Secretory leukoprotease inhibitor: Partnering α1-proteinase inhibitor to combat pulmonary inflammation

Thorax

Volumn 51, Issue 12, 1996, Pages 1273-1274

  Bingle, L ^a   Tetley, T D ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

neutrophil elastase; secretory leukoprotease inhibitor; 1 proteinase inhibitor

Indexed keywords

ALPHA 1 ANTITRYPSIN; ELASTASE; SERINE PROTEINASE INHIBITOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CHRONIC BRONCHITIS; CYSTIC FIBROSIS; HUMAN; LUNG EMPHYSEMA; NEUTROPHIL; PNEUMONIA; PRIORITY JOURNAL;

EID: 0029821647     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.51.12.1273     Document Type: Article

References (13)

1. Laurell CB, Eriksson S. The electrophoretic alpha-1-globulin pattern of serum in alpha-1-antitrypsin deficiency. Scand J Clin Lab Invest 1963;15:132-40.
2. Tetley TD, Smith SF, Burton GH, Winning AJ, Cooke NT, Guz A. Effects of cigarette smoking and drugs on respiratory tract proteases and antiproteases. Eur J Respir Dis 1987;71:93-102.
3. Gauthier F, Fryksmark U, Ohlsson K, Bieth JG. Kinetics of the inhibition of leucocyte elastase by the bronchial inhibitor. Biochim Biophys Acta 1982;700:178-83.
4. Abbinante-Nissen JM, Simpson LG, Leikauf GD. Neutrophil elastase increases secretory leukocyte protease inhibitor transcript levels in airway epithelial cells. Am J Physiol 1993;265:L286-92.
5. Sallenave JM, Shulmann J, Crossley J, Jordana M, Gauldie J. Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specitic inhibitor (ESI Elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes. Am J Respir Cell Mol Biol 1994;11:733-41.
6. McElvaney NG, Nakamura H, Birrer P, Hebert CA, Wong WL, Alphonso M, et al. Modulation of airway inflammation in cystic tibrosis. J Clin Invest 1992;90:1296-301.
7. Gillissen A, Birrer P, McElvaney, NG, Buhl R, Vogelmeier C, Hoyt RF, et al. Recombinant secretory leukoprotease inhibitor augments glutathione levels in lung epithelial lining fluid. J Appl Physiol 1993;75:825-32.
8. Abbinante-Nissen JM, Simpson LG, Leikauf GD, Corticosteroids increase secretory leukocyte protease inhibitor transcript levels in airway epithelial cells. Am J Physiol 1995;268:L601-6.
9. McElvaney NG, Doujaiji B, Moan MJ, Burnham MR, Wu MC, Crystal RG. Pharmacokinetics of recombinant secretory Jeukoprotease inhibitor aerosolised to normals and individuals with cystic fibrosis. Am Rev Respir Dis 1993;148:1056-60.
10. Vogelmeier C, Buhl R, Hoyt RF, Wilson E, Fells GA, Hubbard RC, et al. Aerosolisation of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium. J Appl Physiol 1990;69:1843-8.
11. Stolk J, Camps J, Feitsma HIJ, Jermans J, Dijkman JH, Pauwels EKJ. Pulmonary deposition and disappearance of aerosolised secretory leucocyte protease inhibitor. Thorax 1995;50:645-50.
12. Boudier C, Bieth JG. Oxidized mucus proteinase inhibitor: a fairly potent neutrophil elastase inhibitor. Biochem J 1994;303:61-8.
13. McNeely TB, Dealy M, Dripps DJ, Orenstein JM, Eisenberg SP, Wahl SM. Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro. J Clin Invest 1995; 96:456-64.