Use of external metabolizing systems when testing for endocrine disruption in the T-screen assay

Toxicology and Applied Pharmacology

Volumn 250, Issue 3, 2011, Pages 263-269

  Taxvig, Camilla ^a   Olesen, Pelle Thonning ^a   Nellemann, Christine ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Endocrine disrupters; GH3 cells; In vitro; Metabolism; T screen

Indexed keywords

BUTYL PARABEN; ENDOCRINE DISRUPTOR; ETHYL PARABEN; KETOCONAZOLE; METHYL PARABEN; MICONAZOLE; PHTHALIC ACID DIETHYL ESTER; PHTHALIC ACID DIMETHYL ESTER; PROCHLORAZ; TEBUCONAZOLE;

ARTICLE; BIOTRANSFORMATION; CELL ASSAY; CELL STRAIN GH3; ENDOCRINE DISEASE; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; METABOLIC CAPACITY; MICROSOME; NONHUMAN; QUALITATIVE ANALYSIS; RAT; TOXICOKINETICS;

ANIMALS; ANTIFUNGAL AGENTS; AZOLES; BIOLOGICAL ASSAY; BIOTRANSFORMATION; CELL LINE; CELL LINE, TUMOR; ENDOCRINE DISRUPTORS; FUNGICIDES, INDUSTRIAL; HUMANS; MICROSOMES, LIVER; PARABENS; PHTHALIC ACIDS; RATS; RECEPTORS, THYROID HORMONE;

RATTUS;

EID: 78651426088     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.10.029     Document Type: Article

References (23)

1. Capen C.C. Mechanistic data and risk assessment of selected toxic end points of the thyroid gland. Toxicol. Pathol. 1997, 25:39-48.
2. Cheek A.O., Kow K., Chen J., McLachlan J.A. Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. Environ. Health Perspect. 1999, 107:273-278.
3. Coecke S., Ahr H., Blaauboer B.J., Bremer S., Casati S., Castell J., Combes R., Corvi R., Crespi C.L., Cunningham M.L., Elaut G., Eletti B., Freidig A., Gennari A., Ghersi-Egea J.F., Guillouzo A., Hartung T., Hoet P., Ingelman-Sundberg M., Munn S., Janssens W., Ladstetter B., Leahy D., Long A., Meneguz A., Monshouwer M., Morath S., Nagelkerke F., Pelkonen O., Ponti J., Prieto P., Richert L., Sabbioni E., Schaack B., Steiling W., Testai E., Vericat J.A., Worth A. Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54. Altern. Lab. Anim. 2006, 34:49-84.
4. Coldham N.G., Horton R., Byford M.F., Sauer M.J. A binary screening assay for pro-oestrogens in food: metabolic activation using hepatic microsomes and detection with oestrogen sensitive recombinant yeast cells. Food Addit. Contam. 2002, 19:1138-1147.
5. Combes R.D. The in vivo relevance of in vitro genotoxicity assays incorporating enzyme activation systems. Progress in Drug Metabolism 1992, 295-321. Taylor and Francis Limited, London. G.G. Gibson (Ed.).
6. Craft E.S., DeVito M.J., Crofton K.M. Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL/6J mice exposed to TCDD-like and phenobarbital-like polychlorinated biphenyl congeners. Toxicol. Sci. 2002, 68:372-380.
7. DeVito M., Biegel L., Brouwer A., Brown S., Brucker-Davis F., Cheek A.O., Christensen R., Colborn T., Cooke P., Crissman J., Crofton K., Doerge D., Gray E., Hauser P., Hurley P., Kohn M., Lazar J., McMaster S., McClain M., McConnell E., Meier C., Miller R., Tietge J., Tyl R. Screening methods for thyroid hormone disruptors. Environ. Health Perspect. 1999, 107:407-415.
8. Frandsen H., Nielsen P.A., Grivas S., Larsen J.C. Microsomal metabolism of the food mutagen 2-amino-3, 4, 8-trimethyl-3H-imidazo[4, 5-f]-quinoxaline to mutagenic metabolites. Mutagenesis 1994, 9:59-65.
9. Frederiksen H., Frandsen H. In vitro metabolism of two heterocyclic amines, 2-amino-9H-pyrido[2, 3-b]indole (A(alpha)C) and 2-amino-3-methyl-9H-pyridol2, 3-b]indole (MeA(alpha)C) in human and rat hepatic microsomes. Pharmacol. Toxicol. 2002, 90:127-134.
10. Fritsche E., Cline J.E., Nguyen N.H., Scanlan T.S., Abel J. Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors. Environ. Health Perspect. 2005, 113:871-876.
11. Gauger K.J., Kato Y., Haraguchi K., Lehmler H.J., Robertson L.W., Bansal R., Zoeller R.T. Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors. Environ. Health Perspect. 2004, 112:516-523.
12. Ghisari M., Bonefeld-Jorgensen E.C. Impact of environmental chemicals on the thyroid hormone function in pituitary rat GH3 cells. Mol. Cell. Endocrinol. 2005, 244:31-41.
13. Guillouzo A. Liver cell models in in vitro toxicology. Environ. Health Perspect. 1998, 106(Suppl 2):511-532.
14. Hallgren S., Sinjari T., Hakansson H., Darnerud P.O. Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch. Toxicol. 2001, 75:200-208.
15. Hinkle P.M., Kinsella P.A. Thyroid hormone induction of an autocrine growth factor secreted by pituitary tumor cells. Science 1986, 234:1549-1552.
16. Kato Y., Haraguchi K., Shibahara T., Yumoto S., Masuda Y., Kimura R. Reduction of serum thyroxine concentrations by methylsulfonyl metabolites of tetra-, penta- and hexachlorinated biphenyls in male Sprague-Dawley rats. Chemosphere 2000, 40:1233-1240.
17. Safe S., Connor K., Ramamoorthy K., Gaido K., Maness S. Human exposure to endocrine-active chemicals: hazard assessment problems. Regul. Toxicol. Pharmacol. 1997, 26:52-58.
18. Setchell K.D.R.a.H.A. Mammalian lignans and phytoestrogens. Recent studies on their formation, metabolism, and biological role in health and disease. Role of the Gut Flora in Toxicity and Cancer 1988, 315-345. Academic Press, London. I.R. Rowland (Ed.).
19. Taxvig C., Vinggaard A.M., Hass U., Axelstad M., Boberg J., Hansen P.R., Frederiksen H., Nellemann C. Do parabens have the ability to interfere with steroidogenesis?. Toxicol. Sci. 2008, 106:206-213.
20. Werck-Reichhart D., Feyereisen R. Cytochromes P450: a success story. Genome Biol. 2000, 1. (REVIEWS3003).
21. Wong C., Kelce W.R., Sar M., Wilson E.M. Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. J. Biol. Chem. 1995, 270:19998-20003.
22. Zhou T., Ross D.G., DeVito M.J., Crofton K.M. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol. Sci. 2001, 61:76-82.
23. Zoeller R.T., Bansal R., Parris C. Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain. Endocrinology 2005, 146:607-612.