Chronic low back pain, sleep disturbance, and interleukin-6

Clinical Journal of Pain

Volumn 27, Issue 1, 2011, Pages 35-41

  Heffner, Kathi L ^a   France, Christopher R ^b   Trost, Zina ^b   Mei Ng, H ^b   Pigeon, Wilfred R ^c  

^a Rochester Center for Mind Body Research   (United States)

^b OHIO UNIVERSITY   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

chronic back pain; inflammatory cytokines; interleukin 6; sleep disturbance

Indexed keywords

INTERLEUKIN 6;

ADULT; ARTICLE; CENTER FOR EPIDEMIOLOGICAL STUDIES DEPRESSION SCALE; CHRONIC PAIN; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; HUMAN; INFLAMMATION; LOW BACK PAIN; MALE; MCGILL PAIN QUESTIONNAIRE; NOCICEPTION; PITTSBURGH SLEEP QUALITY INDEX; PRIORITY JOURNAL; RATING SCALE; SLEEP DISORDER;

EID: 78650880230     PISSN: 07498047     EISSN: 15365409     Source Type: Journal    
DOI: 10.1097/AJP.0b013e3181eef761     Document Type: Article

References (59)

1. Lautenbacher S, Kundermann B, Krieg JC. Sleep deprivation and pain perception. Sleep Med Rev. 2006;10:357-369.
2. Moldofsky H. Sleep and pain. Sleep Med Rev. 2001;5:385-396.
3. Pigeon WR, Park H, Satiea MJ. Sleep and pain. In: Lader M, Cardinali DP, Pandi-Perumal SR, eds. Sleep and Sleep Disorders: A Neuropsychopharmacological Approach. New York: Springer; 2006:201-209.
4. Smith MT, Haythornthwaite JA. How do sleep disturbance and chronic pain inter-relate? Insights from the longitudinal and cognitive-behavioral clinical trials literature. Sleep Med Rev. 2004;8:119-132.
5. Chiu YH, Silman AJ, Macfarlane GJ, et al. Poor sleep and depression are independently associated with a reduced pain threshold. Results of a population based study. Pain. 2005;115: 316-321.
6. Marchand F, Perretti M, McMahon SB. Role of the immune system in chronic pain. Nat Rev Neurosci. 2005;6:521-532.
7. Solovieva S, Leino-Arjas P, Saarela J, et al. Possible association of interleukin 1 gene locus polymorphisms with low back pain. Pain. 2004;109:8-19.
8. Watkins LR, Maier SF. The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu Rev Psychol. 2000;51:29-57.
9. Watkins LR, Maier SF. Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev. 2002;82:981-1011.
10. DeLeo JA, Yezierski RP. The role of neuroinflammation and neuroimmune activation in persistent pain. Pain. 2001;90: 1-6.
11. Starkweather A, Witek-Janusek L, Mathews HL. Neural-immune interactions: implications for pain management in patients with low-back pain and sciatica. Biol Res Nurs. 2005; 6:196-206.
12. De Jongh RF, Vissers KC, Meert TF, et al. The role of interleukin-6 in nociception and pain. Anesth Analg. 2003;96: 1096-1103.
13. Sommer C, Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci Lett. 2004;361: 184-187.
14. Mukai E, Nagashima M, Hirano D, et al. Comparative study of symptoms and neuroendocrine-immune network mediator levels between rheumatoid arthritis patients and healthy subjects. Clin Exp Rheumatol. 2000;18:585-590.
15. Maes M, Libbrecht I, Van Hunsel F, et al. The immune-inflammatory pathophysiology of fibromyalgia: increased serum soluble gp130, the common signal transducer protein of various neurotrophic cytokines. Psychoneuroendocrinology. 1999;24:371-383.
16. Geiss A, Varadi E, Steinbach K, et al. Psychoneuroimmunological correlates of persisting sciatic pain in patients who underwent discectomy. Neurosci Lett. 1997;237:65-68.
17. Krueger J, Majde J. Host defense. In: Kryger M, Roth T, Dement W, eds. Principles and Practice of Sleep Medicine. 4th ed. Philadelphia: W.B. Saunders Company; 2005:256-265.
18. Krueger JM, Obal FJ, Fang J, et al. The role of cytokines in physiological sleep regulation. Ann N Y Acad Sci. 2001;933: 211-221.
19. Bauer J, Hohagen F, Ebert T, et al. Interleukin-6 serum levels in healthy persons correspond to the sleep-wake cycle. Clin Investig. 1994;72:315.
20. Redwine L, Hauger RL, Gillin JC, et al. Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J Clin Endocrinol Metab. 2000;85:3597-3603.
21. Hong S, Mills PJ, Loredo JS, et al. The association between interleukin-6, sleep, and demographic characteristics. Brain Behav Immun. 2005;19:165-172.
22. Vgontzas AN, Zoumakis M, Bixler EO, et al. Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels: physiologic and therapeutic implications. J Clin Endocrinol Metab. 2003;88:2087-2095.
23. Haack M, Sanchez E, Mullington JM. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep. 2007;30:1145-1152.
24. Vgontzas AN, Zoumakis E, Bixler EO, et al. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab. 2004;89: 2119-2126.
25. Burke JG, Watson RW, McCormack D, et al. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br. 2002;84:196-201.
26. Dantzer R, O'Connor JC, Freund GG, et al. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9:46-56.
27. Trost Z, France CR, Thomas JS. Exposure to movement in chronic back pain: evidence of successful generalization across a reaching task. Pain. 2008;137:26-33.
28. Buysse DJ, Reynolds CF, Monk TH, et al. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193-213.
29. Backhaus J, Junghanns K, Broocks A, et al. Test-retest reliability and validity of the Pittsburgh sleep quality index in primary insomnia. J Psychosom Res. 2002;53:737-740.
30. Melzack R. The short-form McGill Pain Questionnaire. Pain. 1987;30:191-197.
31. Eaton WW, Smith C, Ybarra M, et al. Center for Epidemiologic Studies Depression Scale: Review and revision (CESD and CESD-R). In: Maruish M, ed. Use of Psychological Testing for Treatment Planning and Outcomes Assessment. Princeton, NJ: Lawrence Erlbaum Associates; 2004: 363-377.
32. Schulberg HC, Saul M, McClelland M, et al. Assessing depression in primary medical and psychiatric practices. Arch Gen Psychiatry. 1985;42:1164-1170.
33. Buysse DJ, Ancoli-Israel S, Edinger JD, et al. Recommendations for a standard research assessment of insomnia. Sleep. 2006;29:1155-1173.
34. Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med. 2000;51:245-270.
35. Papanicolaou DA, Wilder RL, Manolagas SC, et al. The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med. 1998;128:127-137.
36. Ritzwoller DP, Crounse L, Shetterly S, et al. The association of comorbidities, utilization and costs for patients identified with low back pain. BMC Musculoskelet Disord. 2006;7:72.
37. Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, et al. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci USA. 2003;100:9090-9095.
38. Maier SF, Watkins LR. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev. 1998;105:83-107.
39. Leeuw M, Goossens ME, Linton SJ, et al. The fearavoidance model of musculoskeletal pain: current state of scientific evidence. J Behav Med. 2007;30:77-94.
40. Campbell LC, Clauw DJ, Keefe FJ. Persistent pain and depression: a biopsychosocial perspective. Biol Psychiatry. 2003;54:399-409.
41. Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci. 2001;933:222-234.
42. Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009;65:732-741.
43. Sweitzer SM, Colburn RW, Rutkowski M, et al. Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat. Brain Res. 1999;829:209-221.
44. Watkins LR, Hutchinson MR, Milligan ED, et al. "Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev. 2007;56:148-169.
45. Watkins LR, Maier SF. When good pain turns bad. Curr Dir Psychol Sci. 2003;12:232-236.
46. Graham JE, Robles TF, Kiecolt-Glaser JK, et al. Hostility and pain are related to inflammation in older adults. Brain Behav Immun. 2006;20:389-400.
47. Lutgendorf SK, Logan H, Costanzo E, et al. Effects of acute stress, relaxation, and a neurogenic inflammatory stimulus on interleukin-6 in humans. Brain Behav Immun. 2004;18:55-64.
48. Geiss A, Rohleder N, Kirschbaum C, et al. Predicting the failure of disc surgery by a hypofunctional HPA axis: evidence from a prospective study on patients undergoing disc surgery. Pain. 2005;114:104-117.
49. Edwards RR, Kronfli T, Haythornthwaite JA, et al. Association of catastrophizing with interleukin-6 responses to acute pain. Pain. 2008;140:135-144.
50. Meerlo P, Koehl M, van der Borght K, et al. Sleep restriction alters the hypothalamic-pituitary-adrenal response to stress. J Neuroendocrinol. 2002;14:397-402.
51. Meerlo P, Sgoifo A, Suchecki D. Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity. Sleep Med Rev. 2008;12:197-210.
52. Lauderdale DS, Knutson KL, Rathouz PJ, et al. Cross-sectional and longitudinal associations between objectively measured sleep duration and body mass index: the CARDIA Sleep Study. Am J Epidemiol. 2009;170:805-813.
53. Shechter A, Varin F, Boivin DB. Circadian variation of sleep during the follicular and luteal phases of the menstrual cycle. Sleep. 2010;33:647-656.
54. Mohamed-Ali V, Goodrick S, Rawesh A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factoralpha, in vivo. J Clin Endocrinol Metab. 1997;82: 4196-4200.
55. Yasui T, Maegawa M, Tomita J, et al. Changes in serum cytokine concentrations during the menopausal transition. Maturitas. 2007;56:396-403. (Pubitemid 46401105)
56. Nappo F, Esposito K, Cioffi M, et al. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol. 2002;39: 1145-1150.
57. Peterlin BL, Rapoport AM, Kurth T. Migraine and obesity: epidemiology, mechanisms, and implications. Headache. 2009;50:631-648.
58. Kowalczyk WJ, Sullivan MA, Evans SM, et al. Sex differences and hormonal influences on response to mechanical pressure pain in humans. J Pain. 2009;11:330-342.
59. Pigeon WR, Perlis ML, Swan J, et al. CBT for Insomnia is associated with decreased fatigue and diminished IL-6 levels in chronic pain patients. Sleep. 2008;31S:A253.