L-type calcium current (I Ca,L ) and inward rectifier potassium current (I K1 ) are involved in QT prolongation induced by arsenic trioxide in rat

Cellular Physiology and Biochemistry

Volumn 26, Issue 6, 2010, Pages 967-974

  Chen, Xichuang ^a   Shan, Hongli ^a   Zhao, Jinlong ^a   Hong, Yuan ^a   Bai, Yunlong ^a   Sun, Iihua ^a   Pan, Zhenwei ^a   Zhang, Yong ^a   Yang, Baofeng ^a   Du, Zhimin ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Biopharmaceutical Key Laboratory of Heilongjiang Province   (China)

Author keywords

Action potential; Intracellular calcium; QT prolongation; Rat ventricular cardiomyocytes

Indexed keywords

ARSENIC TRIOXIDE; CALCIUM CHANNEL L TYPE; CALCIUM ION; COLLAGENASE; INWARDLY RECTIFYING POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ELECTROCARDIOGRAM; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART RATE; IN VIVO STUDY; ION CURRENT; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; RAT; STEADY STATE; WHOLE CELL;

RATTUS;

EID: 78651262029     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000324005     Document Type: Article

References (39)

1. Cyranoski D: Arsenic patent keeps drug for rare cancer out of reach of many. Nat Med 2007;13:1005.
2. Zhang P, Wang SY, Hu LH, Shi FD, Qiu FQ, Hong LJ, Han XY, Yang HF, Song YZ, Liu YP, Zhou J, Jin ZJ: Arsenic trioxide treated 72 cases of acute promyelocytic leukemia. Chin J Hematol 1996;17:58-62.
3. Au WY, Chim CS, Lie AK, Liang R, Kwong YL: Combined arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia recurring from previous relapses successfully treated using arsenic trioxide. Br J Haematol 2002;117:130-132.
4. Zhou GB, Zhang J, Wang Z Y, Chen SJ, Chen Z: Treatment of acute promy-elocytic leukaemia with all-trans retinoic acid and arsenic trioxide: a paradigm of synergistic molecular targeting therapy. Philos Trans R Soc Lond B Biol Sci 2007;362:959-971.
5. Ammatuna E, Cavaliere A, Divona M, Amadori S, Scambia G, Lo-Coco F: Successful pregnancy after arsenic trioxide therapy for relapsed acute promyelocytic leukaemia. Br J Haematol 2009;146:341.
6. Ohnishi K, Yoshida H, Shigeno K, Nakamura S, Fujisawa S, Naito K, Shinjo K, Fujita Y, Matsui H, Takeshita A, Sugiyama S, Satoh H, Terada H, Ohno R: Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia. Ann Intern Med 2000;133:881-885.
7. Unnikrishnan D, Dutcher JP, Varshneya N, Lucariello R, Api M, Garl S, Wiernik PH, Chiaramida S: Torsade de pointes in 3 patients with leukemia treated with arsenic trioxide. Blood 2001;97:1514-1516.
8. Sun HL, Chu WF, Dong DL, Liu Y, Bai YL, Wang XH, Zhou J, Yang BF: Choline-modulated arsenic trioxide-induced prolongation of cardiac repolarization in Guinea pig. Basic Clin Pharmacol Toxicol 2006;98:381-388.
9. Del Rosario ME, Weachter R, Flaker GC: Drug-induced QT prolongation and sudden death. Mo Med 2010;107:53-58.
10. Chiang CE, Luk HN, Wang TM, Ding PY: Prolongation of cardiac repolariza-tion by arsenic trioxide. Blood 2002;100:2249-2252.
11. Alexander SP, Mathie A, Peters JA: Guide to Receptors and Channels (GRAC), 3rd edition. Br J Pharmacol 2008;153:S1-209.
12. Qi X Y, Yeh YH, Xiao L, Burstein B, Maguy A, Chartier D, Villeneuve LR, Brundel BJ, Dobrev D, Nattel S: Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current. Circ Res 2008;103:845-854.
13. Cordeiro JM, Marieb M, Pfeiffer R, Calloe K, Burashnikov E, Antzelevitch C: Accelerated inactivation of the L-type calcium current due to a mutation in CACNB2b underlies Brugada syndrome. J Mol Cell Cardiol 2009;46:695-703.
14. Wymore RS, Gintant GA, Wymore RT, Dixon JE, McKinnon D, Cohen IS: Tissue and Species Distribution of mRNA for the IKr-like K+ Channel, erg. Circ Res 1997;80:261-268.
15. Pond AL, Scheve BK, Benedict AT, Petrecca K, Van Wagoner DR, Shrier A, Nerbonne JM: Expression of distinct ERG proteins in rat, mouse, and human heart. Relation to functional I(Kr) channels. J Biol Chem 2000;275:5997-6006.
16. Salvayre R, Auge N, Benoist H, Negre-Salvayre A: Oxidized low-density lipoprotein-induced apoptosis. Biochim Biophys Acta 2002;1585:213-221.
17. Goldhaber JI, Weiss JN: Oxygen free radicals and cardiac reperfusion abnormalities. Hypertension 1992;20:118-127.
18. Yang BF, Shan HL, Gong DM, Dong DL, Du ZM: Study on the best targets of antiarrhythmic drugs. J Harbin Univ Commer (Nat Sci Ed) 2002;18:1-5.
19. Dong DL, Li Z, Wang HZ, Du ZM, Song WH, Yang BF: Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related gene (HERG) channels. Basic Clin Pharmacol Toxicol 2004;94:209-212.
20. Xiao L, Coutu P, Villeneuve LR, Tadevosyan A, Maguy A, Le Bouter S, Allen BG, Nattel S: Mechanisms Underlying Rate-Dependent Remodeling of Transient Outward Potassium Current in Canine Ventricular Myocytes. Circ Res 2008;103:733-742.
21. Tamargo J, Caballero R, Gómez R, Valenzuela C, Delpón E: Pharmacology of cardiac potassium channels. Cardiovasc Res 2004;62:9-33.
22. Wang YH, Shi CX, Dong F, Sheng JW, Xu YF: Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor. Br J Pharmacol 2008;154:429-439.
23. Ficker E, Kuryshev YA, Dennis AT, Obejero-Paz C, Wang L, Hawryluk P, Wible BA, Brown AM: Mechanisms of arsenic-induced prolongation of cardiac repolarization. Mol Pharmacol 2004;66:33-44.
24. Hayes E, Pugsley MK, Penz WP, Adaikan G, Walker MJ: Relationship between QaT and RR intervals in rats, guinea pigs, rabbits, and primates. J Pharmacol Toxicol Meth 1994;32:201-207.
25. Zhang Y, Liu Y, Wang T, Li B, Li H, Wang Z, Yang B: Resveratrol, a natural ingredient of grape skin: Antiarrhythmic efficacy and ionic mechanisms. Biochem Biophys Res Commun 2006;340:1192-1199.
26. Yang B, Lin H, Xu C, Liu Y, Wang H, Han H, Wang Z: Choline produces cytoprotective effects against ischemic myocardial injuries: evidence for the role of cardiac M3 subtype muscarinic acetylcholine Receptors. Cell Physio Biochem 2005;16:163-174.
27. Chu WF, Sun HL, Dong DL, Qiao GF, Yang BF: Increasing Intracellular calcium of guinea pig ventricular myocytes induced by platelet activating factor through IP3 pathway. Basic Clin Pharmacol Toxicol 2006;98:104-109.
28. Kubalova Z, Terentyev D, Viatchenko-Karpinski S, Nishijima Y, Györke I, Terentyeva R, da Cuñha DN, Sridhar A, Feldman DS, Hamlin RL, Carnes CA, Györke S: Abnormal intrastore calcium signaling in chronic heart failure. Proc Natl Acad Sci USA 2005;102:14104-14109.
29. Zhang XQ, Zhang LQ, Palmer BM, Ng YC, Musch TI, Moore RL, Cheung JY: Sprint training shortens prolonged action potential duration in postinfarction rat myocyte: mechanisms. J Appl Physiol 2001;90:1720-1728.
30. Diness JG, Hansen RS, Nissen JD, Jespersen T, Grunnet M: Antiarrhythmic effect of IKr activation in a cellular model of LQT3. Heart Rhythm 2009;6:100-106.
31. Lacombe VA, Viatchenko-Karpinski S, Terentyev D, Sridhar A, Emani S, Bonagura JD, Feldman DS, Györke S, Carnes CA: Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes. Am J Physiol Regul Integr Comp Physiol 2007;293:R1787-R1797.
32. Sun L, Du J, Zhang G, Zhang Y, Pan G, Wang L, Yang BF: Aberration of L-type calcium channel in cardiac myocytes is one of the mechanisms of arrhythmia induced by cerebral ischemia. Cell Physiol Biochem 2008;22:147-156.
33. Roden DM: Drug-induced prolongation of the QT interval. N Engl J Med 2004;350:1013-1022.
34. Kamiya K, Niwa R, Mitcheson JS, Sanguinetti MC: Molecular determinants of HERG channel block. Mol Pharmacol 2006;69:1709-1716.
35. Nerbonne JM: Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium. J Physiol 2000;525:285-298.
36. Näbauer M, Kääb S: Potassium channel down-regulation in heart failure. Cardiovasc Res 1998;37:324-334.
37. Tomaselli GF, Marbán E: Electrophysio-logical remodeling in hypertrophy and heart failure. Cardiovasc Res 1999;42:270-283.
38. Sun HL, Dong DL, Li L, Qiao GF, Liu Y, Chu WF, Yang BF: Effects of Arsenic Trioxide on Potassium Current in Isolated Myocytes of Guinea Pig. Chin Pham J 2008;43:1867-1870.
39. Siu CW, Au WY, Yung C, Kumana CR, Lau CP, Kwong YL, Tse HF: Effects of oral arsenic trioxide therapy on QT intervals in patients with acute promy-elocytic leukemia: implications for long-term cardiac safety. Blood 2006;108:103-106.