Involvement of glutamate transporter-1 in neuroprotection against global brain ischemia-reperfusion injury induced by postconditioning in rats

International Journal of Molecular Sciences

Volumn 11, Issue 11, 2010, Pages 4407-4416

  Zhang, Weiqiao ^a,b   Miao, Yifeng ^a   Zhou, Sanquan ^b   Wang, Baofeng ^a   Luo, Qizhong ^a   Qiu, Yongming ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Yuyao People's Hospital   (China)

Author keywords

Brain ischemia reperfusion injury; Glutamate transporter 1(glt 1); Ischemic postconditioning; Neuroprotection

Indexed keywords

VESICULAR GLUTAMATE TRANSPORTER 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL OCCLUSION; BRAIN BLOOD VESSEL; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; HIPPOCAMPUS; ISCHEMIC PRECONDITIONING; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; UPREGULATION;

BRAIN ISCHEMIA REPERFUSION INJURY; GLUTAMATE TRANSPORTER 1(GLT-1); ISCHEMIC POSTCONDITIONING; NEUROPROTECTION;

ANIMALS; CA1 REGION, HIPPOCAMPAL; CELL DEATH; EXCITATORY AMINO ACID TRANSPORTER 2; ISCHEMIC POSTCONDITIONING; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

RATTUS;

EID: 78650969580     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms11114407     Document Type: Article

References (28)

1. Mantz, J.; Degos, V.; Laigle, C. Recent advances in pharmacologic neuroprotection. Eur. J. Anaesthesiol 2010, 27, 6-10.
2. Xing, B.Z.; Chen, H.; Zhang, M.; Zhao, D.M.; Jiang, R.; Liu, X.H.; Zhang, S.M. Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. Stroke 2008, 39, 2362-2369.
3. Wang, J.Y.; Shen, J.; Gao, Q.; Ye, Z.G.; Yang, S.Y.; Liang, H.W.; Bruce, I.C.; Luo, B.Y.; Xia, Q. Ischemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats. Stroke 2008, 39, 983-990
4. Ren, C.C.; Yan, Z.M.; Wei, D.T.; Gao, X.W.; Chen, X.Y.; Zhao, H. Limb remote ischemic postconditioning protects against focal ischemia in rats. Brain Res. 2009, 1288, 88-94.
5. Taskapilioglu, M.O.; Alkan, T.; Goren, B.; Tureyen, K.; Sahin, S.; Taskapilioglu, O.; Korfali, E. Neuronal protective effects of focal ischemic pre- and/or postconditioning on the model of transient focal cerebral ischemia in rats. J. Clin. Neurosci. 2009, 16, 693-697.
6. Lee, S.G.; Su, Z.Z.; Emdad, L.; Gupta, P.; Sarkar, D.; Borjabad, A.; Volsky, D.J.; Fisher, P.B. Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. J. Biol. Chem. 2008, 283, 13116-13123.
7. Guo, Z.H.; Li, F.; Wang, W.Z. The mechanisms of brain ischemic insult and potential protective interventions. Neurosci. Bull. 2009, 25, 139-152.
8. Ozawa, S. Role of glutamate transporters in excitatory synapses in cerebellar Purkinje cells. Brain Nerve 2007, 59, 669-676.
9. Rao, V.L.; Dogan, A.; Todd, K.G.; Bowen, K.K.; Kim, B.T.; Rothstein, J.D.; Dempsey, R.J. Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain. J. Neurosci. 2001, 21, 1876-1883.
10. Gao, X.; Ren, C.; Zhao, H. Protective effects of ischemic postconditioning compared with gradual reperfusion or preconditioning. J. Neurosci. Res. 2008, 86, 2505-2511.
11. Gao, X.; Zhang, H.; Takahashi, T.; Hsieh, J.; Liao, J.; Steinberg, G.K.; Zhao, H. The Akt signaling pathway contributes to postconditioning's protection against stroke; the protection is associated with the MAPK and PKC pathways. J. Neurochem. 2008, 105, 943-955.
12. 2+ entry through TRPM7 channels and anoxic neuronal death. Cell 2003, 115, 768-770.
13. Candelario-Jalil, E. Injury and repair mechanisms in ischemic stroke: Considerations for the development of novel neurotherapeutics. Curr. Opin. Investig. Drugs 2009, 10, 644-654.
14. Taoufik, E.; Probert, L. Ischemic neuronal damage. Curr. Pharm. Des. 2008, 14, 3565-3573.
15. Romera, C.; Hurtado, O.; Mallolas, J.; Pereira, M.P.; Morales, J.R.; Romera, A.; Serena, J.; Vivancos, J.; Nombela, F.; Lorenzo, P.; et al. Ischemic preconditioning reveals that GLT1/EAAT2 glutamate transporter is a novel PPARgamma target gene involved in neuroprotection. J. Cereb. Blood Flow Metab. 2007, 27, 1327-1338.
16. Chen, J.C.; Hsu-Chou, H.; Lu, J.L.; Chiang, Y.C.; Huang, H.M.; Wang, H.L.; Wu, T.; Liao, J.J.; Yeh, T.S. Down-regulation of the glial glutamate transporter GLT-1 in rat hippocampus and striatum and its modulation by a group III metabotropic glutamate receptor antagonist following transient global forebrain ischemia. Neuropharmacology 2005, 49, 703-714.
17. Han, F.; Shioda, N.; Moriguchi, S.; Qin, Z.H.; Fukunaga, K. Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism. Neurosci. Lett. 2008, 430, 275-280.
18. Rao, V.L.R.; Dogan, A.; Rothstein, J.D.; Dempsey, R.J. Decreased glial glutamate transporter GLT-1 protein levels in rat brain following transient middle cerebral artery occlusion. J. Neurochem. 1998, 70, S68.
19. Rothstein, J.D.; Dykes-Hoberg, M.; Pardo, C.A.; Bristol, L.A.; Jin, L.; Kuncl, R.W.; Kanai, Y.; Hediger, M.A.; Wang, Y.; Schielke, J.P.; et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 1996, 16, 675-686.
20. Chu, K.; Lee, S.T.; Sinn, D.I.; Ko, S.Y.; Kim, E.H.; Kim, J.M.; Kim, S.J.; Park, D.K.; Jung, K.H.; Song, E.C.; et al. Pharmacological Induction of Ischemic Tolerance by Glutamate Transporter-1 (EAAT2) Upregulation. Stroke 2007, 38, 177-182.
21. Li, L.; Lundkvist, A.; Andersson, D.; Wilhelmsson, U.; Nagai, N.; Pardo, A.C.; Nodin, C.; Stahlberg, A.; Aprico, K.; Larsson, K.; et al. Protective role of reactive astrocytes in brain ischemia. J. Cereb. Blood Flow Metab. 2008, 28, 468-481.
22. Vanhoutte, N.; Abarca-Quinones, J.; Jordan, B.F.; Gallez, B.; Maloteaux, J.M.; Hermans, E. Enhanced expression of the high affinity glutamate transporter GLT-1 in C6 glioma cells delays tumour progression in rat. Exp. Neurol. 2009, 218, 56-63.
23. Bjornsen, L.P.; Eid, T.; Holmseth, S.; Danbolt, N.C.; Spencer, D.D.; de Lanerolle, N.C. Changes in glial glutamate transporters in human epileptogenic hippocampus: Inadequate explanation for high extracellular glutamate during seizures. Neurobiol. Dis. 2007, 25, 319-330.
24. Yi, J.H.; Hazell, A.S. Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury. Neurochem. Int. 2006, 48, 394-403.
25. Matute, C.; Melone, M.; Vallejo-Illarramendi, A.; Conti, F. Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenics. Glia 2005, 49, 451-455.
26. Namura, S.; Maeno, H.; Takami, S.; Jiang, X.F.; Kamichi, S.; Wada, K.; Nagata, I. Inhibition of glial glutamate transporter GLT-1 augments brain edema after transient focal cerebral ischemia in mice. Neurosci. Lett. 2002, 324, 117-120.
27. Lu, Z.; Zhang, W.; Zhang, N.; Jiang, J.; Luo, Q.; Qiu, Y. The expression of glutamate transporters in chest compression-induced audiogenic epilepsy: a comparative study. Neurol. Res. 2008, 30, 915-919.
28. Miao, Y.; Zhang, W.; Lin, Y.; Lu, X.; Qiu, Y. Neuroprotective effects of ischemic preconditioning on global brain ischemia through up-regulation of acid-sensing ion channel 2a. Int. J. Mol. Sci. 2010, 11, 140-153.