Human sodium iodide symporter added to multidrug resistance 1 small hairpin RNA in a single gene construct enhances the therapeutic effects of radioiodine in a nude mouse model of multidrug resistant colon cancer

Cancer Biotherapy and Radiopharmaceuticals

Volumn 25, Issue 6, 2010, Pages 671-679

  Jeon, Yong Hyun ^a   Ahn, Sohn Joo ^a   Lee, Yong Jin ^b   Lee, You La ^a   Lee, Sang Woo ^a   Park, Seung Yoon ^c   Kim, In San ^c   Ahn, Byeong Cheol ^a   Ha, Jeoung Hee ^a   Lee, Jaetae ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

^c Dongguk University College of Medicine   (South Korea)

Author keywords

131I; Combination therapy; doxorubicin; MDR1; NIS; P gp; shRNA

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; IODINE 131; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; MULTIDRUG RESISTANCE PROTEIN 1 SHORT HAIRPIN RNA; PERTECNETATE TC 99M; RADIOACTIVE IODINE; RADIOPHARMACEUTICAL AGENT; SHORT HAIRPIN RNA; SODIUM IODIDE SYMPORTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; CANCER RESISTANCE; CLONOGENIC ASSAY; COLON CANCER; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG UPTAKE; FUNCTIONAL ASSESSMENT; GENE CONSTRUCT; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MALE; MOLECULAR IMAGING; MONOTHERAPY; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PRIORITY JOURNAL; SCINTIGRAPHY; TUMOR GROWTH; TUMOR REGRESSION; TUMOR VOLUME;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; COMBINED MODALITY THERAPY; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HUMANS; IODINE RADIOISOTOPES; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; P-GLYCOPROTEIN; RNA, SMALL INTERFERING; SYMPORTERS; TECHNETIUM TC 99M SESTAMIBI; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78651312127     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.2010.0837     Document Type: Article

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