Analysis of acrylonitrile and α-methacrylonitrile in vapor phase of mainstream cigarette smoke using a charcoal trap for collection

Beitrage zur Tabakforschung International/ Contributions to Tobacco Research

Volumn 24, Issue 3, 2010, Pages 145-156

  Moldoveanu, Serban C ^a  

^a R J REYNOLDS TOBACCO COMPANY   (United States)

Author keywords

Acrylonitrile; Gc ms analysis; Vapor phase of cigarette smoke; methacrylonitrile

Indexed keywords

EID: 78650844627     PISSN: 0173783X     EISSN: 16129237     Source Type: Journal    
DOI: 10.2478/cttr-2013-0892     Document Type: Article

References (24)

1. Dube, M.F. and C.R. Green: Method for collection of smoke for analytical purposes; Recent Adv. Tob. Sci. 8 (1982) 42-102.
2. Byrd, G.D., K.W. Fowler, R.D. Hicks, M.E. Lovette, and M.F. Borgerding: Isotope dilution gas- chromatography-mass spectrometry in the deter- mination of benzene, toluene, styrene, and acrylonitrile in mainstream cigarette smoke; J. Chromatogr. 503 (1990) 359-368.
3. Dong, J.-Z., J.N. Glass, B.T. Thompson, B.F. Price, J.H. Lauterbach, and S.C. Moldoveanu: A simple technique for determining pH of whole cigarette smoke; Beitr. Tabakforsch. Int. 19 (2000) 33-48.
4. Diekmann, J., C. Biefel, and K. Rustemeier: Analysis of cigarette mainstream smoke for 1,1-dimethyl-hydrazine and vinyl acetate by gas chromatography- mass spectrometry; J. Chromatogr. Sci. 40 (2002) 509-514.
5. Houlgate, P.R., K.S. Dhingra, S.J. Nash, and W.H. Evans: Determination of formaldehyde and acetaldehyde in mainstream cigarette smoke by high- performance liquid chromatography; Analyst, 114 (1989) 355-360.
6. Dong, J.-Z., J.N. Glass, and S.C. Moldoveanu: A simple GC-MS technique for the analysis of vapor phase mainstream cigarette smoke; J. Microcol. Sep. 12 (2000) 142-152.
7. Omori, F., N. Higashi, M. Chida, Y. Sone, and S. Suhara: Internal standard-based analytical method for tobacco smoke vapor phase components; Beitr. Tabakforsch. Int. 18 (1999) 131-146.
8. Higgins C.E., W.H. Griest, and G. Olerich: Application of Tenax trapping to analysis of gas phase organic compounds in ultra-low tar cigarette smoke; J. Assoc. Off. Anal. Chem. 66 (1983) 1074-1083.
9. Hatzinikolaou, D.G., V. Lagesson, A.J. Stavridou, A.E. Pouli, L. Lagesson-Andrasko, and J.C. Stavrides: Analysis of the gas phase of cigarette smoke by gas chromatography coupled with UV-diode array detection; Anal. Chem. 78 (2006) 4509-4516.
10. Takanami, Y., M. Chida, H. Hasebe, Y. Sone, and S. Suhara: Analysis of cigarette smoke by an online thermal desorption system and multidimensional GC- MS; J. Chromatogr. Sci., 41 (2003) 317-322.
11. Koller, K. and C. Thomas: Puff-by-puff mainstream analysis by multiplex gas chromatography spectrometry; Beitr. Tabakforsch. Int. 19 (2001) 345-351.
12. Wagner K.A., R. Higby, and K. Stutt: Puff-by-puff analysis of selected mainstream smoke constituents in the Kentucky reference 2R4F cigarette; Beitr. Tabakforsch. Int. 21 (2005) 273-279.
13. Ye, Q.: Development of solid-phase microextraction followed by gas chromatography-mass spectrometry for rapid analysis of volatile organic chemicals in mainstream cigarette smoke; J. Chromatogr. A. 1213 (2008) 239-244.
14. Hoffmann, D., C. Patrianakos, K.D. Brunnemann, and G.B. Gori: Chemical studies on tobacco smoke. XXXVI. Chromatographic determination of vinyl chloride in tobacco smoke; Anal. Chem., 48 (1976) 47-50.
15. Moldoveanu, S., W.M. Coleman III, and J. Wilkins: Determination of benzene and toluene in exhaled cigarette smoke; Beitr. Tabakforsch. Int. 23 (2008) 106-113.
16. Moldoveanu, S.C. and V. David: Sample preparation in chromatography; Elsevier, Amsterdam, 2002, ISBN 0444503943.
17. EPA (1991): Integrated risk information system. US Environmental Protection Agency. Summary for acrylonitrile (CASRN 107-13-1), http://www.epa.gov/ncea/iris/subst/0206.htm (accessed October 2010).
18. IARC (1999): Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide; Lyon, International Agency for Research on Cancer (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 71).
19. Fennell, T.R., J.P. MacNeela, R.W. Morris, M. Watson, C.L. Thompson, and D.A. Bell: Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypes; Cancer Epidemiol. Biomarkers Prev. 9 (2000) 705-712.
20. Hoffmann D. and I. Hoffmann: Tobacco smoke components; Beitr. Tabakforsch. Int. 18 (1998) 49-52.
21. Nyska, A. and B.I. Ghanayem: Characterization of the toxicity, mutagenicity, and carcinogenicity of methacrylonitrile in F344 rats and B6C3F1 mice; Arch. Toxicol. 77 (2003) 233-242.
22. Pillsbury, H.C., C.C. Bright, K.J. O'Connor, and F.H. Irish: Tar and nicotine in cigarette smoke; J. Assoc. Off. Anal. Chem. 52 (1969) 458-462.
23. Intorp, M., S. Purkis, M. Whittaker, and W. Wright: Determination of "Hoffmann Analytes" in cigarette mainstream smoke. The Coresta 2006 Joint Experiment; Beitr. Tabakforsch. Int. 23 (2009) 161-202.
24. Chen, P.X. and S.C. Moldoveanu: Mainstream smoke chemical analyses for 2R4F Kentucky reference cigarette; Beitr. Tabakforsch. Int. 20 (2003) 448-458.