Myeloperoxidase selectively binds and selectively kills microbes

Infection and Immunity

Volumn 79, Issue 1, 2011, Pages 474-485

  Allen, Robert C ^a   Stephens Jr , Jackson T ^b  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ExOxEmis Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; HYPOCHLORITE; MYELOPEROXIDASE;

ALPHA HEMOLYTIC STREPTOCOCCUS; ARTICLE; BACTERICIDAL ACTIVITY; ENZYME BINDING; ERYTHROCYTE; ESCHERICHIA COLI; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS PYOGENES; STREPTOCOCCUS SANGUINIS;

ANIMALS; BACTERIA; ERYTHROCYTES; HUMANS; MICROBIAL SENSITIVITY TESTS; PEROXIDASE; PROTEIN BINDING; SWINE; TIME FACTORS;

EID: 78650910627     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00910-09     Document Type: Article

References (38)

1. Agner, K. 1958. Crystalline myeloperoxidase. Acta Chem. Scand. 12:89-94.
2. Allen, R. C. 1975. Halide dependence of the myeloperoxidase-mediated antimicrobial system of the polymorphonuclear leukocyte in the phenomenon of electronic excitation. Biochem. Biophys. Res. Commun. 63:675-683.
3. Allen, R. C. 1975. The role of pH in the chemiluminescent response of the myeloperoxidase-halide-HOOH antimicrobial system. Biochem. Biophys. Res. Commun. 63:684-691.
4. Allen, R. C. March 1999. Method for selectively inhibiting the growth of microbes using a haloperoxidase-halide-peroxide system. U.S. patent 5,888,505.
5. Allen, R. C, E. L. Mills, T. R. McNitt, and P. G. Quie. 1981. Role of myeloperoxidase and bacterial metabolism in chemiluminescence of granulocytes from patients with chronic granulomatous disease. J. Infect. Dis. 144:344-348.
6. Allen, R. C. and J. T. Stephens, Jr. 9 February 2010, posting date. Reduced-oxidized difference spectral analysis and chemiluminescence-based Scat-chard analysis demonstrate selective binding of myeloperoxidase to microbes. Luminescence. doi:10.1002/bio.1210.
7. Allen, R. C, P. R. Stevens, T. H. Price, G. S. Chatta, and D. C. Dale. 1997. In vivo effects of recombinant human granulocyte colony-stimulating factor on neutrophil oxidative functions in normal human volunteers. J. Infect. Dis. 175:1184-1192.
8. Bainton, D. F. 1999. Developmental biology of neutrophils and eosinophils, p. 13-34. In J. I. Gallin and R. S. Snyderman (ed.), Inflammation, basic principles and clinical correlates, 3rd ed. Lippincott Williams & Wilkins, Philadelphia, PA.
9. Butterfield, C. T., E. Wattie, S. Megregian, and C. W. Chambers. 1943. Influence of pH and temperature on the survival of coliforms and enteric pathogens when exposed to chlorine. Publ. Health Rep. 58:1837-1866.
10. Carlsson, J., Y. Iwami, and T. Yamada. 1983. Hydrogen peroxide excretion by oral streptococci and effect of lactoperoxidase-thiocyanate-hydrogen peroxide. Infect. Immun. 40:70-80.
11. Cauci, S., S. Guaschino, D. de Aloysio, S. Driussi, D. De Santo, P. Penac-chioni, and F. Quadrifoglio. 2003. Interrelationships of interleukin-8 with interleukin-13 and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women. Mol. Hum. Reprod. 9:53-58.
12. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 7th ed. CLSI M07-A7. Clinical and Laboratory Standards Institute, Wayne, PA
13. Colebrook, L. 1915. Bacterial antagonism, with particular reference to meningococcus. Lancet 186:1136-1138.
14. Dakin, H. D. 1915. The antiseptic action of hypochlorites. Br. Med. J. 2:809-810.
15. Dolin, M. I. 1956. The Streptococcus faecalis oxidases for reduced diphos-phopyridine nucleotide. III. Isolation and properties of a flavin peroxidase for reduced diphosphopyridine nucleotide. J. Biol. Chem. 225:557-573.
16. Fleming, A. 1919. The action of chemical and physiological antiseptics in a septic wound. Br. J. Surg. 7:99-129.
17. Friberg, L., and E. Hammarstrom. 1956. The action of free available chlorine on bacteria and bacterial viruses. Acta Pathol. Microbiol. Scand. 38: 127-134.
18. Garcia-Mendoza, A., J. Liebana, A. M. Castillo, A. de la Higuera, and G. Piedrola. 1993. Evaluation of the capacity of oral streptococci to produce hydrogen peroxide. J. Med. Microbiol. 39:434-439.
19. Held, A. M., D. J. Halko, and J. K. Hurst. 1978. Mechanism of chlorine oxidation by hydrogen peroxide. J. Am. Chem. Soc. 100:5732-5740.
20. Johnston, D. A., and G. P. Bodey. 1970. Semiquantitative oropharyngeal culture technique. Appl. Microbiol. 20:218-223.
21. Kasha, M., and A. U. Khan. 1970. The physics, chemistry, and biology of singlet molecular oxygen. Ann. N. Y. Acad. Sci. 171:5-23.
22. Klebanoff, S. J. 1968. Myeloperoxidase-halide-hydrogen peroxide antibacterial system. J. Bacteriol. 95:2131-2138.
23. Klebanoff, S. J., and R. A. Clark. 1978. The neutrophil: function and clinical disorders. North-Holland Publishing Co., Amsterdam, Netherlands.
24. McLeod, J. W., and J. Gordon. 1922. Production of hydrogen peroxide by bacteria. Biochem. J. 16:499-504.
25. Marks, H. C., O. Wyss, and F. B. Strandskov. 1945. Studies on the mode of action of compounds containing available chlorine. J. Bacteriol. 49:299-305.
26. Mercer, W. A., and I. I. Somers. 1957. Chlorine in food plant sterilization. Adv. Food Res. 7:129-160.
27. Morris, M. W., and F. R. Davey. 2001. Basic examination of blood, p. 480. In J. B. Henry (ed.), Clinical diagnosis and management by laboratory methods, 20th ed. W. B. Saunders Co., Philadelphia, PA.
28. 2-removing enzyme in human erythrocytes. Blood 90:4973-4978
29. NCCLS. 1999. Methods for determining bacterial activity of antimicrobial agents. Approved standard M26-A. National Committee for Clinical Laboratory Standards, Wayne, PA.
30. Redmond, R. W., and I. E. Kochevar. 2006. Spatially resolved cellular responses to singlet oxygen. Photochem. Photobiol. 82:1172-1186.
31. Rosebury, T. 1962. Microorganisms indigenous to man. McGraw-Hill Book Co., New York, NY.
32. Sanders, E. 1969. Bacterial interference. I. Its occurrence among the respiratory tract flora and characterization of inhibition of group A streptococci. J. Infect. Dis. 120:698-707.
33. Schultz, J., and K. Kaminker. 1962. Myeloperoxidase of the leukocyte of normal human blood. I. Content and localization. Arch. Biochem. Biophys. 96:465-467.
34. Seki, M., K. Iida, M. Saito, H. Nakayama, and S. Yoshida. 2004. Hydrogen peroxide production in Streptococcus pyogenes: involvement of lactate oxi-dase and coupling with aerobic utilization of lactate. J. Bacteriol. 186:2046-2051.
35. Skovsen, E., J. W. Snyder, J. D. C. Lambert, and P. R. Ogilby. 2005. Lifetime and diffusion of singlet oxygen in a cell. J. Phys. Chem. B. 109:8570-8573.
36. Sprunt, K., G. A. Leidy, and W. Redman. 1971. Prevention of bacterial overgrowth. J. Infect. Dis. 123:1-10.
37. Tukey, J. W. 1977. Exploratory data analysis. Addison-Wesley, Reading, MA.
38. Wright, D. G., A. I. Meierovics, and J. M. Foxley. 1986. Assessing the delivery of neutrophils to tissues in neutropenia. Blood 67:1023-1030.