Diagnostic use of antibody to smoothelin in the recognition of muscularis propria in transurethral resection of urinary bladder tumor (TURBT) specimens

American Journal of Surgical Pathology

Volumn 34, Issue 6, 2010, Pages 792-799

  Paner, Gladell P ^a   Brown, Jeffrey G ^b   Lapetino, Shawn ^a   Nese, Nalan ^b   Gupta, Ruta ^b   Shen, Steven S ^c   Hansel, Donna E ^d   Amin, Mahul B ^b  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Immunohistochemistry; Invasion; Muscularis mucosae; Muscularis propria; Smoothelin; Staging; TURBT; Urinary bladder cancer

Indexed keywords

ANTIBODY; CYTOSKELETON PROTEIN; DIAGNOSTIC AGENT; MUSCLE PROTEIN; SMTN PROTEIN, HUMAN;

ARTICLE; BLADDER TUMOR; CANCER STAGING; CYSTECTOMY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; METHODOLOGY; PATHOLOGY; SENSITIVITY AND SPECIFICITY; TRANSITIONAL CELL CARCINOMA;

ANTIBODIES; CARCINOMA, TRANSITIONAL CELL; CYSTECTOMY; CYTOSKELETAL PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MUSCLE PROTEINS; NEOPLASM STAGING; SENSITIVITY AND SPECIFICITY; URINARY BLADDER NEOPLASMS;

EID: 77953074379     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181da7650     Document Type: Article

References (17)

1. Amin MB, Gomez JA, Young RH. Urothelial transitional cell carcinoma with endophytic growth patterns: a discussion of patterns of invasion and problems associated with assessment of invasion in 18 cases. Am J Surg Pathol. 1997;21:1057-1068.
2. Bovio IM, Al-Quran SZ, Drew PA, et al. Smoothelin expression is a useful adjunct for assessing muscularis propria invasion in bladder cancer. Mod Pathol. 2009;22:160A.
3. Council L, Hameed O. Differential expression of immunohistochemical markers in bladder smooth muscle and myofibroblasts, and the potential utility of desmin, smoothelin, and vimentin in staging of bladder carcinoma. Mod Pathol. 2009;22:639-650.
4. De Peralta-Venturina M, Cohen C, Amin MB. Potential utility of smooth muscle myosin-heavy chain antibody in the assessment of level of invasion in urothelial carcinoma in transurethral resection of blader tumor specimens. Mod Pathol. 2002;15:160A.
5. Dixon JS, Gosling JA. Histology and fine structure of the muscularis mucosae of the human urinary bladder. J Anat. 1983;136:265-271.
6. Dvorakova M, Dhir M, Bastacky SI, et al. Utility of double immunohistochemical staining for smoothelin/pancytokeratin in the staging of urothelial carcinoma. Mod Pathol. 2009;22:166A.
7. Greene FL, Page DL, Fleming ID, et al. AJCC Cancer Staging Manual. 6th ed. New York, NY: Springer-Verlag; 2002.
8. Hall MC, Chang SS, Dalbagni G, et al. Guideline for the management of nonmuscle invasive bladder cancer (stages Ta, T1, and Tis) : 2007 update. J Urol. 2007;178:2314-2330.
9. Hansel D, Paner GP, Amin MB. Bladder diverticula demonstrate limited diffuse smoothelin expression within the muscularis mucosa. Mod Pathol. 2009;22:172A.
10. Jimenez RE, Keane TE, Hardy HT, et al. pT1 urothelial carcinoma of the bladder: criteria for diagnosis, pitfalls, and clinical implications. Adv Anat Pathol. 2000;7:13-25.
11. Khayyata S, Dudas M, Rohan SM, et al. Distribution of smoothelin expression in the musculature of the genitourinary tract. Mod Pathol. 2009;22:175A.
12. Kramer J, Aguirre-Arteta AM, Thiel C, et al. A novel isoform of the smooth muscle cell differentiation marker smoothelin. J Mol Med. 1999;77:294-298.
13. Paner GP, Ro JY, Wojcik EM, et al. Further characterization of the muscle layers and lamina propria of the urinary bladder by systematic histologic mapping: implications for pathologic staging of invasive urothelial carcinoma. Am J Surg Pathol. 2007;31:1420-1429.
14. Paner GP, Shen SS, Lapetino S, et al. Diagnostic utility of antibody to smoothelin in the distinction of muscularis propria from muscularis mucosae of the urinary bladder: a potential ancillary tool in the pathologic staging of invasive urothelial carcinoma. Am J Surg Pathol. 2009;33:91-98.
15. Ro JY, Ayala AG, el-Naggar A. Muscularis mucosa of urinary bladder. Importance for staging and treatment. Am J Surg Pathol. 1987;11:668-673.
16. Vakar-Lopez F, Shen SS, Zhang S, et al. Muscularis mucosae of the urinary bladder revisited with emphasis on its hyperplastic patterns: a study of a large series of cystectomy specimens. Ann Diagn Pathol. 2007;11:395-401.
17. van der Loop FT, Schaart G, Timmer ED, et al. Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells. J Cell Biol. 1996;134:401-411.