In vivo assessment of parenteral formulations of oligo(3-hydroxybutyric acid) conjugates with the model compound ibuprofen

AAPS PharmSciTech

Volumn 11, Issue 4, 2010, Pages 1636-1641

  Stasiak, Pawel ^a   Sznitowska, Malgorzata ^a   Ehrhardt, Carsten ^b   Luczyk Juzwa, Maria ^c   Grieb, Pawel ^d  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c CENTRE OF POLYMER AND CARBON MATERIALS   (Poland)

^d MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

drug conjugates; ibuprofen; oligo(3 hydroxybutyrates); pharmacokinetics; pro drugs

Indexed keywords

3 HYDROXYBUTYRIC ACID; IBUPROFEN; INDOMETACIN; OIL; OLIGO (3 HYDROXYBUTYRIC ACID) CONJUGATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG STRUCTURE; EMULSION; EXPERIMENTAL RABBIT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MUSCLE TISSUE; NONHUMAN; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; SUSTAINED DRUG RELEASE; TIME TO MAXIMUM PLASMA CONCENTRATION;

3-HYDROXYBUTYRIC ACID; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DOSAGE FORMS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; FEMALE; IBUPROFEN; INJECTIONS, INTRAMUSCULAR; MALE; PHARMACEUTICAL SOLUTIONS; PRODRUGS; RABBITS; REPRODUCIBILITY OF RESULTS; THERAPEUTIC EQUIVALENCY;

EID: 78651503803     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9545-2     Document Type: Article

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