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Volumn 15, Issue 4, 2010, Pages 349-355

Impact of "off-Label" Use of ivabradine on exercise capacity, gas exchange, functional class, quality of life, and neurohormonal modulation in patients with ischemic chronic heart failure

Author keywords

congestive heart failure; exercise capacity; gas exchange; off label ivabradine use

Indexed keywords

ACETYLSALICYLIC ACID; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; AMIODARONE; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISOPROLOL; BRONCHODILATING AGENT; CARVEDILOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IVABRADINE; LISINOPRIL; PLACEBO;

EID: 78651275247     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248410370326     Document Type: Article
Times cited : (48)

References (32)
  • 1
    • 0041408235 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-Added trial
    • McMurray JJ, Ostergren J., Swedberg K., et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet. 2003 ; 362 (9386). 767-771.
    • (2003) Lancet , vol.362 , Issue.9386 , pp. 767-771
    • McMurray, J.J.1    Ostergren, J.2    Swedberg, K.3
  • 2
    • 0041909380 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: The CHARM-Alternative trial
    • Granger CB, McMurray JJ, Yusuf S., et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet. 2003 ; 362 (9386). 772-776.
    • (2003) Lancet , vol.362 , Issue.9386 , pp. 772-776
    • Granger, C.B.1    McMurray, J.J.2    Yusuf, S.3
  • 3
    • 3142776467 scopus 로고    scopus 로고
    • Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol or Metoprolol European Trial (COMET): Randomised controlled trial
    • Poole-Wilson PA, Swedberg K., Cleland JG, et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet. 2003 ; 362 (9377). 7-13.
    • (2003) Lancet , vol.362 , Issue.9377 , pp. 7-13
    • Poole-Wilson, P.A.1    Swedberg, K.2    Cleland, J.G.3
  • 4
    • 0023223146 scopus 로고
    • Heart rate and cardiovascular mortality: The Framingham Study
    • Kannel WB, Kannel C., Paffenbarger Rsjr, Cupples LA Heart rate and cardiovascular mortality: the Framingham Study. Am Heart J. 1987 ; 113 (6). 1489-1494.
    • (1987) Am Heart J. , vol.113 , Issue.6 , pp. 1489-1494
    • Kannel, W.B.1    Kannel, C.2    Rsjr, P.3    Cupples, L.A.4
  • 5
    • 34548032376 scopus 로고    scopus 로고
    • Resting heart rate in cardiovascular disease
    • Fox K., Borer JS, Camm AJ, et al. Resting heart rate in cardiovascular disease. J Am Coll Cardiol. 2007 ; 50 (9). 823-830.
    • (2007) J Am Coll Cardiol , vol.50 , Issue.9 , pp. 823-830
    • Fox, K.1    Borer, J.S.2    Camm, A.J.3
  • 6
    • 35148892823 scopus 로고    scopus 로고
    • European guidelines on cardiovascular disease prevention in clinical practice: Executive summary
    • Graham I., Atar D., Borch-Johnsen K., et al. European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Eur Heart J. 2007 ; 28: 2375-2414.
    • (2007) Eur Heart J , vol.28 , pp. 2375-2414
    • Graham, I.1    Atar, D.2    Borch-Johnsen, K.3
  • 7
    • 12344330346 scopus 로고    scopus 로고
    • Elevated heart rate: A major risk factor for cardiovascular disease
    • Palatini P., Julius S. Elevated heart rate: a major risk factor for cardiovascular disease. Clin Exp Hypertens. 2004 ; 26 (7-8). 637-644.
    • (2004) Clin Exp Hypertens , vol.26 , Issue.7-8 , pp. 637-644
    • Palatini, P.1    Julius, S.2
  • 8
    • 28944438521 scopus 로고    scopus 로고
    • Predictor of mortality and morbidity in patients with chronic heart failure
    • Pocock SJ, Wang D., Pfeffer MA, et al. Predictor of mortality and morbidity in patients with chronic heart failure. Eur Heart J. 2006 ; 27 (1). 65-75.
    • (2006) Eur Heart J , vol.27 , Issue.1 , pp. 65-75
    • Pocock, S.J.1    Wang, D.2    Pfeffer, M.A.3
  • 9
    • 50649089781 scopus 로고    scopus 로고
    • Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): A subgroup analysis of a randomised controlled trial
    • Fox K., Ford I., Steg PG, Tendera M., Robertson M., Ferrari R. Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial. Lancet. 2008 ; 372 (9641). 817-821.
    • (2008) Lancet , vol.372 , Issue.9641 , pp. 817-821
    • Fox, K.1    Ford, I.2    Steg, P.G.3    Tendera, M.4    Robertson, M.5    Ferrari, R.6
  • 10
    • 0035853053 scopus 로고    scopus 로고
    • Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial
    • Lechat P., Hulot JS, Escolano S., et al. Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial. Circulation. 2001 ; 103 (10). 1428-1433.
    • (2001) Circulation , vol.103 , Issue.10 , pp. 1428-1433
    • Lechat, P.1    Hulot, J.S.2    Escolano, S.3
  • 11
    • 0141917494 scopus 로고    scopus 로고
    • I (f) inhibition: A novel mechanism of action
    • Di Francesco D. I (f) inhibition: a novel mechanism of action. Eur Heart J. 2003 ; 5 (suppl G). G19 - G25.
    • (2003) Eur Heart J. , vol.5 , Issue.SUPPL. G
    • Di Francesco, D.1
  • 12
    • 4544344025 scopus 로고    scopus 로고
    • Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: A new therapeutic perspective in cardiovascular disease
    • Di Francesco D., Camm JA Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. Drugs. 2004 ; 64 (16). 1757-1765.
    • (2004) Drugs , vol.64 , Issue.16 , pp. 1757-1765
    • Di Francesco, D.1    Camm, J.A.2
  • 13
    • 11144356194 scopus 로고    scopus 로고
    • Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function ad intrinsic myocardial structure in congestive heart failure
    • Mulder P., Barbier S., Chagraoui A., et al. Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function ad intrinsic myocardial structure in congestive heart failure. Circulation. 2004 ; 109 (13). 1674-1679.
    • (2004) Circulation , vol.109 , Issue.13 , pp. 1674-1679
    • Mulder, P.1    Barbier, S.2    Chagraoui, A.3
  • 14
    • 0022542458 scopus 로고
    • A new method for detecting anaerobic threshold by gas exchange
    • Beaver WL, Wasserman K., Whipp BJ A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol. 1986 ; 60 (6). 2020-2027.
    • (1986) J Appl Physiol , vol.60 , Issue.6 , pp. 2020-2027
    • Beaver, W.L.1    Wasserman, K.2    Whipp, B.J.3
  • 15
    • 0024723470 scopus 로고
    • Recommendations for quantitation of left ventricle by two-dimensional echocardiography: American Society of Echocardiography Committee on Standards and Subcommittee on Quantitation of Two-Dimensional Echocardiograms
    • Schiller NB, Shah PM, Crawford M., et al. Recommendations for quantitation of left ventricle by two-dimensional echocardiography: American Society of Echocardiography Committee on Standards and Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989 ; 2 (5). 358-367.
    • (1989) J Am Soc Echocardiogr , vol.2 , Issue.5 , pp. 358-367
    • Schiller, N.B.1    Shah, P.M.2    Crawford, M.3
  • 16
    • 0026699989 scopus 로고
    • Assessment of patient outcome with the Minnesota Living with Heart Failure questionnaire: Reliability and validity during a randomized, double-bind, placebo-controlled trial of pimobendan
    • the Pimobendan Multicenter Research Group
    • Rector TS, Cohn JN with the Pimobendan Multicenter Research Group. Assessment of patient outcome with the Minnesota Living with Heart Failure questionnaire: reliability and validity during a randomized, double-bind, placebo-controlled trial of pimobendan. Am Heart J. 1992 ; 124 (4). 1017-1025.
    • (1992) Am Heart J. , vol.124 , Issue.4 , pp. 1017-1025
    • Rector, T.S.1    Cohn, J.N.2
  • 18
    • 0026567057 scopus 로고
    • Beneficial effects of pimobendan on exercise tolerance and quality of life in patients with heart failure: Results of a multicenter trial
    • Hubo SH, Gollub S., Buorge R., et al. Beneficial effects of pimobendan on exercise tolerance and quality of life in patients with heart failure: results of a multicenter trial. Circulation. 1992 ; 85 (3). 942-949.
    • (1992) Circulation , vol.85 , Issue.3 , pp. 942-949
    • Hubo, S.H.1    Gollub, S.2    Buorge, R.3
  • 19
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Expert Panel on Detection Evaluation Treatment of High Blood Cholesterol in Adults
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001 ; 285 (19). 2486-2497.
    • (2001) JAMA , vol.285 , Issue.19 , pp. 2486-2497
  • 20
    • 0037322746 scopus 로고    scopus 로고
    • Resting heart rate in older people: A predictor of survival to 85
    • Benetos A., Thomas F., Bean K., et al. Resting heart rate in older people: a predictor of survival to 85. J Am Geriatr Soc. 2003 ; 51 (2). 284-285.
    • (2003) J Am Geriatr Soc , vol.51 , Issue.2 , pp. 284-285
    • Benetos, A.1    Thomas, F.2    Bean, K.3
  • 21
    • 0344394916 scopus 로고    scopus 로고
    • A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction
    • Manz M., Reuter M., Lauck G., Omran H., Jung W. A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction. Cardiology. 2003 ; 100 (3). 149-155.
    • (2003) Cardiology , vol.100 , Issue.3 , pp. 149-155
    • Manz, M.1    Reuter, M.2    Lauck, G.3    Omran, H.4    Jung, W.5
  • 22
    • 0037448788 scopus 로고    scopus 로고
    • Antianginal and antiischemic effects of ivabradine, an I(f) inhibitor, in stable angina: A randomized, double-blind, multicentered, placebo-controlled trial
    • Borer JS, Fox K., Jaillon P., Lerebours G. Antianginal and antiischemic effects of ivabradine, an I(f) inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial. Circulation. 2003 ; 107 (6). 817-823.
    • (2003) Circulation , vol.107 , Issue.6 , pp. 817-823
    • Borer, J.S.1    Fox, K.2    Jaillon, P.3    Lerebours, G.4
  • 23
    • 44649184945 scopus 로고    scopus 로고
    • Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure
    • De Ferrari GM, Mazzuero A., Agnesina L., et al. Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure. Eur J Heart Fail. 2008 ; 10 (6). 550-555.
    • (2008) Eur J Heart Fail , vol.10 , Issue.6 , pp. 550-555
    • De Ferrari, G.M.1    Mazzuero, A.2    Agnesina, L.3
  • 24
    • 43249091146 scopus 로고    scopus 로고
    • Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice
    • Custodis F., Baumhäkel M., Schlimmer N., et al. Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2008 ; 117 (18). 2377-2387.
    • (2008) Circulation , vol.117 , Issue.18 , pp. 2377-2387
    • Custodis, F.1    Baumhäkel, M.2    Schlimmer, N.3
  • 25
    • 0025308219 scopus 로고
    • Influence of heart rate on mortality after acute myocardial infarction
    • Hjalmarson A., Gilpin EA, Kjekshus J., et al. Influence of heart rate on mortality after acute myocardial infarction. Am J Cardiol. 1990 ; 65 (9). 547-553.
    • (1990) Am J Cardiol , vol.65 , Issue.9 , pp. 547-553
    • Hjalmarson, A.1    Gilpin, E.A.2    Kjekshus, J.3
  • 26
    • 0036017520 scopus 로고    scopus 로고
    • Diabetes, heart rate, and mortality
    • Singh N. Diabetes, heart rate, and mortality. J Cardiovasc Pharmacol Ther. 2002 ; 7 (2). 117-129.
    • (2002) J Cardiovasc Pharmacol Ther , vol.7 , Issue.2 , pp. 117-129
    • Singh, N.1
  • 27
    • 0022505487 scopus 로고
    • Effect of timolol on mortality and reinfarction after acute myocardial infarction: Prognostic importance of heart rate at rest
    • Gundersen T., Grottum P., Pedersen T., et al. Effect of timolol on mortality and reinfarction after acute myocardial infarction: prognostic importance of heart rate at rest. Am J Cardiol. 1989 ; 58 (1). 20-24.
    • (1989) Am J Cardiol , vol.58 , Issue.1 , pp. 20-24
    • Gundersen, T.1    Grottum, P.2    Pedersen, T.3
  • 28
    • 0022541191 scopus 로고
    • Importance of heart rate in determining beta-blocker efficacy in acute and long-term acute myocardial infarction intervention trials
    • Kjekshus JK Importance of heart rate in determining beta-blocker efficacy in acute and long-term acute myocardial infarction intervention trials. Am J Cardiol. 1986 ; 57 (12). 43 F-49F.
    • (1986) Am J Cardiol , vol.57 , Issue.12
    • Kjekshus, J.K.1
  • 29
    • 0023585078 scopus 로고
    • Heart rate reduction: A mechanism of benefit?
    • Kjekshus JK Heart rate reduction: a mechanism of benefit? Eur Heart J. 1987 ; 8 (suppl L). 115-122.
    • (1987) Eur Heart J. , vol.8 , Issue.SUPPL. , pp. 115-122
    • Kjekshus, J.K.1
  • 30
    • 3743112785 scopus 로고    scopus 로고
    • Significance of reduction in heart rate in cardiovascular disease
    • Hjalmarson A. Significance of reduction in heart rate in cardiovascular disease. Clin Cardiol. 1998 ; 21 (12 suppl II). 113-117.
    • (1998) Clin Cardiol , vol.21 , Issue.12 SUPPL. II , pp. 113-117
    • Hjalmarson, A.1
  • 31
    • 0345866810 scopus 로고    scopus 로고
    • Effect of graded heart rate reduction with ivabradine on myocardial oxygen consumption and diastolic time in exercising dogs
    • Colin P., Ghaleh B., Monnet X., et al. Effect of graded heart rate reduction with ivabradine on myocardial oxygen consumption and diastolic time in exercising dogs. J Pharmacol Exp Ther. 2004 ; 308 (1). 236-240.
    • (2004) J Pharmacol Exp Ther , vol.308 , Issue.1 , pp. 236-240
    • Colin, P.1    Ghaleh, B.2    Monnet, X.3
  • 32
    • 0028081393 scopus 로고
    • Effects of short and long term carvedilol administration on rest and exercise hemodynamic variables, exercise capacity and clinical conditions in patients with idiopathic dilated cardiomyopathy
    • Metra M., Nardi M., Giubbini R., et al. Effects of short and long term carvedilol administration on rest and exercise hemodynamic variables, exercise capacity and clinical conditions in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 1994 ; 24 (7). 1678-1687.
    • (1994) J Am Coll Cardiol , vol.24 , Issue.7 , pp. 1678-1687
    • Metra, M.1    Nardi, M.2    Giubbini, R.3


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