Simultaneous determination of losartan, EXP-3174 and hydrochlorothiazide in plasma via fully automated 96-well-format-based solid-phase extraction and liquid chromatography-negative electrospray tandem mass spectrometry

Analytical and Bioanalytical Chemistry

Volumn 387, Issue 2, 2007, Pages 593-601

  Kolocouri, Filomila ^a   Dotsikas, Yannis ^a   Apostolou, Constantinos ^a   Kousoulos, Constantinos ^a   Loukas, Yannis L ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

96 deep well; Hydrochlorothiazide; Losartan; Mass spectrometry; Solid phase extraction

Indexed keywords

BIOASSAY; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; METABOLITES; PLASMAS; WASHING;

BIOEQUIVALENCE STUDIES; HYDROCHLOROTHIAZIDE; LOSARTAN; SOLID-PHASE EXTRACTION;

DRUG PRODUCTS;

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; ANTIHYPERTENSIVE AGENT; HYDROCHLOROTHIAZIDE; IMIDAZOLE DERIVATIVE; LOSARTAN; TETRAZOLE DERIVATIVE;

ARTICLE; BLOOD; DRUG COMBINATION; DRUG MONITORING; FRACTIONATION; HUMAN; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION;

ANTIHYPERTENSIVE AGENTS; CHEMICAL FRACTIONATION; DRUG COMBINATIONS; DRUG MONITORING; HUMANS; HYDROCHLOROTHIAZIDE; IMIDAZOLES; LOSARTAN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TETRAZOLES;

EID: 33846084399     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-006-0990-4     Document Type: Article

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