Analysis of cigarette mainstream smoke for 1,1-dimethylhydrazine and vinyl acetate by gas chromatography-mass spectrometry

Journal of Chromatographic Science

Volumn 40, Issue 9, 2002, Pages 509-514

  Diekmann, J ^a   Biefel, C ^a   Rustemeier, K ^a  

^a INBIFO Inst fur Biol Forsch   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIMETHYLHYDRAZINE; CELLULOSE ACETATE; CHARCOAL; CIGARETTE SMOKE; DIMAZINE; DIMETHYLHYDRAZINE; VINYL ACETATE; VINYL DERIVATIVE;

ADSORPTION; ANALYTIC METHOD; ARTICLE; CALIBRATION; CARCINOGENICITY; CHEMICAL ANALYSIS; CIGARETTE SMOKING; DECOMPOSITION; DERIVATIZATION; DRUG DETERMINATION; GAS CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SMOKE; SOLID PHASE MICROEXTRACTION; STANDARD; TOBACCO;

CALIBRATION; DIMETHYLHYDRAZINES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SMOKE; TOBACCO; VINYL COMPOUNDS;

NICOTIANA TABACUM;

EID: 0036801910     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/40.9.509     Document Type: Article

References (45)

1. IARC. Overall evaluations of carcinogenicity: An updating of IARC monographs volumes 1-42. IARC Monographs Suppl. 7: 37-74 (1987).
2. D. Hoffmann, I. Hoffmann, and E.L. Wynder. The Changing Cigarette, 1950-1997: Facts and Expectations. Proc. Canada Conference of Cigarette Toxicity Reduction. W.S. Rickert, Ed. Toronto, Ontario, Canada, 1998, pp. 1-94.
3. D. Hoffmann, I. Hoffmann, and K. El-Bayoumy. The less harmful cigarette: a controversial issue. A tribute to Ernst L. Wynder. Chem. Res. Toxicol. 14: 767-90 (2001).
4. C.J. Smith, T.A. Perfetti, A. Rumple, A. Rodgman, and D.J. Doolittle. "IARC group 2B carcinogens" reported in cigarette mainstream smoke. Food Chem. Toxicol. 39: 183-205 (2001).
5. S. Cathum, V. Atamaniouk, L. Ananieva, C. Ladanowski, and H. Whittaker. Gas chromatography-mass spectrometric determination of unsymdimethyl-hydrazine in soil and water by derivatization with aromatic aldehydes. Can. J. Chem. Engin. 76: 680-85 (1998).
6. V.A. Lopyrev, G.V. Dolgushin, and M.G. Voronkov. Applied chemistry of 1,1-dimethylhydrazine and its derivatives. Russ. J. Appl. Chem. 71: 1295-1309 (1998).
7. L.A. Fedorov. Liquid missile propellants in the former Soviet Union. Environ. Pollut. 105: 157-61 (1999).
8. J.P. Rouganne, A. Cierand, and P. Duca. Effects heÌpatiques d'une intoxication subaiqueÌ par I'hydrazine et la dimeÌthyl-hydrazine chez la souris. C.R. Soc. Biol. 163: 192-95 (1962).
9. C.F. Simpson and M.V. Barrow. Toxicity of a substituted hydrazine for turkeys. Arch. Environ. Health 25: 349-53 (1972).
10. J.-P. Chevrier and A. Pfister. EÌtude sur la toxiciteÌ de la 1,1 dimethylhydrazine chez l'animal: 2. Intoxication chronique. Eur. J. Toxicol. Environ. Hyg. 7: 242-46 (1974).
11. M.L. Barth, C.L. Geakeland, and H.H. Cornish. 1,1-Dimethylhydrazine induced diuresis. Toxicol. Appl. Pharmacol. 11: 26-34 (1967).
12. M. Sakita, H. Imai, M. Kasuga, N. Kageyama, S. Imaki, M. Tamai, Y. Fujita, and S. Majima. Effect of a protein-bound polysaccharide preparation, PS-K, on dimethyl hydrazine induction of intestinal tumors in rats. Gann. 74: 351-59 (1983).
13. O. Kimura, N. Kaibara, Y. Miyano, T. Okamoto, H. Tamura, E. Yurugi, and S. Koga. Nuclear DNA content in dimethylhydrazine-induced colonic carcinoma and muscosal dysplasia in rats. Cancer 53: 1918-22 (1984).
14. T. Tamura, M. Shibutani, K. Toyoda, T. Shoda, K. Takada, C. Uneyama, M. Takahashi, and M. Hirose. Tumor-promoting activities of hydroqinone and 1,1-dimethylhydrazine after initiation of newborn mice with 1-methyl-1-nitrosourea. Cancer Lett. 143: 71-80 (1999).
15. I. Schmeltz, S. Abidi, and D. Hoffmann. Tumorigenic agents in unburned processed tobacco: N-nitrosodiethanolamine and 1,1 - dimethylhydrazine. Cancer Lett. 2: 125-32 (1977).
16. U.S. Department of Health and Human Services. National Toxicology Program. Report on Carcinogens, 9th Ed. 2001. http://ehp.niehs.nih.gov/roc/ninth/rahc/1_1-dimethylehy drazine.pdf. National Institute of Environmental Health Sciences, Triangle Park, NC.
17. D. Hoffmann. Personal communication (2002).
18. M.A. Rutschmann and H.-R. Buser. Determination of daminozide and dimethylhydrazine residues in Swiss apple juice concentrates using gas chromatography-mass spectrometry. J. Agric. Food Chem. 39: 176-81 (1991).
19. J.T. Veal. The analysis of hydrazine, monomethyl hydrazine and 1,1-dimethylhydrazine using GC techniques. Proc. Conf. Environ. Chem. 79-97 (1977).
20. J.R. Holtzclaw, S.L. Rose, J.R. Wyatt, D.P. Rounbehler, and D.H. Fine. Simultanous determination of hydrazine, methylhydrazine, and 1,1-dimethylhydrazine in air by derivatization/gas chromatography. Anal. Chem. 56: 2952-56 (1984).
21. K.T. Faughnan and M.A. Woodruff. Modified gas chromatographic/mass spectrometric method for the determination of daminozide in high protein food products. J. Assoc. Off. Anal. Chem. 74: 682-92 (1991).
22. W.L. Saxton, K. Steinbrecher, and E. Gunderson. Results of a survey for the presence of daminozide and unsymmetrical dimethylhydrazine in food. J. Agric. Food Chem. 37: 570-73 (1989).
23. T.K. Majumdar, P.W. Geno, and A. Yau. Determination of daminozide residues at very low levels in fruits by gas chromatography/mass spectrometry. J. Agric. Food Chem. 43: 1421-23 (1995).
24. J.H. Brinkman, A.G. van Dijk, R. Wagenaar, and J.K. Quirijns. Determination of daminozide residues in apples using gas chromatography with nitrogen-phosphorous detection. J. Chromatogr. A 723: 355-60 (1996).
25. D.P. Samsonov, G.V. Bornovalova, R.I. Pervunina, and N.P. Zhiryukhina. Determination of N,N-dimehtylhydrazine in soil by gas chromatography-mass spectrometry. J. Anal. Chem. 53: 169-72 (1998).
26. C.A. McDaniel and R.W. Howard. Mass spectral determination of aldehydes, ketones, and carboxylic acids using 1,1-dimethylhydrazine. J. Chem. Ecol. 11: 303-10 (1985).
27. W.J.A. VandenHeuvel and E.C. Horning. Gas-chromatographic characterization of steroid ketones as N,N-dimethylhydrazones. Biochim. Biophys. Acta 74: 560-63 (1963).
28. C.N. Kunigami, M.S. Sanctos, and M.H.W. Morelli-Cardoso. Development of a methodology for the identification of volatiles in industrial adhesive formulations by GC/MS with manual head-space sampling. J. High Resol. Chromatogr. 22(8): 477-80 (1999).
29. M.S. Bogdanffy, T.R. Tyler, M.B. Vinegar, R.W. Rickard, F.M.B. Carpanini, and T.C. Cascieri. Chronic exposure and oncogenicity study with vinyl acetate in the rat. In Utero exposure in drinking water. Fundam Appl. Toxicol. 23: 206-14 (1994).
30. M.S. Bogdanffy, D.R. Plowchalk, R. Sarangapani, T.B. Starr, and M.E. Andersen. Mode-of-action-based dosimeters for interspecies extrapolation of vinyl acetate inhalation risk. Inhal. Toxicol. 13: 377-96 (2001).
31. J.R. Newsome, V. Norman, and C.H. Keith. Vapor phase analysis of tobacco smoke. Tob. Sci. 4: 24-32 (1965).
32. V. Norman. An overview of the vapor phase, semivolatile and nonvolatile components of cigarette smoke. Recent Adv. Tob. Sci. 3: 28-58 (1977).
33. M.R. Guerin. "Chemical Composition of Cigarette Smoke." In Banbury Report: A Safe Cigarette? G.B. Gori and F.G. Bock, Eds. CSH Press, Cold Spring Harbor, NY, 1980, Vol. 3, pp. 191-204.
34. IARC. Monographs on the evaluation of carcinogenic risks to human. IARC Monographs Suppl. 63: 443-65 (1995).
35. T.H. Wang, H. Shanfield, and A. Zlatkis. Analysis of trace volatile organic compounds in coffee by headspace concentration and gas chromatography-mass spectrometry. Chromatographia 17: 411-17 (1983).
36. C.N. Kunigami, M.S. Sanctos, and M.H.W. Morelli-Cardoso. Development of a methodology for the identification of volatiles in industrial adhesive formulations by GC/MS with manual head-space sampling. J. High Resol. Chromatogr. 22(8): 477-80 (1999).
37. C.H. Watson and D.L. Ashley. Quantitative analysis of acetates in cigarette tobacco using solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. Sci. 38: 137-44 (2000).
38. International Standard ISO 3402, Tobacco and Tobacco Products - Atmosphere for Conditioning and Testing, 3rd Ed. 1991. International Organization for Standardization, GeneÌve, Switzerland.
39. International Standard ISO 3308, Cigarettes - Routine Analytical Cigarette Smoking Machine - Definitions and Standard Conditions, 3rd Ed. 1991. International Organization for Standardization, GeneÌve, Switzerland.
40. G.D. Byrd, K.W. Fowler, R.D. Hicks, M.E. Lovette, and M.F. Borgerding. Isotope dilution gas chromatography-mass spectrometry in the determination of benzene, toluene, styrene and acrylonitrile in mainstream cigarette smoke. J. Chromatogr. 503: 359-68 (1990).
41. L.S. Bark and P. Prachuabpaibul. The thermometric determination of some aldehydes by hydrazone formation with unsymmetrical dimethylhydrazine. Anal. Chim. Acta 84: 207-10 (1976).
42. R.F. Smith, J.L. Marucci, and P.S. Tingue. Base-promoted elimination reactions of acetaldehyde N-alkyl-N,N-dimethylhydrazonium salts. A convient synthesis of N,N-dimethylalkylamines. Synth. Commun. 22: 381-89 (1992).
43. C.J. Smith, T.A. Perfetti, M.A. Rumple, A. Rodgman, and D.J. Doolittle. IARC group 2A carcinogens" reported in cigarette mainstream smoke. Food Chem. Toxicol. 38: 371-83 (2000).
44. M. Castegnaro, I. Brouet, J. Michelon, G. Lunn, and E.B. Sansone. Oxidative destruction of hydrazines produces N-nitrosamines and other mutagenic species. Am. Ind. Hyg. Assoc. J. 47: 360-64 (1986).
45. G. Lunn and E.B. Sansone. Oxidation of 1,1-dimethylhydrazine (UDMH) in aqueous solution with air and hydrogen peroxide. Chemosphere 29: 1577-90 (1994).