Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma

Journal of Endocrinology

Volumn 208, Issue 1, 2011, Pages 31-39

  Lu, Ming ^a,b   Berglund, Erik ^a   Larsson, Catharina ^a   Höög, Anders ^a   Farnebo, Lars Ove ^a   Bränström, Robert ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; CALCIUM BINDING PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALMIDAZOLIUM; CALMODULIN; SYNAPTOTAGMIN I; UBIQUITIN;

ADULT; AGED; ARTICLE; CALCIUM BINDING; CALCIUM BLOOD LEVEL; CALCIUM CELL LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE INCREASE; EXOCYTOSIS; EXTRACELLULAR CALCIUM; FEMALE; HORMONE RELEASE; HUMAN; IN VITRO STUDY; MALE; NEUROSECRETORY CELL; PARATHYROID ADENOMA; PARATHYROID CELL; PARATHYROID FUNCTION; PRIMARY HYPERPARATHYROIDISM; PRIORITY JOURNAL; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ADENOMA; BLOTTING, WESTERN; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CALMODULIN; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; PARATHYROID GLANDS; PARATHYROID HORMONE; PARATHYROID NEOPLASMS; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNAPTOTAGMIN I;

EID: 78650993398     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-10-0123     Document Type: Article

References (28)

1. Almaden Y, Canalejo A, Ballesteros E, Anon G, Canadillas S & Rodriguez M 2002 Regulation of arachidonic acid production by intracellular calcium in parathyroid cells: effect of extracellular phosphate. Journal of the American Society of Nephrology 13 693-698. (Pubitemid 34183934)
2. Bhatt HS, Conner BP, Prasanna G, Yorio T & Easom RA 2000 Dependence of insulin secretion from permeabilized pancreatic β-cells on the activation of Ca(2+)/calmodulin-dependent protein kinase II. A re-evaluation of inhibitor studies. Biochemical Pharmacology 60 1655-1663. (doi:10.1016/S0006- 2952(00)00483-4)
3. Brown EM, Dawson-Hughes BF, Wilson RE & Adragna N 1981 Calmodulin in dispersed human parathyroid cells. Journal of Clinical Endocrinology and Metabolism 53 1064-1071. (doi:10.1210/jcem-53-5-1064)
4. 2+ release channel (ryanodine receptor) by calmodulin. Biochemical and Biophysical Research Communications 213 1082-1090. (doi:10.1006/bbrc.1995.2238)
5. Conigrave AD, Mun HC, Delbridge L, Quinn SJ, Wilkinson M & Brown EM 2004 L-amino acids regulate parathyroid hormone secretion. Journal of Biological Chemistry 279 38151-38159. (doi:10.1074/jbc.M406373200)
6. Grimelius L, Auerstrom G, Franssila KO, Eng C, DeLellis RA, Arnold A, Hendy GN, Bondeson L & Dupuy D 2004 Parathyroid Adenoma. In: DeLellis RA, Lloyd RV, Heitz PU & Eng C (eds) World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Endocrine Organs. Lyon: IARC Press, pp 128-133.
7. Di Giovanni J, Iborra C, Maulet Y, Leveque C, El Far O & Seagar M 2010 Calcium-dependent regulation of SNARE-mediated membrane fusion by calmodulin. Journal of Biological Chemistry 285 23665-23675. (doi:10.1074/jbc.M109.096073)
8. Fischer R, Koller M, Flura M, Mathews S, Strehler-Page MA, Krebs J, Penniston JT, Carafoli E & Strehler EE 1988 Multiple divergent mRNAs code for a single human calmodulin. Journal of Biological Chemistry 263 17055-17062. (Pubitemid 18268892)
9. Juhlin CC, Kiss NB, Villablanca A, Haglund F, Nordenstrom J, Hoog A & Larsson C 2010 Frequent promoter hypermethylation of the APC and RASSF1A tumour suppressors in parathyroid tumours. PLoS ONE 5 e9472. (doi:10.1371/journal. pone.0009472)
10. Kato M, Hagiwara M, Nimura Y, Shionoya S & Hidaka H 1991 Purification and characterization of calcium-calmodulin kinase II from human parathyroid glands. Journal of Endocrinology 131 155-162. (doi:10.1677/joe.0.1310155)
11. Kifor O, MacLeod RJ, Diaz R, Bai M, Yamaguchi T, Yao T, Kifor I & Brown EM 2001 Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells. American Journal of Physiology. Renal Physiology 280 F291-F302.
12. Kinder BK, Delahunt NG, Jamieson JD & Gorelick FS 1987 Calcium-calmodulin-dependent protein kinase in hyperplastic human parathyroid glands. Endocrinology 120 170-177. (doi:10.1210/endo-120-1-170)
13. Lang J, Fukuda M, Zhang H, Mikoshiba K & Wollheim CB 1997 The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic β-cells: action of synaptotagmin at low micromolar calcium. EMBO Journal 16 5837-5846. (doi:10.1093/emboj/16.19.5837)
14. i and viability in human hepatoma cells. Archives of Toxicology 83 61-68. (doi:10.1007/s00204-008-0328-4)
15. Lu M, Forsberg L, Hoog A, Juhlin CC, Vukojevic V, Larsson C, Conigrave AD, Delbridge LW, Gill A, Bark C et al. 2008 Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue. Molecular and Cellular Endocrinology 287 72-80. (doi:10.1016/j.mce.2008.01.028)
16. Lu M, Bränström R, Berglund E, Hoog A, Bjorklund P,Westin G, Larsson C, Farnebo LO & Forsberg L 2010 Expression and association of TRPC subtypes with Orai1 and STIM1 in human parathyroid. Journal of Molecular Endocrinology 44 285-294. (doi:10.1677/JME-09-0138)
17. 2+. Journal of Biological Chemistry 261 2668-2674.
18. Oldham SB, Lipson LG & Tietjen GE 1982 Presence of calmodulin in parathyroid adenomas. Mineral and Electrolyte Metabolism 7 273-280.
19. 2+. Biochemical Journal 313 661-667.
20. 2+/ calmodulin kinase II inhibitor KN-62. Journal of Cell Science 108 2619-2628.
21. ++ and PTH release in dispersed bovine parathyroid cells. Endocrinology 113 424-426. (doi:10.1210/endo-113-1-424)
22. Shoback DM, Thatcher J, Leombruno R & Brown EM 1984 Relationship between parathyroid hormone secretion and cytosolic calcium concentration in dispersed bovine parathyroid cells. PNAS 81 3113-3117. (doi:10.1073/pnas.81.10. 3113)
23. Stefani G, Onofri F, Valtorta F, Vaccaro P, Greengard P & Benfenati F 1997 Kinetic analysis of the phosphorylation-dependent interactions of synapsin I with rat brain synaptic vesicles. Journal of Physiology 504 501-515. (doi:10.1111/j.1469-7793.1997.501bd.x)
24. Vaca L 1996 Calmodulin inhibits calcium influx current in vascular endothelium. FEBS Letters 390 289-293. (doi:10.1016/0014-5793(96)00675-8) (Pubitemid 26248961)
25. Vaca L & Sampieri A 2002 Calmodulin modulates the delay period between release of calcium from internal stores and activation of calcium influx via endogenous TRP1 channels. Journal of Biological Chemistry 277 42178-42187. (doi:10.1074/jbc.M204531200)
26. Wang ZW 2008 Regulation of synaptic transmission by presynaptic CaMKII and BK channels. Molecular Neurobiology 38 153-166. (doi:10.1007/s12035-008- 8039-7)
27. Watanabe H, Takahashi R, Tran QK, Takeuchi K, Kosuge K, Satoh H, Uehara A, Terada H, Hayashi H, Ohno R et al. 1999 Increased cytosolic Ca(2+) concentration in endothelial cells by calmodulin antagonists. Biochemical and Biophysical Research Communications 265 697-702. (doi:10.1006/bbrc.1999.1755)
28. 2+/ calmodulin-dependent phosphorylation of synapsin I in insulin exocytosis. Journal of Pharmacological Sciences 93 30-34. (doi:10.1254/jphs.93.30)