Sperm and testis mediated DNA transfer as a means of gene therapy

Systems Biology in Reproductive Medicine

Volumn 57, Issue 1-2, 2011, Pages 35-42

  Parrington, John ^a   Coward, Kevin ^b   Gadea, Joaquin ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF MURCIA   (Spain)

Author keywords

gene therapy; sperm; testis; transgene; viral vector

Indexed keywords

ADENOVIRUS VECTOR; DNA; ENHANCED GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; PLASMID DNA; RETROVIRUS VECTOR; VIRUS VECTOR;

CONFERENCE PAPER; DNA TRANSFER; GENE DELIVERY SYSTEM; GENE INSERTION; GENE TARGETING; GENE THERAPY; HEREDITY; HUMAN; IN VITRO GENE TRANSFER; IN VIVO GENE TRANSFER; MALE INFERTILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPERM; SPERM MEDIATED GENE TRANSFER; TESTIS; TESTIS MEDIATED GENE TRANSFER; TRANSGENE; TRANSGENIC ANIMAL; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DNA; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; INFERTILITY, MALE; LENTIVIRUS; MALE; REPRODUCTIVE TECHNIQUES, ASSISTED; RETROVIRIDAE; SPERMATOZOA; TESTIS;

EID: 78651369036     PISSN: 19396368     EISSN: 19396368     Source Type: Journal    
DOI: 10.3109/19396368.2010.514022     Document Type: Conference Paper

References (82)

1. Ashihara, E., Kawata, E. and Maekawa, T. (2010) Future prospect of RNA interference for cancer therapies. Curr Drug Targets 11:345-60.
2. Bachiller, D., Schellander, K., Peli, J. and Ruther, U. (1991) Liposome mediated DNA uptake by sperm cells. Mol Reprod Dev 30:194-200.
3. Blanchard, K.T. and Boekelheide, K. (1997) Adenovirus-mediated gene transfer to rat testis in vivo. Biol Reprod 56:495-500.
4. Brackett, B.G., Baranska, W., Sawicki, W. and Koprowski, H. (1971) Uptake of heterologous genome by mammalian spermatozoa and its transfer to ova through fertilization. Proc Natl Acad Sci USA 68:353-357.
5. Brinster, R.L., Sandgren, E.P., Behringer, R.R. and Palmiter, R.D. (1989) No simple solution for making transgenic mice. Cell 59:239-241.
6. Camaioni, A., Russo, M.A., Odorisio, T., Gandolfi, F., Fazio, V.M. and Siracusa, G. (1992) Uptake of exogenous DNA by mammalian spermatozoa: specific localization of DNA on sperm heads. J Reprod Fertil 961:203-212.
7. Capecchi, M.R. (1989) Altering the genome by homologous recombination. Science 244:1288-1292.
8. Carballada, R. and Esponda, P. (2001) Regulation of foreign DNA uptake by mouse spermatozoa. Exp Cell Res 262:104-113.
9. Chang, K.T., Ikeda, A., Hayashi, K., Furuhata, Y., Nishihara, M., Ohta, A., et al1999a) Production of transgenic rats and mice by the testis-mediated gene transfer. J Reprod Dev 45:29-36.
10. Chang, K.T., Ikeda, A., Hayashi, K., Furuhata, Y., Banai, M., Nishihara, M., et al1999b) Possible mechanisms for the testis-mediated gene transfer as a new method for producing transgenic animals. J Reprod Dev 45:37-42.
11. Coward, K., Kubota, H., Hibbit, O., McIlhinney, J., Kohri, K. and Parrington, J. (2006) Expression of a fluorescent recombinant form of sperm protein phospholipase C zeta in mouse epididymal sperm by in vivo gene transfer into the testis. Fertil Steril 85:1281-1289.
12. Coward, K., Kubota, H. and Parrington, J. (2007) In vivo gene transfer into testis and sperm: developments and future application. Arch Androl 53:187-197.
13. De Miguel, M.P. and Donovan, P.J. (2003) Determinants of retroviral mediated gene delivery to mouse spermatogonia. Biol Reprod 68:860-866.
14. Dobashi, M., Goda, K., Maruyama, H. and Fujisawa, M. (2005) Erythropoietin gene transfer into rat testes by in vivo electroporation may reduce the risk of germ cell loss caused by cryptorchidism. Asian J Androl 7:369-373.
15. Farre, L., Rigau, T., Mogas, T., García-Rocha, M., Canal, M., Gomez- Foix, A.M. and Rodríguez-Gil, J.E. (1999) Adenovirus-mediated introduction of DNA into pig sperm and offspring. Mol Reprod Dev 53:149-158.
16. Francolini, M., Lavitrano, M., Lamia, C.L., French, D., Frati, L., Cotelli, F. and Spadafora, C. (1993) Evidence for nuclear internalization of exogenous DNA into mammalian sperm cells. Mol Reprod Dev 34:133-139.
17. Garcia-Vazquez, F.A., Garcia-Rosello, E., Gutierrez-Adan, A. and Gadea, J. (2009) Effect of sperm treatment on efficiency of EGFP-expressing porcine embryos produced by ICSI-SMGT. Theriogenology 72:506-518.
18. Hamaguchi, I., Woods, N.B., Panagopoulos, I., Andersson, E., Mikkola, H., Fahlman, C., et al2000) Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro. J Virol 74:10778-10784.
19. Hamra, F.K., Gatlin, J., Chapman, K.M., Grellhesl, D.M., Garcia, J.V., Hammer, R.E. and Garbers, D.L. (2002) Production of transgenic rats by lentiviral transduction of male germ-line stem cells. Proc Natl Acad Sci USA 99:14931-14936.
20. Hasenfuss, G. (1998) Animal models of human cardiovascular disease, heart failure and hypertrophy. Cardiovasc Res 39:60-76.
21. Hibbitt, O., Coward, K., Kubota, H., Prathalingham, N., Holt, W., Kohri, K. and Parrington, J. (2006) In vivo gene transfer by electroporation allows expression of a fluorescent transgene in hamster testis and epididymal sperm and has no adverse effects upon testicular integrity or sperm quality. Biol Reprod 74:95-101.
22. Hirabayashi, M. and Hochi, S. (2010) Generation of transgenic rats by ooplasmic injection of sperm cells exposed to exogenous DNA. Methods Mol Biol 597:127-136.
23. Hitt, M., Bett, A., Addison, C., Prevec, L. and Graham, F. (1995) Techniques for human adenovirus vector construction and characterization. Methods Mol Genet 7:13-30.
24. Hoelker, M., Mekchay, S., Schneider, H., Bracket, B., Tesfaye, D., Jennen, D., et al2007) Quantification of DNA binding, uptake, transmission and expression in bovine sperm mediated gene transfer by RT-PCR: effect of transfection reagent and DNA architecture. Theriogenology 67:1097-1107.
25. Huang, Z., Tamura, M., Sakurai, T., Chuma, S., Saito, T. and Nakatsuji, N. (2000) In vivo transfection of testicular germ cells and transgenesis by using the mitochondrially localized jellyfish fluorescent protein gene. FEBS Lett 487:248-251.
26. Ikawa, M., Tergaonkar, V., Ogura, A., Ogonuki, N., Inoue, K. and Verma, I.M. (2002) Restoration of spermatogenesis by lentiviral gene transfer: offspring from infertile mice. Proc Natl Acad Sci USA 99:7524-7529.
27. Ikawa, M., Tanaka, N., Kao,W.W. and Verma, I.M. (2003) Generation of transgenic mice using lentiviral vectors: a novel preclinical assessment of lentiviral vectors for gene therapy. Mol Ther 8:666-673.
28. Ashihara, E., Kawata, E. and Maekawa, T. (2010) Future prospect of RNA interference for cancer therapies. Curr Drug Targets 11:345-60.
29. Bachiller, D., Schellander, K., Peli, J. and Ruther, U. (1991) Liposome mediated DNA uptake by sperm cells. Mol Reprod Dev 30:194-200.
30. Blanchard, K.T. and Boekelheide, K. (1997) Adenovirus-mediated gene transfer to rat testis in vivo. Biol Reprod 56:495-500.
31. Brackett, B.G., Baranska, W., Sawicki, W. and Koprowski, H. (1971) Uptake of heterologous genome by mammalian spermatozoa and its transfer to ova through fertilization. Proc Natl Acad Sci USA 68:353-357.
32. Brinster, R.L., Sandgren, E.P., Behringer, R.R. and Palmiter, R.D. (1989) No simple solution for making transgenic mice. Cell 59:239-241.
33. Camaioni, A., Russo, M.A., Odorisio, T., Gandolfi, F., Fazio, V.M. and Siracusa, G. (1992) Uptake of exogenous DNA by mammalian spermatozoa: specific localization of DNA on sperm heads. J Reprod Fertil 961:203-212.
34. Capecchi, M.R. (1989) Altering the genome by homologous recombination. Science 244:1288-1292.
35. Carballada, R. and Esponda, P. (2001) Regulation of foreign DNA uptake by mouse spermatozoa. Exp Cell Res 262:104-113.
36. Chang, K.T., Ikeda, A., Hayashi, K., Furuhata, Y., Nishihara, M., Ohta, A., et al1999a) Production of transgenic rats and mice by the testis-mediated gene transfer. J Reprod Dev 45:29-36.
37. Chang, K.T., Ikeda, A., Hayashi, K., Furuhata, Y., Banai, M., Nishihara, M., et al1999b) Possible mechanisms for the testis-mediated gene transfer as a new method for producing transgenic animals. J Reprod Dev 45:37-42.
38. Coward, K., Kubota, H., Hibbit, O., McIlhinney, J., Kohri, K. and Parrington, J. (2006) Expression of a fluorescent recombinant form of sperm protein phospholipase C zeta in mouse epididymal sperm by in vivo gene transfer into the testis. Fertil Steril 85:1281-1289.
39. Coward, K., Kubota, H. and Parrington, J. (2007) In vivo gene transfer into testis and sperm: developments and future application. Arch Androl 53:187-197.
40. De Miguel, M.P. and Donovan, P.J. (2003) Determinants of retroviral mediated gene delivery to mouse spermatogonia. Biol Reprod 68:860-866.
41. Dobashi, M., Goda, K., Maruyama, H. and Fujisawa, M. (2005) Erythropoietin gene transfer into rat testes by in vivo electroporation may reduce the risk of germ cell loss caused by cryptorchidism. Asian J Androl 7:369-373.
42. Farre, L., Rigau, T., Mogas, T., García-Rocha, M., Canal, M., Gomez- Foix, A.M. and Rodríguez-Gil, J.E. (1999) Adenovirus-mediated introduction of DNA into pig sperm and offspring. Mol Reprod Dev 53:149-158.
43. Francolini, M., Lavitrano, M., Lamia, C.L., French, D., Frati, L., Cotelli, F. and Spadafora, C. (1993) Evidence for nuclear internalization of exogenous DNA into mammalian sperm cells. Mol Reprod Dev 34:133-139.
44. Garcia-Vazquez, F.A., Garcia-Rosello, E., Gutierrez-Adan, A. and Gadea, J. (2009) Effect of sperm treatment on efficiency of EGFP-expressing porcine embryos produced by ICSI-SMGT. Theriogenology 72:506-518.
45. Hamaguchi, I., Woods, N.B., Panagopoulos, I., Andersson, E., Mikkola, H., Fahlman, C., et al2000) Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro. J Virol 74:10778-10784.
46. Hamra, F.K., Gatlin, J., Chapman, K.M., Grellhesl, D.M., Garcia, J.V., Hammer, R.E. and Garbers, D.L. (2002) Production of transgenic rats by lentiviral transduction of male germ-line stem cells. Proc Natl Acad Sci USA 99:14931-14936.
47. Hasenfuss, G. (1998) Animal models of human cardiovascular disease, heart failure and hypertrophy. Cardiovasc Res 39:60-76.
48. Hibbitt, O., Coward, K., Kubota, H., Prathalingham, N., Holt, W., Kohri, K. and Parrington, J. (2006) In vivo gene transfer by electroporation allows expression of a fluorescent transgene in hamster testis and epididymal sperm and has no adverse effects upon testicular integrity or sperm quality. Biol Reprod 74:95-101.
49. Hirabayashi, M. and Hochi, S. (2010) Generation of transgenic rats by ooplasmic injection of sperm cells exposed to exogenous DNA. Methods Mol Biol 597:127-136.
50. Hitt, M., Bett, A., Addison, C., Prevec, L. and Graham, F. (1995) Techniques for human adenovirus vector construction and characterization. Methods Mol Genet 7:13-30.
51. Hoelker, M., Mekchay, S., Schneider, H., Bracket, B., Tesfaye, D., Jennen, D., et al2007) Quantification of DNA binding, uptake, transmission and expression in bovine sperm mediated gene transfer by RT-PCR: effect of transfection reagent and DNA architecture. Theriogenology 67:1097-1107.
52. Huang, Z., Tamura, M., Sakurai, T., Chuma, S., Saito, T. and Nakatsuji, N. (2000) In vivo transfection of testicular germ cells and transgenesis by using the mitochondrially localized jellyfish fluorescent protein gene. FEBS Lett 487:248-251.
53. Ikawa, M., Tergaonkar, V., Ogura, A., Ogonuki, N., Inoue, K. and Verma, I.M. (2002) Restoration of spermatogenesis by lentiviral gene transfer: offspring from infertile mice. Proc Natl Acad Sci USA 99:7524-7529.
54. Ikawa, M., Tanaka, N., Kao,W.W. and Verma, I.M. (2003) Generation of transgenic mice using lentiviral vectors: a novel preclinical assessment of lentiviral vectors for gene therapy. Mol Ther 8:666-673. sequences into oocytes and detection of homologous recombination events. Mol Reprod Dev 57:338-345.
55. Roach, J. C., Glusman, G., Smit, A.F., Huff, C.D., Hubley, R., Shannon, P.T., et al2010) Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing. Science 328:636-639.
56. Sato, M., Iwase, R., Kasai, K. and Tada, N. (1994) Direct injection of foreign DNA into mouse testis as a possible alternative of sperm mediated gene transfer. Anim Biotechnol 5:19-31.
57. Sato, M., Gotoh, K. and Kimura, M. (1999a) Sperm-mediated gene transfer by direct injection of foreign DNA into mouse testis. Transgenics 2:357-369.
58. Sato, M., Yabuki, K., Watanabe, T. and Kimura, M. (1999b) Testis mediated gene transfer (TMGT) in mice: successful transmission of introduced DNAfrom F0 to F2 generations. Transgenics 3:11-22.
59. Shastry, B. S. (1998) Gene disruption in mice: models of development and disease. Mol Cell Biochem 181:163-179.
60. Shemesh, M., Gurevich, M., Harel-Markowitz, E., Benvenisti, L., Shore, L.S. and Stram, Y. (2000) Gene integration into bovine sperm genome and its expression in transgenic offspring. Mol Reprod Dev 56:306-308.
61. Shoji, M., Chuma, S., Yoshida, K., Morita, T. and Nakatsuji, N. (2005) RNA interference during spermatogenesis in mice. Dev Biol 282:524-534.
62. Smith, K.R. (2003) Gene therapy: theoretical and bioethical concepts. Arch Med Res 34:247-268.
63. Smith, K.R. (2004) Gene Therapy: the Potential Applicability of Gene Transfer Technology to the Human Germline. Int J Med Sci 1:76-91.
64. Snyder, M., Du, J. and Gerstein, M. (2010) Personal genome sequencing: current approaches and challenges. Genes Dev 24:423-431.
65. Somboonthum, P., Ohta, H., Yamada, S., Onishi, M., Ike, A., Nishimune, Y. and Nozaki, M. (2005) cAMP-responsive element in TATA-less core promoter is essential for haploid-specific gene expression in mouse testis. Nucleic Acids Res 33:3401-3411.
66. Suganuma, R., Pelczar, P., Spetz, J.F., Hohn, B., Yanagimachi, R. and Moisyadi, S. (2005) Tn5 transposase-mediated mouse transgenesis. Biol Reprod 73:1157-1163.
67. Szczygiel, M.A., Moisyadi, S. and Ward, M.S. (2003) Expression of foreign DNA is associated with paternal chromosome degradation in intracytoplasmic sperm injection-mediated transgenesis in the mouse. Biol Reprod 68:1903-1910.
68. Tanimoto, R., Abarzua, F., Sakaguchi, M., Takaishi, M., Nasu, Y., Kumon, H. and Huh, N.H. (2007) REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer. Int J Mol Med 19:363-368.
69. Tesarik, J. and Mendoza, C. (2007) Treatment of severe male infertility by micromanipulation-assisted fertilization: an update. Front Biosci 12:105-114.
70. Thomas, C.E., Ehrhardt, A. and Kay, M.A. (2003) Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 4:346-358.
71. Tsai, H.J. (2000) Electroporated sperm mediation of a gene transfer system for finfish and shellfish. Mol Reprod Dev 56:281-284.
72. Wall, R. J. (2001) Pronuclear microinjection. Cloning Stem Cells 3:209-220.
73. Wall, R.J. (2002) New gene transfer methods. Theriogenology 57:189-201.
74. Wang, H.J., Lin, A.X., Zhang, Z.C. and Chen, Y.F. (2001) Expression of porcine growth hormone gene in transgenic rabbits as reported by green fluorescent protein. Anim Biotechnol 12:101-110.
75. Wells, T. and Carter, D.A. (2001) Genetic engineering of neural function in transgenic rodents: towards a comprehensive strategy? J Neurosci Meth 108:111-130.
76. Yamazaki, Y., Fujimoto, H., Ando, H., Ohyama, T., Hirota, Y. and Noce, T. (1998) In vivo gene transfer to mouse spermatogenic cells by deoxyribonucleic acid injection into seminiferous tubules and subsequent electroporation. Biol Reprod 59:1439-1444.
77. Yamazaki, Y., Yagi, T., Ozaki, T. and Imoto, K. (2000) In vivo gene transfer to mouse spermatogenic cells using green fluorescent protein as a marker. J Exp Zool 286:212-218.
78. Yang, C.C., Chang, H.S., Lin, C.J., Hsu, C.C., Cheung, J.I., Hwu, L. and Cheng, W.T.K. (2004) Cock spermatozoa serve as the gene vector for generation of transgenic chicken (Gallus gallus). Asian-Aust J Anim Sci 17:885-891.
79. Yomogida, K., Yagura, Y. and Nishimune, Y. (2002) Electroporated transgene-rescued spermatogenesis in infertile mutant mice with a sertoli cell defect. Biol Reprod 67:712-717.
80. Yonezawa, T., Furuhata, Y., Hirabayashi, K., Suzuki, S., Takahashi, M. and Nishihara, M. (2001) Detection of transgene in progeny at different developmental stages following testis-mediated gene transfer. Mol Reprod Dev 60:196-201.
81. Zani, M., Lavitrano, M., French, D., Lulli, V., Maione, B., Sperandio, S. and Spadafora, C. (1995) The mechanism of binding of exogenous DNA to sperm cells: factors controlling the DNA uptake. Exp Cell Res 217:57-64.
82. Zi, X.D., Chen, S.W., Liang, G.N, Chen, D.W., Zhang, D.W. and Yin, R.H. (2009) The effect of retroviral vector on uptake of human Lactoferrin DNA by Yak (Bos Grunniens) spermatozoa and their fertilizability in vitro. Anim Biotechnol 20:247-251.