Tissue- and cell type-specific modification of prion protein (PrP)-like protein Doppel, which affects PrP endoproteolysis

Biochemical and Biophysical Research Communications

Volumn 404, Issue 1, 2011, Pages 523-527

  Sakudo, Akikazu ^a,b   Onodera, Takashi ^b  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Doppel; Gene targeting; Glycosylation; Prion; Proteolysis

Indexed keywords

GLYCOPROTEIN; PRION PROTEIN; PRION PROTEIN LIKE PROTEIN DOPPEL; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BRAIN; CELL LINE; CELL SPECIFICITY; CELL TYPE; CONTROLLED STUDY; DEGLYCOSYLATION; GENETIC TRANSFECTION; GLYCOSYLATION; IMMUNOBLOTTING; NERVE CELL; NONHUMAN; PRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; TESTIS; TISSUE DISTRIBUTION;

ANIMALS; CELL LINE; EXONS; GLYCOSYLATION; GPI-LINKED PROTEINS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; ORGAN SPECIFICITY; PRIONS; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER;

EID: 78650858059     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.12.016     Document Type: Article

References (15)

1. Prusiner S.B. Prions. Proc. Natl. Acad. Sci. USA 1998, 95:13363-13383.
2. Moore R.C., Lee I.Y., Silverman G.L., Harrison P.M., Strome R., Heinrich C., Karunaratne A., Pasternak S.H., Chishti M.A., Liang Y., Mastrangelo P., Wang K., Smit A.F., Katamine S., Carlson G.A., Cohen F.E., Prusiner S.B., Melton D.W., Tremblay P., Hood L.E., Westaway D. Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J. Mol. Biol. 1999, 292:797-817.
3. c co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells. Biochem. J. 2009, 425:341-351.
4. Sakudo A., Onodera T., Suganuma Y., Kobayashi T., Saeki K., Ikuta K. Recent advances in clarifying prion protein functions using knockout mice and derived cell lines. Mini Rev. Med. Chem. 2006, 6:589-601.
5. Rossi D., Cozzio A., Flechsig E., Klein M.A., Rulicke T., Aguzzi A., Weissmann C. Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. EMBO J. 2001, 20:694-702.
6. Kuwahara C., Takeuchi A.M., Nishimura T., Haraguchi K., Kubosaki A., Matsumoto Y., Saeki K., Yokoyama T., Itohara S., Onodera T. Prions prevent neuronal cell-line death. Nature 1999, 400:225-226.
7. Sakudo A., Lee D.C., Yoshimura E., Nagasaka S., Nitta K., Saeki K., Matsumoto Y., Lehmann S., Itohara S., Sakaguchi S., Onodera T. Prion protein suppresses perturbation of cellular copper homeostasis under oxidative conditions. Biochem. Biophys. Res. Commun. 2004, 313:850-855.
8. Yokoyama T., Kimura K.M., Ushiki Y., Yamada S., Morooka A., Nakashiba T., Sassa T., Itohara S. In vivo conversion of cellular prion protein to pathogenic isoforms as monitored by conformation-specific antibodies. J. Biol. Chem. 2001, 276:11265-11271.
9. Lu K., Wang W., Xie Z., Wong B.S., Li R., Petersen R.B., Sy M.S., Chen S.G. Expression and structural characterization of the recombinant human doppel protein. Biochemistry 2000, 39:13575-13583.
10. Korth C., Stierli B., Streit P., Moser M., Schaller O., Fischer R., Schulz-Schaeffer W., Kretzschmar H., Raeber A., Braun U., Ehrensperger F., Hornemann S., Glockshuber R., Riek R., Billeter M., Wuthrich K., Oesch B. Prion (PrPSc)-specific epitope defined by a monoclonal antibody. Nature 1997, 390:74-77.
11. Perera W.S., Hooper N.M. Proteolytic fragmentation of the murine prion prote role of Tyr-128 and His-177. FEBS Lett. 1999, 463:273-276.
12. Silverman G.L., Qin K., Moore R.C., Yang Y., Mastrangelo P., Tremblay P., Prusiner S.B., Cohen F.E., Westaway D. Doppel is an expression in testis ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss. J. Biol. Chem. 2000, 275:26834-26841.
13. Nishida N., Tremblay P., Sugimoto T., Shigematsu K., Shirabe S., Petromilli C., Erpel S.P., Nakaoke R., Atarashi R., Houtani T., Torchia M., Sakaguchi S., DeArmond S.J., Prusiner S.B., Katamine S. A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelination. Lab. Invest. 1999, 79:689-697.
14. Chen S.G., Teplow D.B., Parchi P., Teller J.K., Gambetti P., Autilio-Gambetti L. Truncated forms of the human prion protein in normal brain and in prion diseases. J. Biol. Chem. 1995, 270:19173-19180.
15. Taylor D.R., Parkin E.T., Cocklin S.L., Ault J.R., Ashcroft A.E., Turner A.J., Hooper N.M. Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein. J. Biol. Chem. 2009, 284:22590-22600.