A porcine model of acute, haematogenous, localized osteomyelitis due to Staphylococcus aureus: A pathomorphological study

APMIS

Volumn 119, Issue 2, 2011, Pages 111-118

  Johansen, Louise Kruse ^a   Frees, Dorte ^a   Aalbæk, Bent ^a   Koch, Janne ^a   Iburg, Tine ^a   Nielsen, Ole Lerberg ^a   Leifsson, Pall Skuli ^a   Jensen, Henrik Elvang ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Haematogenous osteomyelitis; Intra arterial inoculation; Pathomorphology; Pig; Staphylococcus aureus

Indexed keywords

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; BONE DISEASE; COLONY FORMING UNIT; DISEASE MODEL; FEMALE; HEMATOGENOUS OSTEOMYELITIS; NONHUMAN; OSTEOMYELITIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; SWINE;

ACUTE DISEASE; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; OSTEOMYELITIS; STAPHYLOCOCCAL INFECTIONS; SWINE;

EID: 78650807278     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2010.02700.x     Document Type: Article

References (26)

1. Goergens ED, McEvoy A, Watson M, Barrett IR. Acute osteomyelitis and septic arthritis in children. J Paediatr Child Health 2005;41:59-62.
2. Lazzarini L, Mader JT, Calhoun JH. Osteomyelitis in long bones. J Bone Joint Surg Am 2004;86-A:2305-18.
3. Gelfand MS, Cleveland KO, Heck RK, Goswami R. Pathological fracture in acute osteomyelitis of long bones secondary to community-acquired methicillin-resistant Staphylococcus aureus: two cases and review of the literature. Am J Med Sci 2006;332:357-60.
4. Perlman MH, Patzakis MJ, Kumar PJ, Holtom P. The incidence of joint involvement with adjacent osteomyelitis in pediatric patients. J Pediatr Orthop 2000;20:40-3.
5. Kao HC, Huang YC, Chiu CH, Chang LY, Lee ZL, Chung PW, et al. Acute hematogenous osteomyelitis and septic arthritis in children. J Microbiol Immunol Infect 2003;36:260-5.
6. Saavedra-Lozano J, Mejias A, Ahmad N, Peromingo E, Ardura MI, Guillen S, et al. Changing trends in acute osteomyelitis in children: impact of methicillin-resistant Staphylococcus aureus infections. J Pediatr Orthop 2008;28:569-75.
7. An YH, Kang QK, Arciola CR. Animal models of osteomyelitis. Int J Artif Organs 2006;29:407-20.
8. Hau J, Van Hoosier GL, editors. Animal Models. In: Handbook of Laboratory Animal Science, Vol. 2. Florida: CRC Press, 2002:1-9.
9. Lew DP, Waldvogel FA Osteomyelitis. Lance 2004;364:369-79.
10. Deysine M, Rosario E, Isenberg HD. Acute hematogenous osteomyelitis: an experimental model. Surgery 1976;79:97-9.
11. Jensen HE, Nielsen OL, Agerholm JS, Iburg T, Johansen LK, Johannesson E, et al. A non-traumatic Staphylococcus aureus osteomyelitis model in pigs. In vivo 2010;24:257-64.
12. Jensen HE, Jensen B, Arnbjerg J, Aalbæk B. Chronic purulent osteomyelitis complicated by chondritis at the costochondral junction of slaughter pigs. Eur J Vet Pathol 1999;5:3-7.
13. Koschmieder R, Ritzerfeld W, Homeyer L. Gentamycinzusatz zum polymethylmethacrylat zur behandlung von Knocheninfektionen. Z Orthop 1975;113:147-9.
14. Patterson AL, Galloway RH, Baumgartner JC, Barsoum IS. Development of chronic mandibular osteomyelitis in a miniswine model. J Oral Maxillofac Surg 1993;51:1358-62.
15. Leifsson PS, Iburg T, Jensen HE, Agerholm JS, Kjelgaard-Hansen M, Wiinberg B, et al. Intravenous inoculation of Staphylococcus aureus in pigs induces severe sepsis as indicated by increased hypercoagulability and hepatic dysfunction. FEMS Microbiol Lett 2010;309:208-16.
16. Harris DL, Alexander TJL. Methods of Disease Control. In: Taylor DJ, Mengeling WL, Dállaire SY, Straw BE, editors. Diseases of Swine. Iowa: Iowa State University Press, 1999:1077-1110.
17. Nielsen OL, Iburg T, Aalbaek B, Leifsson PS, Agerholm JS, Heegaard P, et al. A pig model of acute Staphylococcus aureus induced pyemia. Acta Vet Scand 2009;51:14.
18. Sambrook J, Russell DW, editors. Molecular Cloning: A Laboratory Manual, Vol. 3. New York: Cold Spring Harbor Laboratory Press, 2001.
19. Bancroft JD, Stevens A, editors. Theory and Practice of Histological Techniques. New York: Churchill Livingstone, 1996.
20. Smeltzer MS, Thomas JR, Hickmon SG, et al. Characterization of a rabbit model of staphylococcal osteomyelitis. J Orthop Res 1997;15:414-21.
21. Hienz SA, Sakamoto H, Flock JI, Morner AC, Reinholt FP, Heimdahl A, et al. Development and characterization of a new model of hematogenous osteomyelitis in the rat. J Infect Dis 1995;171:1230-6.
22. Thompson RH, Dubos RJ. Production of experimental osteomyelitis in rabbits by intravenous injection of Staphylococcus aureus. J Exp Med 1938;68:191-206.
23. Dehring DJ, Crocker SH, Wismar BL, Steinberg SM, Lowery BD, Cloutier CT. Comparison of live bacteria infusions in a porcine model of acute respiratory failure. J Surg Res 1983;34:151-8.
24. Emslie KR, Ozanne NR, Nade SM. Acute haematogenous osteomyelitis: an experimental model. J Pathol 1983;141:157-67.
25. Russell WMS, Burch RL, editors. The principle of Humane Experimental Technique. London: Methuen & Co, 1959.
26. Speers DJ, Nade SM. Ultrastructural studies of adherence of Staphylococcus aureus in experimental acute hematogenous osteomyelitis. Infect Immun 1985;49:443-6.