Porphorymonas gingivalis induces intracellular adhesion molecule-1 expression in endothelial cells through the nuclear factor-kappaB pathway, but not through the p38 MAPK pathway

Journal of Periodontal Research

Volumn 46, Issue 1, 2011, Pages 31-38

  Zhang, D ^a   Zheng, H ^a   Zhao, J ^a   Lin, L ^a   Li, C ^a   Liu, J ^a   Pan, Y ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Inflammation; Periodontal disease; Porphyromonas gingivalis

Indexed keywords

AUTACOID; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; TRANSCRIPTION FACTOR RELA; VIRULENCE FACTOR;

ACTIVE TRANSPORT; ANALYSIS OF VARIANCE; ARTICLE; BIOSYNTHESIS; CELL LINE; CELL NUCLEUS; CYTOLOGY; ENDOTHELIUM CELL; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; PERIODONTITIS; PHOSPHORYLATION; PHYSIOLOGY; PORPHYROMONAS GINGIVALIS; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; UMBILICAL VEIN;

ACTIVE TRANSPORT, CELL NUCLEUS; ANALYSIS OF VARIANCE; CELL LINE; CELL NUCLEUS; ENDOTHELIAL CELLS; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; INTERCELLULAR ADHESION MOLECULE-1; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PERIODONTITIS; PHOSPHORYLATION; PORPHYROMONAS GINGIVALIS; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; TRANSCRIPTION FACTOR RELA; UMBILICAL VEINS; VIRULENCE FACTORS;

EID: 78650861066     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2010.01305.x     Document Type: Article

References (35)

1. Yun PL, Decarlo AA, Chapple CC, Hunter N. Functional implication of the hydrolysis of platelet endothelial cell adhesion molecule 1 (CD31) by gingipains of porphyromonas gingivalis for the pathology of periodontal disease. Infect Immun 2005;73:1386-1398.
2. Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest 1976;34:235-249.
3. Nakamura N, Yoshida M, Umeda M et al. Extended exposure of lipopolysaccharide fraction from porphyromonas gingivalis facilitates mononuclear cell adhesion to vascular endothelium via toll-like receptor-2 dependent mechanism. Atherosclerosis 2008;196:59-67.
4. Klein CL, Bittinger F, Kohler H et al. Comparative studies on vascular endothelium in vitro. Pathobiology 1995;63:83-92.
5. Roebuck KA, Finnegan A. Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J Leukoc Biol 1999;66:876-888.
6. Chen CC, Manning AM. Transcriptional regulation of endothelial cell adhesion molecules: a dominant role for NF-kappa B. Agents Actions Suppl 1995;47:135-41.
7. Voraberger G, Schäfer R, Stratowa C. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester. J Immunol 1991;147:2777-2786.
8. Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination:the control of NF-[kappa]B activity. Annu Rev Immunol 2000;18:621-663.
9. May MJ, Ghosh S. Signal transduction through NF-kappa B. Immunol Today 1998;19:80-88.
10. Tamura DY, Moore EE, Johnson JL, Zallen G, Aiboshi J, Silliman CC. p38 mitogen-activated protein kinase inhibition attenuates intercellular adhesion molecule-1 up-regulation on human pulmonary microvascular endothelial cells. Surgery 1998;124:403-407.
11. Modur V, Zimmerman GA, Prescott SM, McIntyre TM. Endothelial cell inflammatory responses to tumor necrosis factor alpha. Ceramide-dependent and -independent mitogen-activated protein kinase cascades. J Biol Chem 1996;271:13094-13102.
12. Genco CA, Cutler CW, Kapczynski D, Maloney K, Arnold RR. A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis. Infect Immun 1991;59:1255-1263.
13. Sawada K, Kokeguchi S, Hongyo H et al. Identification by subtractive hybridization of a novel insertion sequence specific for virulent strains of Porphyromonas gingivalis. Infect Immun 1999;67:1562-1565.
14. Grenier D, Mayrand D. Selected characteristics of pathogenic and nonpathogenic strains of Bacteroides gingivalis. J Clin Microbiol 1987;25:738-740.
15. Tachibana-Ono M, Yoshida A, Kataoka S et al. Identification of the genes associated with a virulent strain of Porphyromonas gingivalis using the subtractive hybridization technique. Oral Microbiol Immunol 2008;23:84-87.
16. Eick S, Rödel J, Einax JW, Pfister W. Interaction of Porphyromonas gingivalis with KB cells: comparison of different clinical isolates. Oral Microbiol Immunol 2002;17:201-208.
17. Chen T, Hosogi Y, Nishikawa K et al. Comparative whole-genome analysis of virulent and avirulent strains of Porphyromonas gingivalis. J Bacteriol 2004;186:5473-5479.
18. Park Y, Yilmaz O, Jung IY, Lamont RJ. Identification of Porphyromonas gingivalis genes specifically expressed in human gingival epithelial cells by using differential display reverse transcription-PCR. Infect Immun 2004;72:3752-3758.
19. Chou HH, Yumoto H, Davey M et al. Porphyromonas gingivalis fimbria-dependent activation of inflammatory genes in human aortic endothelial cells. Infect Immun 2005;73:5367-5378.
20. Huang GT, Kim D, Lee JK, Kuramitsu HK, Haake SK. Interleukin-8 and intercellular adhesion molecule 1 regulation in oral epithelial cells by selected periodontal bacteria: multiple effects of Porphyromonas gingivalis via antagonistic mechanisms. Infenct Immun 2001;69:1364-1372.
21. Walter C, Zahlten J, Schmeck B et al. Porphyromonas gingivalis strain-dependent activation of human endothelial cells. Infect Immun 2004;72:5910-5918.
22. Dorn BR, Burks JN, Seifert KN, Progulske-Fox A. Invasion of endothelial and epithelial cells by strains of Porphyromonas gingivalis. FEMS Microbiol Lett 2000;187:139-144.
23. von der Hardt K, Kandler MA, Fink L et al. Laser-assisted microdissection and real-time PCR detect anti-inflammatory effect of perfluorocarbon. Am J Physiol Lung Cell Mol Physiol 2003;285:55-62.
24. Beshay VE, Havelock JC, Sirianni R et al. The mechanism for protein kinase C inhibition of androgen production and 17 alpha-hydroxylase expression in a theca cell tumor model. J Clin Endocrinol Metab 2007;92:4802-4809.
25. Bostanci N, Reddi D, Rangarajan M, Curtis MA, Belibasakis GN. Porphyromonas gingivalis stimulates TACE production by T cells. Oral Microbiol Immunol 2009;24:146-151.
26. Gibson FC, Yumoto H, Takahashi Y, Chou HH, Genco CA. Innate immune signaling and porphyromonas gingivalis-accelerated atherosclerosis. J Dent Res 2006;85:106-121.
27. Amar S, Han X. The impact of periodontal infection on systemic diseases. Med Sci Monit 2003;9:RA291-299.
28. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005;352:1685-1695.
29. Khlgatian M, Nassar H, Chou HH, Gibson FC, Genco CA. Fimbria-dependent activation of cell adhesion molecule expression in Porphyromonas gingivalis-infected endothelial cells. Infect Immun 2002;70:257-267.
30. Mao S, Maeno N, Matayoshi S, Yoshiie K, Fujimura T, Oda H. The induction of intercellular adhesion molecule-1 on human umbilical vein endothelial cells by a heat-stable component of Porphyromonas gingivalis. Curr Microbiol 2004;48:108-112.
31. Kusumoto Y, Hirano H, Saitoh K et al. Human gingival epithelial cells produce chemotactic factors interleukin-8 and monocyte chemoattractant protein-1 after stimulation with Porphyromonas gingivalis via toll-like receptor 2. J Periodontol 2004;75:370-379.
32. Baldwin AS. The NF-κB and IκB proteins: new discovers and insights. Ann Rev Immunol 1996;14:649-683.
33. Wu HC, Yeh YL, Kuo WW et al. p38 mitogen-activated protein kinase pathways are involved in the hypertrophy and apoptosis of cardiomyocytes induced by Porphyromonas gingivalis conditioned medium. Cell Biochem Funct 2008;26:246-255.
34. Dumitru CD, Ceci JD, Tsatsanis C et al. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERKdependent pathway. Cell 2000;103:1071-1083.
35. Bainbridge BW, Darveau RP. Porphyromonas gingivalis lipopolysaccharide: an unusual pattern recognition receptor ligand for the innate host defense system. Acta Odontol Scand 2001;59:131-138.