-
1
-
-
0033861084
-
Plasma aprotinin concentrations during cardiac surgery: Full- versus half-dose regimens
-
Beath S.M. Nuttall G.A. Fass D.N. Oliver Jr., W.C. Ereth M.H. Oyen L.J. 2000 Plasma aprotinin concentrations during cardiac surgery: full- versus half-dose regimens. Anesthesia and Analgesia, 91, 257 264.
-
(2000)
Anesthesia and Analgesia
, vol.91
, pp. 257-264
-
-
Beath, S.M.1
Nuttall, G.A.2
Fass, D.N.3
Oliverjr, C.W.4
Ereth, M.H.5
Oyen, L.J.6
-
2
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
Bernard G.R. Vincent J.L. Laterre P.F. LaRosa S.P. Dhainaut J.F. Lopez-Rodriguez A. Steingrub J.S. Garber G.E. Helterbrand J.D. Ely E.W. Fisher Jr., C.J. 2001 Efficacy and safety of recombinant human activated protein C for severe sepsis. New England Journal of Medicine, 344, 699 709.
-
(2001)
New England Journal of Medicine
, vol.344
, pp. 699-709
-
-
Bernard, G.R.1
Vincent, J.L.2
Laterre, P.F.3
Larosa, S.P.4
Dhainaut, J.F.5
Lopez-Rodriguez, A.6
Steingrub, J.S.7
Garber, G.E.8
Helterbrand, J.D.9
Ely, E.W.10
Fisherjr, J.C.11
-
3
-
-
0030893304
-
Chromogenic substrates selective for activated protein C
-
Dang Q.D. Di Cera E. 1997 Chromogenic substrates selective for activated protein C. Blood, 89, 2220 2222.
-
(1997)
Blood
, vol.89
, pp. 2220-2222
-
-
Dang, Q.D.1
Di Cera, E.2
-
4
-
-
7544236615
-
Clinical inhibition of the seven-transmembrane thrombin receptor (PAR1) by intravenous aprotinin during cardiothoracic surgery
-
Day J.R. Punjabi P.P. Randi A.M. Haskard D.O. Landis R.C. Taylor K.M. 2004 Clinical inhibition of the seven-transmembrane thrombin receptor (PAR1) by intravenous aprotinin during cardiothoracic surgery. Circulation, 110, 2597 2600.
-
(2004)
Circulation
, vol.110
, pp. 2597-2600
-
-
Day, J.R.1
Punjabi, P.P.2
Randi, A.M.3
Haskard, D.O.4
Landis, R.C.5
Taylor, K.M.6
-
5
-
-
0037465345
-
Factor V Leiden protects against blood loss and transfusion after cardiac surgery
-
Donahue B.S. Gailani D. Higgins M.S. Drinkwater D.C. George Jr., A.L. 2003 Factor V Leiden protects against blood loss and transfusion after cardiac surgery. Circulation, 107, 1003 1008.
-
(2003)
Circulation
, vol.107
, pp. 1003-1008
-
-
Donahue, B.S.1
Gailani, D.2
Higgins, M.S.3
Drinkwater, D.C.4
Georgejr, L.A.5
-
6
-
-
0031467316
-
Platelet factor 4 binds to glycanated forms of thrombomodulin and to protein C. a potential mechanism for enhancing generation of activated protein C
-
Dudek A.Z. Pennell C.A. Decker T.D. Young T.A. Key N.S. Slungaard A. 1997 Platelet factor 4 binds to glycanated forms of thrombomodulin and to protein C. A potential mechanism for enhancing generation of activated protein C. Journal of Biological Chemistry, 272, 31785 31792.
-
(1997)
Journal of Biological Chemistry
, vol.272
, pp. 31785-31792
-
-
Dudek, A.Z.1
Pennell, C.A.2
Decker, T.D.3
Young, T.A.4
Key, N.S.5
Slungaard, A.6
-
7
-
-
0141819138
-
The protein C pathway
-
Esmon C.T. 2003 The protein C pathway. Chest, 124, 26S 32S.
-
(2003)
Chest
, vol.124
-
-
Esmon, C.T.1
-
9
-
-
0024319915
-
A comparison between activated protein C and des-1-41-light chain-activated protein C in reactions with type 1 plasminogen activator inhibitor
-
Gladson C.L. Schleef R.R. Binder B.R. Loskutoff D.J. Griffin J.H. 1989 A comparison between activated protein C and des-1-41-light chain-activated protein C in reactions with type 1 plasminogen activator inhibitor. Blood, 74, 173 181.
-
(1989)
Blood
, vol.74
, pp. 173-181
-
-
Gladson, C.L.1
Schleef, R.R.2
Binder, B.R.3
Loskutoff, D.J.4
Griffin, J.H.5
-
10
-
-
0024505027
-
Inhibition and complexation of activated protein C by two major inhibitors in plasma
-
Heeb M.J. Espana F. Griffin J.H. 1989 Inhibition and complexation of activated protein C by two major inhibitors in plasma. Blood, 73, 446 454.
-
(1989)
Blood
, vol.73
, pp. 446-454
-
-
Heeb, M.J.1
Espana, F.2
Griffin, J.H.3
-
11
-
-
0025182357
-
Inhibition of activated protein C by recombinant alpha 1-antitrypsin variants with substitution of arginine or leucine for methionine358
-
Heeb M.J. Bischoff R. Courtney M. Griffin J.H. 1990 Inhibition of activated protein C by recombinant alpha 1-antitrypsin variants with substitution of arginine or leucine for methionine358. Journal of Biological Chemistry, 265, 2365 2369.
-
(1990)
Journal of Biological Chemistry
, vol.265
, pp. 2365-2369
-
-
Heeb, M.J.1
Bischoff, R.2
Courtney, M.3
Griffin, J.H.4
-
12
-
-
0242401773
-
Calibrated automated thrombin generation measurement in clotting plasma
-
Hemker H.C. Giesen P. Al Dieri R. Regnault V. de Smedt E. Wagenvoord R. Lecompte T. Beguin S. 2003 Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiology of Haemostasis and Thrombosis, 33, 4 15.
-
(2003)
Pathophysiology of Haemostasis and Thrombosis
, vol.33
, pp. 4-15
-
-
Hemker, H.C.1
Giesen, P.2
Al Dieri, R.3
Regnault, V.4
De Smedt, E.5
Wagenvoord, R.6
Lecompte, T.7
Beguin, S.8
-
13
-
-
23844438376
-
Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement
-
Kearon C. Comp P. Douketis J. Royds R. Yamada K. Gent M. 2005 Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement. Journal of Thrombosis and Haemostasis, 3, 962 968.
-
(2005)
Journal of Thrombosis and Haemostasis
, vol.3
, pp. 962-968
-
-
Kearon, C.1
Comp, P.2
Douketis, J.3
Royds, R.4
Yamada, K.5
Gent, M.6
-
14
-
-
18144364291
-
Aprotinin inhibits protease-dependent platelet aggregation and thrombosis
-
Khan T.A. Bianchi C. Voisine P. Sandmeyer J. Feng J. Sellke F.W. 2005 Aprotinin inhibits protease-dependent platelet aggregation and thrombosis. Annals of Thoracic Surgery, 79, 1545 1550.
-
(2005)
Annals of Thoracic Surgery
, vol.79
, pp. 1545-1550
-
-
Khan, T.A.1
Bianchi, C.2
Voisine, P.3
Sandmeyer, J.4
Feng, J.5
Sellke, F.W.6
-
15
-
-
0037040150
-
Early loss of thrombomodulin expression impairs vein graft thromboresistance: Implications for vein graft failure
-
Kim A.Y. Walinsky P.L. Kolodgie F.D. Bian C. Sperry J.L. Deming C.B. Peck E.A. Shake J.G. Ang G.B. Sohn R.H. Esmon C.T. Virmani R. Stuart R.S. Rade J.J. 2002 Early loss of thrombomodulin expression impairs vein graft thromboresistance: implications for vein graft failure. Circulation Research, 90, 205 212.
-
(2002)
Circulation Research
, vol.90
, pp. 205-212
-
-
Kim, A.Y.1
Walinsky, P.L.2
Kolodgie, F.D.3
Bian, C.4
Sperry, J.L.5
Deming, C.B.6
Peck, E.A.7
Shake, J.G.8
Ang, G.B.9
Sohn, R.H.10
Esmon, C.T.11
Virmani, R.12
Stuart, R.S.13
Rade, J.J.14
-
16
-
-
10244250329
-
Patients with severe sepsis vary markedly in their ability to generate activated protein C
-
Liaw P.C. Esmon C.T. Kahnamoui K. Schmidt S. Kahnamoui S. Ferrell G. Beaudin S. Julian J.A. Weitz J.I. Crowther M. Loeb M. Cook D. 2004 Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood, 104, 3958 3964.
-
(2004)
Blood
, vol.104
, pp. 3958-3964
-
-
Liaw, P.C.1
Esmon, C.T.2
Kahnamoui, K.3
Schmidt, S.4
Kahnamoui, S.5
Ferrell, G.6
Beaudin, S.7
Julian, J.A.8
Weitz, J.I.9
Crowther, M.10
Loeb, M.11
Cook, D.12
-
17
-
-
0345621622
-
Thrombin inhibitors suppress the thrombin-thrombomodulin-mediated generation of activated protein C
-
Linder R. Blomback M. Egberg N. Grip L. 1999 Thrombin inhibitors suppress the thrombin-thrombomodulin-mediated generation of activated protein C. Thrombosis Research, 95, 117 125.
-
(1999)
Thrombosis Research
, vol.95
, pp. 117-125
-
-
Linder, R.1
Blomback, M.2
Egberg, N.3
Grip, L.4
-
19
-
-
0032746547
-
The inhibitory effect of recombinant human soluble thrombomodulin on initiation and extension of coagulation - A comparison with other anticoagulants
-
Mohri M. Sugimoto E. Sata M. Asano T. 1999 The inhibitory effect of recombinant human soluble thrombomodulin on initiation and extension of coagulation - a comparison with other anticoagulants. Thrombosis and Haemostasis, 82, 1687 1693.
-
(1999)
Thrombosis and Haemostasis
, vol.82
, pp. 1687-1693
-
-
Mohri, M.1
Sugimoto, E.2
Sata, M.3
Asano, T.4
-
20
-
-
19944432294
-
Phase I study of a novel recombinant human soluble thrombomodulin, ART-123
-
Moll S. Lindley C. Pescatore S. Morrison D. Tsuruta K. Mohri M. Serada M. Sata M. Shimizu H. Yamada K. White 2nd., G.C. 2004 Phase I study of a novel recombinant human soluble thrombomodulin, ART-123. Journal of Thrombosis and Haemostasis, 2, 1745 1751.
-
(2004)
Journal of Thrombosis and Haemostasis
, vol.2
, pp. 1745-1751
-
-
Moll, S.1
Lindley, C.2
Pescatore, S.3
Morrison, D.4
Tsuruta, K.5
Mohri, M.6
Serada, M.7
Sata, M.8
Shimizu, H.9
Yamada, K.10
White II, C.G.11
-
21
-
-
0037314646
-
High-dose aprotinin reduces activation of hemostasis, allogeneic blood requirement, and duration of postoperative ventilation in pediatric cardiac surgery
-
Mossinger H. Dietrich W. Braun S.L. Jochum M. Meisner H. Richter J.A. 2003 High-dose aprotinin reduces activation of hemostasis, allogeneic blood requirement, and duration of postoperative ventilation in pediatric cardiac surgery. Annals of Thoracic Surgery, 75, 430 437.
-
(2003)
Annals of Thoracic Surgery
, vol.75
, pp. 430-437
-
-
Mossinger, H.1
Dietrich, W.2
Braun, S.L.3
Jochum, M.4
Meisner, H.5
Richter, J.A.6
-
23
-
-
0026753845
-
Aprotinin can inhibit the proteolytic activity of thrombin. a fluorescence and an enzymatic study
-
Pintigny D. Dachary-Prigent J. 1992 Aprotinin can inhibit the proteolytic activity of thrombin. A fluorescence and an enzymatic study. European Journal of Biochemistry, 207, 89 95.
-
(1992)
European Journal of Biochemistry
, vol.207
, pp. 89-95
-
-
Pintigny, D.1
Dachary-Prigent, J.2
-
24
-
-
0033862187
-
The antithrombotic effect of aprotinin: Actions mediated via the protease activated receptor 1
-
Poullis M. Manning R. Laffan M. Haskard D.O. Taylor K.M. Landis R.C. 2000 The antithrombotic effect of aprotinin: actions mediated via the protease activated receptor 1. Journal of Thoracic and Cardiovascular Surgery, 120, 370 378.
-
(2000)
Journal of Thoracic and Cardiovascular Surgery
, vol.120
, pp. 370-378
-
-
Poullis, M.1
Manning, R.2
Laffan, M.3
Haskard, D.O.4
Taylor, K.M.5
Landis, R.C.6
-
25
-
-
0037324197
-
Thrombinography shows acquired resistance to activated protein C in patients with lupus anticoagulants
-
Regnault V. Beguin S. Wahl D. De Maistre E. Hemker H.C. Lecompte T. 2003 Thrombinography shows acquired resistance to activated protein C in patients with lupus anticoagulants. Thrombosis and Haemostasis, 89, 208 212.
-
(2003)
Thrombosis and Haemostasis
, vol.89
, pp. 208-212
-
-
Regnault, V.1
Beguin, S.2
Wahl, D.3
De Maistre, E.4
Hemker, H.C.5
Lecompte, T.6
-
26
-
-
0027220449
-
Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors
-
Rezaie A.R. Esmon C.T. 1993 Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors. Journal of Biological Chemistry, 268, 19943 19948.
-
(1993)
Journal of Biological Chemistry
, vol.268
, pp. 19943-19948
-
-
Rezaie, A.R.1
Esmon, C.T.2
-
27
-
-
4444380033
-
Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: A systematic review and meta-analysis of randomized clinical trials
-
Sedrakyan A. Treasure T. Elefteriades J.A. 2004 Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: a systematic review and meta-analysis of randomized clinical trials. Journal of Thoracic and Cardiovascular Surgery, 128, 442 448.
-
(2004)
Journal of Thoracic and Cardiovascular Surgery
, vol.128
, pp. 442-448
-
-
Sedrakyan, A.1
Treasure, T.2
Elefteriades, J.A.3
-
28
-
-
0037630133
-
Platelet factor 4 enhances generation of activated protein C in vitro and in vivo
-
Slungaard A. Fernandez J.A. Griffin J.H. Key N.S. Long J.R. Piegors D.J. Lentz S.R. 2003 Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. Blood, 102, 146 151.
-
(2003)
Blood
, vol.102
, pp. 146-151
-
-
Slungaard, A.1
Fernandez, J.A.2
Griffin, J.H.3
Key, N.S.4
Long, J.R.5
Piegors, D.J.6
Lentz, S.R.7
-
29
-
-
0025981411
-
Expression of thrombomodulin by smooth muscle cells in culture: Different effects of tumor necrosis factor and cyclic adenosine monophosphate on thrombomodulin expression by endothelial cells and smooth muscle cells in culture
-
Soff G.A. Jackman R.W. Rosenberg R.D. 1991 Expression of thrombomodulin by smooth muscle cells in culture: different effects of tumor necrosis factor and cyclic adenosine monophosphate on thrombomodulin expression by endothelial cells and smooth muscle cells in culture. Blood, 77, 515 518.
-
(1991)
Blood
, vol.77
, pp. 515-518
-
-
Soff, G.A.1
Jackman, R.W.2
Rosenberg, R.D.3
-
31
-
-
0029087665
-
Characterisation of a novel series of aprotinin-derived anticoagulants. I. in vitro and pharmacological properties
-
Stassen J.M. Lambeir A.M. Matthyssens G. Ripka W.C. Nystrom A. Sixma J.J. Vermylen J. 1995 Characterisation of a novel series of aprotinin-derived anticoagulants. I. In vitro and pharmacological properties. Thrombosis and Haemostasis, 74, 646 654.
-
(1995)
Thrombosis and Haemostasis
, vol.74
, pp. 646-654
-
-
Stassen, J.M.1
Lambeir, A.M.2
Matthyssens, G.3
Ripka, W.C.4
Nystrom, A.5
Sixma, J.J.6
Vermylen, J.7
-
32
-
-
0031459233
-
Aprotinin, cardiac surgery, and factor V Leiden
-
Sweeney J.D. Blair A.J. Dupuis M.P. King T.C. Moulton A.L. 1997 Aprotinin, cardiac surgery, and factor V Leiden. Transfusion, 37, 1173 1178.
-
(1997)
Transfusion
, vol.37
, pp. 1173-1178
-
-
Sweeney, J.D.1
Blair, A.J.2
Dupuis, M.P.3
King, T.C.4
Moulton, A.L.5
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