Takotsubo cardiomyopathy: A diagnostic challenge

Postgraduate Medical Journal

Volumn 87, Issue 1023, 2011, Pages 51-59

  Zeb, Mehmood ^a,b   Sambu, Nalyaka ^a   Scott, Paul ^a,b   Curzen, Nick ^a,b  

^a UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CATECHOLAMINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT;

ADRENERGIC SYSTEM; AGED; ANAMNESIS; ANGIOCARDIOGRAPHY; CASE REPORT; CLINICAL ASSESSMENT; CLINICAL FEATURE; CORONARY ARTERY SPASM; DRUG WITHDRAWAL; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; ESTROGEN DEFICIENCY; FEMALE; GENETIC PREDISPOSITION; HEART INFARCTION; HEART LEFT VENTRICLE FAILURE; HEART VENTRICULOGRAPHY; HISTOPATHOLOGY; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PERCUTANEOUS CORONARY INTERVENTION; PROGNOSIS; REVIEW; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STUNNED HEART MUSCLE; TAKOTSUBO CARDIOMYOPATHY; VIRUS INFECTION;

AGED; DIAGNOSTIC TECHNIQUES, CARDIOVASCULAR; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; PROGNOSIS; TAKOTSUBO CARDIOMYOPATHY;

EID: 78651377056     PISSN: 00325473     EISSN: 14690756     Source Type: Journal    
DOI: 10.1136/pgmj.2010.102475     Document Type: Review

References (79)

1. Cebelin MS, Hirsch CS. Human stress cardiomyopathy. Myocardial lesions in victims of homicidal assaults without internal injuries. Hum Pathol 1980;11:123-32.
2. Anon. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 18-1986. A 44-year-old woman with substernal pain and pulmonary edema after severe emotional stress. N Engl J Med 1986;314:1240-7.
3. Pollick C, Cujec B, Parker S, et al. Left ventricular wall motion abnormalities in subarachnoid hemorrhage: an echocardiographic study. J Am Coll Cardiol 1988;12:600-5.
4. Iga K, Gen H, Tomonaga G, et al. Reversible left ventricular wall motion impairment caused by pheochromocytomada case report. Jpn Circ J 1989;53:813-18.
5. Sato H, Tateishi H, Uchida T, et al. Tako-tsubo-like left ventricular dysfunction due to multivessel coronary spasm. In: Kodama K, Haze K, Hori M, eds. Clinical aspect of myocardial injury: from ischemia to heart failure [in Japanese]. Tokyo, Japan: Kagakuhyoronsha Publishing Co, 1990:56-64.
6. Iga K, Hori K, Kitaguchi K, et al. Transient segmental asynergy of the left ventricle of patients with various clinical manifestations possibly unrelated to the coronary artery disease. Jpn Circ J 1991;55:1061-7.
7. Tsuchihashi K, Ueshima K, Uchida T, et al. Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. J Am Coll Cardiol 2001;38:11-18.
8. Kono T, Morita H, Kuroiwa T, et al. Left ventricular wall motion abnormalities in patients with subarachnoid hemorrhage: neurogenic stunned myocardium. J Am Coll Cardiol 1994;24:636-40.
9. Kawai S, Suzuki H, Yamaguchi H, et al. Ampulla cardiomyopathy ("Takotsubo" cardiomyopathy): reversible left ventricular dysfunction with ST segment elevation. Jpn Circ J 2000;64:156-9.
10. Pavin D, Le Breton H, Daubert C. Human stress cardiomyopathy mimicking acute myocardial syndrome. Heart 1997;78:509-11.
11. Brandspiegel HZ, Marinchak RA, Rials SJ, et al. A broken heart. Circulation 1998;98:1349.
12. Pilgrim TM, Wyss TR. Takotsubo-cardiomyopathy or transient left ventricular apical ballooning syndrome: a systematic review. Int J Cardiol 2008;124:283-92.
13. Gianni M, Dentali F, Grandi A, et al. Apical ballooning syndrome or Takotsubocardiomyopathy: a systematic review. Eur Heart J 2006;27:1523-9.
14. Bybee KA, Prasad A, Barsness GW. Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome, Am J Cardiol 2004;94:343-6.
15. Pernicova I, Garg S, Bourantas CV, et al. Takotsubo-cardiomyopathy: a review of the literature. Angiology 2010;61:166-73.
16. Donohue D, Movahed MR. Clinical characteristics, demographics and prognosis of transient left ventricular apical ballooning syndrome. Heart Fail Rev 2005;10:311-16.
17. Park JH, Kang SJ, Song JK, et al. Left ventricular apical ballooning due to severe physical stress in patients admitted to the medical ICU. Chest 2005;128:296-302.
18. Wittstein IS, Thiemann DR, Lima JA, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 2005;352:539-48.
19. Yamabe H, Hanaoka J, Funakoshi T, et al. Deep negative T waves and abnormal cardiac sympathetic image (123I-MIBG) after the great hanshin earthquake of 1995. Am J Med Sci 1996;311:221-4.
20. Watanabe H, Kodama M, Okura Y, et al. Impact of earthquakes on Takotsubocardiomyopathy. JAMA 2005;294:305-7.
21. Ferreira SH, Vane JR. Half-lives of peptides and amines in the circulation. Nature 1967;215:1237-40.
22. Abraham J, Mudd JO, Kapur NK, et al. Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists. J Am Coll Cardiol 2009;53:1320-5.
23. Kume T, Kawamoto T, Okura H, et al. Local release of catecholamines from the hearts of patients with tako-tsubo-like left ventricular dysfunction. Circ J 2008;72:106-8.
24. Nef HM. Abnormalities in intracellular Ca2+ regulation contribute to the pathomechanism of Tako-Tsubo cardiomyopathy. Eur. Heart J 2009;30:2155-64.
25. Ellison GM, Torella D, Karakikes I, et al. Acute β-Adrenergic Overload Produces Myocyte Damage through Calcium Leakage from the Ryanodine Receptor 2 but Spares Cardiac Stem Cells. Biol Chem 2007;282:11397-409.
26. Brutsaert DL, Meulemans AL, Sipido KR. Effects of damaging the endocardial surface on the mechanical performance of isolated cardiac muscle. Circ Res 1988;62:358-66.
27. Brutsaert DL. Cardiac endothelialemyocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity. Physiol Rev 2003;83:59-115.
28. Bielecka-Dabrowa A, Mikhailidis DP, Hannam S, et al. Takotsubocardiomyopathyethe current state of knowledge. Int J Cardiol 2010;142:120-5.
29. Meulemans AL, Andries LJ, Brutsaert DL. Endocardial endothelium mediates positive inotropic response to alpha 1-adrenoceptor agonist in mammalian heart. J Mol Cell Cardiol 1990;22:667-85.
30. Shah AM, Andries LJ, Meulemans AL, et al. Endocardium modulates myocardial inotropic response to 5-hydroxytryptamine. Am J Physiol 1989;257:H1790-7.
31. Handy A, Prasad A, Olson T. Investigating genetic variation of adrenergic receptors in familial stress cardiomyopathy (apical ballooning syndrome). J Cardiol 2009;54:516-17.
32. Heubach JF, Kaumann AJ. Epinephrine activates both Gs and Gi pathways, but norepinephrine activates only the Gs pathway through human beta2- adrenoceptors overexpressed in mouse heart. Mol Pharmacol 2004;65:1313-22.
33. Heubach JF, Blaschke M, Harding SE, et al. Cardiostimulant and cardiodepressant effects through overexpressed human β2-adrenoceptors in murine heart. Naunyn Schmiedebergs Arch Pharmacol 2003;367:380-90.
34. Lyon A, Rees P, Prasad S, et al. Stress (Takotsubo) cardiomyopathyda novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nat Clin Pract Cardiol 2008;5:22-9.
35. Zhu WZ, Zheng M, Koch WJ, et al. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci U S A 2001;98:1607-12.
36. Prison L, De Vusser P, Mullens W. Apical ballooning in relatives. Heart 2004;90:-67.
37. Kumar G, Holmes D Jr, Prasad A. "Familial" apical ballooning syndrome (Takotsubo-cardiomyopathy). Int J Cardiol 2009. doi:10.1016/j.ijcard. 2009 .03.078.
38. Sharkey S, Maron B, Nelson P, et al. Adrenergic receptor polymorphisms in patients with stress (tako-tsubo) cardiomyopathy. J Cardiol 2009;53:53-7.
39. Fournier C, Boujon B, Hebert JL, et al. Stunned myocardium following coronary spasm. Am Heart J 1991;121:593-5.
40. Kurisu S, Sato H, Kawagoe T, et al. Tako-Tsubo-like left ventricular dysfunction with ST-segment elevation: a novel cardiac syndrome mimicking acute myocardial infarction. Am Heart J 2002;143:448-55. (Pubitemid 34185175)
41. Giordan M, Rigatelli G, Cardaioli P, et al. Angiographic long-term follow-up of primary apical ballooning of the left ventricle. Int J Cardiovasc Imaging 2006;22:349-52. (Pubitemid 43816366)
42. Abe Y, Kondo M, Matsuoka R, et al. Assessment of clinical features in transient left ventricular apical ballooning. J Am Coll Cardiol 2003;41:737-42. (Pubitemid 36308378)
43. Prasad A. Apical Ballooning Syndrome An Important Differential Diagnosis of Acute Myocardial Infarction. Circulation 2007;115:e56-9. (Pubitemid 46226154)
44. Ibanez B, Navarro F, Cordoba M, et al. Tako-tsubo transient left ventricular apical ballooning: is intravascular ultrasound the key to resolve the enigma?. Heart 2005;91:102-4. (Pubitemid 39665011)
45. Nissen SE. Pathobiology, not angiography, should guide management in acute coronary syndrome/non-ST-segment elevation myocardial infarction. J Am Coll Cardiol 2003;41:103S-12S.
46. Hackett D, Davies G, Chierchia S, et al. Intermittent coronary occlusion in acute myocardial infarction. Value of combined thrombolytic and vasodilator therapy. N Engl J Med 1987;317:1055-9. (Pubitemid 17146897)
47. Ueyama T, Hano T, Kasamatsu K, et al. Estrogen attenuates the emotional stress-induced cardiac responses in the animal model of Tako-tsubo (Ampulla) cardiomyopathy. J Cardiovasc Pharmacol 2003;42:117-19. (Pubitemid 37467088)
48. Elesber A, Lerman A, Bybee KA, et al. Myocardial perfusion in apical ballooning syndrome correlate of myocardial injury. Am Heart J 2006;152:469.e9-13. (Pubitemid 44233441)
49. Kurisu S, Inoue I, Kawagoe T, et al. Myocardial perfusion and fatty acid metabolism in patients with Tako-Tsubo-like left ventricular dysfunction. J Am Coll Cardiol 2003;41:743-8. (Pubitemid 36308379)
50. Ito K, Sugihara H, Katoh S, et al. Assessment of Takotsubo (ampulla) cardiomyopathy using 99mTc-tetrofosmin myocardial SPECTdcomparison with acute coronary syndrome. Ann Nucl Med 2003;17:115-22.
51. Akashi YJ, Nakazawa K, Sakakibara M, et al. 123I-MIBG myocardial scintigraphy in patients with "takotsubo" cardiomyopathy. J Nucl Med 2004;45:1121-7.
52. Ako J, Takenaka K, Uno K, et al. Reversible left ventricular systolic dysfunctionereversibility of coronary microvascular abnormality. Jpn Heart J 2001;42:355-63.
53. Ueyama T, Kawabe T, Hano T, et al. Upregulation of heme oxygenase-1 in an animal model of takotsubo cardiomyopathy. Circ J 2009;73:1141-6.
54. Akashi YJ, Nef HM, Möllmann H, et al. Stress cardiomyopathy. Annu Rev Med 2010;61:271-86.
55. Movahed MR, Donohue D. Review: transient left ventricular apical ballooning, broken heart syndrome, ampulla cardiomyopathy, atypical apical ballooning, or Tako-Tsubo cardiomyopathy. Cardiovasc Revasc Med 2007;8:289-92.
56. Ueyama T, Ishikura F, Matsuda A, et al. Chronic estrogen supplementation following ovariectomy improves the emotional stress-induced cardiovascular responses by indirect action on the nervous system and by direct action on the heart. Circ J 2007;71:565-73.
57. Ueyama T, Kasamatsu K, Hano T, et al. Catecholamines and estrogen are involved in the pathogenesis of emotional stress-induced acute heart attack. Ann N Y Acad Sci 2008;1148:479-85.
58. Ibáñez B, Navarro F, Farré J, et al. Tako-tsubo syndrome associated with a long course of the left anterior descending coronary artery along the apical diaphragmatic surface of the left ventricle (in Spanish; Castilian). Revista española de cardiología 2004;57:209-16.
59. Eshtehardi P, Koestner SC, Adorjan P, et al. "Transient apical ballooning syndromeeclinical characteristics, ballooning pattern, and long-term follow-up in a Swiss population". Int J Cardiol 2009;135:370-5.
60. Bybee K, Motiei A, Syed I, et al. Electrocardiography cannot reliably differentiate transient left ventricular apical ballooning syndrome from anterior ST-segment elevation myocardial infarction. J Electrocardiol 2007;40:38.e1-6.
61. Dib C, Asirvatham S, Elesber A, et al. Clinical correlates and prognostic significance of electrocardiographic abnormalities in apical ballooning syndrome (Takotsubo/stress-induced cardiomyopathy). Am Heart J 2009;157:933-8.
62. Shimizu M, Kato Y, Masai H, et al. Recurrent episodes of takotsubo-like transient left ventricular ballooning occurring in different regions: a case report. J Cardiol 2006;48:101-7.
63. Margey R, Diamond P, McCann H, et al. Dobutamine stress echo-induced apical ballooning (Takotsubo) syndrome. Eur J Echocardiogr 2009;10:395-9.
64. Cherian J, Kothari S, Angelis D, et al. Atypical takotsubo cardiomyopathy: dobutamine-precipitated apical ballooning with left ventricular outflow tract obstruction. Tex Heart Inst J 2008;35:73-5.
65. Bellenger N, Peebles C, Harden S, et al. Troponin-positive chest pain with unobstructed coronary arteries: A role for delayed enhanced cardiovascular magnetic resonnance in the diagnosis of non-ST elevation myocardial infarction? J Invasive Cardiol 2006;12:594-8.
66. Eitel I, Behrendt F, Schindler K, et al. Differential diagnosis of suspected apical ballooning syndrome using contrast-enhanced magnetic resonance imaging. Eur Heart J 2008;29:2651-9.
67. Haghi D, Athanasiadis A, Papavassiliu T, et al. Right ventricular involvement in Takotsubo cardiomyopathy. Eur Heart J 2006;27:2433-9.
68. Elesber AA, Prasad A, Bybee KA, et al. Transient cardiac apical ballooning syndrome: prevalence and clinical implications of right ventricular involvement. J Am Coll Cardiol 2006;47:1082-3.
69. Hurst RT, Prasad A, Askew JW, et al. Takotsubo Cardiomyopathy: a unique cardiomyopathy with variable ventricular morphology. JACC Cardiovasc Imaging 2010;3:641-9.
70. Nef HM, Mollmann H, Kostin S, et al. Tako-Tsubo cardiomyopathy: intraindividual structural analysis in the acute phase and after functional recovery. Eur Heart J 2007;28:2456-64.
71. Kloner RA, Przyklenk K, Patel B. Altered myocardial states. The stunned and hibernating myocardium. Am J Med 1989;86:14-22.
72. Ueyama T. Emotional stress-induced Tako-tsubo cardiomyopathy: animal model and molecular mechanism. Ann N Y Acad Sci 2004;1018:437-44.
73. Uchida M, Egawa M, Yamaguchi S, et al. Protective effects of emotional stresseinduced cardiac dysfunction depend on α/β ratio of adrenoceptor blocker. Circ J 2009;73(Suppl 1):595.
74. Denney SD, Lakkireddy DR, Khan IA. Long QT syndrome and torsade de pointes in transient left ventricular apical ballooning syndrome. Int J Cardiol 2005;100:499-501. (Pubitemid 40503300)
75. Elesber AA, Prasad A, Lennon RJ, et al. Four-year recurrence rate and prognosis of the apical ballooning syndrome. J Am Coll Cardiol 2007;50:448-52. (Pubitemid 47088125)
76. Jabara R, Gadesam R, Pendyala L, et al. Comparison of the clinical characteristics of apical and non-apical variants of "broken heart" (takotsubo) syndrome in the United States. J Invasive Cardiol 2009;21:216-22.
77. Nef HM, Mollmann H, Weber M, et al. Release pattern of cardiac biomarkers in left ventricular apical ballooning. Int J Cardiol 2007;115:128-9. (Pubitemid 44855196)
78. Cherian J, Angelis D, Filiberti A, et al. Recurrence of stress-induced (Takotsubo) cardiomyopathy. Cardiology 2006;108:144-6.
79. Kurisu S, Inoue I, Kawagoe T, et al. Persistent left ventricular dysfunction in Takotsubo cardiomyopathy after pacemaker implantation. Circ J 2006;70:641-4.