Difficult-to-control arterial hypertension or uncooperative patients the assessment of serum antihypertensive drug levels to differentiate non-responsiveness from non-adherence to recommended therapy

Hypertension Research

Volumn 34, Issue 1, 2011, Pages 87-90

  Ceral, Jiri ^a   Habrdova, Vilma ^a   Vorisek, Viktor ^a   Bima, Marcel ^a   Pelouch, Radek ^a   Solar, Miroslav ^a  

^a UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

Author keywords

arterial hypertension; chromatography; compliance; drug therapy

Indexed keywords

ALDOSTERONE ANTAGONIST; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMLODIPINE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETAXOLOL; BISOPROLOL; CALCIUM CHANNEL BLOCKING AGENT; CHLORTALIDONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXAZOSIN; FUROSEMIDE; HYDROCHLOROTHIAZIDE; LOOP DIURETIC AGENT; LOSARTAN; METOPROLOL; NITRENDIPINE; RILMENIDINE; TELMISARTAN; THIAZIDE DIURETIC AGENT; URAPIDIL; VERAPAMIL;

ADULT; ANTIHYPERTENSIVE THERAPY; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIFFICULT TO CONTROL ARTERIAL HYPERTENSION; DRUG BLOOD LEVEL; FEMALE; HEART RATE; HUMAN; HYPERTENSION; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETER; MASS SPECTROMETRY; PATIENT COMPLIANCE; PRESCRIPTION; PROBLEM PATIENT; QUANTITATIVE ANALYSIS; SYSTOLIC BLOOD PRESSURE; TREATMENT RESPONSE;

ADULT; AGED; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; HYPERTENSION; MALE; MASS SPECTROMETRY; MEDICATION ADHERENCE; MIDDLE AGED; TREATMENT FAILURE;

EID: 78650904654     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2010.183     Document Type: Article

References (20)

1. Burnier M, Schneider MP, Chiolero A, Stubi CL, Brunner HR. Electronic compliance monitoring in resistant hypertension: the basis for rational therapeutic decisions. J Hypertens 2001; 19: 335-341.
2. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005; 353: 487-497.
3. Cramer JA, Mattson RH, Prevey ML, Scheyer RD, Ouellette VL. How often is medication taken as prescribed? A novel assessment technique. JAMA 1989; 261: 3273-3277.
4. Farmer KC. Methods for measuring and monitoring medication regimen adherence in clinical trials and clinical practice. Clin Ther 1999; 21: 1074-1090.
5. Zeller A, Schroeder K, Peters TJ. Electronic pillboxes (MEMS) to assess the relationship between medication adherence and blood pressure control in primary care. Scand J Prim Health Care 2007; 25: 202-207.
6. van Onzenoort HA, Verberk WJ, Kessels AG, Kroon AA, Neef C, van der Kuy PH, de Leeuw PW. Assessing medication adherence simultaneously by electronic monitoring and pill count in patients with mild-to-moderate hypertension. Am J Hypertens 2010; 23: 149-154.
7. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo Jr JL, Jones DW, Materson BJ, Oparil S, Wright Jr JT, Roccella EJ, the National High Blood Pressure Education Program Coordinating Committee. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42: 1206-1252. (Pubitemid 37553153)
8. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K, Ruilope L, Rynkiewicz A, Schmieder RE, Struijker Boudier HA, Zanchetti A, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Kjeldsen SE, Erdine S, Narkiewicz K, Kiowski W, Agabiti-Rosei E, Ambrosioni E, Cifkova R, Dominiczak A, Fagard R, Heagerty AM, Laurent S, Lindholm LH, Mancia G, Manolis A, Nilsson PM, Redon J, Schmieder RE, Struijker-Boudier HA, Viigimaa M, Filippatos G, Adamopoulos S, Agabiti-Rosei E, Ambrosioni E, Bertomeu V, Clement D, Erdine S, Farsang C, Gaita D, Kiowski W, Lip G, Mallion JM, Manolis AJ, Nilsson PM, O'Brien E, Ponikowski P, Redon J, Ruschitzka F, Tamargo J, van Zwieten P, Viigimaa M, Waeber B, Williams B, Zamorano JL, The task force for the management of arterial hypertension of the European Society of Hypertension: The task force for the management of arterial hypertension of the European Society of Cardiology. 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2007; 28: 1462-1536.
9. Maurer HH. Multi-analyte procedures for screening for and quantification of drugs in blood, plasma, or serum by liquid chromatography-single stage or tandem mass spectrometry (LC-MS or LC-MS/MS) relevant to clinical and forensic toxicology. Clin Biochem 2005; 38: 310-318.
10. Kolocouri F, Dotsikas Y, Apostolou C, Kousoulos C, Loukas YL. Simultaneous determination of losartan, EXP-3174 and hydrochlorothiazide in plasma via fully automated 96-well-format-based solid-phase extraction and liquid chromatography-negative elec-trospray tandem mass spectrometry. Anal Bioanal Chem 2007; 387: 593-601.
11. Vrijens B, Vincze G, Kristanto P, Urquhart J, Burnier M. Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories. BMJ 2008; 336: 1114-1117.
12. Burke TA, Sturkenboom MC, Lu SE, Wentworth CE, Lin Y, Rhoads GG. Discontinuation of antihypertensive drugs among newly diagnosed hypertensive patients in UK general practice. J Hypertens 2006; 24: 1193-1200.
13. Mazzaglia G, Mantovani LG, Sturkenboom MC, Filippi A, Trifiro G, Cricelli C, Brignoli O, Caputi AP. Patterns of persistence with antihypertensive medications in newly diagnosed hypertensive patients in Italy: a retrospective cohort study in primary care. J Hypertens 2005; 23: 2093-2100.
14. Lim LL. Estimating compliance to study medication from serum drug levels: application to an AIDS clinical trial of zidovudine. Biometrics 1992; 48: 619-630.
15. Serebruany V, Malinin A, Dragan V, Atar D, van Zyl L, Dragan A. Fluorimetric quantitation of citalopram and escitalopram in plasma: developing an express method to monitor compliance in clinical trials. Clin Chem Lab Med 2007; 45: 513-520.
16. Mani H, Toennes SW, Linnemann B, Urbanek DA, Schwonberg J, Kauert GF, Lindhoff-Last E. Determination of clopidogrel main metabolite in plasma: a useful tool for monitoring therapy? Ther Drug Monit 2008; 30: 84-89.
17. Maurer HH. Position of chromatographic techniques in screening for detection of drugs or poisons in clinical and forensic toxicology and/or doping control. Clin Chem Lab Med 2004; 42: 1310-1324.
18. Baroletti S, Dell'Orfano H. Medication adherence in cardiovascular disease. Circulation 2010; 121: 1455-1458.
19. Jackevicius CA, Mamdani M, Tu JV. Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA 2002; 288: 462-467.
20. Waeber B, Leonetti G, Kolloch R, McInnes GT. Compliance with aspirin or placebo in the hypertension optimal treatment (HOT) study. J Hypertens 1999; 17: 1041-1045. (Pubitemid 29322194)