Penta-O-galloyl-β-D-glucose induces G1 arrest and DNA replicative S-phase arrest independently of P21 cyclin-dependent kinase inhibitor 1A, P27 cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple-negative xenograft growth

Breast Cancer Research

Volumn 12, Issue 5, 2010, Pages

  Chai, Yubo ^a   Lee, Hyo Jeong ^b   Shaik, Ahmad Ali ^a,c   Nkhata, Katai ^a   Xing, Chengguo ^c   Zhang, Jinhui ^a   Jeong, Soo Jin ^b   Kim, Sung Hoon ^a,b   Lü, Junxuan ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Kyung Hee University   (South Korea)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DNA; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; P21 CYCLIN DEPENDENT KINASE INHIBITOR 1A; P27 CYCLIN DEPENDENT KINASE INHIBITOR 1B; PENTA 1,2,3,4,6 O GALLOYL BETA D GLUCOSE; PROGESTERONE RECEPTOR; PROTEIN P53; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; BETA-PENTA-O-GALLOYL-GLUCOSE; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOSE PENTAGALLATE; TANNIN;

ABSENCE OF SIDE EFFECTS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; BREAST CANCER; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; DNA REPLICATION; DOWN REGULATION; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; GALLA RHOIS; HUMAN; HUMAN CELL; MEDICINAL PLANT; MOUSE; NONHUMAN; PAEONIA SUFFRUTICOSA; PHOSPHORYLATION; PLANT ROOT; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RHUS CHINENSIS; TUMOR GROWTH; XENOGRAFT; ANIMAL; BREAST TUMOR; CELL PROLIFERATION; CELL STRAIN MCF 7; DRUG EFFECT; DRUG SCREENING; G1 PHASE CELL CYCLE CHECKPOINT; METABOLISM; NUDE MOUSE; S PHASE CELL CYCLE CHECKPOINT; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; HYDROLYZABLE TANNINS; MCF-7 CELLS; MICE; MICE, NUDE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; S PHASE CELL CYCLE CHECKPOINTS; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78650872273     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2634     Document Type: Article

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