P53 is transported into the nucleus via an Hsf1-dependent nuclear localization mechanism

Molecular Carcinogenesis

Volumn 50, Issue 2, 2011, Pages 143-152

  Li, Qiang ^a   Martinez, Jesse D ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Heat shock factor; Hsf1; Microtubules; Nuclear localization; P53

Indexed keywords

COLCHICINE; HEAT SHOCK TRANSCRIPTION FACTOR 1; PACLITAXEL; PROTEIN P53; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CYTOTOXICITY; MICROTUBULE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL LINE; CELL NUCLEUS; COLCHICINE; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; MICE; MICROTUBULES; PACLITAXEL; RATS; TRANSCRIPTION FACTORS; TUBULIN MODULATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 78651444742     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20713     Document Type: Article

References (27)

1. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997;88:323-331.
2. Moll UM, Riou G, Levine AJ. Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci USA 1992;89:7262-7266.
3. Moll UM, LaQuaglia M, Benard J, et al. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci USA 1995;92:4407-4411.
4. Bosari S, Viale G, Roncalli M, et al. p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma. Am J Pathol 1995;147:790-798.
5. Shaulsky G, Goldfinger N, Ben-Ze'ev A, et al. Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis. Mol Cell Biol 1990;10:6565-6577.
6. Liang SH, Clarke MF. A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain. J Biol Chem 1999;274:32699-32703.
7. Kim IS, Kim DH, Han SM, et al. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. J Biol Chem 2000;275:23139-23145.
8. Giannakakou P, Sackett DL, Ward Y, et al. p53 is associated with cellular microtubules and is transported to the nucleus by dynein. Nat Cell Biol 2000;2:709-717.
9. Goldman SC, Chen CY, Lansing TJ, et al. The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization. Am J Pathol 1996;148:1381-1385.
10. Martinez J, Georgoff I, Martinez J, et al. Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev 1991;5:151-159.
11. Li Q, Falsey RR, Gaitonde S, et al. Genetic analysis of p53 nuclear importation. Oncogene 2007;26:7885-7893.
12. Adam SA, Marr RS, Gerace L. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J Cell Biol 1990;111:807-816.
13. Donkor FF, Monnich M, Czirr E, et al. Outer dense fibre protein 2 (ODF2) is a self-interacting centrosomal protein with affinity for microtubules. J Cell Sci 2004;117:4643-4651.
14. Gaitonde SV, Riley JR, Qiao D, et al. Conformational phenotype of p53 is linked to nuclear translocation. Oncogene 2000;19:4042-4049.
15. Li Q, Feldman RA, Radhakrishnan VM, et al. Hsf1 is required for the nuclear translocation of p53 tumor suppressor. Neoplasia (New York) 2008;10:1138-1145.
16. Moore KA, Ema H, Lemischka IR. In vitro maintenance of highly purified, transplantable hematopoietic stem cells. Blood 1997;89:4337-4347.
17. Panno ML, Giordano F, Mastroianni F, et al. Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells. FEBS Lett 2006;580:2371-2380.
18. Westerheide SD, Morimoto RI. Heat shock response modulators as therapeutic tools for diseases of protein conformation. J Biol Chem 2005;280:33097-33100.
19. Salmand PA, Jungas T, Fernandez M, et al. Mouse heat-shock factor 1 (HSF1) is involved in testicular response to genotoxic stress induced by doxorubicin. Biol Reprod 2008;79:1092-1101.
20. Liang P, MacRae TH. Molecular chaperones and the cytoskeleton. J Cell Sci 1997;110:1431-1440.
21. Pratt WB, Toft DO. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp Biol Med 2003;228:111-133.
22. Whitesell L, Sutphin PD, Pulcini EJ, et al. The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. Mol Cell Biol 1998;18:1517-1524.
23. Galigniana MD, Harrell JM, O'Hagen HM, et al. Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus. J Biol Chem 2004;279:22483-22489.
24. Akakura S, Yoshida M, Yoneda Y, et al. A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135). J Biol Chem 2001;276:14649-14657.
25. Peng Y, Chen L, Li C, et al. Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization. J Biol Chem 2001;276:40583-40590.
26. Tan G, Heqing L, Jiangbo C, et al. Apoptosis induced by low-dose paclitaxel is associated with p53 upregulation in nasopharyngeal carcinoma cells. Int J Cancer 2002;97:168-172.
27. Bacus SS, Gudkov AV, Lowe M, et al. Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 2001;20:147-155.