Identification of 1- and 3-methylhistidine as biomarkers of skeletal muscle toxicity by nuclear magnetic resonance-based metabolic profiling

Analytical Biochemistry

Volumn 410, Issue 1, 2011, Pages 84-91

  Aranibar, Nelly ^a   Vassallo, Jeffrey D ^a   Rathmacher, John ^b   Stryker, Steve ^a   Zhang, Yingru ^a   Dai, Jun ^a   Janovitz, Evan B ^a   Robertson, Don ^a   Reily, Michael ^a   Lowe Krentz, Linda ^c   Lehman Mckeeman, Lois ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b IOWA STATE UNIVERSITY   (United States)

^c LEHIGH UNIVERSITY   (United States)

Author keywords

1 Methylhistidine; 3 Methylhistidine; Cerivastatin; GC MS; Isoproterenol; Metabolomics; Metabonomics; Muscle toxicity; Myopathy; NMR

Indexed keywords

BIOMARKERS; GAS CHROMATOGRAPHY; ISOMERS; MASS SPECTROMETRY; METABOLITES; NUCLEAR MAGNETIC RESONANCE; RATS; TOXICITY;

1-METHYLHISTIDINE; 3-METHYLHISTIDINE; CERIVASTATIN; GC-MS; ISOPROTERENOL; METABOLOMICS; METABONOMICS; MYOPATHY;

MUSCLE;

1 METHYLHISTIDINE; 3 METHYLHISTIDINE; CERIVASTATIN; HISTIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE; MALE; MASS FRAGMENTOGRAPHY; MYOPATHY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RAT; SEX DIFFERENCE; SKELETAL MUSCLE;

RATTUS;

EID: 78651379622     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2010.11.023     Document Type: Article

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