The effects of lactose, microcrystalline cellulose and dicalcium phosphate on swelling and erosion of compressed HPMC matrix tablets: Texture analyzer

Iranian Journal of Pharmaceutical Research

Volumn 9, Issue 4, 2010, Pages 349-358

  Tukarama, Bendgude Namdeo ^a   Rajagopalana, Iyer Vidaya ^a   Shartchandraa, Poddar Sushi Ikumar ^a  

^a PRIN K M KUNDNANI COLLEGE OF PHARMACY   (India)

Author keywords

Diltiazem HCl; Erosion; Hydroxy propyl methyl cellulose (HPMC); Solute transport; Swelling; Texture analysis

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; DILTIAZEM; HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; MICROCRYSTALLINE CELLULOSE;

ARTICLE; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; FLOW KINETICS; HYDROPHILICITY; MATHEMATICAL MODEL; TABLET COMPRESSION; WATER TRANSPORT;

EID: 78651262606     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Fukui E, Miyamura N and Kobayashi M. An investigation of the suitability of press-coated tablets with hydroxypropymethyll cellulose acetate succinate (HPMCAS) and hydrophobic additives in the outer shell for colon targeting. J. Control. Rel. (2001) 70: 97-107.
2. Mulley NV and Turco SJ. Matrix type tablet of formulation for controlled release of highly water soluble drugs. Drug Develop. Ind. Pharm. (1994) 20: 2633-2643.
3. Bettini R, Catellani PL, Santi P, Massimo G, Peppas NA and Colombo P. Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate. J. Control. Rel. (2001) 70: 383-391.
4. Colombo P, Bettini R and Peppas NA. Observation of swelling process and diffusion front position during swelling in hydroxy propyl methyl cellulose (HPMC) matrices containing a soluble drug. J. Control. Rel. (1999) 61: 83-91.
5. Lee BJ, Ryu SG and Cui JH. Formulation and release characteristics of hydroxy propyl methyl cellulose matrix tablet containing melatonin. Drug Dev. Ind. Pharm. (1999) 25: 493-501.
6. Velasco MV, Ford JL, Rowe P and Rajabi-Siahboomi AR. Influence of drug: hydroxy propyl methyl cellulose ratio, drug and polymer particle size and compression force on the release of diclofenac sodium from HPMC tablets. J. Control. Rel. (1999) 57: 75-85.
7. Pillay V and Fassihi R. A novel approach for constant rate delivery of highly soluble bioactives from a simple monolithic system. J. Control. Rel. (2000) 67: 67-78.
8. Shah N, Zhang G, Apelian V, Zeng F, Infeld MH and Malick AW. Prediction of drug release from hydroxy propyl methyl cellulose (HPMC) matrices: effect of polymer concentration. Pharm. Res. (1993) 10: 1693-1695.
9. Williams III RO, Reynolds TD, Cabelka TD, Sykora MA and Mahaguna V. Investigation of excipient type and level on drug release from controlled release tablets containing HPMC. Pharm. Dev. Technol. (2002) 7: 181-193.
10. Nazzal S, Nazzal M and El-Malah Y. A novel texture-probe for the simultaneous and real-time measurement of swelling and erosion rates of matrix tablets. Int. J. Pharm. (2007) 330: 195-198.
11. Reynolds TD, Gehrke SH, Hussain AS and Shenouda LS. Polymer erosion and drug release characterization of hydroxy propyl methyl cellulose matrices. J. Pharm. Sci. (1998) 87: 1115-1123.
12. Rinaki E, Valsami G and Macheras P. The power law can describe the "entire" drug release curve from HPMC based matrix tablets: a hypothesis. Int. J. Pharm. (2003) 255: 199-207.
13. Colombo P, Santi P, Bettini R, Brazel CS and Peppas NA. Drug release from swelling-controlled systems. In: Wise DL. (ed.) Handbook of Pharmaceutical Controlled Release Technology. Marcel Dekker Inc., New York (2000) 183-209.
14. Sako K, Sawada T, Nakashima H, Yokohama S and Sonobe T. Influence of water-soluble fillers in hydroxy propyl methyl cellulose matrices on in-vitro and in-vivo drug release. J. Control. Rel. (2002) 81: 165-172.
15. Shams J, Sahraei H, Faghih-Monzavi Z, Salimi SH, Fatemi SM, Pourmotabbed A, Ghoshooni H and Kamalinejad M. Determination of synthetic precursors as impurities in diclofenac sodium raw material. Iranian J. Pharm. Res. (2002) 1: 51-53.
16. Safigul Islam M, Reza M and Rahman H. In-vitro release kinetics study of diltiazem hydrochloride from wax and kollidon SR based matrix tablets. Iranian J. Pharm. Res. (2008) 7: 101-108.
17. Mulye NV and Turco SJ. Use of dicalcium phosphate dihydrate for sustained release of highly water soluble drugs. Drug Develop. Ind. Pharm. (1994) 20: 2621-2632.
18. Mei X, Etzler FM and Wang Z. Use of texture analysis to study hydrophilic solvent effects on the mechanical properties of hard gelatin capsules. Int. J. Pharm. (2006) 324: 128-135.
19. Li H and Gu X. Correlation between drug dissolution and polymer hydration: A study using texture analysis. Int. J. Pharm. (2007) 342: 18-25.
20. Jamzad S, Tutunji L and Fassihi R. Analysis of macromolecular changes and drug release from hydrophilic matrix systems. Int. J. Pharm. (2005) 292: 75-85