Azaindoles as potent CRTH2 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 2, 2011, Pages 841-845

  Simard, Daniel ^a   Leblanc, Yves ^a   Berthelette, Carl ^a   Zaghdane, M Helmi ^a   Molinaro, Carmela ^a   Wang, Zhaoyin ^a   Gallant, Michel ^a   Lau, Stephen ^a   Thao, Trinh ^a   Hamel, Martine ^a   Stocco, Rino ^a   Sawyer, Nicole ^a   Sillaots, Susan ^a   Gervais, Francois ^a   Houle, Robert ^a   Lévesque, Jean Franois ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Azaindole; Chemoattractant receptor homologous; CRTH2; PGD2; Prostanoid; Tetrahydropyridoindolizines

Indexed keywords

AZAINDOLE DERIVATIVE; CELL RECEPTOR; CRTH2 RECEPTOR; INDOLE DERIVATIVE; MK 7246; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COVALENT BOND; CYCLIZATION; DISTRIBUTION VOLUME; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STRUCTURE; ISOMERISM; MITSUNOBU REACTION; NONHUMAN; POLYMERIZATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBOLINES; HUMANS; INDOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78651233023     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.084     Document Type: Article

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