Aberrant expression of the P2 promoter-specific transcript Runx1 in epiphyseal cartilage of Trps1-null mice

Experimental and Molecular Pathology

Volumn 90, Issue 2, 2011, Pages 143-148

  Kanno, Seiji ^a   Gui, Ting ^a   Itoh, Shunji ^a   Gai, Zhibo ^a   Sun, Yujing ^a   Oikawa, Kosuke ^a   Yoshida, Munehito ^a   Muragaki, Yasuteru ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Alternative transcripts; Cartilage; Chondrocyte; Promoter; Runx1; Trps1

Indexed keywords

TRANSCRIPTION FACTOR GATA;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL GROWTH; CELL STRAIN; CELL STRAIN ATDC5; CHONDROGENESIS; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; EPIPHYSEAL CARTILAGE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE TARGETING; GENETIC TRANSCRIPTION; GROWTH PLATE; HEMATOPOIESIS; MOUSE; MOUSE STRAIN; NONHUMAN; NULL MOUSE; P2 GENE; PROMOTER REGION; PROTEIN DOMAIN; RUNX1 GENE; TRPS1 GENE;

ANIMALS; BINDING SITES; BLOTTING, WESTERN; CARTILAGE; CELL LINE; CHONDROCYTES; CHONDROGENESIS; CHROMATIN IMMUNOPRECIPITATION; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DOWN-REGULATION; EPIPHYSES; GATA TRANSCRIPTION FACTORS; GROWTH PLATE; LUCIFERASES; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

MUS;

EID: 78650924039     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2010.11.010     Document Type: Article

References (35)

1. Baek D., Davis C., Ewing B., Gordon D., Green P. Characterization and predictive discovery of evolutionarily conserved mammalian alternative promoters. Genome Res. 2007, 17:145-155.
2. Banerjee C., Hiebert S.W., Stein J.L., Lian J.B., Stein G.S. An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene. Proc. Natl Acad. Sci. USA 1996, 93:4968-4973.
3. Bee T., Ashley E.L., Bickley S.R., Jarratt A., Li P.S., Sloane-Stanley J., Gottgens B., de Bruijn M.F. The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters. Blood 2009, 113:5121-5124.
4. Bee T., Liddiard K., Swiers G., Bickley S.R., Vink C.S., Jarratt A., Hughes J.R., Medvinsky A., de Bruijn M.F. Alternative Runx1 promoter usage in mouse developmental hematopoiesis. Blood Cells Mol. Dis. 2009, 43:35-42.
5. Fantauzzo K.A., Bazzi H., Jahoda C.A., Christiano A.M. Dynamic expression of the zinc-finger transcription factor Trps1 during hair follicle morphogenesis and cycling. Gene Expr. Patterns 2008, 8:51-57.
6. Fujita T., Azuma Y., Fukuyama R., Hattori Y., Yoshida C., Koida M., Ogita K., Komori T. Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J. Cell Biol. 2004, 166:85-95.
7. Ghozi M.C., Bernstein Y., Negreanu V., Levanon D., Groner Y. Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions. Proc. Natl Acad. Sci. USA 1996, 93:1935-1940.
8. Giedion A., Burdea M., Fruchter Z., Meloni T., Trosc V. Autosomal-dominant transmission of the tricho-rhino-phalangeal syndrome. Report of 4 unrelated families, review of 60 cases. Helv. Paediatr. Acta 1973, 28:249-259.
9. Hollberg K., Hultenby K., Hayman A., Cox T., Andersson G. Osteoclasts from mice deficient in tartrate-resistant acid phosphatase have altered ruffled borders and disturbed intracellular vesicular transport. Exp. Cell Res. 2002, 279:227-238.
10. Holmbeck K., Bianco P., Caterina J., Yamada S., Kromer M., Kuznetsov S.A., Mankani M., Robey P.G., Poole A.R., Pidoux I., Ward J.M., Birkedal-Hansen H. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell 1999, 99:81-92.
11. Itoh S., Kanno S., Gai Z., Suemoto H., Kawakatsu M., Tanishima H., Morimoto Y., Nishioka K., Hatamura I., Yoshida M., Muragaki Y. Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. Genes Cells 2008, 13:355-363.
12. Kunath M., Ludecke H.J., Vortkamp A. Expression of Trps1 during mouse embryonic development. Mech. Dev. 2002, 119(Suppl 1):S117-S120.
13. Levanon D., Groner Y. Structure and regulated expression of mammalian RUNX genes. Oncogene 2004, 23:4211-4219.
14. Levanon D., Brenner O., Negreanu V., Bettoun D., Woolf E., Eilam R., Lotem J., Gat U., Otto F., Speck N., Groner Y. Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis. Mech. Dev. 2001, 109:413-417.
15. Lian J.B., Balint E., Javed A., Drissi H., Vitti R., Quinlan E.J., Zhang L., Van Wijnen A.J., Stein J.L., Speck N., Stein G.S. Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo. J. Cell. Physiol. 2003, 196:301-311.
16. Maes C., Stockmans I., Moermans K., Van Looveren R., Smets N., Carmeliet P., Bouillon R., Carmeliet G. Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J. Clin. Invest. 2004, 113:188-199.
17. Malik T.H., Shoichet S.A., Latham P., Kroll T.G., Peters L.L., Shivdasani R.A. Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1. EMBO J. 2001, 20:1715-1725.
18. Momeni P., Glockner G., Schmidt O., von Holtum D., Albrecht B., Gillessen-Kaesbach G., Hennekam R., Meinecke P., Zabel B., Rosenthal A., Horsthemke B., Ludecke H.J. Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I. Nat. Genet. 2000, 24:71-74.
19. Napierala D., Sam K., Morello R., Zheng Q., Munivez E., Shivdasani R.A., Lee B. Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Hum. Mol. Genet. 2008, 17:2244-2254.
20. Nishioka K., Itoh S., Suemoto H., Kanno S., Gai Z., Kawakatsu M., Tanishima H., Morimoto Y., Hatamura I., Yoshida M., Muragaki Y. Trps1 deficiency enlarges the proliferative zone of growth plate cartilage by upregulation of Pthrp. Bone 2008, 43:64-71.
21. Nottingham W.T., Jarratt A., Burgess M., Speck C.L., Cheng J.F., Prabhakar S., Rubin E.M., Li P.S., Sloane-Stanley J., Kong A.S.J., de Bruijn M.F. Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer. Blood 2007, 110:4188-4197.
22. Ogasawara T., Kawaguchi H., Jinno S., Hoshi K., Itaka K., Takato T., Nakamura K., Okayama H. Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6. Mol. Cell. Biol. 2004, 24:6560-6568.
23. Okuda T., van Deursen J., Hiebert S.W., Grosveld G., Downing J.R. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 1996, 84:321-330.
24. Otto F., Lubbert M., Stock M. Upstream and downstream targets of RUNX proteins. J. Cell. Biochem. 2003, 89:9-18.
25. Patterson L.J., Gering M., Eckfeldt C.E., Green A.R., Verfaillie C.M., Ekker S.C., Patient R. The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish. Blood 2007, 109:2389-2398.
26. Pimanda J.E., Donaldson I.J., de Bruijn M.F., Kinston S., Knezevic K., Huckle L., Piltz S., Landry J.R., Green A.R., Tannahill D., Gottgens B. The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity. Proc. Natl Acad. Sci. USA 2007, 104:840-845.
27. Piscopo D.M., Johansen E.B., Derynck R. Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter. J. Biol. Chem. 2009.
28. Smith N., Dong Y., Lian J.B., Pratap J., Kingsley P.D., van Wijnen A.J., Stein J.L., Schwarz E.M., O'Keefe R.J., Stein G.S., Drissi M.H. Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J. Cell. Physiol. 2005, 203:133-143.
29. Suemoto H., Muragaki Y., Nishioka K., Sato M., Ooshima A., Itoh S., Hatamura I., Ozaki M., Braun A., Gustafsson E., Fassler R. Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Dev. Biol. 2007, 312:572-581.
30. Takeda S., Bonnamy J.P., Owen M.J., Ducy P., Karsenty G. Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev. 2001, 15:467-481.
31. Wang Q., Stacy T., Binder M., Marin-Padilla M., Sharpe A.H., Speck N.A. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc. Natl Acad. Sci. USA 1996, 93:3444-3449.
32. Wang Y., Belflower R.M., Dong Y.F., Schwarz E.M., O'Keefe R.J., Drissi H. Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis. J. Bone Miner. Res. 2005, 20:1624-1636.
33. Yoshida C.A., Komori T. Role of Runx proteins in chondrogenesis. Crit. Rev. Eukaryot. Gene Expr. 2005, 15:243-254.
34. Yoshida C.A., Yamamoto H., Fujita T., Furuichi T., Ito K., Inoue K., Yamana K., Zanma A., Takada K., Ito Y., Komori T. Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 2004, 18:952-963.
35. Zhang Y.W., Bae S.C., Huang G., Fu Y.X., Lu J., Ahn M.Y., Kanno Y., Kanno T., Ito Y. A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells. Mol. Cell. Biol. 1997, 17:4133-4145.