The mechanism for protein kinase C inhibition of androgen production and 17α-hydroxylase expression in a theca cell tumor model

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 12, 2007, Pages 4802-4809

  Beshay, Victor E ^a   Havelock, Jon C ^a   Sirianni, Rosa ^b   Ye, Ping ^c   Suzuki, Takashi ^d   Rainey, William E ^c   Carr, Bruce R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALABRIA   (Italy)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROGESTERONE; PROTEIN C FOS; PROTEIN KINASE C; SMALL INTERFERING RNA; STEROID 17ALPHA MONOOXYGENASE; STEROIDOGENIC FACTOR 1; TRANSCRIPTION FACTOR AP 1;

ANDROGEN SYNTHESIS; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; EXPERIMENTAL STUDY; FEMALE; GENE SILENCING; GENETIC TRANSFECTION; GRANULOSA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; MOLECULAR DYNAMICS; OVARY; PRIORITY JOURNAL; PROGESTERONE SYNTHESIS; PROMOTER REGION; QUANTITATIVE ANALYSIS; RNA EXTRACTION; THECA CELL; THECOMA; TUMOR MODEL;

EID: 36849028138     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-1394     Document Type: Article

References (39)

1. Suzuki T, Sasano H, Tamura M, Aoki H, Fukaya T, Yajima A, Nagura H, Mason JI 1993 Temporal and spatial localization of steroidogenic enzymes in premenopausal human ovaries-in-situ hybridization and immunohistochemical study. Mol Cell Endocrinol 97:135-143
2. Hanley NA, Rainey WE, Wilson DI, Ball SG, Parker KL 2001 Expression profiles of SF-1, DAX1, and CYP17 in the human fetal adrenal gland: potential interactions in gene regulation. Mol Endocrinol 15:57-68
3. Urs AN, Dammer E, Sewer MB 2006 Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1. Endocrinology 147:5249-5258
4. Dammer EB, Leon A, Sewer MB 2007 Coregulator exchange and sphingosine-sensitive cooperativity of steroidogenic factor-1, general control nonderepressed 5, p54, and p160 coactivators regulate cyclic adenosine 3′,5′-monophosphate-dependent cytochrome P450c17 transcription rate. Mol Endocrinol 21:415-438
5. McAllister JM, Hornsby PJ 1987 TPA inhibits the synthesis of androgens and cortisol and enhances the synthesis non-17 α-hydroxylated steroids in cultured human adrenocortical cells. Endocrinology 121:1908-1910
6. McAllister JM, Byrd W, Simpson ER 1994 The effects of growth factors and phorbol esters on steroid biosynthesis in isolated human theca interna and granulosa-lutein cells in long term culture. J Clin Endocrinol Metab 79:106-112
7. Bird IM, Pasquarette MM, Rainey WE, Mason JI 1996 Differential control of 17 α-hydroxylase and 3 β-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells. J Clin Endocrinol Metab 81:2171-2178
8. McGee EA, Nguyen A, Mason JI, Rainey WE, Carr BR 1996 Protein kinase A and protein kinase C differentially regulate steroidogenesis in human ovarian thecal tumor cells. Endocrine 4:151-157
9. Corbalan-Garcia S, Gomez-Fernandez JC 2006 Protein kinase C regulatory domains: the art of decoding many different signals in membranes. Biochim Biophys Acta 1761:633-654
10. Angel P, Karin M 1991 The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072:129-157
11. Jansen E, Laven JS, Dommerholt HB, Polman J, van Rijt C, van den HC, Westland J, Mosselman S, Fauser BC 2004 Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients. Mol Endocrinol 18:3050-3063
12. Carr BR, McGee EA, Sawetawan C, Rainey WE Development of a human thecal tumor cell model: regulation of steroidogenesis and enzyme expression. Symposium on Polycystic Ovarian Syndrome, Serono Symposia, Boston, MA, 1995, pp 165-195 (Abstract)
13. Rainey WE, Sawetawan C, McCarthy JL, McGee EA, Bird IM, Word RA, Carr BR 1996 Human ovarian tumor cells: a potential model for thecal cell steroidogenesis. J Clin Endocrinol Metab 81:257-263
14. Sawetawan C, Rainey WE, Word RA, Carr BR 1995 Immunohistochemical and biochemical analysis of a human Sertoli-Leydig cell tumor: autonomous steroid production characteristic of ovarian theca cells. J Soc Gynecol Investig 2:30-37
15. Attia GR, Rainey WE, Carr BR 2001 Metformin directly inhibits androgen production in human thecal cells. Fertil Steril 76:517-524
16. McGee EA, Sawetawan C, Bird I, Rainey WE, Carr BR 1996 The effect of insulin and insulin-like growth factors on the expression of steroidogenic enzymes in a human ovarian thecal-like tumor cell model. Fertil Steril 65:87-93
17. Sawetawan C, Carr BR, McGee E, Bird IM, Hong TL, Rainey WE 1996 Inhibin and activin differentially regulate androgen production and 17α-hydroxylase expression in human ovarian thecal-like tumor cells. J Endocrinol 148:213-221
18. Carr BR, McGee EA, Sawetawan C, Clyne CD, Rainey WE 1996 The effect of transforming growth factor-β on steroidogenesis and expression of key steroidogenic enzymes with a human ovarian thecal-like tumor cell model. Am J Obstet Gynecol 174:1109-1116
19. Bassett MH, Suzuki T, Sasano H, White PC, Rainey WE 2004 The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production. Mol Endocrinol 18:279-290
20. Sasano H, Mason JI, Sasano N 1989 Immunohistochemical study of cytochrome P-45017-α in human adrenocortical disorders. Hum Pathol 20:113-117
21. Shea-Eaton W, Sandhoff TW, Lopez D, Hales DB, McLean MP 2002 Transcriptional repression of the rat steroidogenic acute regulatory (StAR) protein gene by the AP-1 family member c-Fos. Mol Cell Endocrinol 188:161-170
22. Jo Y, King SR, Khan SA, Stocco DM 2005 Involvement of protein kinase C and cyclic adenosine 3′,5′-monophosphate-dependent kinase in steroidogenic acute regulatory protein expression and steroid biosynthesis in Leydig cells. Biol Reprod 73:244-255
23. Guo IC, Huang CY, Wang CK, Chung BC 2007 Activating protein-1 cooperates with steroidogenic factor-1 to regulate 3′,5′-cyclic adenosine 5′-monophosphate-dependent human CYP11A1 transcription in vitro and in vivo. Endocrinology 148:1804-1812
24. Kouzarides T, Ziff E 1988 The role of the leucine zipper in the fos-jun interaction. Nature 336:646-651
25. Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P 1988 c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 55:917-924
26. Wickenheisser JK, Quinn PG, Nelson VL, Legro RS, Strauss III JF, McAllister JM 2000 Differential activity of the cytochrome P450 17α-hydroxylase and steroidogenic acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells. J Clin Endocrinol Metab 85:2304-2311
27. Carey AH, Waterworth D, Patel K, White D, Little J, Novelli P, Franks S, Williamson R 1994 Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17. Hum Mol Genet 3:1873-1876
28. Gonzalez A, Abril E, Roca A, Aragon MJ, Figueroa MJ, Velarde P, Royo JL, Real LM, Ruiz A 2002 Comment: CAPN10 alleles are associated with polycystic ovary syndrome. J Clin Endocrinol Metab 87:3971-3976
29. Ehrmann DA, Schwarz PE, Hara M, Tang X, Horikawa Y, Imperial J, Bell GI, Cox NJ 2002 Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome. J Clin Endocrinol Metab 87:1669-1673
30. Gilling-Smith C, Willis DS, Beard RW, Franks S 1994 Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries. J Clin Endocrinol Metab 79:1158-1165
31. Curran T, Franza Jr BR 1988 Fos and Jun: the AP-1 connection. Cell 55:395-397.
32. Sharma SC, Richards JS 2000 Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation. J Biol Chem 275:33718-33728
33. Hall SH, Berthelon MC, Avallet O, Saez JM 1991 Regulation of c-fos, c-jun, jun-B, and c-myc messenger ribonucleic acids by gonadotropin and growth factors in cultured pig Leydig cell. Endocrinology 129:1243-1249
34. Bruder JM, Spaulding AJ, Wierman ME 1996 Phorbol ester inhibition of rat gonadotropin-releasing hormone promoter activity: role of Fos and Jun in the repression of transcription. Mol Endocrinol 10:35-44
35. Morgan JI, Curran T 1991 Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu Rev Neurosci 14:421-451
36. Morgan JI, Curran T 1995 Immediate-early genes: ten years on. Trends Neurosci 18:66-67
37. Rusovici R, LaVoie HA 2003 Expression and distribution of AP-1 transcription factors in the porcine ovary. Biol Reprod 69:64-74
38. Oktay KH, Oktay MH 2004 Immunohistochemical analysis of tyrosine phosphorylation and AP-1 transcription factors c-Jun, Jun D, and Fos family during early ovarian follicle development in the mouse. Appl Immunohistochem Mol Morphol 12:364-369
39. Ghosh S, Wu Y, Li R, Hu Y 2005 Jun proteins modulate the ovary-specific promoter of aromatase gene in ovarian granulosa cells via a cAMP-responsive element. Oncogene 24:2236-2246