Immune reconstitution after haploidentical hematopoietic cell transplantation: Impact of reduced intensity conditioning and CD3/CD19 depleted grafts

Leukemia

Volumn 25, Issue 1, 2011, Pages 121-129

  Federmann, B ^a   Hagele M ^a   Pfeiffer, M ^b   Wirths, S ^a   Schumm, M ^b   Faul, C ^a   Vogel, W ^a   Handgretinger, R ^b   Kanz, L ^a   Bethge, W A ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

CD3 CD19 depletion; haploidentical hematopoietic cell transplantation; immune reconstitution; reduced intensity conditioning

Indexed keywords

CD19 ANTIBODY; CD20 ANTIBODY; CD3 ANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CD3+ CD4+ T LYMPHOCYTE; CHIMERA; CHRONIC GRAFT VERSUS HOST DISEASE; CLINICAL ARTICLE; CYTOTOXICITY; ENGRAFTMENT; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; REDUCED INTENSITY CONDITIONING; T LYMPHOCYTE;

EID: 78651308065     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.235     Document Type: Article

References (39)

1. Gale RP, Reisner Y. Graft rejection and graft-versus-host disease: mirror images. Lancet 1986; 1: 1468-1470.
2. Aversa F, Tabilio A, Velardi A, Cunningham I, Terenzi A, Falzetti F et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med 1998; 339: 1186-1193.
3. Aversa F, Terenzi A, Tabilio A, Falzetti F, Carotti A, Ballanti S et al. Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse. J Clin Oncol 2005; 23: 3447-3454.
4. Lang P, Bader P, Schumm M, Feuchtinger T, Einsele H, Fuhrer M et al. Transplantation of a combination of CD133+ and CD34+ selected progenitor cells from alternative donors. Br J Haematol 2004; 124: 72-79.
5. Bethge WA, Haegele M, Faul C, Lang P, Schumm M, Bornhauser M et al. Haploidentical allogeneic hematopoietic cell transplantation in adults with reduced-intensity conditioning and CD3/CD19 depletion: fast engraftment and low toxicity. Exp Hematol 2006; 34: 1746-1752.
6. Barfield RC, Otto M, Houston J, Holladay M, Geiger T, Martin J et al. A one-step large-scale method for T- and B-cell depletion of mobilized PBSC for allogeneic transplantation. Cytotherapy 2004; 6: 1-6.
7. Grimes HL, Schanie CL, Huang Y, Cramer D, Rezzoug F, Fugier-Vivier I et al. Graft facilitating cells are derived from hematopoietic stem cells and functionally require CD3, but are distinct from T lymphocytes. Exp Hematol 2004; 32: 946-954.
8. Bethge WA, Faul C, Bornhauser M, Stuhler G, Beelen DW, Lang P et al. Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning: an update. Blood Cells Mol Dis 2008; 40: 13-19.
9. Schumm M, Feuchtinger T, Pfeiffer M, Hoelle W, Bethge W, Ebinger M et al. Flow cytometry with anti HLA-antibodies: a simple but highly sensitive method for monitoring chimerism and minimal residual disease after HLA-mismatched stem cell transplantation. Bone Marrow Transplant 2007; 39: 767-773.
10. Bader P, Beck J, Frey A, Schlegel PG, Hebarth H, Handgretinger R et al. Serial and quantitative analysis of mixed hematopoietic chimerism by PCR in patients with acute leukemias allows the prediction of relapse after allogeneic BMT. Bone Marrow Transplant 1998; 21: 487-495.
11. Schumm M, Feuchtinger T, Pfeiffer M, Hoelle W, Bethge W, Ebinger M et al. Flow cytometry with anti HLA-antibodies: a simple but highly sensitive method for monitoring chimerism and minimal residual disease after HLA-mismatched stem cell transplantation. Bone Marrow Transplant 2007; 39: 767-773.
12. van den Beemd R, Boor PP, van Lochem EG, Hop WC, Langerak AW, Wolvers-Tettero IL et al. Flow cytometric analysis of the Vb repertoire in healthy controls. Cytometry 2000; 40: 336-345.
13. Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002; 295: 2097-2100.
14. Mackall CL, Bare CV, Granger LA, Sharrow SO, Titus JA, Gress RE. Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing. J Immunol 1996; 156: 4609-4616.
15. Mackall CL, Gress RE. Pathways of T-cell regeneration in mice and humans: implications for bone marrow transplantation and immunotherapy. Immunol Rev 1997; 157: 61-72.
16. Heitger A, Neu N, Kern H, Panzer-Grumayer ER, Greinix H, Nachbaur D et al. Essential role of the thymus to reconstitute naive (CD45RA+) T-helper cells after human allogeneic bone marrow transplantation. Blood 1997; 90: 850-857.
17. Lang P, Schumm M, Greil J, Bader P, Klingebiel T, Muller I et al. A comparison between three graft manipulation methods for haploidentical stem cell transplantation in pediatric patients: preliminary results of a pilot study. Klin Padiatr 2005; 217: 334-338.
18. Novitzky N, Davison GM, Hale G, Waldmann H. Immune reconstitution at 6 months following T-cell depleted hematopoietic stem cell transplantation is predictive for treatment outcome. Transplantation 2002; 74: 1551-1559.
19. Geddes M, Storek J. Immune reconstitution following hemato-poietic stem-cell transplantation. Best Pract Res Clin Haematol 2007; 20: 329-348.
20. Shaffer J, Villard J, Means TK, Alexander S, Dombkowski D, Dey BR et al. Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2mAb, MEDI-507, with or without fludarabine. Exp Hematol 2007; 35: 1140-1152.
21. Eyrich M, Lang P, Lal S, Bader P, Handgretinger R, Klingebiel T et al. A prospective analysis of the pattern of immune reconstitu-tion in a paediatric cohort following transplantation of positively selected human leucocyte antigen-disparate haematopoietic stem cells from parental donors. Br J Haematol 2001; 114: 422-432.
22. Volpi I, Perruccio K, Tosti A, Capanni M, Ruggeri L, Posati S et al. Postgrafting administration of granulocyte colony-stimulating factor impairs functional immune recovery in recipients of human leukocyte antigen haplotype-mismatched hematopoietic transplants. Blood 2001; 97: 2514-2521.
23. Verfuerth S, Peggs K, Vyas P, Barnett L, O'Reilly RJ, MacKinnon S. Longitudinal monitoring of immune reconstitution by CDR3 size spectratyping after T-cell-depleted allogeneic bone marrow transplant and the effect of donor lymphocyte infusions on T-cell repertoire. Blood 2000; 95: 3990-3995.
24. Eyrich M, Croner T, Leiler C, Lang P, Bader P, Klingebiel T et al. Distinct contributions of CD4(+) and CD8(+) naive and memory T-cell subsets to overall T-cell-receptor repertoire complexity following transplantation of T-cell-depleted CD34-selected hema-topoietic progenitor cells from unrelated donors. Blood 2002; 100: 1915-1918.
25. Kook H, Goldman F, Padley D, Giller R, Rumelhart S, Holida M et al. Reconstruction of the immune system after unrelated or partially matched T-cell-depleted bone marrow transplantation in children: immunophenotypic analysis and factors affecting the speed of recovery. Blood 1996; 88: 1089-1097.
26. Banfi A, Bianchi G, Galotto M, Cancedda R, Quarto R. Bone marrow stromal damage after chemo/radiotherapy: occurrence, consequences and possibilities of treatment. Leuk Lymphoma 2001; 42: 863-870.
27. Ruggeri L, Capanni M, Casucci M, Volpi I, Tosti A, Perruccio K et al. Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood 1999; 94: 333-339.
28. Cook M, Briggs D, Craddock C, Mahendra P, Milligan D, Fegan C et al. Donor KIR genotype has a major influence on the rate of cytomegalovirus reactivation following T-cell replete stem cell transplantation. Blood 2006; 107: 1230-1232.
29. Morrison BE, Park SJ, Mooney JM, Mehrad B. Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis. J Clin Invest 2003; 112: 1862-1870.
30. Martinez C, Urbano-Ispizua A, Rozman C, Marin P, Rovira M, Sierra J et al. Immune reconstitution following allogeneic peripheral blood progenitor cell transplantation: comparison of recipients of positive CD34+ selected grafts with recipients of unmanipulated grafts. Exp Hematol 1999; 27: 561-568.
31. Davies JK, Gribben JG, Brennan LL, Yuk D, Nadler LM, Guinan EC. Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies. Blood 2008; 112: 2232-2241.
32. Pfeiffer MM, Feuchtinger T, Teltschik HM, Schumm M, Muller I, Handgretinger R et al. Reconstitution of NK cell receptors influences NK activity and relapse rate after haploidentical transplantation of T and B cell depleted grafts in children. Haematologica 2010; 95: 1381-1388.
33. Eissens DN, Schaap NP, Preijers FW, Dolstra H, van Cranenbroek B, Schattenberg AV et al. CD3(+)/CD19(+)-depleted grafts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A. Leukemia 2010; 24: 583-591.
34. Gentilini C, Haegele M, Muessig A, Nogai A, Kliem C, Bartsch K et al. NK-cell recovery and immune reconstitution after haplo-identical hematopoietic cell transplantation using either CD34 selected grafts and adoptive NK-cell transfer or CD3/CD19 depleted grafts: comparison of two strategies for NK cell based immunotherapy. Blood (ASH Abstracts) 2007; 110: 2988. 2010.
35. Chen X, Hale GA, Barfield R, Benaim E, Leung WH, Knowles J et al. Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies. Br J Haematol 2006; 135: 524-532.
36. Nguyen S, Dhedin N, Vernant JP, Kuentz M, Al Jijakli A, Rouas-Freiss N et al. NK-cell reconstitution after haploidentical hemato-poietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect. Blood 2005; 105: 4135-4142.
37. Cooley S, McCullar V, Wangen R, Bergemann TL, Spellman S, Weisdorf DJ et al. KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation. Blood 2005; 106: 4370-4376.
38. Ruggeri L, Mancusi A, Capanni M, Urbani E, Carotti A, Aloisi T et al. Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value. Blood 2007; 110: 433-440.
39. Traversari C, Marktel S, Magnani Z, Mangia P, Russo V, Ciceri F et al. The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies. Blood 2007; 109: 4708-4715.