Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: Immunology of glycoconjugates with high carbohydrate loading

Glycoconjugate Journal

Volumn 27, Issue 7-9, 2010, Pages 643-648

  Cox, Andrew D ^a   St Michael, Frank ^a   Neelamegan, Dhamodharan ^a   Lacelle, Suzanne ^a   Cairns, Chantelle M ^a   Giuliani, Marzia M ^b   Biolchi, Alessia ^b   Hoe, J Claire ^c   Moxon, E Richard ^c   Richards, James C ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Conjugate vaccine; LPS; Neisseria meningitidis

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; EPITOPE; GLYCOCONJUGATE; MENINGOCOCCUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ANTIBODY TITER; ANTIGEN ANTIBODY REACTION; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; CONJUGATION; CONTROLLED STUDY; IMMUNIZATION; IMMUNOLOGY; IMMUNOREACTIVITY; MENINGOCOCCOSIS; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; WILD TYPE;

ANIMALS; ANTIBODIES, BACTERIAL; GLYCOCONJUGATES; IMMUNE SERA; LIPOPOLYSACCHARIDES; MENINGOCOCCAL INFECTIONS; MENINGOCOCCAL VACCINES; NEISSERIA MENINGITIDIS; RABBITS;

NEISSERIA MENINGITIDIS; ORYCTOLAGUS CUNICULUS;

EID: 78651247304     PISSN: 02820080     EISSN: 15734986     Source Type: Journal    
DOI: 10.1007/s10719-010-9309-y     Document Type: Article

References (13)

1. JS Plested K Makepeace MP Jennings MA Gidney S Lacelle JR Brisson AD Cox, et al. 1999 Conservation and accessibility of an inner core lipopolysaccharide epitope of Neisseria meningitidis Infect. Immun. 67 5417 5426 1:CAS:528:DyaK1MXmsFWmsrY%3D 10496924
2. MAJ Gidney JS Plested S Lacelle PA Coull JC Wright K Makepeace, et al. 2004 Development, characterisation and functional activity of a panel of specific monoclonal antibodies to inner core lipopolysaccharide (LPS) epitopes in Neisseria meningitidis Infect. Immun. 72 559 569 1:CAS:528:DC%2BD2cXpvFOh 10.1128/IAI.72.1.559-569.2004 14688137 (Pubitemid 38018217)
3. JS Plested SL Harris JC Wright PA Coull K Makepeace MAJ Gidney, et al. 2003 Highly conserved Neisseria meningitidis inner-core lipopolysaccharide epitope confers protection against experimental meningococcal bacteremia J. Infect. Dis. 187 1223 1234 1:CAS:528:DC%2BD3sXjslensr0%3D 10.1086/368360 12696001 (Pubitemid 36438962)
4. AD Cox W Zou MAJ Gidney S Lacelle JS Plested K Makepeace, et al. 2005 Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: developmental chemistry and investigation of immunological responses following immunization of mice and rabbits Vaccine 23 5045 5054 1:CAS:528:DC%2BD2MXhtVehsrvO 10.1016/j.vaccine.2005.06.011 16046037 (Pubitemid 41318152)
5. AD Cox F St. Michael D Neelamegan S Lacelle CM Cairns JC Richards 2010 Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: chemical strategies to prepare glycoconjugates with good carbohydrate loading Glycoconjugate J. 27 401 417 1:CAS:528:DC%2BC3cXmsVSmtrY%3D 10.1007/s10719-010-9287-0
6. MM Giuliani L Santini B Brunelli A Biolchi B Arico F Di Marcello, et al. 2005 The region comprising amino acids 100 to 255 of Neisseria meningitidis lipoprotein GNA 1870 elicits bactericidal antibodies Infect. Immun. 73 1151 1160 1:CAS:528:DC%2BD2MXhtVWgsL4%3D 10.1128/IAI.73.2.1151-1160.2005 15664958 (Pubitemid 40165775)
7. H Masoud MB Perry J-R Brisson D Uhrin JC Richards 1994 Structural elucidation of the backbone oligosaccharide from the lipopolysaccharide of Moraxella catarrhalis serotype A Can. J. Chem. 72 1466 1477 1:CAS:528: DyaK2cXmtVGrt74%3D 10.1139/v94-182
8. P Edebrink P-E Jansson G Widmalm T Holme M Rahman 1996 The structures of oligosaccharides isolated from the lipopolysaccharide of Moraxella catarrhalis serotype B, strain CCUG 3292 Carbohydr. Res. 295 127 146 1:CAS:528: DyaK2sXltFOmtA%3D%3D 9002189
9. P Edebrink P-E Jansson MM Rahman G Widmalm T Holme M Rahman 1995 Structural studies on the O-antigen oligosaccharides from two strains of Moraxella catarrhalis serotype C Carbohydr. Res. 266 237 261 1:CAS:528:DyaK2MXjt1Snsb8%3D 10.1016/0008-6215(94)00276-L 7535189
10. A Bartoloni F Norelli C Ceccarini R Rappuoli P Costantino 1995 Immunogenicity of meningococcal B polysaccharide conjugated to tetanus toxoid or CRM197 via adipic acid dihydrazide Vaccine 13 463 470 1:CAS:528: DyaK2MXmtFajur4%3D 10.1016/0264-410X(94)00007-A 7543714
11. JM Peeters TG Hazendonk EC Beuvery GI Tesser 1989 Comparison of four bifunctional reagents for coupling peptides to proteins and the effect of the three moieties on the immunogenicity of the conjugates J. Immunol. Methods 120 133 143 1:CAS:528:DyaL1MXlslajs7k%3D 10.1016/0022-1759(89)90298-6 2499636 (Pubitemid 19144205)
12. V Verez-Bencomo V Fernández-Santana E Hardy ME Toledo MC Rodríguez L Heynngnezz, et al. 2004 A synthetic conjugate polysaccharide vaccine against Haemophilus influenzae type B Science 305 522 525 1:CAS:528:DC%2BD2cXlvVOktbc%3D 10.1126/science.1095209 15273395 (Pubitemid 38971343)
13. G Torano ME Toledo A Baly V Fernandez-Santana F Rodriguez Y Alvarez, et al. 2006 Phase I clinical evaluation of a synthetic oligosaccharide-protein conjugate vaccine against Haemophilus influenzae type B in human adult volunteers Clin. Vaccine. Immunol. 13 1052 1056 1:CAS:528:DC%2BD28XhtVWgt7rI 10.1128/CVI.00144-06 16960118 (Pubitemid 44518975)