Neonatal rat model of intraventricular haemorrhage and post-haemorrhagic ventricular dilatation with long-term survival into adulthood

Neuropathology and Applied Neurobiology

Volumn 37, Issue 2, 2011, Pages 156-165

  Aquilina, K ^a,b   Chakkarapani, E ^a   Love, S ^a   Thoresen, M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b FRENCHAY HOSPITAL   (United Kingdom)

Author keywords

Histopathology; Motor and cognitive function; Neonatal intraventricular haemorrhage; Neonatal rat model; Post haemorrhagic ventricular dilatation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HEMORRHAGE; BRAIN VENTRICLE DILATATION; COGNITION; CONTROLLED STUDY; CORPUS CALLOSUM; DISEASE MODEL; FEMALE; HISTOPATHOLOGY; MALE; MOTOR PERFORMANCE; NEUROPATHOLOGY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL TIME;

ANIMALS; ANIMALS, NEWBORN; CEREBRAL HEMORRHAGE; CEREBRAL VENTRICLES; COGNITION DISORDERS; DILATATION, PATHOLOGIC; DISEASE MODELS, ANIMAL; FEMALE; LEARNING; MALE; RATS; RATS, WISTAR;

EID: 78651107344     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2010.01118.x     Document Type: Article

References (47)

1. Volpe J. Neurology of the Newborn 5th edn. Philadelphia: WB Saunders, 2008
2. Murphy BP, Inder TE, Rooks V, Taylor GA, Anderson NJ, Mogridge N, Horwood LJ, Volpe JJ. Posthaemorrhagic ventricular dilatation in the premature infant: natural history and predictors of outcome. Arch Dis Child 2002; 87: F37-41
3. Ventriculomegaly Trial Group. Randomised trial of early tapping in neonatal posthaemorrhagic ventricular dilatation: results at 30 months. Arch Dis Child 1994; 70: F129-36
4. Whitelaw A, Kennedy CR, Brion LP. Diuretic therapy for newborn infants with posthemorrhagic ventricular dilatation. Cochrane Database Syst Rev (Online) 2001; (2): CD002270
5. Whitelaw A, Evans D, Carter M, Thoresen M, Wroblewska J, Mandera M, Swietlinski J, Simpson J, Hajivassiliou C, Hunt LP, Pople I. Randomized clinical trial of prevention of hydrocephalus after intraventricular hemorrhage in preterm infants: brain-washing versus tapping fluid. Pediatrics 2007; 119: e1071-8
6. Pople IK, Bayston R, Hayward RD. Infection of cerebrospinal fluid shunts in infants: a study of etiological factors. J Neurosurg 1992; 77: 29-36
7. Shah SS, Smith MJ, Zaoutis TE. Device-related infections in children. Pediatr Clin North Am 2005; 52: 1189-208
8. Cherian SS, Love S, Silver IA, Porter HJ, Whitelaw AG, Thoresen M. Posthemorrhagic ventricular dilation in the neonate: development and characterization of a rat model. J Neuropathol Exp Neurol 2003; 62: 292-303
9. Aquilina K, Hobbs C, Tucker A, Whitelaw A, Thoresen M. Do drugs that block transforming growth factor beta reduce posthaemorrhagic ventricular dilatation in a neonatal rat model? Acta Paediatr 2008; 97: 1181-6
10. Khan OH, Enno T, Del Bigio MR. Tacrolimus and cyclosporine A are of no benefit to young rats with kaolin-induced hydrocephalus. Pediatr Neurosurg 2003; 39: 309-13
11. Khan OH, Enno T, Del Bigio MR. Magnesium sulfate therapy is of mild benefit to young rats with kaolin-induced hydrocephalus. Pediatr Res 2003; 53: 970-6
12. Del Bigio MR, Massicotte EM. Protective effect of nimodipine on behavior and white matter of rats with hydrocephalus. J Neurosurg 2001; 94: 788-94
13. Altman J, Sudarshan K. Postnatal development of locomotion in the laboratory rat. Anim Behav 1975; 23: 896-920
14. Khan OH, Enno TL, Del Bigio MR. Brain damage in neonatal rats following kaolin induction of hydrocephalus. Exp Neurol 2006; 200: 311-20
15. Xue M, Balasubramaniam J, Buist RJ, Peeling J, Del Bigio MR. Periventricular/intraventricular hemorrhage in neonatal mouse cerebrum. J Neuropathol Exp Neurol 2003; 62: 1154-65
16. Balasubramaniam J, Xue M, Buist RJ, Ivanco TL, Natuik S, Del Bigio MR. Persistent motor deficit following infusion of autologous blood into the periventricular region of neonatal rats. Exp Neurol 2006; 197: 122-32
17. Montoya CP, Campbell-Hope LJ, Pemberton KD, Dunnett SB. The 'staircase test': a measure of independent forelimb reaching and grasping abilities in rats. J Neurosci Methods 1991; 36: 219-28
18. Jarrard LE. Selective hippocampal lesions and behavior: effects of kainic acid lesions on performance of place and cue tasks. Behav Neurosci 1983; 97: 873-89
19. Aquilina K, Hobbs C, Cherian S, Tucker A, Porter H, Whitelaw A, Thoresen M. A neonatal piglet model of intraventricular hemorrhage and posthemorrhagic ventricular dilation. J Neurosurg 2007; 107: 126-36
20. Reynolds ML, Evans CA, Reynolds EO, Saunders NR, Durbin GM, Wigglesworth JS. Intracranial haemorrhage in the preterm sheep fetus. Early Hum Dev 1979; 3: 163-86
21. Goddard J, Lewis RM, Armstrong DL, Zeller RS. Moderate, rapidly induced hypertension as a cause of intraventricular hemorrhage in the newborn beagle model. J Pediatr 1980; 96: 1057-60
22. Fukushima N, Yokouchi K, Kawagishi K, Ren G, Higashiyama F, Moriizumi T. Proliferating cell populations in experimentally-induced hydrocephalus in developing rats. J Clin Neurosci 2003; 10: 334-7
23. Cosan TE, Guner AI, Akcar N, Uzuner K, Tel E. Progressive ventricular enlargement in the absence of high ventricular pressure in an experimental neonatal rat model. Childs Nerv Syst 2002; 18: 10-14
24. Ishizaki R, Tashiro Y, Inomoto T, Hashimoto N. Acute and subacute hydrocephalus in a rat neonatal model: correlation with functional injury of neurotransmitter systems. Pediatr Neurosurg 2000; 33: 298-305
25. Shoesmith CL, Buist R, Del Bigio MR. Magnetic resonance imaging study of extracellular fluid tracer movement in brains of immature rats with hydrocephalus. Neurol Res 2000; 22: 111-16
26. Chovanes GI, McAllister JP 2nd, Lamperti AA, Salotto AG, Truex RC Jr. Monoamine alterations during experimental hydrocephalus in neonatal rats. Neurosurgery 1988; 22: 86-91
27. McAllister JP 2nd, Maugans TA, Shah MV, Truex RC Jr. Neuronal effects of experimentally induced hydrocephalus in newborn rats. J Neurosurg 1985; 63: 776-83
28. Wagner KR, Sharp FR, Ardizzone TD, Lu A, Clark JF. Heme and iron metabolism: role in cerebral hemorrhage. J Cereb Blood Flow Metab 2003; 23: 629-52
29. Savman K, Nilsson UA, Blennow M, Kjellmer I, Whitelaw A. Non-protein-bound iron is elevated in cerebrospinal fluid from preterm infants with posthemorrhagic ventricular dilatation. Pediatr Res 2001; 49: 208-12
30. Donovan FM, Pike CJ, Cotman CW, Cunningham DD. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci 1997; 17: 5316-26
31. Moller T, Hanisch UK, Ransom BR. Thrombin-induced activation of cultured rodent microglia. J Neurochem 2000; 75: 1539-47
32. Gingrich MB, Junge CE, Lyuboslavsky P, Traynelis SF. Potentiation of NMDA receptor function by the serine protease thrombin. J Neurosci 2000; 20: 4582-95
33. Tang Y, Lu A, Aronow BJ, Wagner KR, Sharp FR. Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia. Eur J Neurosci 2002; 15: 1937-52
34. Grainger DJ, Wakefield L, Bethell HW, Farndale RW, Metcalfe JC. Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin. Nat Med 1995; 1: 932-7
35. Flood C, Akinwunmi J, Lagord C, Daniel M, Berry M, Jackowski A, Logan A. Transforming growth factor-beta1 in the cerebrospinal fluid of patients with subarachnoid hemorrhage: titers derived from exogenous and endogenous sources. J Cereb Blood Flow Metab 2001; 21: 157-62
36. Bottner M, Krieglstein K, Unsicker K. The transforming growth factor-betas: structure, signaling, and roles in nervous system development and functions. J Neurochem 2000; 75: 2227-40
37. Dudchenko PA. An overview of the tasks used to test working memory in rodents. Neurosci Biobehav Rev 2004; 28: 699-709
38. Egawa T, Mishima K, Egashira N, Fukuzawa M, Abe K, Yae T, Iwasaki K, Fujiwara M. Impairment of spatial memory in kaolin-induced hydrocephalic rats is associated with changes in the hippocampal cholinergic and noradrenergic contents. Behav Brain Res 2002; 129: 31-9
39. Whitelaw AJS, Kmita G, Wroblewska J, Musiliak-Swietlinska E, Mandera M, Hunt L, Carter M, Pople I. Brain-washing for post-haemorrhagic ventricular dilatation: outcome at 2 years. Pediatrics 2010; 125: 852-8
40. Del Bigio MR, Wilson MJ, Enno T. Chronic hydrocephalus in rats and humans: white matter loss and behavior changes. Ann Neurol 2003; 53: 337-46
41. Del Bigio MR, Kanfer JN, Zhang YW. Myelination delay in the cerebral white matter of immature rats with kaolin-induced hydrocephalus is reversible. J Neuropathol Exp Neurol 1997; 56: 1053-66
42. Del Bigio MR, Crook CR, Buist R. Magnetic resonance imaging and behavioral analysis of immature rats with kaolin-induced hydrocephalus: pre- and postshunting observations. Exp Neurol 1997; 148: 256-64
43. Kuban K, Sanocka U, Leviton A, Allred EN, Pagano M, Dammann O, Share J, Rosenfeld D, Abiri M, DiSalvo D, Doubilet P, Kairam R, Kazam E, Kirpekar M, Schonfield S. White matter disorders of prematurity: association with intraventricular hemorrhage and ventriculomegaly. The Developmental Epidemiology Network. J Pediatr 1999; 134: 539-46
44. Bass NH, Netsky MG, Young E. Effect of neonatal malnutrition on developing cerebrum. II. Microchemical and histologic study of myelin formation in the rat. Arch Neurol 1970; 23: 303-13
45. Rice JE 3rd, Vannucci RC, Brierley JB. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 1981; 9: 131-41
46. Romijn HJ, Hofman MA, Gramsbergen A. At what age is the developing cerebral cortex of the rat comparable to that of the full-term newborn human baby? Early Hum Dev 1991; 26: 61-7
47. Tucker AM, Aquilina K, Chakkarapani E, Hobbs CE, Thoresen M. Development of amplitude integrated EEG and interburst interval in the rat. Pediatr Res 2009; 65: 62-6