CXC receptor knockout mice: Characterization of skeletal features and membranous bone healing in the adult mouse

Bone

Volumn 48, Issue 2, 2011, Pages 267-274

  Bischoff, David S ^a,c   Sakamoto, Taylor ^a   Ishida, Kenji ^a   Makhijani, Nalini S ^a   Gruber, Helen E ^b   Yamaguchi, Dean T ^a,c  

^a VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^b CAROLINAS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bone Repair; Cranial Defect; CXC Receptor; DXA; MicroCT; Murine

Indexed keywords

CHEMOKINE RECEPTOR CXCR; CHEMOKINE RECEPTOR CXCR2;

AMINO ACID COMPOSITION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; BONE GROWTH; BONE MINERAL; BONE REMODELING; BONE STRENGTH; BONE STRUCTURE; CALVARIA; CELL COUNT; CONTROLLED STUDY; CORTICAL BONE; CYTOKINE RELEASE; FEMUR; FRACTURE HEALING; INFLAMMATION; INFLAMMATORY CELL; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCYTE; OSTEOLYSIS; PROTEIN FUNCTION; SKULL DEFECT; TIBIA; TRABECULAR BONE; WILD TYPE;

ABSORPTIOMETRY, PHOTON; ANIMALS; BONE AND BONES; BONE DENSITY; CALCIUM; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; PHOSPHORUS; RECEPTORS, CXCR; WOUND HEALING;

EID: 78650979972     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.09.026     Document Type: Article

References (29)

1. Kilarski W.W., Samolov B., Petersson L., Kvanta A., Gerwins P. Biomechanial regulation of blood vessel growth during tissue vascularization. Nat Med 2009, 15:657-664.
2. Strieter M.R., Polverini P.J., Kunkel S.L., Arenberg D.A., Burdick M.D., Kasper J., et al. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem 1995, 270:27348-27357.
3. Engelhardt E., Toksoy A., Goebeler M., Debus S., Brocker E.-B., Gillitzer R. Chemokines IL-8, GROα, MCP-1, IP-10, and Mig are sequentially and differentially expressed during phase-specific infiltration of leukocyte subsets in human wound healing. Am J Pathol 1998, 153:1849-1860.
4. Devalaraja R.M., Nanney L.B., Qian Q., Du J., Yu Y., Devalaraja M.N., et al. Delayed wound healing in CXCR2 knockout mice. J Invest Dermatol 2000, 115:234-244.
5. Milatovic S., Nanney L.B., Yu Y., White J.R., Richmond A. Impaired healing of nitrogen mustard wounds in CXCR2 null mice. Wound Rep Reg 2003, 11:213-219.
6. Cacalano G., Lee J., Kikly K., Ryan A.M., Pitts-Meek S., Hultgren B., et al. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science 1994, 265:682-684.
7. Mihara K., Smit M.-J., Krajnc-Franken M., Gossen J., Rooseboom M., Dokter W. Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice. Eur J Immunol 2005, 35:2573-2582.
8. Fu W., Zhang Y., Zhang J., Chen W.-F. Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1. Cytokine 2005, 31:9-17.
9. Luan J., Furuta Y., Du J., Richmond A. Developmental expression of two CXC chemokines, MIP-2 and KC, and their receptors. Cytokine 2001, 14:253-263.
10. Bouxsein M.L., Boyd S.K., Christiansen B.A., Guldberg R.E., Jepsen K.J., Müller R. Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res 2010, 25:1468-1486.
11. Gruber H.E. Adaptations of Goldner's-Masson trichrome stain for the study of undecalcified plastic-embedded bone. Biotech Histochem 1992, 67:30-34.
12. Gruber H.E., Marshall G.J., Nolasco L.M., Kirchen M.E., Rimoin D.L. Alkaline and acid phosphate demonstration in human bone and cartilage: effects of fixation intervals and methacrylate embedments. Stain Technol 1988, 63:299-305.
13. Rude R.K., Gruber H.E., Wei L.Y., Frausto A., Mills B.G. Magnesium deficiency: effect on bone and mineral metabolism in the mouse. Calcif Tissue Int 2003, 72:32-41.
14. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Mulluche H., Meunier P.J., et al. Bone histomorphometry nomenclature, symbols and units: report of the ASBMR histomorphometry nomenclature committee. J Bone Miner Res 1987, 2:595-610.
15. Pereira R., Khillan J.S., Helminen H.J., Hume E.L., Prockop D.J. Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral. J Clin Invest 1993, 91:709-716.
16. Amling M., Priemel M., Holzmann T., Chapin K., Rueger J.M., Baron R., et al. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endo. 1999, 140:4982-4987.
17. Hoff A.O., Catala-Lehnen P., Thomas P.M., Priemel M., Rueger J.M., Nasonkin I., et al. Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene. J Clin Invest 2002, 110:1849-1857.
18. Yamada K., Nishii K., Sawada H., Ito M., Aizu N., Dohi S., et al. Shaking stimuli may prevent bone fracture by restraining a bone density decrease gently. J Anal Bio-Sci 2010, 33:141-150.
19. Padovani-Claudio D.A., Liu L., Ransohoff R.M., Miller R.H. Alterations in the oligodendrocyte lineage, myelin, and white matter in adult mice lacking the chemokine receptor CXCR2. Glia 2006, 54:471-483.
20. Yu J.J., Ruddy M.J., Wong G.C., Sfintescu C., Baker P.J., Smith J.B., et al. An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood 2007, 109:3794-3802.
21. Street J., Bao M., deGuzman L., Bunting S., Peale F.P., Ferrara N., et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA 2002, 99:9656-9661.
22. Addison C.L., Daniel T.O., Burdick M.D., Liu H., Ehlert J.E., Xue Y.Y., et al. The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. J Immunol 2000, 165:5269-5277.
23. Bischoff D.S., Zhu J.H., Makhijani N.S., Yamaguchi D.T. KC chemokine expression by TGF-β in C3H10T1/2 cells induced towards osteoblasts. BBRC 2005, 326:364-370.
24. Bischoff D.S., Zhu J.H., Makhijani N.S., Yamaguchi D.T. Angiogenesis CXC chemokine expression during differentiation of human mesenchymal stem cells towards the osteoblastic lineage. J Cell Biochem 2008, 103:812-824.
25. Martin D., Galisteo R., Gutkind J.S. CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFκB through the CBM (Carma3/Bcl10/Malt1) complex. J Biol Chem 2009, 284:6038-6042.
26. Bonewald L.F., Johnson M.L. Osteocytes, mechanosensing and Wnt signaling. Bone 2008, 42:606-615.
27. Lin C., Jiang X., Dai Z., Guo X., Weng T., Wang J., et al. Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res 2009, 24:1651-1661.
28. Emerton K.B., Hu B., Woo A.A., Sinofsky A., Hernandez C., Majeska R.J. Osteocyte apoptosis and control of bone resorption following ovariectomy in mice. Bone 2010, 46:577-583.
29. Kramer I., Halleux C., Keller H., Pegurri M., Gooi J.H., Weber P.B., et al. Osteocyte Wnt/β-catenin signaling is required for normal bone homeostasis. Mol Cell Biol 2010, 30:3071-3085.