Diffusion and perfusion characteristics of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode) in thirteen patients

Korean Journal of Radiology

Volumn 12, Issue 1, 2011, Pages 15-24

  Kim, Ji Hye ^a   Lim, Myung Kwan ^b   Jeon, Tae Yeon ^a   Rha, Jung Ho ^b   Eo, Hong ^a   Yoo, So Young ^a   Shu, Chang Hae ^b  

^a Samsung Medical Center   (South Korea)

^b Inha University Hospital   (South Korea)

Author keywords

Diffusion weighted imaging; Mitochondrial encephalopathy; Perfusion MR imaging; Stroke

Indexed keywords

ACUTE DISEASE; ADOLESCENT; ADULT; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; ENCEPHALOMALACIA; FEMALE; FOLLOW UP; HUMAN; IMAGE ANALYSIS; MALE; MELAS SYNDROME; PERFUSION WEIGHTED IMAGING; SCHOOL CHILD;

ADOLESCENT; ADULT; BRAIN; BRAIN EDEMA; CHILD; DIFFUSION MAGNETIC RESONANCE IMAGING; FEMALE; HUMANS; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MELAS SYNDROME; MIDDLE AGED; STROKE; YOUNG ADULT;

EID: 78651505891     PISSN: 12296929     EISSN: None     Source Type: Journal    
DOI: 10.3348/kjr.2011.12.1.15     Document Type: Article

References (25)

1. Kim IO, Kim JH, Kim WS, Hwang YS, Yeon KM, Han MC. Mitochondrial myopathy-encephalopathy-lactic acidosis-and strokelike episodes (MELAS) syndrome: CT and MR fi ndings in seven children. AJR Am J Roentgenol 1996;166:641-645
2. Ohama E, Ohara S, Ikuta F, Tanaka K, Nishizawa M, Miyatake T. Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy. Acta Neuropathol 1987;74:226-233
3. Iizuka T, Sakai F, Suzuki N, Hata T, Tsukahara S, Fukuda M, et al. Neuronal hyperexcitability in stroke-like episodes of MELAS syndrome. Neurology 2002;59:816-824
4. Schaefer PW, Buonanno FS, Gonzalez RG, Schwamm LH. Diffusion-weighted imaging discriminates between cytotoxic and vasogenic edema in a patient with eclampsia. Stroke 1997;28:1082-1085
5. Yoneda M, Maeda M, Kimura H, Fujii A, Katayama K, Kuriyama M. Vasogenic edema on MELAS: a serial study with diffusionweighted MR imaging. Neurology 1999;53:2182-2184
6. Oppenheim C, Galanaud D, Samson Y, Sahel M, Dormont D, Wechsler B, et al. Can diffusion weighted magnetic resonance imaging help differentiate stroke from stroke-like events in MELAS? J Neurol Neurosurg Psychiatry 2000;69:248-250
7. Ohshita T, Oka M, Imon Y, Watanabe C, Katayama S, Yamaguchi S, et al. Serial diffusion-weighted imaging in MELAS. Neuroradiology 2000;42:651-656
8. Yonemura K, Hasegawa Y, Kimura K, Minematsu K, Yamaguchi T. Diffusion-weighted MR imaging in a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. AJNR Am J Neuroradiol 2001;22:269-272
9. Kolb SJ, Costello F, Lee AG, White M, Wong S, Schwartz ED, et al. Distinguishing ischemic stroke from the stroke-like lesions of MELAS using apparent diffusion coeffi cient mapping. J Neurol Sci 2003;216:11-15
10. Abe K, Yoshimura H, Tanaka H, Fujita N, Hikita T, Sakoda S. Comparison of conventional and diffusion-weighted MRI and proton MR spectroscopy in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like events. Neuroradiology 2004;46:113-117
11. Jian-Ren L. Precipitation of stroke-like event by chickenpox in a child with MELAS syndrome. Neurol India 2005;53:323-325
12. Alemdar M, Iseri P, Selekler M, Budak F, Demirci A, Komsuoglu SS. MELAS presented with status epilepticus and Anton- Babinski syndrome; value of ADC mapping in MELAS. J Neuropsychiatry Clin Neurosci 2007;19:482-483
13. Ito H, Mori K, Harada M, Minato M, Naito E, Takeuchi M, et al. Serial brain imaging analysis of stroke-like episodes in MELAS. Brain Dev 2008;30:483-488
14. Wang XY, Noguchi K, Takashima S, Hayashi N, Ogawa S, Seto H. Serial diffusion-weighted imaging in a patient with MELAS and presumed cytotoxic oedema. Neuroradiology 2003;45:640-643
15. Iizuka T, Sakai F, Kan S, Suzuki N. Slowly progressive spread of the stroke-like lesions in MELAS. Neurology 2003;61:1238-1244
16. Mizrachi IB, Gomez-Hassan D, Blaivas M, Trobe JD. Pitfalls in the diagnosis of mitochondrial encephalopathy with lactic acidosis and stroke-like episodes. J Neuroophthalmol 2006;26:38-43
17. Bi WL, Baehring JM, Lesser RL. Evolution of brain imaging abnormalities in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes. J Neuroophthalmol 2006;26:251-256
18. Tzoulis C, Bindoff LA. Serial diffusion imaging in a case of mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes. Stroke 2009;40:e15-e17
19. Sheerin F, Pretorius PM, Briley D, Meagher T. Differential diagnosis of restricted diffusion confi ned to the cerebral cortex. Clin Radiol 2008;63:1245-1253
20. Hasegawa Y, Formato JE, Latour LL, Gutierrez JA, Liu KF, Garcia JH, et al. Severe transient hypoglycemia causes reversible change in the apparent diffusion coeffi cient of water. Stroke 1996;27:1648-1655
21. Hasegawa D, Orima H, Fujita M, Nakamura S, Takahashi K, Ohkubo S, et al. Diffusion-weighted imaging in kainic acidinduced complex partial status epilepticus in dogs. Brain Res 2003;983:115-127
22. Bradley DP, Smith JM, Smith MI, Bockhorst KH, Papadakis NG, Hall LD, et al. Cortical spreading depression in the feline brain following sustained and transient stimuli studied using diffusion-weighted imaging. J Physiol 2002;544:39-56
23. Tsujikawa T, Yoneda M, Shimizu Y, Uematsu H, Toyooka M, Ikawa M, et al. Pathophysiologic evaluation of MELAS strokes by serially quantifi ed MRS and CASL perfusion images. Brain Dev 2010;32:143-149
24. Clark JM, Marks MP, Adalsteinsson E, Spielman DM, Shuster D, Horoupian D, et al. MELAS: Clinical and pathologic correlations with MRI, xenon/CT, and MR spectroscopy. Neurology 1996;46:223-227
25. Ooiwa Y, Uematsu Y, Terada T, Nakai K, Itakura T, Komai N, et al. Cerebral blood fl ow in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. Stroke 1993;24:304-309