Immunohistochemical staining for smoothelin in the duplicated versus the true muscularis mucosae of barrett esophagus

American Journal of Surgical Pathology

Volumn 35, Issue 1, 2011, Pages 55-59

  Faragalla, Hala F ^a   Marcon, Norman E ^b   Yousef, George M ^a,c   Streutker, Catherine J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Barrett esophagus; intramucosal carcinoma; muscularis mucosae; smoothelin

Indexed keywords

ACTIN; CYTOSKELETON PROTEIN; MUSCLE PROTEIN; MYOSIN; SMTN PROTEIN, HUMAN; TUMOR MARKER;

ADENOCARCINOMA; ARTICLE; BARRETT ESOPHAGUS; CANADA; CANCER INVASION; CANCER STAGING; CHEMISTRY; ESOPHAGUS; ESOPHAGUS TUMOR; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; METAPLASIA; MUCOSA; PATHOLOGY; PREDICTIVE VALUE;

ACTINS; ADENOCARCINOMA; BARRETT ESOPHAGUS; CYTOSKELETAL PROTEINS; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; HUMANS; IMMUNOHISTOCHEMISTRY; METAPLASIA; MUCOUS MEMBRANE; MUSCLE PROTEINS; NEOPLASM INVASIVENESS; NEOPLASM STAGING; ONTARIO; PREDICTIVE VALUE OF TESTS; SMOOTH MUSCLE MYOSINS; TUMOR MARKERS, BIOLOGICAL;

EID: 78650882924     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3182035fb6     Document Type: Article

References (20)

1. Abraham SC, Krasinskas AM, Correa AM, et al. Duplication of the muscularis mucosae in Barrett esophagus: an underrecognized feature and its implication for staging of adenocarcinoma. Am J Surg Pathol. 2007;31:1719-1725.
2. Bergman JJ. Endoscopic treatment of high-grade intraepithelial neoplasia and early cancer in Barrett oesophagus. Best Pract Res Clin Gastroenterol. 2005;19:889-907.
3. Coco DP, Hirsch MS, Hornick JL. Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract. Am J Surg Pathol. 2009;33:1795-1801.
4. Council L, Hameed O. Differential expression of immunohistochemical markers in bladder smooth muscle and myofibroblasts, and the potential utility of desmin, smoothelin, and vimentin in staging of bladder carcinoma. Mod Pathol. 2009;22:639-650.
5. Hahn HP, Shahsafaei A, Odze RD. Vascular and lymphatic properties of the superficial and deep lamina propria in Barrett esophagus. Am J Surg Pathol. 2008;32:1454-1461.
6. Kramer J, Aguirre-Arteta AM, Thiel C, et al. A novel isoform of the smooth muscle cell differentiation marker smoothelin. J Mol Med. 1999;77:294-298.
7. Lewis JT, Wang KK, Abraham SC. Muscularis mucosae duplication and the musculo-fibrous anomaly in endoscopic mucosal resections for barrett esophagus: implications for staging of adenocarcinoma. Am J Surg Pathol. 2008;32:566-571.
8. Liu L, Hofstetter WL, Rashid A, et al. Significance of the depth of tumor invasion and lymph node metastasis in superficially invasive (T1) esophageal adenocarcinoma. Am J Surg Pathol. 2005;29: 1079-1085.
9. Lu D, Vohra P, Chu PG, et al. An oncofetal protein IMP3: a new molecular marker for the detection of esophageal adenocarcinoma and high-grade dysplasia. Am J Surg Pathol. 2009;33: 521-525.
10. Miyamoto H, Sharma RB, Illei PB, et al. Pitfalls in the use of smoothelin to identify muscularis propria invasion by urothelial carcinoma. Am J Surg Pathol. 2010;34:418-422.
11. Montani M, Thiesler T, Kristiansen G. Smoothelin is a specific and robust marker for distinction of muscularis propria and muscularis mucosae in the gastrointestinal tract. Histopathology. 2010;57: 244-249.
12. Odze RD. Update on the diagnosis and treatment of Barrett esophagus and related neoplastic precursor lesions. Arch Pathol Lab Med. 2008;132:1577-1585.
13. Odze RD, Lauwers GY. Histopathology of Barrett's esophagus after ablation and endoscopic mucosal resection therapy. Endoscopy. 2008;40:1008-1015.
14. Paner GP, Shen SS, Lapetino S, et al. Diagnostic utility of antibody to smoothelin in the distinction of muscularis propria from muscularis mucosae of the urinary bladder: a potential ancillary tool in the pathologic staging of invasive urothelial carcinoma. Am J Surg Pathol. 2009;33:91-98.
15. Paner GP, Brown JG, Lapetino S, et al. Diagnostic use of antibody to smoothelin in the recognition of muscularis propria in transurethral resection of urinary bladder tumor (TURBT) specimens. Am J Surg Pathol. 2010;34:792-799.
16. Pouw RE, Bergman JJ. Endoscopic resection of early oesophageal and gastric neoplasia. Best Pract Res Clin Gastroenterol. 2008;22: 929-943.
17. Solaymani-Dodaran M, Logan RF, West J, et al. Risk of oesophageal cancer in Barrett's oesophagus and gastro-oesophageal reflux. Gut. 2004;53:1070-1074.
18. Stein HJ, Feith M, Bruecher BL, et al. Early esophageal cancer: pattern of lymphatic spread and prognostic factors for long-term survival after surgical resection. Ann Surg. 2005;242:566-573.
19. Van der Loop FT, Schaart G, Timmer ED, et al. Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells. J Cell Biol. 1996;134:401-411.
20. Vieth M, Stolte M. Pathology of early upper GI cancers. Best Pract Res Clin Gastroenterol. 2005;19:857-869.