Qualitative and quantitative analysis of 15 active constituents in jiweiling freeze-dried powder by high performance liquid chromatography-tandem mass spectrometry

Journal of Liquid Chromatography and Related Technologies

Volumn 34, Issue 1, 2011, Pages 1-17

  Liu, Minyan ^a,b   Zhao, Shaohua ^b   Jia, Jiming ^b   Shi, Xiaowei ^a   Song, Jian ^b   Wang, Hongtao ^b   Du, Yingfeng ^a   Zhang, Lantong ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Yiling Pharmaceutical Corporation   (China)

Author keywords

fifteen constituents; HPLC ESI MS MS; Jiweiling freeze dried powder; MRM; qualitative characterization; quantitative analysis

Indexed keywords

DRIED POWDER; FIFTEEN CONSTITUENTS; HPLC-ESI-MS/MS; MRM; QUALITATIVE CHARACTERIZATION; QUANTITATIVE ANALYSIS;

ACETONITRILE; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; FORMIC ACID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY;

QUALITY CONTROL;

ACETONITRILE; ANION; ARABINOSE; EPIMEDIN A; EPIMEDIN B; EPIMEDIN C; EPIMEDIUM EXTRACT; FLAVONOID; FORMIC ACID; GINSENG EXTRACT; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RF; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RG 3; GLUCOSE; HYPERIN; ICARIIN; RHAMNOSE; UNCLASSIFIED DRUG; XYLOSE;

ACCURACY; AQUEOUS SOLUTION; ARTICLE; BIOCHEMICAL COMPOSITION; CALIBRATION; CORRELATION COEFFICIENT; DRY POWDER; ELECTROSPRAY; ELUTION; FRAGMENTATION REACTION; FREEZE DRYING; HUMAN; INSTRUMENT VALIDATION; JIWEILING FREEZE DRIED POWDER; LIMIT OF DETECTION; LIMIT OF QUANTITATION; NONHUMAN; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; STRUCTURE ACTIVITY RELATION; TANDEM MASS SPECTROMETRY;

EID: 78651061487     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2011.534687     Document Type: Article

References (27)

1. Burvill, E. The Current Understanding of Motorneuron Disease. Curr. Anaesth. Crit. Care. 2009, 20, 236-239.
2. Wu, Y. L. Collateral Disease Theory in Practice, People's Medical Publishing House: Beijing, 2008; pp 340-341.
3. Patel, B. P.; Hamadeh, M. J. Nutritional and Exercise-Based Interventions in the Treatment of Amyotrophic Laterals Clerosis. Clin. Nutr. 2009, 28, 604-617.
4. Gros-Louis, F.; Gaspar, C.; Rouleau, G. A. Genetics of Familial and Sporadic Amyotrophicl Ateral Sclerosis. Biochim. Biophys. Acta 2006, 1762, 956-972.
5. Blatzheim, K. CMT, NMT. Interdisciplinary Palliative Care, Including Massage, in Treatment of Amyotrophic Lateral Sclerosis. J. Bodyw. Mov. Ther. 2009, 13, 328-335.
6. Bensimon, G.; Lacomblez, L.; Meininger, V. A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis. N. Engl. J. Med. 1994, 330, 585-591.
7. Zhao, J. F.; Yu, S. W. Riluzole, a New Drug for Motor Neuron Disease. Acad. J. Jiangsu Univ. (med.) 2002, 12 (2), 301-301.
8. Zhu, M. X.; Tan, X. L. Overview of TCM Treatment of Motor Neuron Disease. JETCM 2008, 17 (1), 92-94.
9. Chen, J. L.; Wang, D. H.; Zhou, S. L. Effective Observation of the Parenteral Solution of Jiweiling on Motor Neuron Disease. Chin. J. Clin. Rehabil. 2004, 8 (35), 7927-7929.
10. Wu, Y. L.; Wang, J. M.; Yang, P.; Song, L.; Li, Z. Q. Influence of Jiweiling Injection on Motoneurons Apoptosis Cultured in vitro Induced by Guutamate. J. TMC Brain Dis. 2006, 2 (2), 161-164.
11. Wang, J. M.; Wu, Y. L.; Yang, P.; Song, L. Experimental Study of Jiweiling Injection on Motoneuron Protection Effect. J. TMC Brain Dis. 2006, 2 (1), 168-171.
12. Yang, P.; Wang, J. M.; Ying, D. J.; Song, L.; Li, Z. Q.; Wu, Y. L. Effects of Jiweiling Injection on the Growth of Primary Cultured Motoneurons of Rats. Chin. J. Neuroanat. 2005, 21 (2), 203-206.
13. Qian, Z. M.; Lu, J.; Gao, Q. P.; Li, S. P. Rapid Method for Simultaneous Determination of Flavonoid, Saponins and Polyacetylenes in Folium Ginseng and Radix Ginseng by Pressurized Liquid Extraction and High-Performance Liquid Chromatography Coupled with Diode Array Detection and Mass Spectrometry. J. Chromatogr. A 2009, 1216, 3825-3830.
14. Qu, C. L.; Bai, Y. P.; Jin, X. Q.; Wang, Y. T.; Zhang, K.; You, J. Y.; Zhang, H. Q. Study on Ginsenosides in Different Parts and Ages of Panax quinquefolius L. Food Chem. 2009, 115, 340-346.
15. Ma, L.; Tang, J. Y.; Li, Z. L.; Xiao, X. H.; Liao, Q. W.; Feng, S. H. Determination of Ginsenoside Rg1 and Rb1 in WEIKANG CAPSULe by HPLC. Chin. Tradit. Herba. Drugs 2006, 37 (5), 705-707.
16. Sun, B. S.; Gu, L. J.; Fang, Z. M.; Wang, C. Y.; Wang, Z.; Lee, M. R.; Li, Z.; Li, J. J.; Sung, C. K. Simultaneous Quantification of 19 Ginsenosides in Black Ginseng Developed from Panax ginseng by HPLC-ELSD. J. Pharm. Biomed. Anal. 2009, 50, 15-22.
17. Chen, X. J.; Tu, P. F.; Jiang, Y.; Wang, Y. T.; Li, S. P. Effect of Stability of Internal Standard on Quantification of 15 Flavonoids in Epimedium using CZE. J. Sep. Sci. 2009, 32, 275-281.
18. Huang, H.; Liang, M. J.; Zhang, X. M.; Zhang, C.; Shen, Z. Y.; Zhang, W. D. Simultaneous Determination of Nine Flavonoids and Qualitative Evaluation of Herba Epimedii by High Performance Liquid Chromatography with Ultraviolet Detection. J. Sep. Sci. 2007, 30, 3207-3213.
19. Yang, G. D.; Feng, S. X.; Qi, L.; He, L. C.; Zhang, X. M.; Zhou, S. L. Determination of Icariin in Herba Epimedii by TLC-UV. Nat. Prod. Res. Dev. 2002, 14 (3), 11-13.
20. Chen, X. J.; Ji, H.; Zhang, Q. W.; Tu, P. F.; Wang, Y. T.; Guo, B. L.; Li, S. P. A Rapid Method for Simultaneous Determination of 15 Flavonoids in Epimedium using Pressurized Liquid Extraction and Ultra-Performance Liquid Chromatography. J. Pharm. Biomed. Anal. 2008, 46, 226-235.
21. Liang, X.; Zhang, L.; Zhang, X.; Dai, W. X.; Li, H. Y.; Hu, L. W.; Liu, H.; Su, J.; Zhang, W. D. Qualitative and Quantitative Analysis of Traditional Chinese Medicine Niu Huang Jie Du Pill Using Ultra Performance Liquid Chromatography Coupled with Tunable UV Detector and Rapid Resolution Liquid Chromatography Coupled with Time-of-Flight Tandem Mass Spectrometry. J. Pharm. Biomed. Anal. 2010, 51, 565-571.
22. Zhang, T.; Liu, H.; Liu, X. T.; Xu, D. R.; Chen, X. Q.; Wang, Q. Qualitative and Quantitative Analysis of Steroidal Saponins in Crude Extracts from Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis by High Performance Liquid Chromatography Coupled with Mass Spectrometry. J. Pharm. Biomed. Anal. 2010, 51, 114-124.
23. Taylor, P. J. Matrix Effects: The Achilles Heel of Quantitative High-Performance Liquid Chromatography-Electrospray-Tandem Mass Spectrometry. Clin. Biochem. 2005, 38, 328-334.
24. Kruve, A.; Kunnaps, A.; Herodes, K.; Leito, I. Matrix Effects in Pesticide Multi-Residue Analysis by Liquid Chromatography-Mass Spectrometry. J. Chromatogr. A 2008, 1187, 58-66.
25. Islam, N. M.; Yoo, H. H.; Lee, M. W.; Dong, M. S.; Park, Y. I.; Jeong, H. S.; Kim, D. H. Simultaneous Quantitation of Five Flavonoid Glycosidesin Herba Epimedii by High-Performance Liquid Chromatography- Tandem Mass Spectrometry. Phytochem. Anal. 2008, 19, 71-77.
26. Li, K.; Chen, X. Y.; Xu, J. H.; Li, X.; Zhong, D. F. Liquid Chromatography=Tandem Mass Spectrometry for Pharmacokinetic Studies of 20(R)-ginsenoside Rg3 in Dog. Rapid Commun. Mass Spectrom. 2005, 19, 813-817.
27. The Pharmacopoeia Commission of PRC. Pharmacopoeia of the People's Republic of China, Vol. 1, Chemical Industry Publishing House: Beijing, 2005.