Sex and age related differences in drug induced QT prolongation by dofetilide under reduced repolarization reserve in simulated ventricular cells

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10

Volumn , Issue , 2010, Pages 3245-3248

  Gonzalez, Rodolfo ^a,b   Gomis Tena, Julio ^b   Corrias, Alberto ^c   Ferrero, Maria Jose ^a   Rodriguez, Blanca ^c   Saiz, Javier ^b  

^a INSTITUTO TECNOLÓGICO DE MORELIA   (Mexico)

^b UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIALS; ADULT FEMALES; AGE-DEPENDENT DIFFERENCES; AGE-RELATED; ANTIARRHYTHMIC DRUG; DOFETILIDE; LEFT VENTRICULAR; LUO-RUDY MODEL; MALE CELLS; QT PROLONGATION; REGIONAL DIFFERENCES; REPOLARIZATION; VENTRICULAR CELLS;

ELECTROPHYSIOLOGY;

COMPUTER SIMULATION;

ANTIARRHYTHMIC AGENT; DOFETILIDE; PHENETHYLAMINE DERIVATIVE; SULFONAMIDE;

ACTION POTENTIAL; AGING; ARTICLE; BIOLOGICAL MODEL; CHEMICALLY INDUCED DISORDER; COMPUTER SIMULATION; DRUG EFFECT; FEMALE; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HEART VENTRICLE; HUMAN; LONG QT SYNDROME; MALE; PATHOLOGY; PATHOPHYSIOLOGY; SEX DIFFERENCE;

ACTION POTENTIALS; AGING; ANTI-ARRHYTHMIA AGENTS; COMPUTER SIMULATION; FEMALE; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HUMANS; LONG QT SYNDROME; MALE; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; PHENETHYLAMINES; SEX FACTORS; SULFONAMIDES;

EID: 78650804481     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2010.5627415     Document Type: Conference Paper

References (14)

1. R.R. Makkar, B.S. Fromm, R.T. Steinman, M.D. Meissner, M.H. Lehmann,-Female gender as a risk factor for Torsade de Pointes associated with cardiovascular drugs," J Am Med Assoc, vol 270, pp 2590-2597, 1993.
2. P.M. Rautaharju, S.H. Zhuo, S. Wong et al, -Sex differences in the evolution of the electrocardiographic QT interval with age ," Can J Cardiol, vol 8, pp. 690-695,1992.
3. E.H. Locati, W. Zareba, A.J. Moss et al, -Age-sex-related differences in clinical manifestations in patients with congenital long QT syndrome: findings from the International LQTS Registry," Circulation, vol 97 pp. 2237-2244, 1998.
4. E Carmeliet, -Repolarization reserve in cardiac cells," Journal of Medical and Biological Engineering, vol 26(3) pp. 97-105, 2006.
5. D.M. Roden, -Long QT syndrome: reduced repolarization reserve and the genetic link," J. Intern. Med., vol 259 pp. 59-69, 2006.
6. C.H. Luo, Y. Rudy, -A dynamic model of the cardiac ventricular action potential. I. Simlations of ionic currents and concentration changes, Circ. Res., vol 74, pp. 1071-1096, 1994.
7. R. Dumaine, J.A. Towbin, P. Brugada et al, -Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent," Circ. Res., vol 85, pp. 803-809, 1999.
8. C. Sims, S. Reisenweber, P.C. Viswanathan et al, -Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with druginduced long QT type 2, Circ. Res., vol. 102, pp. 86-100, 2008.
9. X.K. Liu, A. Katchman, M.D. Drici et al, - Gender difference in the cycle length-dependent QT and potassium currents in rabbits, J Pharmacol Exp Ther, vol 285,pp. 672-679, 1998.
10. P.C. Viswanathan, R.M. Shaw,Y. Rudy, -Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: A simulation study," Circulation, vol. 99, pp. 2466-2474,1999.
11. M.N. Obreztchikova, E.A. Sosunov, A. Plotnikov et al, -Developmental changes in IKr and IKs contribute to age-related expression of dofetilide effects on repolarization and proarrhythmia," Cardiovascular Research, vol. 59, pp. 339-350, 2003.
12. R.H. Clayton, A.V. Holden -Propagation of normal beats and re-entry in a computational model of ventricular cardiac tissue with regional differences in action potential shape and duration," Progress in Biophysics and Molecular Biology, vol. 85, pp. 473-499, 2004.
13. M. Weerapura,T.E. Herbert, S. Nattel, -Dofetilide block involves interactions with open and inactivated states of Herg channels, Pflugers Archiv, vol 443, pp. 520-531, 2002.
14. W. Zareba, A.J. Moss, E.H. Locati et al, -Modulating effects of age and gender on the clinical course of long QT syndrome by genotype, J. American Coll. Of Cardiology, vol. 42, pp. 103-109, 2003.