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Volumn 30, Issue 1, 2011, Pages 36-42

The future, faster: Roles for high-throughput experimentation in accelerating discovery in organometallic chemistry and catalysis

Author keywords

[No Author keywords available]

Indexed keywords

HIGH THROUGHPUT EXPERIMENTATION; ORGANOMETALLIC CATALYSIS; ORGANOMETALLIC CHEMISTRY; TECHNICAL CHALLENGES;

EID: 78650883973     PISSN: 02767333     EISSN: 15206041     Source Type: Journal    
DOI: 10.1021/om1010319     Document Type: Article
Times cited : (25)

References (43)
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    • Palladium-catalyzed amination of aryl halides and related reactions
    • In;, Ed.; Wiley: Hoboken, NJ
    • Hartwig, J. F., Palladium-catalyzed amination of aryl halides and related reactions. In Handbook of Organopalladium Chemistry for Organic Synthesis; Negishi, E.-i., Ed.; Wiley: Hoboken, NJ, 2002; Vol. 1, pp 1051 - 1096.
    • (2002) Handbook of Organopalladium Chemistry for Organic Synthesis , vol.1 , pp. 1051-1096
    • Hartwig, J.F.1    Negishi, E.-I.2
  • 14
    • 69949145497 scopus 로고    scopus 로고
    • New Riders Publishing: New York,; p.
    • Crawford, C., On Game Design; New Riders Publishing: New York, 2003; p 440.
    • (2003) On Game Design , pp. 440
    • Crawford, C.1
  • 26
    • 53849095713 scopus 로고    scopus 로고
    • A highly parallelized alternative to HTE offers the possibility of compiling large volumes of mechanistic data (including activation parameters) by screening multiple substrates in a single reaction vessel. Opportunities and limitations (in particular, the importance of conducting separate screening reactions for each catalyst system, and caution regarding cross-reactions), were usefully discussed. See
    • A highly parallelized alternative to HTE offers the possibility of compiling large volumes of mechanistic data (including activation parameters) by screening multiple substrates in a single reaction vessel. Opportunities and limitations (in particular, the importance of conducting separate screening reactions for each catalyst system, and caution regarding cross-reactions), were usefully discussed. See: an der Heiden, M. R.; Plenio, H.; Immel, S.; Burello, E.; Rothenberg, G.; Hoefsloot, H. C. J. Chem. Eur. J. 2008, 14, 2857-2866
    • (2008) Chem. Eur. J. , vol.14 , pp. 2857-2866
    • An Der Heiden, M.R.1    Plenio, H.2    Immel, S.3    Burello, E.4    Rothenberg, G.5    Hoefsloot, H.C.J.6
  • 29
    • 68949161995 scopus 로고    scopus 로고
    • In fact, GC-FID can also give grossly misleading results in screening ruthenium metathesis catalysts for the synthesis of large and medium rings by ring-closing metathesis, depending on concentration and the time point chosen for interrogation of reactions. See:;, These and other challenges specific to olefin metathesis will be discussed in a subsequent publication.
    • In fact, GC-FID can also give grossly misleading results in screening ruthenium metathesis catalysts for the synthesis of large and medium rings by ring-closing metathesis, depending on concentration and the time point chosen for interrogation of reactions. See: Monfette, S.; Fogg, D. E. Chem. Rev. 2009, 109, 3783-3816 These and other challenges specific to olefin metathesis will be discussed in a subsequent publication.
    • (2009) Chem. Rev. , vol.109 , pp. 3783-3816
    • Monfette, S.1    Fogg, D.E.2
  • 43


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.