Embryonic stem cells produce neurotrophins in response to cerebral tissue extract: Cell line-dependent differences

Journal of Neuroscience Research

Volumn 85, Issue 5, 2007, Pages 1057-1064

  Bentz, Kristine ^a   Molcanyi, Marek ^b,d   Riess, Peter ^c   Elbers, Andrea ^d   Pohl, Esther ^d   Sachinidis, Agapios ^b   Hescheler, Jürgen ^b   Neugebauer, Edmund ^d   Schäfer, Ute ^d  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^d UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

BDNF; Fluid percussion injury; Neurotrophin 3; NGF; Sprague Dawley rats

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIC FACTOR; NEUROTROPHIN 3;

ANIMAL CELL; ARTICLE; BRAIN INJURY; BRAIN TISSUE; CELL LINE; EMBRYONIC STEM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN CHEMISTRY; BRAIN TISSUE TRANSPLANTATION; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DIFFERENTIATION; CELL EXTRACTS; CELL LINE; CEREBRAL CORTEX; CULTURE MEDIA, CONDITIONED; EMBRYONIC STEM CELLS; MICE; NERVE GROWTH FACTORS; NERVE REGENERATION; NEUROTROPHIN 3; STEM CELL TRANSPLANTATION; TIME FACTORS;

EID: 34147208140     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21219     Document Type: Article

References (38)

1. Arnhold S, Lenartz D, Kruttwig K, Klinz FJ, Kolossov E, Hescheler J, Sturm V, Andressen C, Addicks K. 2000. Differentiation of green fluorescent protein-labeled embryonic stem cell-derived neural precursor cells into Thy-1-positive neurons and glia after transplantation into adult rat striatum. J Neurosurg 93:1026-1032.
2. Boockvar JA, Schouten J, Royo N, Millard M, Spangler Z, Castelbuono D, Snyder E, O'Rourke D, McIntosh T. 2005. Experimental traumatic brain injury modulates the survival, migration, and terminal phenotype of transplanted epidermal growth factor receptor-activated neural stem cells. Neurosurgery 56:163-171; discussion 171.
3. Borlongan CV, Koutouzis TK, Jorden JR, Martinez R, Rodriguez AI, Poulos SG, Freeman TB, McKeown P, Cahill DW, Nishino H, Sanberg PR. 1997. Neural transplantation as an experimental treatment modality for cerebral ischemia. Neurosci Biobehav Rev 21:79-90.
4. Cao QL, Howard RM, Dennison JB, Whittemore SR. 2002. Differentiation of engrafted neuronal-restricted precursor cells is inhibited in the traumatically injured spinal cord. Exp Neurol 177:349-359.
5. Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, Chopp M. 2001. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32:1005-1011.
6. Chen Q, Long Y, Yuan X, Zou L, Sun J, Chen S, Perez-Polo JR, Yang K. 2005. Protective effects of bone marrow stromal cell transplantation in injured rodent brain: synthesis of neurotrophic factors. J Neurosci Res 80:611-619.
7. Chen X, Katakowski M, Li Y, Lu D, Wang L, Zhang L, Chen J, Xu Y, Gautam S, Mahmood A, Chopp M. 2002a. Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production. J Neurosci Res 69:687-691.
8. Chen X, Li Y, Wang L, Katakowski M, Zhang L, Chen J, Xu Y, Gautam SC, Chopp M. 2002b. Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Neuropathology 22: 275-279.
9. Davis AE. 2000. Mechanisms of traumatic brain injury: biomechanical, structural and cellular considerations. Crit Care Nurs Q 23:1-13.
10. Dixon CE, Lyeth BG, Povlishock JT, Findling RL, Hamm RJ, Marmarou A, Young HF, Hayes RL. 1987. A fluid percussion model of experimental brain injury in the rat. J Neurosurg 67:110-119.
11. Emery DL, Fulp CT, Saatman KE, Schutz C, Neugebauer E, McIntosh TK. 2005. Newly born granule cells in the dentate gyrus rapidly extend axons into the hippocampal CA3 region following experimental brain injury. J Neurotrauma 22:978-988.
12. Giehl KM, Rohrig S, Bonatz H, Gutjahr M, Leiner B, Bartke I, Yan Q, Reichardt LF, Backus C, Welcher AA, Dethleffsen K, Mestres P, Meyer M. 2001. Endogenous brain-derived neurotrophic factor and neurotrophin-3 antagonistically regulate survival of axotomized corticospinal neurons in vivo. J Neurosci 21:3492-3502.
13. Hicks RR, Numan S, Dhillon HS, Prasad MR, Seroogy KB. 1997. Alterations in BDNF and NT-3 mRNAs in rat hippocampus after experimental brain trauma. Brain Res Mol Brain Res 48:401-406.
14. Hicks RR, Martin VB, Zhang L, Seroogy KB. 1999. Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus. Exp Neurol 160:469-478.
15. Iguchi F, Nakagawa T, Tateya I, Kim TS, Endo T, Taniguchi Z, Naito Y, Ito J. 2003. Trophic support of mouse inner ear by neural stem cell transplantation. Neuroreport 14:77-80.
16. Karchewski LA, Gratto KA, Wetmore C, Verge VM. 2002. Dynamic patterns of BDNF expression in injured sensory neurons: differential modulation by NGF and NT-3. Eur J Neurosci 16:1449-1462.
17. Lacza Z, Horvath E, Busija DW. 2003a. Neural stem cell transplantation in cold lesion: a novel approach for the investigation of brain trauma and repair. Brain Res Brain Res Protoc 11:145-154.
18. Lacza Z, Horvath EM, Komjati K, Hortobagyi T, Szabo C, Busija DW. 2003b. PARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma. Int J Mol Med 12:153-159.
19. Le Belle JE, Svendsen CN. 2002. Stem cells for neurodegenerative disorders: where can we go from here? BioDrugs 16:389-401.
20. Lenzlinger PM, Morganti-Kossmann MC, Laurer HL, McIntosh TK. 2001. The duality of the inflammatory response to traumatic brain injury. Mol Neurobiol 24:169-181.
21. Longhi L, Zanier ER, Royo N, Stocchetti N, McIntosh TK. 2005. Stem cell transplantation as a therapeutic strategy for traumatic brain injury. Transpl Immunol 15:143-148.
22. Lu D, Mahmood A, Wang L, Li Y, Lu M, Chopp M. 2001. Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Neuroreport 12:559-563.
23. Lu D, Li Y, Mahmood A, Wang L, Rafiq T, Chopp M. 2002. Neural and marrow-derived stromal cell sphere transplantation in a rat model of traumatic brain injury. J Neurosurg 97:935-940.
24. Mahmood A, Lu D, Lu M, Chopp M. 2003. Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells. Neurosurgery 53:697-702; discussion 702-693.
25. McAllister AK, Katz LC, Lo DC. 1997. Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth. Neuron 18:767-778.
26. McIntosh TK, Vink R, Noble L, Yamakami I, Fernyak S, Soares H, Faden AL. 1989. Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model. Neuroscience 28:233-244.
27. Molcanyi M, Riess P, Bentz K, Maegele M, Hescheler J, Schafke B, Trapp T, Neugebauer E, Klug N, Schafer U. 2007. Trauma associated inflammatory response impairs embryonic stem cell survival and integration after implantation into injured rat brain. J Neurotrauma (in press).
28. Okano H, Ogawa Y, Nakamura M, Kaneko S, Iwanami A, Toyama Y. 2003. Transplantation of neural stem cells into the spinal cord after injury. Semin Cell Dev Biol 14:191-198.
29. Philips MF, Mattiasson G, Wieloch T, Bjorklund A, Johansson BB, Tomasevic G, Martinez-Serrano A, Lenzlinger PM, Sinson G, Grady MS, McIntosh TK. 2001. Neuroprotective and behavioral efficacy of nerve growth factor-transfected hippocampal progenitor cell transplants after experimental traumatic brain injury. J Neurosurg 94:765-774.
30. Ricci-Vitiani L, Casalbore P, Petrucci G, Lauretti L, Montano N, Larocca LM, Falchetti ML, Lombardi DG, Gerevini VD, Cenciarelli C, D'Alessandris QG, Fernandez E, De Maria R, Maira G, Peschle C, Parati E, Pallini R. 2006. Influence of local environment on the differentiation of neural stem cells engrafted onto the injured spinal cord. Neurol Res 28:488-492.
31. Riess P, Molcanyi M, Bentz K, Maegele M, Simanski C, Carlitscheck C, Schneider A, Hescheler J, Bouillon B, Schafer U, Neugebauer E. 2007. Embryonic stem cell transplantation after experimental traumatic brain injury dramatically improves neurological outcome, but may cause tumors. J Neurotrauma 24:216-225.
32. Riess P, Zhang C, Saatman KE, Laurer HL, Longhi LG, Raghupathi R, Lenzlinger PM, Lifshitz J, Boockvar J, Neugebauer E, Snyder EY, McIntosh TK. 2002. Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury. Neurosurgery 51:1043-1052; discussion 1052-1044.
33. Rohwedel J, Maltsev V, Bober E, Arnold H, Hescheler J, Wobus A. 1994. Muscle cell differentiation of embryonic stem cell reflects myogenesis in vivo: developmentally regulated expression of myogenic determination genes and functional expression of ionic currents. Dev Biol:87-101.
34. Saporta S, Borlongan CV, Sanberg PR. 1999. Neural transplantation of human neuroteratocarcinoma (hNT) neurons into ischemic rats. A quantitative dose-response analysis of cell survival and behavioral recovery. Neuroscience 91:519-525.
35. Sinson G, Voddi M, McIntosh TK. 1996. Combined fetal neural transplantation and nerve growth factor infusion: effects on neurological outcome following fluid-percussion brain injury in the rat. J Neurosurg 84:655-662.
36. Veizovic T, Beech JS, Stroemer RP, Watson WP, Hodges H. 2001. Resolution ot stroke deficits following contralateral grafts of conditionally immortal neuroepithelial stem cells. Stroke 32:1012-1019.
37. Watson DJ, Longhi L, Lee EB, Fulp CT, Fujimoto S, Royo NC, Passini MA, Trojanowski JQ, Lee VM, McIntosh TK, Wolfe JH. 2003. Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury. J Neuropathol Exp Neurol 62:368-380.
38. Wong G, Goldshmit Y, Turnley AM. 2004. Interferon-gamma but not TNF alpha promotes neuronal differentiation and neurite outgrowth of murine adult neural stem cells. Exp Neurol 187:171-177.