Sub-Cellular Distribution and Translocation of TRP Channels

Current Pharmaceutical Biotechnology

Volumn 12, Issue 1, 2011, Pages 12-23

  Toro, Carlos A ^a   Arias, Luis A ^a   Brauchi, Sebastian ^a  

^a UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

Author keywords

Regulated exocytosis; Traffic; Trp channels; Vesicles

Indexed keywords

CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL; CAVEOLIN 1; CLATHRIN; DYNAMIN; EARLY ENDOSOME ANTIGEN 1; LIPID; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; RAB PROTEIN; SYNAPTOBREVIN 2; SYNAPTOSOMAL ASSOCIATED PROTEIN 23; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL 7; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR 5; VANILLOID RECEPTOR 6;

ARTICLE; CELL COMMUNICATION; CELL MIGRATION; CELL VACUOLE; CELLULAR DISTRIBUTION; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; EXOCYTOSIS; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HUMAN; INTRACELLULAR MEMBRANE; INTRACELLULAR SIGNALING; INVERTEBRATE; LIPID RAFT; NERVE CELL; NERVE FIBER; NONHUMAN; SENSORY SYSTEM ELECTROPHYSIOLOGY; SIGNAL TRANSDUCTION; SYNAPSE VESICLE;

CELL MEMBRANE; CELL MOVEMENT; CLATHRIN; ENDOCYTOSIS; HUMANS; INTRACELLULAR MEMBRANES; ION CHANNEL GATING; PROTEIN TRANSPORT; SENSATION; SIGNAL TRANSDUCTION; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 78650871500     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920111793937899     Document Type: Article

References (139)

1. Clapham, D.E. TRP channels as cellular sensors. Nature, 2003, 426, 517-524
2. Voets, T.; Talavera, K.; Owsianik, G.; Nilius, B. Sensing with TRP channels. Nat. Chem. Biol., 2005, 1, 85-92
3. Ramsey, I.S.; Delling, M.; Clapham, D.E. An introduction to TRP channels. Annu. Rev. Physiol., 2006, 68, 619-647
4. Latorre, R.; Brauchi, S.; Orta, G.; Zaelzer, C.; Vargas, G. ThermoTRP channels as modular proteins with allosteric gating. Cell Calcium, 2007, 42, 427-438
5. Moiseenkovabell, V.Y.; Stanciu, L.A.; Serysheva, I.I.; Tobe, B.J.; Wensel, T.G. Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc. Natl. Acad. Sci. USA, 2008, 105, 7451-7455
6. Latorre, R.; Zaelzer, C.; Brauchi, S. Structure-functional intimacies of transient receptor potential channels. Q. Rev. Biophys., 2009, 42, 201-246
7. Owsianik, G.; Talavera, K.; Voets, T.; Nilius, B. Permeation and selectivity of TRP channels. Annu. Rev. Physiol., 2006, 68, 685-717
8. Buckley, K.M.; Melikian, H.E.; Provoda, C.J.; Waring, M.T. Regulation of neuronal function by protein trafficking: a role for the endosomal pathway. J. Physiol., 2000, 525, 11-19
9. Royle, S.J.; Murrell-Lagnado, R.D. Constitutive cycling: a general mechanism to regulate cell surface proteins. Bioessays, 2003, 25, 39-46
10. Kanzaki, M.; Zhang, Y.Q.; Mashima, H.; Li, L.; Shibata, H.; Kojima, I. Translocation of a calcium permeable cation channel induced by insulin like growth factor I. Nat. Cell Biol., 1999, 1, 165-170
11. Cayouette, S.; Boulay, G. Intracellular trafficking of TRP channels. Cell Calcium, 2007, 42, 225-232
12. Montell, C. Exciting trips for TRPs. Nat. Cell Biol., 2004, 6, 690-692
13. Le Roy, C.; Wrana, J.L. Clathrin and non clathrin mediated endocytic regulation of cell signalling. Nat. Rev. Mol. Cell Biol., 2005, 6, 112-126
14. Cheng, X.; Shen, D.; Samie, M.; Xu, H. Mucolipins: Intracellular TRPML1-3 channels. FEBS Lett., 2010, 584(10), 2013-2021.
15. Barry, M.F.; Ziff, E.B. Receptor trafficking and the plasticity of excitatory synapses. Curr. Opin. Neurobiol., 2002, 12, 279-286.
16. Watson, R.T.; Kanzaki, M.; Pessin, J.E. Regulated membrane trafficking of the insulin responsive glucose transporter 4 in adipocytes. Endocr. Rev., 2004, 25, 177-204
17. Peters, K.W.; Qi, J.; Johnson, J.P.; Watkins, S.C.; Frizzell, R.A. Role of snare proteins in CFTR and ENaC trafficking. Pflugers Arch., 2001, 443, S65-69
18. Tamma, G.; Procino, G.; Strafino, A.; Bononi, E.; Meyer, G.; Paul michl, M.; Formoso, V.; Svelto, M.; Valenti, G. Hypotonicity induces aquaporin-2 internalization and cytosol to membrane translocation of ICln in renal cells. Endocrinology, 2007, 148,1118-1130
19. Oancea, E.; Vriens, J.; Brauchi, S.; Jun, J.; Splawski, I.; Clapham, D.E. TRPM1 forms ion channels associated with melanin content in melanocytes. Sci. Signal., 2009, 2,21-21
20. 2+-release channel in beta cells. Sci. Signal., 2009, 2, ra23. Sub-Cellular Distribution and Translocation of TRP Channels
21. Krapivinsky, G.; Mochida, S.; Krapivinsky, L.; Cibulsky, S.M.; Clapham, D.E. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron, 2006, 52, 485-496
22. Brauchi, S.; Krapivinsky, G.; Krapivinsky, L.; Clapham, D.E. TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proc. Natl. Acad. Sci. USA, 2008, 105, 8304-8308.
23. Thebault, S.; Lemonnier, L.; Bidaux, G.; Flourakis, M.; Baven-coffe, A.; Gordienko, D.; Roudbaraki, M.; Delcourt, P.; Panchin, Y.; Shuba, Y. Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store operated channels in LNCaP human prostate cancer epithelial cells. J. Biol. Chem., 2005, 280, 39423-39435
24. Turner, H.; Fleig, A.; Stokes, A.; Kinet, J.; Penner, R. Discrimination of intracellular calcium store subcompartments using TRPV1 (transient receptor potential channel, vanilloid subfamily member 1) release channel activity. Biochem. J., 2003, 371, 341-350.
25. van de Graaf, S.F.J.; Hoenderop, J.G.J.; Bindels, R.J.M. Regulation of TRPV5 and TRPV6 by associated proteins. Am. J. Phys. Ren. Phys., 2006, 290, F1295-302
26. 2+)-permeable channel in the yeast vacuolar membrane. Proc. Natl. Acad. Sci. USA, 2001, 98, 7801-7805
27. 2+) release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue. J. Cell Biol., 2002, 156, 29-34
28. Bargal, R.; Bach, G. Mucolipidosis type IV: abnormal transport of lipids to lysosomes. J Inherit. Metab. Dis., 1997, 20, 625-632.
29. Sun, M.; Goldin, E.; Stahl, S.; Falardeau, J.L.; Kennedy, J.C.; Acierno, J.S.J.; Bove, C.; Kaneski, C.R.; Nagle, J.; Bromley, M.C.; Colman, M.; Schiffmann, R.; Slaugenhaupt, S.A. Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel. Hum. Mol. Genet., 2000, 9, 2471-2478.
30. Bach, G.; Webb, M.B.T.; Bargal, R. Zeigler, M.; Ekstein, J. The frequency of mucolipidosis type IV in the Ashkenazi Jewish population and the identification of 3 novel MCOLN1 mutations. Hum. Mutat., 2005, 26, 591
31. Xu, H.; Delling, M.; Li, L.; Dong, X.; Clapham, D.E. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc. Natl. Acad. Sci. USA, 2007, 104, 18321-18326
32. Kiselyov, K.; Chen, J.; Rbaibi, Y.; Oberdick, D.; Tjon-Kon-Sang, S.; Shcheynikov, N.; Muallem, S.; Soyombo, A. TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage. J. Biol. Chem., 2005, 280, 43218-43223
33. Manzoni, M.; Monti, E.; Bresciani, R.; Bozzato, A.; Barlati, S.; Bassi, M.T.; Borsani, G. Overexpression of wild-type and mutant mucolipin proteins in mammalian cells: effects on the late endocytic compartment organization. FEBS Lett., 2004, 567, 219-224.
34. Venkatachalam, K.; Hofmann, T.; Montell, C. Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis associated protein TRPML1. J. Biol. Chem., 2006, 281, 17517-17527
35. Karacsonyi, C.; Miguel, A.S.; Puertollano, R. Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs. Traffic, 2007, 8, 1404-1414
36. Martina, J.A.; Lelouvier, B.; Puertollano, R. The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway. Traffic, 2009, 10, 1143-1156
37. Nilius, B.; Owsianik, G.; Voets, T.; Peters, J.A. Transient receptor potential cation channels in disease. Physiol. Rev., 2007, 87, 165-217
38. Hunter, J.J.; Shao, J.; Smutko, J.S.; Dussault, B.J. Nagle, D.L.; Woolf, E.A.; Holmgren, L.M.; Moore, K.J.; Shyjan, A.W. Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1). Genomics, 1998, 54, 116-123
39. Duncan, L.M.; Deeds, J.; Cronin, F.E.; Donovan, M.; Sober, A.J.; Kauffman, M.; McCarthy, J.J. Melastatin expression and prognosis in cutaneous malignant melanoma. J. Clin. Oncol., 2001, 19, 568-576
40. Devi, S.; Kedlaya, R.; Maddodi, N.; Bhat, K.M.R.; Weber, C.S.; Valdivia, H.; Setaletaletaluri, V. Calcium homeostasis in human melano-cytes: role of transient receptor potential melastatin 1 (TRPM1) and its regulation by ultraviolet light. Am. J. Phys. Cell Phys., 2009, 297, C679-87. Current Pharmaceutical Biotechnology, 2011, Vol. 12, No. 1 21
41. Morgans, C.W.; Zhang, J.; Jeffrey, B.G.; Nelson, S.M.; Burke, N.S.; Duvoisin, R.M.; Brown, R.L. TRPM1 is required for the de-polarizing light response in retinal ON-bipolar cells. Proc. Natl. Acad. Sci. USA, 2009, 106, 19174-19178
42. Perraud, A.L.; Fleig, A.; Dunn, C.A.; Bagley, L.A.; Launay, P.; Schmitz, C.; Stokes, A.J.; Zhu, Q.; Bessman, M.J.; Penner, R.; Kinet, J.P.; Scharenberg, A.M. ADP-ribose gating of the calcium permeable LTRPC2 channel revealed by Nudix motif homology. Nature, 2001, 411, 595-599
43. Beck, A.; Kolisek, M.; Bagley, L.A.; Fleig, A.; Penner, R. Nico-tinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. FASEB J., 2006, 20, 962-964
44. Du, J.; Xie, J.; Yue, L. Intracellular calcium activates TRPM2 and its alternative spliced isoforms. Proc. Natl. Acad. Sci. USA, 2009, 106, 7239-7244
45. Starkus, J.; Beck, A.; Fleig, A.; Penner, R. Regulation of TRPM2 by Extra-and Intracellular Calcium. J. Gen. Physiol., 2007, 130, 427-440
46. Du, J.; Xie, J.; Yue, L. Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity. J. Gen. Physiol., 2009, 134, 471-488
47. Dhaka, A.; Viswanath, V.; Patapoutian, A. TRP ion channels and temperature sensation. Annu. Rev. Neurosci., 2006, 29, 135-161.
48. Caterina, M.J.; Schumacher, M.A.; Tominaga, M.; Rosen, T.A.; Levine, J.D.; Julius, D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature, 1997, 389, 816-824.
49. Olah, Z.; Szabo, T.; Karai, L.; Hough, C.; Fields, R.D.; Caudle, R.M.; Blumberg, P.M.; Iadarola, M.J. Ligand-induced Dynamic Membrane Changes and Cell Deletion Conferred by Vanilloid Re-ceptor 1. J. Biol. Chem., 2001, 276, 11021-11030
50. 2+ by vanilloid receptor I in rat dorsal root ganglion neurons. J. Biol. Chem., 2003, 278, 5462-5472
51. Marshall, I.C.B.; Owen, D.E.; Cripps, T.V.; Davis, J.B.; McNulty, S.; Smart, D. Activation of vanilloid receptor 1 by resiniferatoxin mobilizes calcium from inositol 1,4,5-trisphosphate-sensitive stores. Br. J. Pharmacol., 2003, 138, 172-176
52. + entry. Biochem. J., 2003, 372, 517-528.
53. McKemy, D.D.; Neuhausser, W.M.; Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosen-sation. Nature, 2002, 416, 52-58
54. Dhaka, A.; Murray, A.N.; Mathur, J.; Earley, T.J.; Petrus, M.J.; Patapoutian, A. Report TRPM8 is required for cold sensation in mice. Neuron, 2007, 54(3), 371-378
55. Colburn, R.W.; Lubin, M.L.; Stone, D.J.; Wang, Y.; Lawrence, D.; Andrea, M.R.D.; Brandt, M.R.; Liu, Y.; Flores, C.M.; Qin, N. Report attenuated cold sensitivity in TRPM8 null mice. Neuron, 2007, 379-386
56. Bautista, D.M.; Siemens, J.; Glazer, J.M.; Tsuruda, P.R.; Basbaum, A.I.; Stucky, C.L.; Jordt, S.E.; Julius, D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature, 2007, 448, 204-208
57. 2+ channel required for the survival of prostate cancer cells. Cancer Res., 2004, 64, 8365-8373
58. 2+ release from endoplasmic reticulum and Golgi. J. Biol. Chem., 2007, 282, 3325-3336
59. Runnels, L.W.; Yue, L.; Clapham, D.E. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science, 2001, 291, 1043-1047
60. Rahamimoff, R.; Fernandez, J.M. Pre-and postfusion regulation of transmitter release. Neuron, 1997, 18, 17-27
61. Takahashi, M.; Itakura, M.; Kataoka, M. New aspects of neuro-transmitter release and exocytosis: regulation of neurotransmitter release by phosphorylation. J. Pharmacol. Sci., 2003, 93, 41-45.
62. Gaffield, M.A.; Rizzoli, S.O.; Betz, W.J. Mobility of synaptic vesicles in different pools in resting and stimulated frog motor nerve terminals. Neuron, 2006, 51, 317-325
63. Rohrbough, J.; Broadie, K. Lipid regulation of the synaptic vesicle cycle. Nat. Rev. Neurosci., 2005, 6, 139-150. 22 Current Pharmaceutical Biotechnology, 2011, Vol. 12, No. 1
64. Runnels, L.W.; Yue, L.; Clapham, D.E. The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat. Cell Biol., 2002, 4, 329-336.
65. Putney, J.J. TRP inositol 1,4,5-trisphosphate receptors, and capaci-tative calcium entry. Proc. Natl. Acad. Sci. USA, 1999, 96, 14669-14671
66. Hoth, M.; Penner, R. Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature, 1992, 355, 353-356
67. Clapham, D.E. TRP Is Cracked but Is CRAC TRP?. Cell, 1996, 16, 1069-1072
68. Putney, J.W. Capacitative calcium entry: from concept to mole-cules. Immunol. Rev., 2009, 231, 10-22
69. Burgoyne, R.D.; Clague, M.J. Calcium and calmodulin in membrane fusion. Biochim. Biophys. Acta, 2003, 1641, 137-143.
70. Hay, J.C. Calcium: a fundamental regulator of intracellular membrane fusion?. EMBO Rep., 2007, 8, 236-240
71. Sudhof, T.C. The synaptic vesicle cycle. Ann. Rev. Neurosci., 2004, 27, 509-547
72. Cosens, D.J.; Manning, A. Abnormal electroretinogram from a drosophila mutant. Nature, 1969, 224, 285-287
73. Montell, C. Drosophila TRP channels. Pflugers Arch., 2005, 451, 19-28
74. Montell, C.; Rubin, G.M. Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron, 1989, 2, 1313-1323
75. Bähner, M.; Frechter, S.; Da Silva, N.; Minke, B.; Paulsen, R.; Huber, A. Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current. Neuron, 2002, 34, 83-93
76. Meyer, N.E.; Joel-Almagor, T.; Frechter, S.; Minke, B.; Huber, A. Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade. J. Cell Sci., 2006, 119, 2592-2603
77. Xu, X.S.; Sternberg, P.W. A C. elegans sperm TRP protein required for sperm-egg interactions during fertilization. Cell, 2003, 114, 285-297
78. Caterina, M.J.; Rosen, T.A.; Tominaga, M.; Brake, A.J.; Julius, D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature, 1999, 398, 436-441
79. Saito, M.; Hanson, P.I.; Schlesinger, P. Luminal chloride-dependent activation of endosome calcium channels: patch clamp study of enlarged endosomes. J. Biol. Chem., 2007, 282, 27327-27333
80. Morenilla-palao, C.; Planells-cases, R.; Garcia-sanz, N.; Ferrermontiel, A. Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity, J. Biol. Chem., 2004, 279, 25665-25672
81. Zhang, X.; Huang, J.; Mcnaughton, P.A. NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. EMBO J., 2005, 24, 4211-4223
82. Stein, A.T.; Ufret-vincenty, C.A.; Hua, L.; Santana, L.F.M.; Gordon, S.E. Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane. J. Gen. Phys., 2006, 128, 509-522
83. Fu, Y.; Subramanya, A.; Rozansky, D.; Cohen, D.M. WNK kinases influence TRPV4 channel function and localization. Am. J. Physiol. Renal Physiol., 2006, 290, 1305-1314
84. Cuajungco, M.P.; Grimm, C.; Oshima, K.; D'hoedt, D.; Nilius, B.; Mensenkamp, A.R.; Bindels, R.J.; Plomann, M.; Heller, S. PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J. Biol. Chem., 2006, 281, 18753-18762
85. D'hoedt, D.; Owsianik, G.; Prenen, J.; Cuajungco, M.P.; Grimm, C.; Heller, S.; Voets, T.; Nilius, B. Stimulus-specific modulation of the cation channel TRPV4 by PACSIN3. J. Biol. Chem., 2008, 283, 6272-6280
86. Hoenderop, J.G.J.; Nilius, B.; Bindels, R.J. Calcium absorption across epithelia. Physiol. Rev., 2005, 85, 373-422
87. Cha, S.; Ortega, B.; Kurosu, H; Rosenblatt, K.P.; Kuro-O, M.; Huang, C. Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc. Natl. Acad. Sci. USA, 2008, 105, 9805-9810
88. 2+ channels TRPV5 and TRPV6 to the plasma membrane. Mol. Cell. Biol., 2006, 26, 303-312. Toro et al.
89. 2+-controlled recycling path-way. J. Biol. Chem., 2008, 283, 4077-4086
90. Glunde, K.; Guggino, S.E.; Solaiyappan, M.; Pathak, A.P.; Ichi-kawa, Y.; Bhujwalla, Z.M. Extracellular acidification alters lysosomal trafficking in human breast cancer cells. Neoplasia 2003, 5, 533-545
91. Keyes, S.R.; Rudnick, G. Coupling of transmembrane proton gra-dients to platelet serotonin transport. J. Biol. Chem., 1982, 257, 1172-1176
92. Lambers, T.T.; Oancea, E.; de Groot, T.; Topala, C.N.; Hoenderop, J.G.; Bindels, R.J. Extracellular pH dynamically controls cell sur-face delivery of functional TRPV5 channels. Mol. Cell Biol. 2007, 27, 1486-1494
93. Bezzerides, V.J.; Ramsey, I.S.; Kotecha, S.; Greka, A.; Clapham, D.E. Rapid vesicular translocation and insertion of TRP channels. Nat. Cell Biol., 2004, 6, 709-720
94. 2+ influx. Mol. Cell, 2004, 15, 635-646
95. Cayouette, S.; Lussier, M.P.; Mathieu, E.; Bousquet, S.M.; Boulay, G. Exocytotic insertion of TRPC6 channel into the plasma membrane upon Gq protein-coupled receptor activation. J. Biol. Chem., 2004, 279, 7241-7246
96. Oancea, E.; Wolfe, J.T.; Clapham, D.E. Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ. Res., 2006, 98, 245-253
97. Numata, T.; Shimizu, T.; Okada, Y. Direct mechano-stress sensitivity of TRPM7 channel. Cell Physiol. Biochem., 2007, 19, 1-8.
98. Prasad, P.; Yanagihara, A.A.; Small-Howard, A.L.; Turner, H.; Stokes, A.J. Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromo-granin A. J. Immunol., 2008, 181, 5024-5034
99. Schmidt, M.; Dubin, A.E.; Petrus, M.J.; Earley, T.J.; Patapoutian, A. Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron, 2009, 64, 498-509
100. Jahn, R.; Scheller, R.H. SNAREs-engines for membrane fusion. Nat. Rev. Mol. Cell Biol., 2006, 7, 631-643
101. 2+ entry in human platelets. J. Physiol., 2004, 558, 99-109
102. Somsel R.J.; Wandinger-Ness, A. Rab GTPases coordinate endocy-tosis. J. Cell Sci., 2000, 113, 183-192
103. Satoh, A.K.; Tousa, J.E.O.; Ozaki, K.; Ready, D.F. Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors. Development, 2005, 132, 1487-1497
104. Nichols, B.J.; Lippincott-Schwartz, J. Endocytosis without clathrin coats. Trends Cell Biol., 2001, 11, 406-412
105. Pelkmans, L.; Helenius, A. Endocytosis via caveolae. Traffic, 2002, 3, 311-320
106. Anderson, R.G.W.; Jacobson, K. A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science, 2002, 296, 1821-1825
107. Cha, S.; Wu, T.; Huang, C. Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5. Am. J. Physiol. Renal Physiol., 2008, 294, 1212-1221
108. Remillard, C.V.; Yuan, J.X. Transient receptor potential channels and caveolin-1: good friends in tight spaces. Mol. Pharmacol., 2006, 70, 1151-1154
109. Zhu, W.; Oxford, G.S. Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1. Mol. Cell Neurosci., 2007, 34, 689-700.
110. 2+ influx without disruption of Trp3-inositol trisphosphate recep-tor association. J. Biol. Chem., 2001, 276, 42401-42408
111. [111] Goswami, C.; Hucho, T.B.; Hucho, F. Identification and characterisation of novel tubulin-binding motifs located within the C-terminus of TRPV1. J. Neurochem., 2007, 101, 250-262. Sub-Cellular Distribution and Translocation of TRP Channels
112. 2+ influx channels by regulating plasma membrane localization of TRPC1. J. Biol. Chem., 2003, 278, 27208-27215
113. Rohacs, T.; Thyagarajan, B.; Lukacs, V. Phospholipase C mediated modulation of TRPV1 channels. Mol. Neurobiol., 2008, 37, 153-163
114. Torihashi, S.; Fujimoto, T.; Trost, C.; Nakayama, S. Calcium oscil-lation linked to pacemaking of interstitial cells of Cajal: require-ment of calcium influx and localization of TRP4 in caveolae. J. Biol. Chem., 2002, 277, 19191-19197
115. Stokes, A.J.; Wakano, C.; Del Carmen, K.A.; Koblan-Huberson, M.; Turner, H. Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2. J. Cell Biochem., 2005, 94, 669-683
116. Formigli, L.; Sassoli, C.; Squecco, R.; Bini, F.; Martinesi, M.; Chellini, F.; Luciani, G.; Sbrana, F.; Zecchi-Orlandini, S.; Francini, F.; Meacci, E. Regulation of transient receptor potential canonical channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts and its relevance for a role of mechanotransduction in skeletal muscle differentiation. J. Cell Sci., 2009, 122, 1322-1333. [117] Barnhill, J.C.; Stokes, A.J.; Koblan-Huberson, M.; Shimoda, L.M.; Muraguchi, A.; Adra, C.N.; Turner, H. RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. J. Cell Biochem., 2004, 91, 808-820
117. Morenilla-Palao, C.; Pertusa, M.; Meseguer, V.; Cabedo, H.; Viana, F. Lipid raft segregation modulates TRPM8 channel activity. J. Biol. Chem., 2009, 284, 9215-9224
118. Garcia-Elias, A.; Lorenzo, I.M.; Vicente, R.; Valverde, M.A. IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site. J. Biol. Chem., 2008, 283, 31284-31288
119. Lussier, M.P.; Cayouette, S.; Lepage, P.K.; Bernier, C.L.; Francoeur, N.; St-Hilaire, M.; Pinard, M.; Boulay, G. MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. J. Biol. Chem., 2005, 280, 19393-19400.
120. Alessandri-Haber, N.; Dina, O.A.; Joseph, E.K.; Reichling, D.B.; Levine, J.D. Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J. Neurosci., 2008, 28, 1046-1057
121. Schoeber, J.P.; Hoenderop, J.G.; Bindels, R.J. Concerted action of associated proteins in the regulation of TRPV5 and TRPV6. Bio-chem. Soc. Trans., 2007, 35, 115-119
122. Patel, S.; Docampo, R. In with the TRP channels: intracellular functions for TRPM1 and TRPM2. Sci. Signal., 2009, 2, 69. [124] Arniges, M.; Fernández-Fernández, J.M.; Albrecht, N.; Schaefer, M.; Valverde, M.A. Human TRPV4 channel splice variants re-vealed a key role of ankyrin domains in multimerization and traf-ficking. J. Biol. Chem., 2006, 281, 1580-1586
123. Zeevi, D.A.; Frumkin, A.; Bach, G. TRPML and lysosomal func-tion. Biochim. Biophys. Acta, 2007, 1772, 851-858
124. Grubisha, O.; Rafty, L.A.; Takanishi, C.L.; Xu, X.; Tong, L.; Perraud, A.L.; Scharenberg, A.M.; Denu, J.M. Metabolite of SIR2 re-action modulates TRPM2 ion channel. J. Biol. Chem., 2006, 281, 14057-14065
125. Simard, J.M.; Kahle, K.T.; Gerzanich, V. Molecular mechanisms of microvascular failure in central nervous system injury-synergistic roles of NKCC1 and SUR1/TRPM4. J.Neurosurg., 2010, 113(3), 622-9
126. Vennekens, R.; Nilius, B. Insights into TRPM4 function, regulation and physiological role. Handb. Exp. Pharmacol., 2007, 179, 269-285
127. Thompson, E.G.; Schaheen, L.; Dang, H.; Fares, H. Lysosomal trafficking functions of mucolipin-1 in murine macrophages. BMC Cell Biol., 2007, 21, 54
128. Touyz, R.M. Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension. Am. J. Physiol. Heart Circ. Physiol., 2008, 294, 1103-1118
129. 2+ entry. Role in signaling increased endothelial permeability. J. Biol. Chem., 2003, 278, 33492-33500
130. 2+)-binding proteins in the functional regulation of TRP channels. Pflugers Arch., 2005, 451, 105-115
131. Ko, K.D.; Bhardwaj, G.; Hong, Y.; Chang, G.S.; Kiselyov, K.; van Rossum, D.B.; Patterson, R.L. Phylogenetic profiles reveal struc-tural/functional determinants of TRPC3 signal-sensing antennae. Commun. Integr. Biol., 2009, 2, 133-137
132. Kim, J.Y.; Zeng, W.; Kiselyov, K.; Yuan, J.P.; Dehoff, M.H.; Mikoshiba, K.; Worley, P.F.; Muallem, S. Homer 1 mediates store-and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J. Biol. Chem., 2006, 281, 32540-32549
133. Bach, G. Mucolipin 1: endocytosis and cation channel-a review. Pflugers Arch., 2005, 451, 313-317
134. Miehe, S.; Bieberstein, A.; Arnould, I.; Ihdene, O.; Rüetten, H.; Strubing, C. The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. J. Biol. Chem., 2010, 285, 12426-12434
135. Puertollano, R.; Kiselyov, K. TRPMLs: in sickness and in health. Am. J. Physiol. Renal Physiol., 2009, 296, F1245-1254.
136. Obukhov, A.G.; Nowycky, M.C. TRPC5 activation kinetics are modulated by the scaffolding protein ezrin/radixin/moesin-binding phosphoprotein-50 (EBP50). J. Cell Physiol., 2004, 201, 227-235
137. Zhou, J.; Du, W.; Zhou, K.; Tai, Y.; Yao, H.; Jia, Y.; Ding, Y.; Wang, Y. Critical role of TRPC6 channels in the formation of excitatory synapses. Nat. Neurosci., 2008, 11, 741-743
138. Cronin, M.A.; Lieu, M.H.; Tsunoda, S. Two stages of light-dependent TRPL-channel translocation in Drosophila photorecep-tors. J. Cell Sci., 2006, 119, 2935-2944
139. 2+ channel by INAD in Drosophila photoreceptors. Neuron, 1996, 16, 991-998.