Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells

Experimental and Molecular Medicine

Volumn 42, Issue 12, 2010, Pages 849-855

  Kwon, Haw Young ^a   Kim, Seok Jo ^a   Kim, Cheorl Ho ^b   Son, Sung Wook ^a   Kim, Kyoung Sook ^a   Lee, Jai Heon ^a   Do, Su Il ^c   Lee, Young Choon ^a  

^a Dong A University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c Ajou University   (South Korea)

Author keywords

8 sialyltransferase; Gene expression regulation; Melanoma; NF B; Triptolide; n acetylneuraminate 2

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GD3 SYNTHASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SYNTHETASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR ETS 1; TRIPTOLIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA FLANKING REGION; DOWN REGULATION; DRUG MECHANISM; GENE; GENE DELETION; GENE EXPRESSION; GENE REPRESSION; HST8SIA I GENE; HUMAN; HUMAN CELL; MELANOMA CELL; PROMOTER REGION; SITE DIRECTED MUTAGENESIS;

EID: 78650837399     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2010.42.12.088     Document Type: Article

References (45)

1. Baeuerle PA, Baltimore D. NF-k{cyrillic}B: ten years after. Cell 1996;87:13-20
2. Brinker AM, Ma J, Lipsky PE, Raskin I. Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry 2007;68:732-766
3. Carter BZ, Mak DH, Schober WD, McQueen T, Harris D, Estrov Z, Evans RL, Andreeff M. Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells. Blood 2006;108:630-637
4. Chang HJ, Kim MH, Baek MK, Park JS, Chung IJ, Shin BA, Ahn BW, Jung YD. Triptolide inhibits tumor promoterinduced uPAR expression via blocking NF-k{cyrillic}B signaling in human gastric AGS cells. Anticancer Res 2007;27:3411-3417
5. Chen BJ. Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F. Leuk Lymphoma 2001; 42:253-265
6. Chen F, Castranova V, Shi X. New insights into the role of nuclear factor-k{cyrillic}B in cell growth regulation. Am J Pathol 2001;159:387-397
7. Chen Q, Lu Z, Jin Y, Wu Y, Pan J. Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1. Cancer Lett 2010; 291:246-255
8. Cheung NK, Saarinen UM, Neely JE, Landmeier B, Donovan D, Coccia PF. Monoclonal antibodies to a glycolipid antigen on human neuroblastoma cells. Cancer Res 1985;45: 2642-2649
9. Choi YJ, Kim TG, Kim YH, Lee SH, Kwon YK, Suh SI, Park JW, Kwon TK. Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells. Biochem Pharmacol 2003;66:273-280
10. Dippold WG, Lloyd KO, Li LT, Ikeda H, Oettgen HF, Old LJ. Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies. Proc Natl Acad Sci USA 1980;77:6114-6118
11. Fukuda M, Horibe K, Furukawa K. Enhancement of in vitro and in vivo anti-tumor activity of anti-GD2 monoclonal antibody 220-51 against human neuroblastoma by granulocyte- macrophage colony-stimulating factor and granulocyte colony-stimulating factor. Int J Mol Med 1998;2:471-475
12. Hakomori S. Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. Annu Rev Biochem 1981; 50:733-764
13. Hakomori S, Igarashi Y. Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling. Adv Lipid Res 1993;25:147-162
14. Hakomori S. Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism. Cancer Res 1996;56:5309-5318
15. Haraguchi M, Yamashiro S, Yamamoto A, Furukawa K, Takamiya K, Lloyd KO, Shiku H, Furukawa K. Isolation of GD3 synthase gene by expression cloning of GM3 α-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. Proc Natl Acad Sci USA 1994;91:10455-10459
16. Jang BC, Lim KJ, Choi IH, Suh MH, Park JG, Mun KC, Bae JH, Shin DH, Suh SI. Triptolide suppresses interleukin- 1β-induced human β-defensin-2 mRNA expression through inhibition of transcriptional activation of NF-k{cyrillic}B in A549 cells. Int J Mol Med 2007;19:757-763
17. Johnson SM, Wang X, Mark Evers B. Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors. J Surg Res 2009 Aug 5 [Epub ahead of print]
18. Kang DW, Lee JY, Oh DH, Park SY, Woo TM, Kim MK, Park MH, Jang YH, Min DS. Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDAMB-231 breast cancer cells. Exp Mol Med 2009;41:678-685
19. Kang NY, Kang SK, Lee YC, Choi HJ, Lee YS, Cho SY, Kim YS, Ko JH, Kim CH. Transcriptional regulation of the human GD3 synthase gene expression in Fas-induced Jurkat T cells: a critical role of transcription factor NF-k{cyrillic}B in regulated expression. Glycobiology 2006;16:375-389
20. Kang NY, Kim CH, Kim KS, Ko JH, Lee JH, Jeong YK, Lee YC. Expression of the human CMP-NeuAc:GM3 α-2,8 sialyltransferase (GD3 synthase) gene through the NF-k{cyrillic}B activation in human melanoma SK-MEL-2 cells. Biochim Biophys Acta 2007;1769:622-630
21. Kwon HY, Dae HM, Song NR, Kim KS, Kim CH, Lee YC. Valproic acid induces transcriptional activation of human GD3 synthase (hST8Sia I) gene in SK-N-BE(2)-C human neuroblastoma cells. Mol Cells 2009;27:113-118
22. Lee KY, Chang W, Qiu D, Kao PN, Rosen GD. PG490 (triptolide) cooperates with tumor necrosis factor-α to induce apoptosis in tumor cells. J Biol Chem 1999;274:13451-13455
23. Liu H, Liu ZH, Chen ZH, Yang JW, Li LS. Triptolide: a potent inhibitor of NF-k{cyrillic}B in T-lymphocytes. Acta Pharmacol Sin 2000;21:782-786
24. Yinjun L, Jie J, Yungui W. Triptolide inhibits transcription factor NF-kB and induces apoptosis of multiple myeloma cells. Leuk Res 2005;29:99-105
25. Old LJ. Cancer immunology: the search for specificity--G. H. A. Clowes Memorial lecture. Cancer Res 1981;41:361-375
26. Pan J. RNA polymerase - An important molecular target of triptolide in cancer cells. Cancer Lett 2010;292:149-152
27. Phillips PA, Dudeja V, McCarroll JA, Borja-Cacho D, Dawra RK, Grizzle WE, Vickers SM, Saluja AK. Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70. Cancer Res 2007;67:9407-9416
28. Portoukalian J, Zwingelstein G, Dore JF. Lipid composition of human malignant melanoma tumors at various levels of malignant growth. Eur J Biochem 1979;94:19-23
29. Pukel CS, Lloyd KO, Travassos LR, Dippold WG, Oettgen HF, Old LJ. GD3, a prominent ganglioside of human melanoma. Detection and characterisation by mouse monoclonal antibody. J Exp Med 1982;155:1133-1147
30. Qiu D, Kao PN. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook F. Drugs R D 2003;4:1-18
31. Ruan S, Raj BK, Lloyd KO. Relationship of glycosyltransferases and mRNA levels to ganglioside expression in neuroblastoma and melanoma cells. J Neurochem 1999; 72:514-521
32. Sasaki K, Kurata K, Kojima N, Kurosawa N, Ohta S, Hanai N, Tsuji S, Nishi T. Expression cloning of a GM3-specific α-2,8-sialyltransferase (GD3 synthase). J Biol Chem 1994; 269:15950-15956
33. Shi X, Jin Y, Cheng C, Zhang H, Zou W, Zheng Q, Lu Z, Chen Q, Lai Y, Pan J. Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation. Clin Cancer Res 2009;15:1686-1697
34. Svennerholm L. Gangliosides and synaptic transmission. Adv Exp Med Biol 1980;125:533-544
35. Thampoe IJ, Furukawa K, Vellvé E, Lloyd KO. Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells. Cancer Res 1989; 49:6258-664
36. Varki A. Biological roles of oligosaccharides: all of the theories are correct. Glycobiology 1993;3:97-130
37. Wang Z, Jin H, Xu R, Mei Q, Fan D. Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression. Exp Mol Med 2009;41:717-727
38. Xu B, Guo X, Mathew S, Armesilla AL, Cassidy J, Darling JL, Wang W. Triptolide simultaneously induces reactive oxygen species, inhibits NF-k{cyrillic}B activity and sensitizes 5-fluorouracil in colorectal cancer cell lines. Cancer Lett 2010;291:200-208
39. Yamaguchi H, Furukawa K, Fortunato SR, Livingston PO, Lloyd KO, Oettgen HF, Old LJ. Cell-surface antigens of melanoma recognized by human monoclonal antibodies. Proc Natl Acad Sci USA 1987;84:2416-2420
40. Yamashiro S, Okada M, Haraguchi M, Furukawa K, Lloyd KO, Shiku H, Furukawa K. Expression of α2,8-sialyltransferase (GD3 synthase) gene in human cancer cell lines: high level expression in melanomas and up-regulation in activated T lymphocytes. Glycoconj J 1995;12:894-900
41. Yang S, Chen J, Guo Z, Xu XM, Wang L, Pei XF, Yang J, Underhill CB, Zhang L. Triptolide inhibits the growth and metastasis of solid tumors. Mol Cancer Ther 2003;2:65-72
42. Zhang H, Zhang S, Cheung NK, Ragupathi G, Livingston PO. Antibodies against GD2 ganglioside can eradicate syngeneic cancer micrometastases. Cancer Res 1998;58: 2844-2849
43. Zhou HF, Niu DB, Xue B, Li FQ, Liu XY, He QH, Wang XH, Wang XM. Triptolide inhibits TNF-α, IL-1β and NO production in primary microglial cultures. Neuroreport 2003;14:1091-1095
44. Zhu W, Hu H, Qiu P, Yan G. Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-k{cyrillic}B-related mechanism. Oncol Rep 2009a;22:1397-1401
45. Zhu W, Ou Y, Li Y, Xiao R, Shu M, Zhou Y, Xie J, He S, Qiu P, Yan G. A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-k{cyrillic}B pathway. Mol Pharmacol 2009b;75:812-819