Intact JAK-STAT signaling pathway is a prerequisite for STAT1 to reinforce the expression of RIG-G gene

Experimental Cell Research

Volumn 317, Issue 4, 2011, Pages 513-520

  Lou, Ye Jiang ^a,b   Zhang, Zhang Lin ^a   Pan, Xiao Rong ^a   Xu, Gui Ping ^a   Jia, Pei Min ^a   Li, Dong ^a   Tong, Jian Hua ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Gene expression; IFN; JAK STAT; RIG G; Signal transduction; STAT1

Indexed keywords

ALPHA INTERFERON; INTERFERON; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 9; JANUS KINASE; STAT PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN;

ARTICLE; CELL STRAIN HEK293; CYTOKINE RELEASE; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; IN VITRO STUDY; PRIORITY JOURNAL; PROMOTER REGION; RIG G GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION;

EID: 78651448947     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2010.10.025     Document Type: Article

References (29)

1. Levy D.E., Darnell J.E. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 2002, 3:651-662.
2. Calo V., Migliavacca M., Bazan V., Macaluso M., Buscemi M., Gebbia N., Russo A. STAT proteins: from normal control of cellular events to tumorigenesis. J. Cell. Physiol. 2003, 197:157-168.
3. Shuai K. Modulation of STAT signaling by STAT-interacting proteins. Oncogene 2000, 19:2638-2644.
4. Akira S. Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 1999, 17:138-146.
5. Schindler C., Levy D.E., Decker T. JAK-STAT signaling: from interferons to cytokines. J. Biol. Chem. 2007, 282:20059-20063.
6. Platanias L.C. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat. Rev. Immunol. 2005, 5:375-386.
7. Wesoly J., Szweykowska-Kulinska Z., Bluyssen H.A. STAT activation and differential complex formation dictate selectivity of interferon responses. Acta Biochim. Pol. 2007, 54:27-38.
8. Gupta S., Jiang M., Pernis A.B. IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells. J. Immunol. 1999, 163:3834-3841.
9. Bluyssen H.A., Muzaffar R., Vlieststra R.J., van der Made A.C., Leung S., Stark G.R., Kerr I.M., Trapman J., Levy D.E. Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses. Proc. Natl Acad. Sci. USA 1995, 92:5645-5649.
10. Hahm B., Trifilo M.J., Zuniga E.I., Oldstone M.B. Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. Immunity 2005, 22:247-257.
11. Sarkis P.T., Ying S., Xu R., Yu X.F. STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-alpha. J. Immunol. 2006, 177:4530-4540.
12. George C.X., Das S., Samuel C.E. Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5'-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon. Virology 2008, 380:338-343.
13. Kraus T.A., Lau J.F., Parisien J.P., Horvath C.M. A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response. J. Biol. Chem. 2003, 278:13033-13038.
14. Wan L., Lin C.W., Lin Y.J., Sheu J.J., Chen B.H., Liao C.C., Tsai Y., Lin W.Y., Lai C.H., Tsai F.J. Type I IFN induced IL1-Ra expression in hepatocytes is mediated by activating STAT6 through the formation of STAT2: STAT6 heterodimer. J. Cell. Mol. Med. 2008, 12:876-888.
15. Brierley M.M., Marchington K.L., Jurisica I., Fish E.N. Identification of GAS-dependent interferon-sensitive target genes whose transcription is STAT2-dependent but ISGF3-independent. FEBS J. 2006, 273:1569-1581.
16. Lou Y.J., Pan X.R., Jia P.M., Li D., Xiao S., Zhang Z.L., Chen S.J., Chen Z., Tong J.H. IRF-9/STAT2 [corrected] functional interaction drives retinoic acid-induced gene G expression independently of STAT1. Cancer Res. 2009, 69:3673-3680.
17. Yu M., Tong J.H., Mao M., Kan L.X., Liu M.M., Sun Y.W., Fu G., Jing Y.K., Yu L., Lepaslier D., Lanotte M., Wang Z.Y., Chen Z., Waxman S., Wang Y.X., Tan J.Z., Chen S.J. Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes. Proc. Natl Acad. Sci. USA 1997, 94:7406-7411.
18. Xiao S., Li D., Zhu H.Q., Song M.G., Pan X.R., Jia P.M., Peng L.L., Dou A.X., Chen G.Q., Chen S.J., Chen Z., Tong J.H. RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. Proc. Natl Acad. Sci. USA 2006, 103:16448-16453.
19. Honda K., Taniguchi T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 2006, 6:644-658.
20. Xie R., van Wijnen A.J., van Der Meijden C., Luong M.X., Stein J.L., Stein G.S. The cell cycle control element of histone H4 gene transcription is maximally responsive to interferon regulatory factor pairs IRF-1/IRF-3 and IRF-1/IRF-7. J. Biol. Chem. 2001, 276:18624-18632.
21. Xiong H., Zhu C., Li H., Chen F., Mayer L., Ozato K., Unkeless J.C., Plevy S.E. Complex formation of the interferon (IFN) consensus sequence-binding protein with IRF-1 is essential for murine macrophage IFN-gamma-induced iNOS gene expression. J. Biol. Chem. 2003, 278:2271-2277.
22. Kumatori A., Yang D., Suzuki S., Nakamura M. Cooperation of STAT-1 and IRF-1 in interferon-gamma-induced transcription of the gp91(phox) gene. J. Biol. Chem. 2002, 277:9103-9111.
23. John J., McKendry R., Pellegrini S., Flavell D., Kerr I.M., Stark G.R. Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons. Mol. Cell. Biol. 1991, 11:4189-4195.
24. McKendry R., John J., Flavell D., Muller M., Kerr I.M., Stark G.R. High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons. Proc. Natl Acad. Sci. USA 1991, 88:11455-11459.
25. van de Wetering M., Oving I., Muncan V., Pon Fong M.T., Brantjes H., van Leenen D., Holstege F.C., Brummelkamp T.R., Agami R., Clevers H. Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep. 2003, 4:609-615.
26. Pilz A., Ramsauer K., Heidari H., Leitges M., Kovarik P., Decker T. Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons. EMBO Rep. 2003, 4:368-373.
27. Chatterjee-Kishore M., Wright K.L., Ting J.P., Stark G.R. How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J. 2000, 19:4111-4122.
28. Brucet M., Marques L., Sebastian C., Lloberas J., Celada A. Regulation of murine Tap1 and Lmp2 genes in macrophages by interferon gamma is mediated by STAT1 and IRF-1. Genes Immun. 2004, 5:26-35.
29. Remoli A.L., Marsili G., Perrotti E., Gallerani E., Ilari R., Nappi F., Cafaro A., Ensoli B., Gavioli R., Battistini A. Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1. Biochem. J. 2006, 396:371-380.