas A, Sourla A, Philippou A, Papageorgiou E, Papalois A, Koutsilieris M. (2009) IGF-1 expression in infarcted myocardium and MGF E peptide actions in rat cardiomyocytes in vitro. Mol. Med. 15:127-135.
23. Milingos D, et al. (2006) Insulin-like growth factor- 1 isoform mRNA expression in women with endometriosis: eutopic endometrium versus endometriotic cyst. Ann. N. Y. Acad. Sci. 1092:434-439.
24. Noyes RW, Hertig AT, Rock J. (1975) Dating the endometrial biopsy. Am. J. Obstet. Gynecol. 122:262-263.
25. Philippou A, Stavropoulou A, Sourla A, Pissimissis N, Halapas A, Maridaki M, Koutsilieris M. (2008) Characterization of a rabbit antihuman mechano growth factor (MGF) polyclonal antibody against the last 24 amino acids of the E domain. In Vivo 22:27-35.
26. Koutsilieris M, Rabbani SA, Goltzman D. (1987) Effects of human prostatic mitogens on rat bone cells and fibroblasts. J. Endocrinol. 115:447-454.
27. Koutsilieris M, Sourla A, Pelletier G, Doillon CJ. (1994) Three-dimensional type I collagen gel system for the study of osteoblastic metastases produced by metastatic prostate cancer. J. Bone Miner. Res. 9:1823-1832.
28. Donnez J, Squifflet J, Casanas-Roux F, Pirard C, Jadoul P, van Langendonckt A. (2003) Typical and subtle atypical presentations of endometriosis. Obstet. Gynecol. Clin. N. Am. 30:83-93.
29. Bogdanos J, Karamanolakis D, Tenta R, Tsintavis A, Milathianakis C, Mitsiades C, Koutsilieris M. (2003) Endocrine/paracrine/autocrine survival factor activity of bone microenvironment participates in the development of androgen ablation and chemotherapy refractoriness of prostate cancer metastasis in skeleton. Endocr. Relat. Cancer 10:279-289.
30. Koutsilieris M, Mitsiades C, Sourla A. (2000) Insulin- like growth factor I and urokinase-type plasminogen activator bioregulation system as a survival mechanism of prostate cancer cells in osteoblastic metastases: development of antisurvival factor therapy for hormone-refractory prostate cancer. Mol. Med. 6:251-267.
31. Koutsilieris M. (1992) Pathophysiology of uterine leiomyomas. Biochem. Cell Biol. 70:273-278.
32. Cox ME, et al. (2009) Insulin receptor expression by human prostate cancers. Prostate 69:33-40.