Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription

BMC Molecular Biology

Volumn 12, Issue , 2011, Pages

  Tan, Jen Jen ^a,b   Ong, Shufen Angeline ^a   Chen, Ken Shiung ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; EAR 2 PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; LUCIFERASE; MESSENGER RNA; PLASMID DNA; RAS PROTEIN; RASD 1 PROTEIN; REGULATOR PROTEIN; RENIN; RETINOIC ACID; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; NR2F6 PROTEIN, HUMAN; NR2F6 PROTEIN, MOUSE; RASD1 PROTEIN, HUMAN; RASD1 PROTEIN, MOUSE; SMALL INTERFERING RNA; STEROID RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL STRAIN COS7; CELL STRAIN HEK293; CONTROLLED STUDY; GENE CONSTRUCT; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIGAND BINDING; MISSENSE MUTATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM; YEAST; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; COUP TRANSCRIPTION FACTORS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENES, REPORTER; HEK293 CELLS; HUMANS; MICE; RAS PROTEINS; RECEPTORS, STEROID; RENIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRETINOIN; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 78651497282     PISSN: None     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-12-4     Document Type: Article

References (70)

1. Nishimura H, Ichikawa I. What have we learned from gene targeting studies for the renin angiotensin system of the kidney?. Intern Med 1999, 38:315-323. 10.2169/internalmedicine.38.315, 10361903.
2. Harrison-Bernard LM. The renal renin-angiotensin system. Adv Physiol Educ 2009, 33:270-274. 10.1152/advan.00049.2009, 19948673.
3. von Bohlen und Halbach O. The renin-angiotensin system in the mammalian central nervous system. Curr Protein Pept Sci 2005, 6:355-371. 10.2174/1389203054546361, 16101434.
4. Sinn PL, Sigmund CD. Human renin mRNA stability is increased in response to cAMP in Calu-6 cells. Hypertension 1999, 33:900-905.
5. Lang JA, Ying LH, Morris BJ, Sigmund CD. Transcriptional and posttranscriptional mechanisms regulate human renin gene expression in Calu-6 cells. Am J Physiol 1996, 271:F94-100.
6. Petrovic N, Black TA, Fabian JR, Kane C, Jones CA, Loudon JA, Abonia JP, Sigmund CD, Gross KW. Role of proximal promoter elements in regulation of renin gene transcription. J Biol Chem 1996, 271:22499-22505. 10.1074/jbc.271.37.22499, 8798416.
7. Shi Q, Black TA, Gross KW, Sigmund CD. Species-specific differences in positive and negative regulatory elements in the renin gene enhancer. Circ Res 1999, 85:479-488.
8. Yan Y, Jones CA, Sigmund CD, Gross KW, Catanzaro DF. Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells. Circ Res 1997, 81:558-566.
9. Shi Q, Gross KW, Sigmund CD. Retinoic acid-mediated activation of the mouse renin enhancer. J Biol Chem 2001, 276:3597-3603. 10.1074/jbc.M008361200, 11058598.
10. Shi Q, Gross KW, Sigmund CD. NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors. Hypertension 2001, 38:332-336.
11. Pan L, Black TA, Shi Q, Jones CA, Petrovic N, Loudon J, Kane C, Sigmund CD, Gross KW. Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. J Biol Chem 2001, 276:45530-45538. 10.1074/jbc.M103010200, 11564732.
12. Pan L, Gross KW. Transcriptional regulation of renin: an update. Hypertension 2005, 45:3-8. 10.1161/01.HYP.0000151886.26341.4b, 15545507.
13. Liu X, Huang X, Sigmund CD. Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription. Circ Res 2003, 92:1033-1040. 10.1161/01.RES.0000071355.82009.43, 12690040.
14. Tsai SY, Tsai MJ. Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. Endocr Rev 1997, 18:229-240. 10.1210/er.18.2.229, 9101138.
15. Cooney AJ, Tsai SY, O'Malley BW, Tsai MJ. Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors. Mol Cell Biol 1992, 12:4153-4163. 360317, 1324415.
16. Ladias JA, Hadzopoulou-Cladaras M, Kardassis D, Cardot P, Cheng J, Zannis V, Cladaras C. Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3. J Biol Chem 1992, 267:15849-15860.
17. Chu K, Zingg HH. The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter. J Mol Endocrinol 1997, 19:163-172. 10.1677/jme.0.0190163, 9343308.
18. Zhang Y, Dufau ML. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. J Biol Chem 2000, 275:2763-2770. 10.1074/jbc.275.4.2763, 10644740.
19. Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY. The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function. Mol Cell Biol 2000, 20:2604-2618. 10.1128/MCB.20.7.2604-2618.2000, 85476, 10713182.
20. Kastner P, Mark M, Chambon P. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?. Cell 1995, 83:859-869. 10.1016/0092-8674(95)90202-3, 8521510.
21. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM. The nuclear receptor superfamily: the second decade. Cell 1995, 83:835-839. 10.1016/0092-8674(95)90199-X, 8521507.
22. Leng X, Cooney AJ, Tsai SY, Tsai MJ. Molecular mechanisms of COUP-TF-mediated transcriptional repression: evidence for transrepression and active repression. Mol Cell Biol 1996, 16:2332-2340. 231221, 8628300.
23. Aranda A, Pascual A. Nuclear hormone receptors and gene expression. Physiol Rev 2001, 81:1269-1304.
24. Duez H, Staels B. Nuclear receptors linking circadian rhythms and cardiometabolic control. Arterioscler Thromb Vasc Biol 2010, 30:1529-1534. 10.1161/ATVBAHA.110.209098, 20631353.
25. Warnecke M, Oster H, Revelli JP, Alvarez-Bolado G, Eichele G. Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception. Genes Dev 2005, 19:614-625. 10.1101/gad.317905, 551581, 15741322.
26. Jonk LJ, de Jonge ME, Pals CE, Wissink S, Vervaart JM, Schoorlemmer J, Kruijer W. Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors. Mech Dev 1994, 47:81-97. 10.1016/0925-4773(94)90098-1, 7947324.
27. Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T. Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. Nucleic Acids Res 1988, 16:11057-11074. 10.1093/nar/16.23.11057, 338996, 2905047.
28. Kemppainen RJ, Behrend EN. Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells. J Biol Chem 1998, 273:3129-3131. 10.1074/jbc.273.6.3129, 9452419.
29. Takahashi H, Umeda N, Tsutsumi Y, Fukumura R, Ohkaze H, Sujino M, van der Horst G, Yasui A, Inouye ST, Fujimori A, et al. Mouse dexamethasone-induced RAS protein 1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus. Brain Res Mol Brain Res 2003, 110:1-6. 10.1016/S0169-328X(02)00543-0, 12573527.
30. Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH. Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron 2000, 28:183-193. 10.1016/S0896-6273(00)00095-7, 11086993.
31. Cheng HY, Obrietan K. Dexras1: shaping the responsiveness of the circadian clock. Semin Cell Dev Biol 2006, 17:345-351. 10.1016/j.semcdb.2006.03.006, 16765612.
32. Jones CA, Sigmund CD, McGowan RA, Kane-Haas CM, Gross KW. Expression of murine renin genes during fetal development. Mol Endocrinol 1990, 4:375-383. 10.1210/mend-4-3-375, 2188116.
33. Sigmund CD, Okuyama K, Ingelfinger J, Jones CA, Mullins JJ, Kane C, Kim U, Wu CZ, Kenny L, Rustum Y, et al. Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct. J Biol Chem 1990, 265:19916-19922.
34. Colicelli J. Human RAS superfamily proteins and related GTPases. Sci STKE 2004, 2004:RE13. 10.1126/stke.2502004re13, 2828947, 15367757.
35. Lowy DR, Willumsen BM. Function and regulation of ras. Annu Rev Biochem 1993, 62:851-891. 10.1146/annurev.bi.62.070193.004223, 8352603.
36. Lau K-F, Chan W-M, Perkinton MS, Tudor EL, Chang RCC, Chan HYE, McLoughlin DM, Miller CCJ. Dexras1 Interacts with FE65 to Regulate FE65-Amyloid Precursor Protein-dependent Transcription. J Biol Chem 2008, 283:34728-34737. 10.1074/jbc.M801874200, 18922798.
37. Dever TE, Glynias MJ, Merrick WC. GTP-binding domain: three consensus sequence elements with distinct spacing. Proc Natl Acad Sci USA 1987, 84:1814-1818. 10.1073/pnas.84.7.1814, 304531, 3104905.
38. Hwang MC, Sung YJ, Hwang YW. The differential effects of the Gly-60 to Ala mutation on the interaction of H-Ras p21 with different downstream targets. J Biol Chem 1996, 271:8196-8202. 10.1074/jbc.271.14.8196, 8626511.
39. Chen SY, Huff SY, Lai CC, Der CJ, Powers S. Ras-15A protein shares highly similar dominant-negative biological properties with Ras-17N and forms a stable, guanine-nucleotide resistant complex with CDC25 exchange factor. Oncogene 1994, 9:2691-2698.
40. Feig LA, Cooper GM. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol Cell Biol 1988, 8:3235-3243. 363555, 3145408.
41. Okamura T, Clemens DL, Inagami T. Renin, angiotensins, and angiotensin-converting enzyme in neuroblastoma cells: evidence for intracellular formation of angiotensins. Proc Natl Acad Sci USA 1981, 78:6940-6943. 10.1073/pnas.78.11.6940, 349168, 6273896.
42. Graham TE, Key TA, Kilpatrick K, Dorin RI. Dexras1/AGS-1, a steroid hormone-induced guanosine triphosphate-binding protein, inhibits 3',5'-cyclic adenosine monophosphate-stimulated secretion in AtT-20 corticotroph cells. Endocrinology 2001, 142:2631-2640. 10.1210/en.142.6.2631, 11356714.
43. Sung YJ, Carter M, Zhong JM, Hwang YW. Mutagenesis of the H-ras p21 at glycine-60 residue disrupts GTP-induced conformational change. Biochemistry 1995, 34:3470-3477. 10.1021/bi00010a040, 7880841.
44. Kjaersgard IV, Knudsen CR, Wiborg O. Mutation of the conserved Gly83 and Gly94 in Escherichia coli elongation factor Tu. Indication of structural pivots. Eur J Biochem 1995, 228:184-190. 10.1111/j.1432-1033.1995.tb20248.x, 7883002.
45. Guo H, Brewer JM, Champhekar A, Harris RB, Bittman EL. Differential control of peripheral circadian rhythms by suprachiasmatic-dependent neural signals. Proc Natl Acad Sci USA 2005, 102:3111-3116. 10.1073/pnas.0409734102, 548796, 15710878.
46. Pando MP, Morse D, Cermakian N, Sassone-Corsi P. Phenotypic rescue of a peripheral clock genetic defect via SCN hierarchical dominance. Cell 2002, 110:107-117. 10.1016/S0092-8674(02)00803-6, 12151001.
47. Silver R, LeSauter J, Tresco PA, Lehman MN. A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms. Nature 1996, 382:810-813. 10.1038/382810a0, 8752274.
48. Teboul M, Grechez-Cassiau A, Guillaumond F, Delaunay F. How nuclear receptors tell time. J Appl Physiol 2009,
49. Wright JW, Harding JW. Brain angiotensin receptor subtypes in the control of physiological and behavioral responses. Neurosci Biobehav Rev 1994, 18:21-53. 10.1016/0149-7634(94)90034-5, 8170622.
50. Lavoie JL, Liu X, Bianco RA, Beltz TG, Johnson AK, Sigmund CD. Evidence supporting a functional role for intracellular renin in the brain. Hypertension 2006, 47:461-466. 10.1161/01.HYP.0000203308.52919.dc, 16446393.
51. Grobe JL, Xu D, Sigmund CD. An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy. Physiology (Bethesda) 2008, 23:187-193. 2538674, 18697992.
52. Wright JW, Reichert JR, Davis CJ, Harding JW. Neural plasticity and the brain renin-angiotensin system. Neurosci Biobehav Rev 2002, 26:529-552. 10.1016/S0149-7634(02)00019-2, 12367589.
53. Emeric-Sauval E. Corticotropin-releasing factor (CRF)--a review. Psychoneuroendocrinology 1986, 11:277-294. 10.1016/0306-4530(86)90014-4, 3538110.
54. Kiss A, Jurkovicova D, Jezova D, Krizanova O. Changes in angiotensin AT1 receptor mRNA levels in the rat brain after immobilization stress and inhibition of central nitric oxide synthase. Endocr Regul 2001, 35:65-70.
55. Watanabe T, Fujioka T, Hashimoto M, Nakamura S. Stress and brain angiotensin II receptors. Crit Rev Neurobiol 1998, 12:305-317.
56. Dumont EC, Rafrafi S, Laforest S, Drolet G. Involvement of central angiotensin receptors in stress adaptation. Neuroscience 1999, 93:877-884. 10.1016/S0306-4522(99)00206-7, 10473253.
57. Amouyel P, Richard F, Berr C, David-Fromentin I, Helbecque N. The renin angiotensin system and Alzheimer's disease. Ann N Y Acad Sci 2000, 903:437-441. 10.1111/j.1749-6632.2000.tb06395.x, 10818534.
58. Barnes NM, Cheng CH, Costall B, Naylor RJ, Williams TJ, Wischik CM. Angiotensin converting enzyme density is increased in temporal cortex from patients with Alzheimer's disease. Eur J Pharmacol 1991, 200:289-292. 10.1016/0014-2999(91)90584-D, 1664329.
59. Savaskan E, Hock C, Olivieri G, Bruttel S, Rosenberg C, Hulette C, Muller-Spahn F. Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia. Neurobiol Aging 2001, 22:541-546. 10.1016/S0197-4580(00)00259-1, 11445253.
60. Ge J, Towers P, Patel AC, Barnes NM. [125I]S(-)-zacopride labels a novel 5-hydroxytryptamine sensitive recognition site in rat duodenum and ileum. Eur J Pharmacol 1996, 300:113-117. 10.1016/0014-2999(95)00854-3, 8741175.
61. Lin JJ, Yueh KC, Chang DC, Lin SZ. Association between genetic polymorphism of angiotensin-converting enzyme gene and Parkinson's disease. J Neurol Sci 2002, 199:25-29. 10.1016/S0022-510X(02)00081-3, 12084438.
62. Turini GA, Brunner HR, Gribic M, Waeber B, Gavras H. Improvement of chronic congestive heart-failure by oral captopril. Lancet 1979, 1:1213-1215. 10.1016/S0140-6736(79)91897-X, 87679.
63. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM, et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992, 71:169-180. 10.1016/0092-8674(92)90275-H, 1394429.
64. Rapp JP, Wang SM, Dene H. A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure. Science 1989, 243:542-544. 10.1126/science.2563177, 2563177.
65. Brunner HR, Gavras H, Waeber B, Kershaw GR, Turini GA, Vukovich RA, McKinstry DN, Gavras I. Oral angiotensin-converting enzyme inhibitor in long-term treatment of hypertensive patients. Ann Intern Med 1979, 90:19-23.
66. Brunner HR, Gavras H, Waeber B, Turini GA, McKinstry DN, Vukovich RA, Gavras I. Orally active angiotensin-converting enzyme inhibitor (SO 14,225) as a treatment for essential hypertension. Br J Clin Pharmacol 1979, 7(2):205S-211S. 1429327, 223614.
67. Tifft CP, Gavras H, Kershaw GR, Gavras I, Brunner HR, Liang CS, Chobanian AV. Converting enzyme inhibition in hypertensive emergencies. Ann Intern Med 1979, 90:43-47.
68. Gietz RD, Woods RA. Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. Methods Enzymol 2002, 350:87-96. full_text, 12073338.
69. Ho SN, Hunt HD, Horton RM, Pullen JK, Pease LR. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 1989, 77:51-59. 10.1016/0378-1119(89)90358-2, 2744487.
70. Manser E, Huang HY, Loo TH, Chen XQ, Dong JM, Leung T, Lim L. Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes. Mol Cell Biol 1997, 17:1129-1143. 231838, 9032240.