A novel coenzyme A:diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity

European Journal of Pharmacology

Volumn 650, Issue 2-3, 2011, Pages 663-672

  Yamamoto, Toshihiro ^a   Yamaguchi, Hiroshi ^a,c   Miki, Hiroshi ^a   Kitamura, Shuji ^a   Nakada, Yoshihisa ^a   Aicher, Thomas D ^b   Pratt, Scott A ^b   Kato, Koki ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b ARRAY BIOPHARMA INC   (United States)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

DGAT1; Diabetes; Fatty acid oxidation; Hepatic steatosis; Obesity; Triacylglycerol

Indexed keywords

DIACYLGLYCEROL ACYLTRANSFERASE 1; DIACYLGLYCEROL ACYLTRANSFERASE 1 INHIBITOR; ENZYME INHIBITOR; FATTY ACID; N [2 [[[1 PHENYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]CARBONYL]AMINO]ETHYL] 6 (2,2,2 TRIFLUOROETHOXY)PYRIDINE 3 CARBOXAMIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; EX VIVO STUDY; FATTY ACID OXIDATION; FEMALE; FOOD INTAKE; IN VITRO STUDY; INTRAABDOMINAL FAT; LIPID METABOLISM; MALE; MOUSE; MUSCLE CELL; MYOTUBE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; SKELETAL MUSCLE; WEIGHT REDUCTION;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; DIACYLGLYCEROL O-ACYLTRANSFERASE; DIETARY CARBOHYDRATES; DIETARY FATS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; NIACINAMIDE; OBESITY; PYRAZOLES; SPECIES SPECIFICITY; TRIGLYCERIDES;

EID: 78651112673     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.040     Document Type: Article

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