Extract derived from rat brains in the acute phase following traumatic brain injury impairs survival of undifferentiated stem cells and induces rapid differentiation of surviving cells

Cellular Physiology and Biochemistry

Volumn 26, Issue 6, 2010, Pages 821-830

  Bentz, Kristine ^a   Molcanyi, Marek ^b   Schneider, Annette ^c   Riess, Peter ^d   Maegele, Marc ^c   Bosche, Bert ^b   Hampl, Jürgen A ^b   Hescheler, Jürgen ^b   Patz, Silke ^e   Schäfer, Ute ^e  

^a Syddanskuniversitet   (United Kingdom)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF WITTEN HERDECKE   (Germany)

^d Department of Trauma and Orthopaedic Surgery   (Germany)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Differentiation; Fgf5; Inhibition; Nestin; Oct 4; Stem cell; TBI

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2; NESTIN; OCTAMER TRANSCRIPTION FACTOR 4; TISSUE EXTRACT;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN TISSUE; CELL LOSS; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL; HEMISPHERE; MALE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; TRAUMATIC BRAIN INJURY; UPREGULATION;

MURINAE; RATTUS;

EID: 78651239744     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000323991     Document Type: Article

References (27)

1. Heile AM, Wallrapp C, Klinge PM, Samii A, Kassem M, Silverberg G, Brinker T: Cerebral transplantation of encapsulated mesenchymal stem cells improves cellular pathology after experimental traumatic brain injury. Neurosci Lett 2009;463:176-181.
2. Hoane MR, Becerra GD, Shank JE, Tatko L, Pak ES, Smith M, Murashov AK: Transplantation of neuronal and glial precursors dramatically improves senso-rimotor function but not cognitive function in the traumatically injured brain. J Neurotrauma 2004;21:163-174.
3. Wennersten A, Meier X, Holmin S, Wahlberg L, Mathiesen T: Proliferation, migration, and differentiation of human neural stem/progenitor cells after transplantation into a rat model of traumatic brain injury. J Neurosurg 2004;100:88-96.
4. Riess P, Zhang C, Saatman KE, Laurer HL, Longhi LG, Raghupathi R, Lenzlinger P, Lifshitz J, Boockvar J, Neugebauer E, Snyder EY, McIntosh TK: Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury. Neurosurgery 2002;51:1043-1052.
5. Kim HJ, Lee JH, Kim SH: Therapeutic effects of human mesenchymal stem cells on traumatic brain injury in rats: secretion of neurotrophic factors and inhibition of apoptosis. J Neurotrauma 2009;27:131-138.
6. Chiba S, Ikeda R, Kurokawa MS, Yoshikawa H, Takeno M, Nagafuchi H, Tadokoro M, Sekino H, Hashimoto T, Suzuki N: Anatomical and functional recovery by embryonic stem cell-derived neural tissue of a mouse model of brain damage. J Neurol Sci 2004;219:107-117.
7. Gao J, Prough DS, McAdoo DJ, Grady JJ, Parsley MO, Ma L, Tarensenko YI, Wu P: Transplantation of primed human fetal neural stem cells improves cognitive function in rats after traumatic brain injury. Exp Neurol 2006;201:281-292.
8. Kelly S, Bliss TM, Shah AK, Sim GH, Ma M, Foo WC, Masel J, Yenari MA, Weissmann IL, Uchida N, Palmer T, Steinberg GK: Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex. Proc Natl Acad Sci USA 2004;101:11839-11844.
9. Wallenquist U, Brannvall K, Clausen F, Lewen A, Hillered L, Forsberg-Nilsson K: Grafted neural progenitors migrate and form neurons after experimental traumatic brain injury. Restor Neurol Neurosci 2009;27:323-334.
10. Davis AE: Mechanisms of traumatic brain injury: biomechanical, structural and cellular considerations. Crit Care Nurs Q 2000;23:1-13.
11. Lenzlinger PM, Morganti-Kossmann MC, Laurer HL, McIntosh TK: The duality of the inflammatory response to traumatic brain injury. Mol Neurobiol 2001;24:169-181.
12. Potts MB, Koh SE, Whetstone WD, Walker BA, Yoneyama T, Claus CP, Manvelyan HM, Noble-Haeusslein: Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx 2006;3:143-153.
13. Molcanyi M, Riess P, Bentz K, Maegele M, Hescheler J, Schäfke B, Trapp T, Neugebauer E, Klug N, Schäfer U: Trauma-associated inflammatory response impairs murine embryonic stem cell survival and differentiation post-implantation into a fluid -percussion injured rat brain. J Neurotrauma 2007;24:625-637.
14. Okano H, Ogawa Y, Nakamura M, Kaneko S, Iwanami A, Toyama Y: Transplantation of neural stem cells into the spinal cord after injury. Semin Cell Dev Biol 2003;14:191-198.
15. Eghwrudjakpor PO, Allison AB: Oxidative stress following traumatic brain injury: enhancement of endogenous antioxidant defense systems and the promise of improved outcome. Niger J Med 2010;19:14-21.
16. Petronilho F, Feier G, de Souza B, Guglielmi C, Constantino LS, Walz R, Quevedo J, Dal-Pizzol F: Oxidative Stress in Brain According to Traumatic Brain Injury Intensity. J Surg Res 2010;164:316-320.
17. Wong G, Goldshmit Y, Turnley AM: In-terferon-gamma but not TNF alpha promotes neuronal differentiation and neu-rite outgrowth of murine adult neural stem cells. Exp Neurol 2004;187:171-177.
18. McIntosh TK, Vink R, Noble L, Yamakami I, Fernyak S, Soares H, Faden AL: Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model. Neuroscience 1989;28:233-244. (Pubitemid 19026758)
19. Dixon CE, Lyeth BG, Povlishock JT, Findling RL, Hamm RJ, Marmarou A, Young HF, Hayes RL: A fluid percussion model of experimental brain injury in the rat. J Neurosurg 1987;67:110-119.
20. Chen X, Katakowski M, Li Y, Lu D, Wang L, Zhang L, Chen J, Xu Y, Gautam S, Mahmood A, Chopp M: Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production. J Neurosci Res 2002;69:687-691. (Pubitemid 34966882)
21. Rivera FJ, Couillard-Despress S, Pedre X, Ploetz S, Caioni M, Lois C, Bogdahn U, Aigner L: Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells. Stem Cells 2006;24:2209-2219.
22. Bentz K, Molcanyi M, Riess P, Elbers A, Pohl E, Sachinidis A, Hescheler J, Neugebauer E, Schäfer U: Embryonic stem cells produce neurotrophins in response to cerebral tissue extract: Cell line-dependent differences. J Neurosci Res 2007;85:1057-1064.
23. Tseng HC, Ruegg SJ, Maronski M, Messam CA, Grinspan JB, Dichter MA: Injuring neurons induces neuronal differentiation in a population of hippocam-pal precursor cells in culture. Neurobiol Dis 2006;22:88-97.
24. Yu TS, Zhang G, Liebl DJ, Kernie SG: Traumatic brain injury-induced hippoc-ampal neurogenesis requires activation of early nestin-expressing progenitors. J Neurosci 2008;28:12901-12912.
25. Heath JK, Smith AG: Regulatory factors of embryonic stem cells. J Cell Sci Suppl 1988;10:257-256.
26. Rathjen PD, Nichols J, Toth S, Edwards DR, Heath JK, Smith AG: Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations. Genes Dev 1990;4:2308-2318.
27. Rathjen PD, Toth S, Willis A, Heath JK, Smith AG: Differentiation inhibiting activity is produced in matrix-associated and diffusible forms that are generated by alternate promoter usage. Cell 1990;62:1105-1114.