The genetics of epigenetics: Is there a link with cardiovascular disease

Heart

Volumn 97, Issue 2, 2011, Pages 96-97

  Xiao, Qingzhong ^a   Ye, Shu ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE ACETYLTRANSFERASE PCAF;

CARDIOVASCULAR DISEASE; EDITORIAL; ENZYME ACTIVITY; EPIGENETICS; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; NONHUMAN; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION;

CARDIOVASCULAR DISEASES; EPIGENESIS, GENETIC; HUMANS;

EID: 78651236076     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/hrt.2010.214833     Document Type: Editorial

References (11)

1. Ordovas JM, Smith CE. Epigenetics and cardiovascular disease. Nat Rev Cardiol 2010;7:510-19.
2. Grunstein M. Histone acetylation in chromatin structure and transcription. Nature 1997;389:349-52. (Pubitemid 27415209)
3. Imhof A, Yang XJ, Ogryzko VV, et al. Acetylation of general transcription factors by histone acetyltransferases. Curr Biol 1997;7:689-92. (Pubitemid 27408867)
4. Okumura K, Mendoza M, Bachoo RM, et al. PCAF modulates PTEN activity. J Biol Chem 2006;281:26562-8.
5. Ge X, Jin Q, Zhang F, et al. PCAF acetylates {beta}-catenin and improves its stability. Mol Biol Cell 2009;20:419-27.
6. Song CZ, Keller K, Murata K, et al. Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2. J Biol Chem 2002;277:7029-36. (Pubitemid 34953090)
7. Pons D, Trompet S, de Craen AJM, et al. Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies. Heart 2011;97:143-50.
8. Samani NJ, Erdmann J, Hall AS, et al. Genomewide association analysis of coronary artery disease. N Engl J Med 2007;357:443-53.
9. Kathiresan S, Voight BF, Purcell S, et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 2009;41:334-41.
10. Samani NJ, Deloukas P, Erdmann J, et al. Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol 2009;29:774-80.
11. Ye S, Willeit J, Kronenberg F, et al. Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study. J Am Coll Cardiol 2008;52:378-84. (Pubitemid 352001349)