Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: Chemical strategies to prepare glycoconjugates with good carbohydrate loading

Glycoconjugate Journal

Volumn 27, Issue 4, 2010, Pages 401-417

  Cox, Andrew D ^a   Michael, Frank St ^a   Neelamegan, Dhamodharan ^a   Lacelle, Suzanne ^a   Cairns, Chantelle ^a   Richards, James C ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Conjugate vaccine; LPS; Neisseria meningitidis

Indexed keywords

AMIDASE; CARBOXYL GROUP; CARRIER PROTEIN; CYSTAMINE; FATTY ACID; GLYCOCONJUGATE; LIPID A; LIPOPOLYSACCHARIDE; LYSINE; MALEIMIDE; OLIGOSACCHARIDE; PHOSPHATE; PHOSPHOETHANOLAMINE; TERT BUTYL OXYCARBONYL; THIOL; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DEACYLATION; DICTYOSTELIUM DISCOIDEUM; MENINGOCOCCOSIS; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL;

ALKALINE PHOSPHATASE; AMIDOHYDROLASES; CARBOHYDRATE SEQUENCE; CARBOHYDRATES; DICTYOSTELIUM; HUMANS; LIPOPOLYSACCHARIDES; MENINGOCOCCAL INFECTIONS; MENINGOCOCCAL VACCINES; MOLECULAR SEQUENCE DATA; NEISSERIA MENINGITIDIS, SEROGROUP B; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; VACCINES, CONJUGATE;

DICTYOSTELIUM DISCOIDEUM; NEISSERIA MENINGITIDIS; NEISSERIA MENINGITIDIS SEROGROUP B;

EID: 77955659959     PISSN: 02820080     EISSN: 15734986     Source Type: Journal    
DOI: 10.1007/s10719-010-9287-0     Document Type: Article

References (26)

1. Moe, G.R., Dave, A., Granoff, D.M.: Epitopes recognized by a non-autoreactive murine anti-N-propionyl meningococcal group B polysaccharide monoclonal antibody. Infect. Immun. 73, 2123- 2128 (2005).
2. Pon, R.A., Lussier, M., Yang, Q.L., Jennings, H.J.: N-Propionylated group B meningococcal polysaccharide mimics a unique bactericidal capsular epitope in group B Neisseria meningitidis. J. Exp. Med. 185, 1929-1938 (1997).
3. Holst, J., Feiring, B., Fuglesang, J.E., Hoiby, E.A., Nokleby, H., Aaberge, I.S., Rosenqvist, E.: Serum bactericidal activity correlates with the vaccine efficacy of outer membrane vesicle vaccines against Neisseria meningitidis serogroup B disease. Vaccine 21, 734-737 (2003).
4. Oster, P., Lennon, D., O'Hallahan, J., Mulholland, K., Reid, S., Martin, D.: MeNZB: a safe and highly immunogenic tailor-made vaccine against the New Zealand Neisseria meningitidis serogroup B disease epidemic strain. Vaccine 23, 2191-2196 (2005).
5. Li, Y., Sun, Y.H., Ison, C., Levine, M.M., Tang, C.M.: Vaccination with attenuated Neisseria meningitidis strains protects against challenge with live meningococci. Infect. Immun. 72, 345-351 (2004).
6. Gorringe, A.: Can Neisseria lactamica antigens provide an effective vaccine to prevent meningococcal disease? Expert Rev. Vaccines 4, 373-379 (2005).
7. Pizza, M., Scarlato, V., Masignani, V., Giuliani, M.M., Arico, B., Comanducci, M., et al.: Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science 287, 1816-1820 (2000).
8. Gorringe, A., Halliwell, D., Matheson, M., Reddin, K., Finney, M., Hudson, M.: The development of a meningococcal disease vaccine based on Neisseria lactamica outer membrane vesicles. Vaccine 23, 2210-2213 (2005).
9. Vermont, C.L., Van Dijken, H.H., De Groot, R., Van Alphen, L., Van Den Dobblestein, G.P.: PorA-specific differences in antibody avidity after vaccination with a hexavalent menB outer membrane vesicle vaccine in toddlers and school children. Vaccine 22, 3008- 3013 (2004).
10. Giuliani, M.M., Adu-Bobie, J., Comanducci, M., Arico, B., Savino, S., Santini, L., et al.: A universal vaccine for serogroup B meningococcus. PNAS 103, 10834-10839 (2006).
11. Plested, J.S., Makepeace, K., Jennings, M.P., Gidney, M.A., Lacelle, S., Brisson, J.R., Cox, A.D., et al.: Conservation and accessibility of an inner core lipopolysaccharide epitope of Neisseria meningitidis. Infect. Immun. 67, 5417-5426 (1999).
12. Plested, J.S., Harris, S.L., Wright, J.C., Coull, P.A., Makepeace, K., Gidney, M.A.J., et al.: Highly conserved Neisseria meningitidis inner-core lipopolysaccharide epitope confers protection against experimental meningococcal bacteremia. J. Infect. Dis. 187, 1223-1234 (2003).
13. Cox, A.D., Zou, W., Gidney, M.A.J., Lacelle, S., Plested, J.S., Makepeace, K., et al.: Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: developmental chemistry and investigation of immunological responses following immunization of mice and rabbits. Vaccine 23, 5045-5054 (2005).
14. Pavliak, V., et al.: Neisseria meningitidis LOS conjugate vaccine against meningococcal disease. 14th IPNC, Milwaukee, USA (2004).
15. Gidney, M.A.J., Plested, J.S., Lacelle, S., Coull, P.A., Wright, J. C., Makepeace, K., et al.: Development, characterisation and functional activity of a panel of specific monoclonal antibodies to inner core lipopolysaccharide (LPS) epitopes in Neisseria meningitidis. Infect. Immun. 72, 559-569 (2004).
16. Mackinnon, F.G., Cox, A.D., Plested, J.S., Tang, C.M., Makepeace, K., Coull, P.A., et al.: Identification of a gene (lpt-3) required for the addition of phosphoethanolamine to the lipopolysaccharide inner core of Neisseria meningitidis and its role in mediating susceptibility to bactericidal killing and opsonophagocytosis. Mol. Microbiol. 43, 931-943 (2002).
17. Jäkel, A., Plested, J.S., Hoe, J.C., Makepeace, K., Gidney, M.A.J., Lacelle, S., et al.: Naturally-occurring human serum antibodies to inner core lipopolysaccharide epitopes of Neisseria meningitidis protect against invasive meningococcal disease caused by isolates displaying homologous inner core structures. Vaccine 26, 6655- 6663 (2008).
18. Westphal, O., Jann, K.: Bacterial lipopolysaccharide. Methods Carbohydr. Chem. 5, 88-91 (1965).
19. Smith, P.K., Krohn, R.I., Hermanson, G.T., Mallia, A.K., Gartner, F.H., Provenzano, M.D., et al.: Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85 (1985).
20. Dubois, M., Gilles, K.A., Hamilton, J.K., Rebers, P.A., Smith, F.: Colorimetric method for determination of sugars and related substances. Anal. Chem. 28, 350-356 (1956).
21. Claviez, M., Pagh, K., Maruta, H., Baltes, W., Fisher, P., Gerisch, G.: Electron microscopic mapping of monoclonal antibodies on the tail region of Dictyostelium myosin. EMBO J. 1, 1017-1022 (1982).
22. Sawardeker, D.G., Sloneker, J.H., Jeanes, A.: Quantitative determination of monosaccharides as their alditol acetates by gas liquid chromatography. Anal. Chem. 37, 1602-1604 (1965).
23. Cox, A.D., Li, J., Brisson, J.-R., Moxon, E.R., Richards, J.C.: Structural analysis of the lipopolysaccharide from Neisseria meningitidis strain BZ157 galE: localisation of two phosphoethanolamine residues in the inner core oligosaccharide. Carbohydr. Res. 337, 1435-1444 (2002).
24. Laemmli, U.K.: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685 (1970).
25. Pozsgay, V., Chu, C., Pannell, L., Wolfe, J., Robbins, J.B., Schneerson, R.: Protein conjugates of synthetic saccharides elicit higher levels of serum IgG lipopolysaccharide antibodies in mice than do those of the O-specific polysaccharide from Shigella dysenteriae type 1. PNAS 96, 5194-5197 (1999).
26. Rosner, M.R., Verret, R.C., Khorana, H.G.: The structure of lipopolysaccharide from an Escherichia coli heptose-less mutant. III. Two fatty acid amidases from Dictyostelium discoideum and their action on lipopolysaccharide derivatives. J. Biol. Chem. 254, 5926-5933 (1979).